当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Modulation of glomerular proteoglycans by insulin-like growth factor-1.

Modulation of glomerular proteoglycans by insulin-like growth factor-1.

Abstract：

:Effect of insulin-like growth factor-1 (IGF) on the synthesis of glomerular proteoglycans (PGs) in an ex vivo recirculating organ perfusion system was investigated. Kidneys were perfused with a medium (approximately 80 ml) containing [35S]-sulfate (250 microCi/ml) and IGF (62.5 to 625 ng/ml). After radiolabeling, a small cortical piece was saved for tissue autoradiography, and the remaining kidney and the perfusion medium were utilized for biochemical studies. The glomeruli were isolated; their PGs extracted and characterized. A two- to threefold increase of the total radioactivities in tissue and media fractions was observed with the exposure to IGF. By Sepharose CL-6B chromatography, the tissue PGs eluted as two peaks (A and B) with Kav = 0.24 and 0.48, and the majority of the radioactivity was confined to peak A. This peak contained intact PGs while peak B included glycosaminoglycan (GAG) chains. Elution profiles of the glomerular PGs were similar in the control and IGF groups. However, there was a disproportionate increase of chondroitin/dermatan sulfate in the IGF group. The media fractions also had two peaks, and most of the radioactivity was associated with peak B containing GAG chains. A remarkable accentuation of peak B along with significant increase in the chondroitin/dermatan sulfate were observed in the IGF group. By DEAE-Sephacel chromatography, the PGs/GAGs of IGF group eluted at a relatively lower salt concentration as compared to the control. Autoradiography revealed a relatively high concentration of radioactivity over the mesangium as compared to the other cell types of the glomerulus. [35S]-methionine studies revealed a generalized increase of protein synthesis in the IGF group, but comparatively much less than that of PGs/GAGs. These results indicate that IGF enhances the biosynthesis of PGs/GAGs by various cell types of the renal glomerulus, especially that of the mesangial cell, as reflected by the selective increase of chondroitin/dermatan sulfate.

journal_name

Kidney Int

journal_title

Kidney international

authors

Watanabe Y,Kashihara N,Makino H,Kanwar YS

doi

10.1038/ki.1992.188

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

1262-73

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)57617-5

journal_volume

41

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study.

    abstract：:The purpose of this study was to explore risk factors affecting the incidence of chronic kidney disease (CKD) in general population. We conducted a 10-year follow-up study with 123 764 (male: 41 012, female: 82 752) adults aged 40 years and over who received community-based annual examinations. The primary outcome for...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002017

    authors： Yamagata K,Ishida K,Sairenchi T,Takahashi H,Ohba S,Shiigai T,Narita M,Koyama A

    更新日期：2007-01-01 00:00:00

  • Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening.

    abstract：BACKGROUND:Somatic cells in vitro have a finite life expectancy before entering a state of senescence, but it is unclear whether this state occurs in vivo in kidney development, growth, and aging. We previously showed that human kidney cortex displays telomere shortening with age. In this study, we compared the structu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00032.x

    authors： Melk A,Kittikowit W,Sandhu I,Halloran KM,Grimm P,Schmidt BM,Halloran PF

    更新日期：2003-06-01 00:00:00

  • Phenylalanine metabolism in uremic and normal man.

    abstract：:The metabolism of phenylalanine and tyrosine was evaluated in six normal men, five chronically uremic men, and three men undergoing maintenance hemodialysis. Phenylalanine, tyrosine, and 13 acidic metabolites of those amino acids were measured in plasma postabsorptively and in plasma and urine after a phenylalanine lo...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1978.104

    authors： Jones MR,Kopple JD,Swendseid ME

    更新日期：1978-08-01 00:00:00

  • TNF-alpha--accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.

    abstract：BACKGROUND:Tumor necrosis factor (TNF)-alpha rapidly primes neutrophils (PMN) for an anti-neutrophil cytoplasmic antibody (ANCA)-induced respiratory burst and is thus proinflammatory. TNF-alpha also progressively accelerates apoptosis. We investigated the effect of TNF-alpha-mediated apoptosis on ANCA antigen expressio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00161.x

    authors： Kettritz R,Scheumann J,Xu Y,Luft FC,Haller H

    更新日期：2002-02-01 00:00:00

  • Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics.

