Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists.

abstract：:In the epidemiologic study of end-stage renal disease (ESRD), accurate adjustment for comorbidity is essential to controlling bias in the comparison of outcomes across groups of patients or dialysis facilities. Liu et al. derive and validate a novel comorbidity index using data from the United States Renal Data System...

journal_title：Kidney international

authors： Seliger SL

更新日期：2010-01-01 00:00:00

abstract：:The present study was undertaken to: (a) clarify the comparative renal potency of bolus injection of the natriuretic peptides urodilatin and ANF99-126 in the rat; (b) establish whether or not intravenous (i.v.) infusion of urodilatin (200 ng/min) combined with dopamine (UD) to maintain mean arterial pressure could imp...

journal_title：Kidney international

authors： Shaw S,Weidmann P,Zimmermann A

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:It is not known whether angiotensin-converting-enzyme (ACE) inhibitors slow the progression of polycystic kidney disease (PKD). We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease...

journal_title：Kidney international

authors： Jafar TH,Stark PC,Schmid CH,Strandgaard S,Kamper AL,Maschio G,Becker G,Perrone RD,Levey AS,ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group.

更新日期：2005-01-01 00:00:00

abstract：:Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we tested hierarchical immunofluorescence criteria with varying stringency for C3 glomerulopathy in a cohort with dense deposit disease as the gold standard and then applied these criteria to analyze the incidence of C3 glomerulopathy...

journal_title：Kidney international

authors： Hou J,Markowitz GS,Bomback AS,Appel GB,Herlitz LC,Barry Stokes M,D'Agati VD

更新日期：2014-02-01 00:00:00

abstract：:Leukocytes play a major role in the development and progression of autoimmune diseases. We measured gene expression differences in leukocytes from patients that were antineutrophil cytoplasmic autoantibody (ANCA) positive, patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), and healthy donor...

journal_title：Kidney international

authors： Alcorta DA,Barnes DA,Dooley MA,Sullivan P,Jonas B,Liu Y,Lionaki S,Reddy CB,Chin H,Dempsey AA,Jennette JC,Falk RJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

journal_title：Kidney international

authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

更新日期：1999-08-01 00:00:00

abstract：:The hormonal responsiveness profile of the cortical collecting duct varies from one species to another. To identify the hormones and agonists that modulate the functions of this tubule segment in the human species, we generated a cell line (HCD) immortalized by SV40 virus. The tubular origin of this cell line was asse...

journal_title：Kidney international

authors： Prié D,Friedlander G,Coureau C,Vandewalle A,Cassingéna R,Ronco PM

更新日期：1995-05-01 00:00:00

abstract：:We studied the glomerular architecture in renal biopsies of 95 patients undergoing bariatric surgery for extreme obesity but whose renal function was normal. The comparison group was 40 control patients having protocol biopsies. These latter patients had normal weight and renal function, were non-diabetic, non-hyperte...

journal_title：Kidney international

authors： Serra A,Romero R,Lopez D,Navarro M,Esteve A,Perez N,Alastrue A,Ariza A

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The beneficial effect of blood transfusions before cadaveric renal transplantation on allograft survival, although previously well documented, has become controversial in light of their adverse effects. Recently, it has been suggested that their clinical benefits are due to HLA-DR sharing between the blood d...

journal_title：Kidney international

authors： Hiesse C,Busson M,Buisson C,Farahmand H,Bierling P,Benbunan M,Bedrossian J,Aubert P,Glotz D,Loirat C,Rondeau E,Viron B,Bleux H,Lang P

更新日期：2001-07-01 00:00:00

abstract：:The vasopressin inhibitor tolvaptan is clinically effective in slowing growth of renal cysts and reduction in estimated glomerular filtration rate (eGFR) in autosomal dominant polycystic kidney disease (ADPKD), but these effects are mitigated by the associated polyuria. Changes of total kidney volume, eGFR, and sympto...

