Abstract：
:Few studies have examined tubular function after subtotal nephrectomy (Nx) and conservative treatments. The effects of 70% and 80% Nx (associated with dietary phosphate restriction in the latter case) on the apical brush border membrane (BBM) enzymes 5'-nucleotidase, gamma glutamyl-transferase and alkaline-phosphatase, and one BBM Na-phosphate cotransporter (NaPi-2) were studied in rats after a six week period. Changes in activity and mRNA abundance of the BBM enzymes and in NaPi-2 protein and mRNA abundance were compared with changes in the distal markers of Na,K-ATPase activity and epidermal growth factor (EGF) production. The activity, but not the mRNA of BBM enzymes, was moderately reduced by the 70% Nx. Both the mRNA and activity of gamma glutamyl-transferase and alkaline-phosphatase were decreased in the 80% Nx, and the NaPi-2 mRNA, protein and Na,K-ATPase activities were also reduced. These effects (except for 5'nucleotidase and Na,K-ATPase) were partly reversed by phosphate restriction. Overproduction of EGF occurred after the 70% Nx, was blunted in the 80% Nx, and then partially restored by phosphate restriction. Aggravation of tubular alteration was associated with enhanced renal hyperplasia (increased DNA mass), reduced GFR and hyperphosphatemia, and high PTH levels, but reduced cAMP excretion. Improvement following phosphate restriction was associated with reduced hyperplasia and lowering of phosphatemia and PTH levels. These data demonstrate that Nx selectively affected BBM function through transcriptional changes that were partially reversed by phosphate restriction. Regulatory factors involved in these changes may include intracellular phosphate content and growth factors, but not the PTH effects that are impaired in chronic renal failure.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Laouari D,Friedlander G,Burtin M,Silve C,Dechaux M,Garabedian M,Kleinknecht Cdoi
10.1038/ki.1997.485subject
Has Abstractpub_date
1997-12-01 00:00:00pages
1550-60issue
6eissn
0085-2538issn
1523-1755pii
S0085-2538(15)60325-8journal_volume
52pub_type
杂志文章abstract：:Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducibl...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.06.015
更新日期：2017-12-01 00:00:00
abstract：:The cross talk between the immune and nervous systems is critical not only for maintaining normal homeostasis but also for the progression of a variety of inflammatory diseases. Macrophage activation and β2-adrenergic receptors are known to play important roles in facilitating this communication between these 2 system...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2017.03.024
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The mechanisms of cyclosporine (CsA)-induced nephrotoxicity are not fully understood. While hemodynamic changes may be involved in vivo, there is also some evidence for tubular involvement. We previously showed direct toxicity of CsA in the LLC-PK1 renal tubular cell line. In the current study we examined me...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1998.00202.x
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D3, is a potent immunomodulatory agent on several cell types such as monocytes and mesangial cells. Recruitment of inflammatory cells, as well as stimulation of resident cells and mesangial matrix accumulation are key features of various expe...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.00775.x
更新日期：2001-07-01 00:00:00
abstract：:We evaluated the contribution of intrarenal factors in the increased renal accumulation of bovine serum albumin (BSA) in chronic serum sickness (CSS). Renal transplantation was used to study 125I BSA uptake (single and paired label techniques) in normal and CSS kidneys exposed to the same immunologic milieu. In CSS, t...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1986.244
更新日期：1986-11-01 00:00:00
abstract：:In vitro metabolic acidosis (Met) induces greater bone mineral resorption than respiratory acidosis (Resp). Met, but not Resp, inhibits osteoblasts which control many aspects of osteoclastic function. To determine whether at a similar decrement in extracellular pH, Met and Resp would induce different changes in intrac...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.247
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:Dendritic cells (DCs) uniquely serve as conduits between innate and cognate arms of the immune system. The normal kidney contains an extensive population of interstitial DCs but their role in the pathogenesis of acute renal injury is not known. METHODS:Renal DCs were studied by flow cytometric analysis of c...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00502.x
更新日期：2005-09-01 00:00:00
abstract：:Injury resulting from ischemia-reperfusion injury is a multifactorial process involving compromised function in both the tubular and the vascular compartments. Multiple vasoactive compounds have been implicated in the profound vasoconstriction that occurs in response to ischemia-reperfusion injury, and many of these f...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2011.145
更新日期：2011-08-01 00:00:00
abstract：:Meprins are zinc-dependent metalloproteinases that are highly expressed in the brush-border membranes of both the kidney and the intestines. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. In this ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002189
更新日期：2007-05-01 00:00:00
abstract：:The possibility that hypercalciuria could cause calcium stone formation through a mechanism other than by increasing urinary saturation of stone-forming calcium salts was explored. The effect of increasing calcium concentration on the inhibitor activity against the spontaneous precipitation of calcium oxalate was exam...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1988.100
更新日期：1988-05-01 00:00:00
abstract：:We described the characteristics in a referred cohort of type II diabetic patients in the Developing Education on Microalbuminuria for Awareness of renal and cardiovascular risk in Diabetes study evaluating the global prevalence and determinants of microalbuminuria (MA). A cross-sectional study evaluating 32,208 type ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000377
更新日期：2006-06-01 00:00:00
abstract：:The intracellular distribution of carbonic anhydrase was studied in nine human donor kidneys by the histochemical method of Hansson and by an immunofluorescence technique using antisera specific against the cytoplasmic isoenzymes HCA B and HCA C. Only HCA C was found in the renal tubules. Convoluted proximal tubules s...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1984.106
更新日期：1984-06-01 00:00:00
abstract：:Antibody-mediated rejection represents the first cause of graft loss in renal transplant recipients, and it is imperative to identify appropriate tools to enable risk stratification of such patients. Lately, the usefulness of measuring complement-binding anti-human leukocyte antigen (HLA) donor-specific antibodies (DS...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2018.06.032