    abstract：BACKGROUND:Current renal substitution therapy for acute or chronic renal failure with hemodialysis or hemofiltration is life sustaining, but continues to have unacceptably high morbidity and mortality rates. This therapy is not complete renal replacement therapy because it does not provide active transport nor metaboli...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00486.x

    authors： Humes HD,MacKay SM,Funke AJ,Buffington DA

    更新日期：1999-06-01 00:00:00

  • Mesangial cell signaling cascades in response to mechanical strain and glucose.

    abstract：BACKGROUND:Elevated glucose levels and glomerular hypertension (Pgc) are considered to contribute to the elaboration of matrix protein by mesangial cells (MCs) in diabetic glomeruli. MCs grown in 30 mM of glucose produce excessive matrix protein, as do MCs exposed to cyclic strain, and the combination of the two exacer...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00743.x

    authors： Ingram AJ,Ly H,Thai K,Kang MJ,Scholey JW

    更新日期：1999-11-01 00:00:00

  • Time course studies on phosphate transfer in frog urinary bladder.

    abstract：:Unidirectional 32P-phosphate and 3H-mannitol fluxes were simultaneously measured, at two minutes intervals, in frog urinary bladders. The spontaneous or externally imposed transepithelial potential (PD) and short circuit current (SCC) were also recorded in most experiments. It was observed that: (1) Phosphate transfer...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.9

    authors： Parisi M,Cancela L

    更新日期：1988-01-01 00:00:00

  • Transgenic rats carrying the mouse renin gene--morphological characterization of a low-renin hypertension model.

    abstract：:Transgenic rats [TGR; strain name TGR(mRen2)27] harboring the mouse Ren-2 renin gene have been recently generated as a model for the study of primary hypertension that offers the advantage of a clearly-defined genetic alteration. Expression of the mouse Ren-2 gene causes severe hypertension (200 to 260 mm Hg) which is...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.4

    authors： Bachmann S,Peters J,Engler E,Ganten D,Mullins J

    更新日期：1992-01-01 00:00:00

  • Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism.

    abstract：BACKGROUND:Non-(1-84) parathyroid hormone (PTH) fragments are large circulating carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. hPTH (7-84), a synthetic surrogate, has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those of hPTH (1-34) on ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00493.x

    authors： D'Amour P,Brossard JH,Rousseau L,Nguyen-Yamamoto L,Nassif E,Lazure C,Gauthier D,Lavigne JR,Zahradnik RJ

    更新日期：2005-09-01 00:00:00

  • Regulation of the renal Na-HCO3 cotransporter: VI. Mechanism of the stimulatory effect of protein kinase C.

    abstract：:We have previously shown that the activity of the Na-HCO3 cotransporter is stimulated by protein kinase C (PKC) activation, but the mechanism responsible for this effect is not clear. We have shown that cultured proximal tubule cells of the rabbit have DIDS-sensitive Na-HCO3 cotransporter activity as assessed by HCO3-...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.98

    authors： Ruiz OS,Wang LJ,Qiu YY,Kear F,Bernardo A,Arruda JA

    更新日期：1996-03-01 00:00:00

  • Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat.

    abstract：:Tubulointerstitial fibrosis is one of the most important histologic features that predicts progression in kidney disease. Thrombospondin 1 is an extracellular matrix protein that can activate latent TGF-beta, a cytokine implicated in the pathogenesis of tubulointerstitial fibrosis. We examined the expression of thromb...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00774.x

    authors： Hugo C,Shankland SJ,Pichler RH,Couser WG,Johnson RJ

    更新日期：1998-02-01 00:00:00

  • Effects of reduced renal function and dietary protein on muscle protein synthesis.

    abstract：:We describe a rat model of renal failure that separates catabolic and anabolic states from each other. Muscle protein synthesis was compared during the anabolic period between sham (S) operated and renal failure (RF) rats that were fed different levels of dietary protein. Male rats weighing between 60 and 80 g first h...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.104

    authors： Baliga R,George VT,Ray PE,Holliday MA

    更新日期：1991-05-01 00:00:00

  • The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis.

