MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells.

abstract：:The involvement of sodium/potassium-ATPase in regulating parathyroid hormone (PTH) secretion is inferred from in vitro studies. Recently, the α-klotho-dependent rapid recruitment of this ATPase to the parathyroid cell plasma membrane in response to low extracellular calcium ion was suggested to be linked to increased ...

journal_title：Kidney international

authors： Martuseviciene G,Hofman-Bang J,Clausen T,Olgaard K,Lewin E

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Macrophages have been regarded as "blackguards" in the generation of glomerular injury. However, it is still unclear what kind of cellular machinery is responsible for their pathogenic actions. To explore this issue, this investigation aims at developing a novel strategy using adoptive transfer of "loss-of-f...

journal_title：Kidney international

authors： Kitamura M

更新日期：2000-02-01 00:00:00

abstract：:Fibroblast growth factor-23 (FGF23), a regulator of mineral metabolism, has been linked to cardiovascular disease in chronic kidney disease. As community-based data of the longitudinal association between FGF23 and cardiovascular events are lacking, we investigated a possible relationship in 727 men of the Uppsala Lon...

journal_title：Kidney international

authors： Ärnlöv J,Carlsson AC,Sundström J,Ingelsson E,Larsson A,Lind L,Larsson TE

更新日期：2013-01-01 00:00:00

abstract：:In vitro metabolic acidosis (Met) induces greater bone mineral resorption than respiratory acidosis (Resp). Met, but not Resp, inhibits osteoblasts which control many aspects of osteoclastic function. To determine whether at a similar decrement in extracellular pH, Met and Resp would induce different changes in intrac...

journal_title：Kidney international

authors： Ori Y,Lee SG,Krieger NS,Bushinsky DA

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Nephrotoxic glomerulonephritis is induced by the administration of antibody against the glomerular basement membrane (GBM). We demonstrated previously that Fc receptors for immunoglobulin G (IgG) (FcgammaR) play crucial roles in the induction of accelerated nephrotoxic glomerulonephritis by using FcRgamma-de...

journal_title：Kidney international

authors： Fujii T,Hamano Y,Ueda S,Akikusa B,Yamasaki S,Ogawa M,Saisho H,Verbeek JS,Taki S,Saito T

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Hypertriglyceridemia is a result of reduced triglyceride (TG)-rich lipoprotein (TRL) catabolism and occurs in rats with nephrotic syndrome (NS) and in Nagase analbuminemic rats (NARs). While the heparin-releasable lipoprotein lipase (LpL) pool in NAR and in NS is similar, TG levels are significantly greater ...

journal_title：Kidney international

authors： Shearer GC,Stevenson FT,Atkinson DN,Jones H,Staprans I,Kaysen GA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Mice overexpressing thymic stromal lymphopoietin (TSLP) develop mixed cryoglobulinemia with renal disease closely resembling human cryoglobulin-associated membranoproliferative glomerulonephritis (MPGN), including glomerular deposits of immunoglobulins and complement. We assessed the effect of complement inh...

journal_title：Kidney international

authors： Mühlfeld AS,Segerer S,Hudkins K,Farr AG,Bao L,Kraus D,Holers VM,Quigg RJ,Alpers CE

更新日期：2004-04-01 00:00:00

abstract：:This study was undertaken to test the hypothesis that, given equal arterial pressure reductions, the combination of an angiotensin converting enzyme (ACE) inhibitor and calcium antagonist slows declines in renal function and yields greater reductions in albuminuria over either agent alone. This hypothesis was evaluate...

journal_title：Kidney international

authors： Bakris GL,Barnhill BW,Sadler R

更新日期：1992-04-01 00:00:00

abstract：:Our genetic hypercalciuric (GH) rats have been selected and inbred for 29 generations to maximize urine calcium (UCa) excretion compared to identical gender controls (Ctl). To determine the effect of the increased UCa on urinary supersaturation and stone formation, we pair fed 15 GH and 15 Ctl rats a standard 1.2% cal...

journal_title：Kidney international

authors： Bushinsky DA,Grynpas MD,Nilsson EL,Nakagawa Y,Coe FL

更新日期：1995-12-01 00:00:00

abstract：:Dopamine plays an important role in regulation of renal sodium transport. Proximal tubule cells produce dopamine after decarboxylation of L-DOPA via the enzyme aromatic L-amino acid decarboxylase (AADC). The presence and cellular localization of AADC-like immunoreactivity (-LI) and AADC mRNA were examined during pre- ...