journal_title：Kidney international

authors： Horie S

更新日期：2015-07-01 00:00:00

abstract：:McAdoo et al. propose that patients with both circulating antiglomerular basement membrane antibody and antineutrophil cytoplasm antibody demonstrate a phenotype that lies between that of single-positive antiglomerular basement membrane disease and antineutrophil cytoplasm antibody-associated vasculitis. Specifically,...

journal_title：Kidney international

authors： Canney M,Little MA

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Somatic cells in vitro have a finite life expectancy before entering a state of senescence, but it is unclear whether this state occurs in vivo in kidney development, growth, and aging. We previously showed that human kidney cortex displays telomere shortening with age. In this study, we compared the structu...

journal_title：Kidney international

authors： Melk A,Kittikowit W,Sandhu I,Halloran KM,Grimm P,Schmidt BM,Halloran PF

更新日期：2003-06-01 00:00:00

abstract：:Antibody-mediated rejection represents the first cause of graft loss in renal transplant recipients, and it is imperative to identify appropriate tools to enable risk stratification of such patients. Lately, the usefulness of measuring complement-binding anti-human leukocyte antigen (HLA) donor-specific antibodies (DS...

journal_title：Kidney international

authors： Cozzi E,Biancone L

更新日期：2018-10-01 00:00:00

abstract：:Because of high risk of cardiovascular disease, patients with chronic kidney disease may benefit from cholesterol-lowering therapy beyond statins. A cost-effectiveness analysis of adding ezetimibe to high-dose statins for primary cardiovascular disease prevention in patients with non-dialysis-dependent chronic kidney ...

journal_title：Kidney international

authors： Walther CP,Erickson KF

更新日期：2019-07-01 00:00:00

abstract：:Leucocyte interaction with other cells is facilitated by the adhesion molecules, leucocyte function-associated antigen-1 (LFA-1)-binding to intercellular adhesion molecule-1 (ICAM-1) and for T cells and natural killer (NK) cells the binding of LFA-2 (CD2) to LFA-3. As these interactions are critical for the mediation ...

journal_title：Kidney international

authors： Bishop GA,Hall BM

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to define cut-off values for serum creatinine as an indicator of several levels of renal impairment. METHODS:To identify the suitable values, receiver operating characteristic curves were constructed based on the data of 984 laboratory assessments of renal function. The glomerular ...

journal_title：Kidney international

authors： Couchoud C,Pozet N,Labeeuw M,Pouteil-Noble C

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

journal_title：Kidney international

authors： Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The growth hormone (GH)/insulin-like growth factor (IGF) system is thought to participate in the glomerulosclerosis process. Because IGF-binding proteins (IGFBPs) modulate IGF actions and hence GH secretion, this study assessed whether mice transgenic for human IGFBP-1 have altered susceptibility to glomerul...

journal_title：Kidney international

authors： Doublier S,Seurin D,Fouqueray B,Verpont MC,Callard P,Striker LJ,Striker GE,Binoux M,Baud L

更新日期：2000-06-01 00:00:00

abstract：:Spontaneous and aspirated blood samples were collected from the welling points of surface efferent arterioles in the rat kidney. The amount of tubular reabsorbate in each sample was calculated from measurements of the inulin concentration in the sample and systemic arterial plasma. Both spontaneous and aspirated sampl...

journal_title：Kidney international

authors： Jensen PK,Blaehr H,Steven K

更新日期：1984-03-01 00:00:00

abstract：:The involvement of cysteinyl leukotrienes (LT) in the etiology of glomerulonephritis (GN) was investigated in a rat model of nephrotoxic serum nephritis in which renal function, morphology, LTC4 synthase activity and urinary cysteinyl LT excretion were monitored over seven days. Significant alterations in renal functi...

journal_title：Kidney international

authors： Petric R,Ford-Hutchinson AW

更新日期：1994-11-01 00:00:00

abstract：:Renal involvement in von Hippel-Lindau (VHL) disease has emerged as the most prevalent cause of death in this hereditary disorder. In a group of 43 VHL patients (23 unrelated families) with renal lesions we examined whether severity of renal disease is affected by parental inheritance and VHL subtype (1, without pheoc...