    abstract：:Primary distal renal tubular acidosis is a rare genetic disease. Mutations in SLC4A1, ATP6V0A4, and ATP6V1B1 genes have been described as the cause of the disease, transmitted as either an autosomal dominant or recessive trait. Particular clinical features, such as sensorineural hearing loss, have been mainly describe...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.12.017

    authors： Palazzo V,Provenzano A,Becherucci F,Sansavini G,Mazzinghi B,Orlandini V,Giunti L,Roperto RM,Pantaleo M,Artuso R,Andreucci E,Bargiacchi S,Traficante G,Stagi S,Murer L,Benetti E,Emma F,Giordano M,Rivieri F,Colussi G,

    更新日期：2017-05-01 00:00:00

  • Recurrence of ANCA-associated vasculitis following renal transplantation in the modern era of immunosupression.

    abstract：:Progressive glomerulonephritis and attendant end-stage renal disease (ESRD) result from antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The optimum time of kidney transplantation in patients with ESRD due to ANCA-associated vasculitis (AAV) and the risk of renal or nonrenal recurrence of vasculitis a...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002244

    authors： Gera M,Griffin MD,Specks U,Leung N,Stegall MD,Fervenza FC

    更新日期：2007-06-01 00:00:00

  • Anesthetics influence the incidence of acute kidney injury following valvular heart surgery.

    abstract：:Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is lacking. Here we studied the effect of propofol anesthesia on the occurrence of acute kidney injury following heart surgery with cardiopulmonary bypass. One hundred and twelve patients who u...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ki.2013.532

    authors： Yoo YC,Shim JK,Song Y,Yang SY,Kwak YL

    更新日期：2014-08-01 00:00:00

  • N-acetylcysteine attenuates the progression of chronic renal failure.

    abstract：BACKGROUND:Lipid peroxidation impairs renal function. Aldosterone contributes to renal injury in the remnant kidney model. This study aimed to determine the effects of the antioxidant N-acetylcysteine (NAC) on renal function and aldosterone levels in chronic renal failure. METHODS:Adult male Wistar rats were submitted...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00677.x

    authors： Shimizu MH,Coimbra TM,de Araujo M,Menezes LF,Seguro AC

    更新日期：2005-11-01 00:00:00

  • Therapeutic effects of oral nutritional supplementation during hemodialysis.

    abstract：BACKGROUND:Protein-calorie malnutrition is common in chronic hemodialysis (CHD) patients and correlates with morbidity and mortality in these patients. There are limited trials evaluating the efficacy of oral nutritional supplementation in malnourished CHD patients. METHODS:Eighty-five CHD patients with evidence of ma...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2002.00530.x

    authors： Caglar K,Fedje L,Dimmitt R,Hakim RM,Shyr Y,Ikizler TA

    更新日期：2002-09-01 00:00:00

  • Low oxygen stimulates the immune system.

    abstract：:Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.15

    authors： Maltzman JS,Haase VH

    更新日期：2008-04-01 00:00:00

  • Stone formation in genetic hypercalciuric rats.

    abstract：:Our genetic hypercalciuric (GH) rats have been selected and inbred for 29 generations to maximize urine calcium (UCa) excretion compared to identical gender controls (Ctl). To determine the effect of the increased UCa on urinary supersaturation and stone formation, we pair fed 15 GH and 15 Ctl rats a standard 1.2% cal...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.468

    authors： Bushinsky DA,Grynpas MD,Nilsson EL,Nakagawa Y,Coe FL

    更新日期：1995-12-01 00:00:00

  • Effect of nitric oxide modulation on TGF-beta1 and matrix proteins in chronic cyclosporine nephrotoxicity.

    abstract：BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis and afferent arteriolar hyalinosis. L-arginine (L-Arg), the substrate for nitric oxide (NO) synthase and N-nitro-L-arginine-methyl ester (L-NAME), the NO synthase inhibitor, were shown to modulate acute CsA nephrotoxicity. Ho...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00273.x

    authors： Shihab FS,Yi H,Bennett WM,Andoh TF

    更新日期：2000-09-01 00:00:00

  • Association between hypertension and variation in the alpha- and beta-adducin genes in a white population.

    abstract：BACKGROUND:The substitution of tryptophan for glycine at amino acid 460 (Gly460Trp polymorphism) of the alpha-subunit of the heterodimeric cytoskeleton protein adducin increases renal sodium reabsorption and may be involved in the pathophysiology of essential hypertension. In the present study, we investigated in multi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00691.x

    authors： Wang JG,Staessen JA,Barlassina C,Fagard R,Kuznetsova T,Struijker-Boudier HA,Zagato L,Citterio L,Messaggio E,Bianchi G