journal_title：Kidney international

authors： Meister B,Fried G,Holgert H,Aperia A,Hökfelt T

更新日期：1992-09-01 00:00:00

abstract：:Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normox...

journal_title：Kidney international

authors： Haase VH

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:High blood glucose levels play major roles in the pathogenesis of renal diabetic complications through non-enzymatic glycation. For long-lived molecules this leads to formation of advanced glycation end products (AGE), and the renal extracellular matrix appears to be one of the targets for such processes. Us...

journal_title：Kidney international

authors： Bendayan M

更新日期：1998-08-01 00:00:00

abstract：:Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Despite its low affinity for the vitamin D receptor (VDR), both deficient and excessive 25(OH)D levels are associated with poor clinical outcomes. Here we studied direct effects of 25(OH)D3 on the kidney using 25(...

journal_title：Kidney international

authors： Kusunoki Y,Matsui I,Hamano T,Shimomura A,Mori D,Yonemoto S,Takabatake Y,Tsubakihara Y,St-Arnaud R,Isaka Y,Rakugi H

更新日期：2015-11-01 00:00:00

abstract：:Polycystin-1 (PC1) and -2 (PC2), products of the PKD1 and PKD2 genes, are mutated in autosomal dominant polycystic kidney disease (ADPKD). They localize to the primary cilia; however, their ciliary function is in dispute. Loss of either the primary cilia or PC1 or PC2 causes cyst formation. However, loss of both cilia...

journal_title：Kidney international

authors： Shao L,El-Jouni W,Kong F,Ramesh J,Kumar RS,Shen X,Ren J,Devendra S,Dorschel A,Wu M,Barrera I,Tabari A,Hu K,Haque N,Yambayev I,Li S,Kumar A,Behera TR,McDonough G,Furuichi M,Xifaras M,Lu T,Alhayaza RM,Miyabaya

更新日期：2020-11-01 00:00:00

abstract：:Renal stone disease, which affects 12% of males and 5% of females by the seventh decade, occurs as an inherited disorder in 45% of patients and is most commonly associated with hypercalciuria. The biochemical basis for hereditary nephrolithiasis and hypercalciuria is unknown, and this has therefore been investigated b...

journal_title：Kidney international

authors： Thakker RV

更新日期：2000-03-01 00:00:00

abstract：:Methods for estimating glomerular volume were compared in Zenker-fixed, paraffin-embedded biopsies from 10 patients with insulin-dependent diabetes mellitus and 6 normal kidney donors. Two methods of measurement of individual glomerular volumes were used: the Cavalieri method (considered the "gold standard") and the m...

journal_title：Kidney international

authors： Lane PH,Steffes MW,Mauer SM

更新日期：1992-04-01 00:00:00

abstract：:Besides its procoagulant activity, thrombin has been shown to stimulate cell proliferation and to regulate the fibrinolytic pathway. We report here the effect of purified human alpha thrombin on the synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) by cultured human me...

journal_title：Kidney international

authors： Villamediana LM,Rondeau E,He CJ,Medcalf RL,Peraldi MN,Lacave R,Delarue F,Sraer JD

更新日期：1990-11-01 00:00:00

abstract：:Kidney fibrosis is the common consequence of chronic kidney diseases that inexorably progresses to end-stage kidney disease with organ failure treatable only with replacement therapy. Since transforming growth factor-β1 is the main player in the pathogenesis of kidney fibrosis, we posed the hypothesis that recombinant...

journal_title：Kidney international

authors： Takeshita A,Yasuma T,Nishihama K,D'Alessandro-Gabazza CN,Toda M,Totoki T,Okano Y,Uchida A,Inoue R,Qin L,Wang S,D'Alessandro VF,Kobayashi T,Takei Y,Mizoguchi A,Yano Y,Gabazza EC

更新日期：2020-11-01 00:00:00

abstract：:Mice chronically infected with the virus of lymphocytic choriomeningitis (LCM) develop immune complex glomerulonephritis. Others have shown that adoptive immunization of these mice by the i.p. injection of syngeneic immune spleen cells terminates the chronic viral carrier state. The present studies were designed to de...

journal_title：Kidney international

authors： Hoffsten PE,Villalobos R,Hill C,Klahr S

更新日期：1977-05-01 00:00:00

abstract：:To maintain nitrogen equilibrium when prescribed a low protein diet (LPD), metabolic adaptations occur involving a reduction protein turnover, principally decreased muscle protein degradation. Studies suggest that in patients with chronic renal failure (CRF) uncomplicated by metabolic acidosis (MA), these adaptive res...