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Previous reports have shown the presence of erythrogenic toxin type B (ETB), apoptosis, proliferation, and leukocyte infiltration in biopsies from patients with acute poststreptococcal glomerulonephritis (APSGN). METHODS:Attempting to correlate the apoptotic and proliferative events with the interaction of ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.059003950.x
更新日期：2001-03-01 00:00:00
abstract：:The importance of the endothelial isoform of nitric oxide synthase (eNOS) has been well established. Endothelium-derived nitric oxide has been shown to be essential for vascular homeostasis and modulation of eNOS has thus become a target in prevention of cardiovascular disease. The role of the inducible form of nitric...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1046/j.1523-1755.2002.00235.x
更新日期：2002-03-01 00:00:00
abstract：:Staphylococcal neutral phosphatase (NPtase) is a highly cationic bacterial surface bound protein. It has significant affinity for human and rat immunoglobulins in vitro and an electrostatic interaction may be involved. Radioisotopic studies showed that NPtase had a high affinity for the polyanionic structures of the r...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.314
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Chronic oversecretion of parathyroid hormone (PTH) is associated with parathyroid hyperplasia, reflecting a disturbed balance between cell proliferation and apoptosis. This study addressed the unsolved issue of apoptosis in hyperparathyroidism. METHODS:Parathyroid glands from 19 patients with primary (1 deg...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00863.x
更新日期：2000-02-01 00:00:00
abstract：:Gain-of-function variants in CFB encoding factor B (FB), a component of the alternative pathway C3 convertase, have been reported in a minority of patients with aHUS and result in massive C3 activation. Zhang et al. describe the functional characterization of a novel FB variant (p.Ser367Arg) that they identified in 2 ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2020.06.026
更新日期：2020-11-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its activation results in beneficial or detrimental consequences, depending on the particular setting. Earlier studies in the animal model of acute kidney injury showed that EGFR activation promotes renal tubular cell proliferation. Activation of E...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2012.435
更新日期：2013-05-01 00:00:00
abstract：:The impact of dialysis on cognitive trends is uncertain. Kurella Tamura et al. evaluated cognitive trajectories in 212 participants from the Chronic Renal Insufficiency Cohort study and found that dialysis initiation was associated with a decline in executive function. This is consistent with a cerebrovascular basis f...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2017.01.022
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Unilateral ureteral obstruction (UUO) leads to interstitial fibrosis of the obstructed kidney, and TGF-beta is considered to play an important role in this fibrotic process. Smad7 has been recently identified as an antagonist of TGF-beta signaling. To investigate whether this novel molecule can be exploited ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.0610s1094.x
更新日期：2002-01-01 00:00:00
abstract：:Factor H is a regulator of the alternative pathway of complement, and genetic studies have shown that patients with mutations in factor H are at increased risk for several types of renal disease. Pathogenic activation of the alternative pathway in acquired diseases, such as ischemic acute kidney injury, suggests that ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.115
更新日期：2011-07-01 00:00:00
abstract：:We examined the circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 alpha, IL-6, granulocyte macrophage-colony stimulating factor (GM-CSF), and the anti-inflammatory cytokine IL-10, and their expression in kidneys acutely infected with murine malaria parasite...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.1998.00848.x
更新日期：1998-04-01 00:00:00
abstract：:Management of idiopathic glomerular disease associated with nephrotic syndrome (INS) remains controversial and one of the most complex areas relates to utilization of the drug cyclosporin. This is despite its demonstrated effectiveness in several histologic types of the INS in randomized controlled trials. Cyclosporin...
journal_title：Kidney international
pub_type： 共识发展会议,杂志文章
doi：10.1038/sj.ki.5002553
更新日期：2007-12-01 00:00:00
abstract：:Adynamic bone disease (ABD) is increasingly recognized, especially in dialysis patients treated with oral calcium carbonate, vitamin D supplements, or supraphysiological dialysate calcium. We undertook this study to assess the effect of lowering dialysate calcium on episodes of hypercalcemia, serum parathyroid hormone...
journal_title：Kidney international
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ki.5001666
更新日期：2006-09-01 00:00:00
abstract：:To define the pattern of recovery from postischemic acute renal failure (ARF), we performed clearance and micropuncture studies at intervals of 1, 2, 4, and 8 weeks following 60 min of complete unilateral renal artery occlusion in the rat. At 1 week, the inulin clearance (CIn) of the postischemic kidney was less than ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1979.112
更新日期：1979-08-01 00:00:00
abstract：:A genome-wide association study (GWAS) indicated that myeloperoxidase-ANCA associated vasculitis (AAV) is associated with HLA-DQ. However, susceptibility alleles in these loci have been under-investigated. Here we genotyped 258 Chinese patients with myeloperoxidase-AAV and 597 healthy control individuals at HLA DRB1, ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2019.06.015
更新日期：2019-10-01 00:00:00
abstract：:Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common....
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2020.08.028
更新日期：2021-01-01 00:00:00
abstract：:Pathologic calcification is a significant cause of increased morbidity and mortality in patients with chronic kidney disease. The precise mechanisms of ectopic calcification are not fully elucidated, but it is known to be caused by an imbalance of procalcific and anticalcific factors. In the chronic kidney disease pop...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2015.12.046
更新日期：2016-05-01 00:00:00
abstract：:A dose escalation study of adipose-derived human mesenchymal stem cell (MSC) therapy was studied in 21 subjects. This dose escalation study confirmed no significant cellular toxicity, but it showed improvement in renal oxygenation and glomerular filtration rate. No significant renal toxicity from cell therapy was show...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2019.12.020
更新日期：2020-04-01 00:00:00