journal_title：Kidney international

authors： Chauveau D,Duvic C,Chrétien Y,Paraf F,Droz D,Melki P,Hélénon O,Richard S,Grünfeld JP

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 (15dPGJ2) affects mesangial proliferation, survival and production of proinflammatory proteins. During a survey of the mesangial cell proteome after treatment with 15dPGJ2, heat shock protein 70 (HSP70) was found to be the most conspicuous...

journal_title：Kidney international

authors： Zhang X,Lu L,Dixon C,Wilmer W,Song H,Chen X,Rovin BH

更新日期：2004-03-01 00:00:00

abstract：:Effect of varying concentrations (0 to 800 microM) of three different light chains on sodium-dependent L-(14C)alanine and D-(14C)glucose uptake by rat renal brush border membrane vesicles were studied. One kappa and two lambda type light chains (lambda-1 and lambda-2) were isolated from urines of patients with multipl...

journal_title：Kidney international

authors： Batuman V,Sastrasinh M,Sastrasinh S

更新日期：1986-11-01 00:00:00

abstract：:Acute elevations in intracellular adenosine 3',5'-cyclic monophosphate (cAMP) concentrations are known to increase ionic chloride permeability in diverse tissues. To determine if chronic endogenous increases in cAMP are associated with sustained alterations in membrane ionic permeabilities, renal cortical brush border...

journal_title：Kidney international

authors： London RD,Lipkowitz MS,Abramson RG

更新日期：1992-08-01 00:00:00

abstract：:A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR...

journal_title：Kidney international

authors： Abboud HE

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Human mesothelial cells (HMCs) have an important role in maintaining an adequately functioning fibrinolytic system in the peritoneal cavity by secreting the fibrinolytic enzymes tissue-type and urokinase-type plasminogen activator (t-PA and u-PA), as well as a specific PA inhibitor, PA inhibitor type 1 (PAI-...

journal_title：Kidney international

authors： Sitter T,Toet K,Quax P,Kooistra T

更新日期：1999-01-01 00:00:00

abstract：:Levels of prepro epidermal growth factor (EGF) mRNA in renal cortical tissue and urinary EGF excretion have been determined during cisplatin and ischemia-induced acute renal failure in the rat. Northern analysis of polyadenylated RNAs of kidney cortical tissue showed diminished renal preproEGF mRNA in rats injected wi...

journal_title：Kidney international

authors： Safirstein R,Zelent AZ,Price PM

更新日期：1989-11-01 00:00:00

abstract：:Thrombomodulin (TM), an endothelial receptor for thrombin, endowed with a powerful anticoagulant activity, plays an important role in the antithrombogenicity of the vascular endothelium. Its presence within the human renal glomerulus is already known but was thought to be only endothelial. We looked for TM expression ...

journal_title：Kidney international

authors： Pruna A,Peyri N,Berard M,Boffa MC

更新日期：1997-03-01 00:00:00

abstract：:The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has been linked with recurrent dehydration. Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that might subsequently in...

journal_title：Kidney international

authors： Roncal Jimenez CA,Ishimoto T,Lanaspa MA,Rivard CJ,Nakagawa T,Ejaz AA,Cicerchi C,Inaba S,Le M,Miyazaki M,Glaser J,Correa-Rotter R,González MA,Aragón A,Wesseling C,Sánchez-Lozada LG,Johnson RJ

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Optimal nutrient intake is important in the maintenance of a positive nitrogen balance in hemodialysis (HD) patients. The objectives of this study were (1) to assess the influence of two levels of protein intakes on nitrogen balance in stable adult HD patients, and (2) to identify a minimum level of protein ...

journal_title：Kidney international

authors： Rao M,Sharma M,Juneja R,Jacob S,Jacob CK

更新日期：2000-07-01 00:00:00