    更新日期：2002-12-01 00:00:00

  • The paracellular permeability of opossum kidney cells, a proximal tubule cell line.

    abstract：UNLABELLED:The paracellular permeability of opossum kidney cells, a proximal tubule cell line. BACKGROUND:The regulation of the unusually leaky paracellular pathway of the proximal tubule is poorly understood partially because of the lack of an appropriate in vitro cell model. In this study, we determined whether the ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00787.x

    authors： Liang M,Ramsey CR,Knox FG

    更新日期：1999-12-01 00:00:00

  • PGF2 alpha activation of Na/H antiporter and ammoniagenesis in parent/variant LLC-PK1 cells.

    abstract：:A novel variant of the LLC-PK1 cell line was used to examine directly the mechanism whereby PGF2 alpha and TPA inhibit renal ammoniagenesis. The variant cells, which exhibit a growth pattern and morphology similar to the parent cell line, were isolated by a self selection process utilizing long-term cultures of parent...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.368

    authors： Sahai A,Fadda GZ,Sandler RS,Tannen RL

    更新日期：1994-10-01 00:00:00

  • CD11b is protective in complement-mediated immune complex glomerulonephritis.

    abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.373

    authors： Alexander JJ,Chaves LD,Chang A,Jacob A,Ritchie M,Quigg RJ

    更新日期：2015-05-01 00:00:00

  • Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling.

    abstract：:Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker and a mediator of kidney fibrogenesis by impairing tubular integrity. Tenascin-C was found to be increased in kidney biopsies from pa...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.01.026

    authors： Zhu H,Liao J,Zhou X,Hong X,Song D,Hou FF,Liu Y,Fu H

    更新日期：2020-05-01 00:00:00

  • Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.

    abstract：:Membranous nephropathy is a major cause of nephrotic syndrome in adults where podocyte injuries were found to mediate the development of proteinuria. Triptolide, a major active component of Tripterygium wilfordii Hook F, has potent immunosuppressive, anti-inflammatory and antiproteinuric effects. To study its antiprot...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.41

    authors： Chen ZH,Qin WS,Zeng CH,Zheng CX,Hong YM,Lu YZ,Li LS,Liu ZH

    更新日期：2010-06-01 00:00:00

  • Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice.

    abstract：:Nephropathy is among the most frequent complications of diabetes and the leading cause of end-stage renal disease. Despite the success of novel drugs in animal models, the majority of the subsequent clinical trials employing those drugs targeting diabetic nephropathy failed. This lack of translational value may in par...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.06.023

    authors： Klein J,Ramirez-Torres A,Ericsson A,Huang Y,Breuil B,Siwy J,Mischak H,Peng XR,Bascands JL,Schanstra JP

    更新日期：2016-11-01 00:00:00

  • Acetate and bicarbonate hemodialysis in patients with and without autonomic dysfunction.

    abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1984.134

    authors： Velez RL,Woodard TD,Henrich WL

    更新日期：1984-07-01 00:00:00

  • C1q-binding donor-specific antibody assays help define risk and prognosis in antibody-mediated rejection.

    abstract：:Antibody-mediated rejection represents the first cause of graft loss in renal transplant recipients, and it is imperative to identify appropriate tools to enable risk stratification of such patients. Lately, the usefulness of measuring complement-binding anti-human leukocyte antigen (HLA) donor-specific antibodies (DS...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2018.06.032

    authors： Cozzi E,Biancone L

    更新日期：2018-10-01 00:00:00

  • Gene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression.

    abstract：BACKGROUND:Gene expression profiling of nephropathies may facilitate development of diagnostic strategies for complex renal diseases as well as provide insight into the molecular pathogenesis of kidney diseases. To test molecular based renal disease categorization, differential gene expression profiles were compared be...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00499.x

    authors： Henger A,Kretzler M,Doran P,Bonrouhi M,Schmid H,Kiss E,Cohen CD,Madden S,Porubsky S,Gröne EF,Schlöndorff D,Nelson PJ,Gröne HJ

    更新日期：2004-03-01 00:00:00