journal_title：Kidney international

authors： Williams B,Hattersley J,Layward E,Walls J

更新日期：1991-10-01 00:00:00

abstract：:Females across their lifespan and certain male populations are susceptible to urinary tract infections (UTI). The influence of female vs. male sex on UTI is incompletely understood, in part because preclinical modeling has been performed almost exclusively in female mice. Here, we employed established and new mouse mo...

journal_title：Kidney international

authors： Olson PD,McLellan LK,Hreha TN,Liu A,Briden KE,Hruska KA,Hunstad DA

更新日期：2018-09-01 00:00:00

abstract：:The present studies address the metabolic processes that support the reabsorption of sodium and the secretion of bicarbonate in the interspersed but distinct principal and intercalated cells of the cortical collecting duct (CCD). In microperfused rabbit CCD, sodium reabsorption was measured by lumen-to-bath 22Na flux,...

journal_title：Kidney international

authors： Hering-Smith KS,Hamm LL

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Autosomal-dominant medullary cystic kidney disease type 2 (MCKD2) is a tubulointerstitial nephropathy that causes renal salt wasting, hyperuricemia, gout, and end-stage renal failure in the fifth decade of life. The chromosomal locus for MCKD2 was localized on chromosome 16p12. Within this chromosomal region...

journal_title：Kidney international

authors： Wolf MT,Mucha BE,Attanasio M,Zalewski I,Karle SM,Neumann HP,Rahman N,Bader B,Baldamus CA,Otto E,Witzgall R,Fuchshuber A,Hildebrandt F

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Familial nephrotic syndrome (NS) has both autosomal dominant and recessive forms of inheritance. Recent studies in families with an autosomal dominant form of focal segmental glomerulosclerosis (FSGS) have been at odds concerning linkage to chromosome 19q13 (Mathis et al, Kidney Int 53:282-286, 1998; Winn et...

journal_title：Kidney international

authors： Vats A,Nayak A,Ellis D,Randhawa PS,Finegold DN,Levinson KL,Ferrell RE

更新日期：2000-03-01 00:00:00

abstract：:Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...

journal_title：Kidney international

authors： Pepper RJ,Hamour S,Chavele KM,Todd SK,Rasmussen N,Flint S,Lyons PA,Smith KG,Pusey CD,Cook HT,Salama AD

更新日期：2013-06-01 00:00:00

abstract：:Long-term outcomes of kidney allografts have shown only marginal improvement over the last three decades, despite the remarkable improvement in acute rejection and one-year graft survival. Novel biomarkers of tubular injury may prevent irreversible damage to the tubulointerstitial compartment and improve allograft sur...

journal_title：Kidney international

authors： Abulezz S

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Recent advances enable the direct measurement of small molecule clearance, Kecn, during each dialysis. Average Kecn and treatment length, t, are multiplied giving total clearance, Kt. The body surface area (BSA) is a fixed transformation of height and weight and is a well recognized measure of body size. Thi...

journal_title：Kidney international

authors： Lowrie EG,Li Z,Ofsthun N,Lazarus JM

更新日期：2005-09-01 00:00:00

abstract：:Low-density lipoprotein was derived from carbamyl (carbamyl-LDL) by incubating LDL in potassium cyanate (KCNO). The proportion of free amino groups in the carbamyl-LDL was negatively correlated (r = -0.95) with the time of incubation in potassium cyanate (ranged from 5 to 360 min). The carbamylation did not change the...

journal_title：Kidney international

authors： Hörkkö S,Savolainen MJ,Kervinen K,Kesäniemi YA

更新日期：1992-05-01 00:00:00

abstract：:Chronic kidney disease (CKD) is usually associated with interstitial leukocytic cell infiltrates, which may contribute to disease progression by production of proinflammatory, proapoptotic, and profibrotic mediators. Recruiting leukocytes into the kidney involves local expression of chemotactic cytokines, that is, che...

journal_title：Kidney international

authors： Anders HJ,Ninichuk V,Schlöndorff D

更新日期：2006-01-01 00:00:00

abstract：:Dysregulated production of adipocytokines may be involved in the development of atherosclerotic cardiovascular disease in metabolic syndrome and chronic kidney disease (CKD) associated with metabolic syndrome. The aim of this study was to determine the effects of treatment with angiotensin II (Ang II) type-1 receptor ...

journal_title：Kidney international

authors： Kurata A,Nishizawa H,Kihara S,Maeda N,Sonoda M,Okada T,Ohashi K,Hibuse T,Fujita K,Yasui A,Hiuge A,Kumada M,Kuriyama H,Shimomura I,Funahashi T

更新日期：2006-11-01 00:00:00