Efficacy and tolerance of alpha-2b interferon therapy on HCV infection of hemodialyzed patients.


:A high frequency (25%) of anti-hepatitis C virus (HCV) antibodies is observed in French hemodialyzed patients; this is associated with detectable viremia in 85% and results in chronic hepatitis in more than 90%. We conducted a pilot study to examine the tolerance and efficacy of alpha-2b Interferon therapy upon HCV infection in hemodialyzed patients. Nineteen anti-HCV positive hemodialyzed patients were given a standard alpha-2b interferon regimen (3 megaunits subcutaneously three times weekly, following each hemodialysis) over six months as a treatment of biopsy-proven chronic hepatitis (N = 16) or acute hepatitis (N = 3). Thirteen of these 19 had increased levels of aminotransferase at the time of treatment. Serum HCV RNA was tested qualitatively and quantitatively by the polymerase chain reaction and the bDNA test, respectively, at the beginning and at the end of antiviral treatment, and a third time at least six months after the end of therapy (mean follow-up 18 +/- 9 months). HCV genotype was determined in the 15 patients who had detectable HCV RNA before treatment. The biological response (long-term response, relapse or non-response) was defined as usual according to the serum aminotransferase levels during therapy and at least six months after. A post-treatment liver biopsy, allowing comparison with semiquantitative pathological scores, was performed in 14 patients. Only one of the 19 treated patients did not complete therapy because of poor tolerance, while 18 of the 19 fairly tolerated a complete six month course of alpha-2b interferon.(ABSTRACT TRUNCATED AT 250 WORDS)


Kidney Int


Kidney international


Pol S,Thiers V,Carnot F,Zins B,Romeo R,Berthelot P,Bréchot C




Has Abstract


1995-05-01 00:00:00














  • Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis.

    abstract::Osteopontin is an arginine-glycine-aspartate (RGD) containing secreted phosphoprotein recently shown to stimulate a local macrophage influx when injected subcutaneously in mice. We examined the effect of angiotensin II infusion on renal injury and osteopontin expression in the rat kidney by in situ hybridization and i...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Giachelli CM,Pichler R,Lombardi D,Denhardt DT,Alpers CE,Schwartz SM,Johnson RJ

    更新日期:1994-02-01 00:00:00

  • Intraerythrocytic pH variations during hemodialysis: a 31P NMR study.

    abstract::Before hemodialysis, patients have an intraerythrocytic pH (pHi) and an extracellular pH, measured in whole blood (pHo), which are lower than those of healthy controls. During bicarbonate hemodialysis, pHi values continuously increase, approaching a normal value at the end of the session. Concomitantly, pHo values fol...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Monti JP,Gallice P,Baz M,Murisasco A,Crevat A,Elsen R

    更新日期:1989-03-01 00:00:00

  • Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans.

    abstract::Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calc...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lorthioir A,Joannidès R,Rémy-Jouet I,Fréguin-Bouilland C,Iacob M,Roche C,Monteil C,Lucas D,Renet S,Audrézet MP,Godin M,Richard V,Thuillez C,Guerrot D,Bellien J

    更新日期:2015-02-01 00:00:00

  • Interleukin-1 beta up-regulates the plasminogen activator/plasmin system in human mesangial cells.

    abstract::The plasminogen activators (PA), which are regulated by their specific inhibitor, PAI-1, convert the zymogen plasminogen to plasmin, a protease involved in fibrinolysis and extracellular matrix turnover. Interleukin 1 beta (IL-1) is a key cytokine released from infiltrating monocytes/macrophages during the initial sta...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Wilson HM,Haites NE,Reid FJ,Booth NA

    更新日期:1996-04-01 00:00:00

  • Lipoprotein phospholipid composition and LCAT activity in nephrotic and analbuminemic rats.

    abstract::Albumin is an acceptor of lysophosphatidylcholine (LPC), product of the lecithin:cholesterol acyl transferase (LCAT) reaction, and it has been suggested that low LCAT activity and reduced cholesterol esterification rate in patients with the nephrotic syndrome may be linked to depletion of albumin. Effects of low plasm...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Joles JA,Willekes-Koolschijn N,Scheek LM,Koomans HA,Rabelink TJ,van Tol A

    更新日期:1994-07-01 00:00:00

  • Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF.

    abstract:BACKGROUND:Caveolin is a principal component of caveolae and regulates signaling in caveolae. Mesangial cells contain many caveolae, and thus manipulation of caveolin-1 expression level might be useful to control mesangial cell proliferation, which is an important aggravating factor in many renal diseases. METHODS:In ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Fujita Y,Maruyama S,Kogo H,Matsuo S,Fujimoto T

    更新日期:2004-11-01 00:00:00

  • Dietary sodium restriction prevents kidney damage in high fructose-fed rats.

    abstract::Sodium depletion has a protective effect on target-organ damage in hypertension independent of blood pressure. Here we tested whether chronic dietary sodium restriction may prevent the development of renal alterations associated with insulin resistance by reducing the inflammatory and oxidant state. Rats were fed norm...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Oudot C,Lajoix AD,Jover B,Rugale C

    更新日期:2013-04-01 00:00:00

  • Developmental regulation and partial-length cloning of tubulointerstitial nephritis antigen of murine metanephros.

    abstract::Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix (ECM) glycoprotein that has been recently isolated and cloned from the rabbit kidney. It is an integral component of the basal lamina, and unlike other basement membrane proteins it is exclusively expressed in the tubular basement membranes (TBMs...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kumar A,Ota K,Wada J,Wallner EI,Charonis AS,Carone FA,Kanwar YS

    更新日期:1997-09-01 00:00:00

  • Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery.

    abstract::Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We studied methods for collection, storage, and preservation of urinary exosomal proteins. We collected urine fro...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Zhou H,Yuen PS,Pisitkun T,Gonzales PA,Yasuda H,Dear JW,Gross P,Knepper MA,Star RA

    更新日期:2006-04-01 00:00:00

  • Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease.

    abstract:BACKGROUND:The fluid filling renal cysts in human polycystic kidneys is secreted chiefly by the tubular epithelium lining the cysts via secondary chloride transport. Inhibiting this process by somatostatin therapy should induce shrinking of renal cysts. METHODS:In this randomized, cross-over, placebo-controlled trial ...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ruggenenti P,Remuzzi A,Ondei P,Fasolini G,Antiga L,Ene-Iordache B,Remuzzi G,Epstein FH

    更新日期:2005-07-01 00:00:00

  • Acid and mineral balances and bone in familial proximal renal tubular acidosis.

    abstract:BACKGROUND:Metabolic acidosis caused by increased rates of fixed acid production is associated with increased urinary excretion of Ca and negative Ca balances. Metabolic acidosis caused by a reduced capacity of the kidneys to excrete acid contributes to the development of bone disease in the course of chronic renal fai...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lemann J Jr,Adams ND,Wilz DR,Brenes LG

    更新日期:2000-09-01 00:00:00

  • Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy.

    abstract::In membranous nephropathy (MN) overproduction of matrix by glomerular epithelial cells (GEC) is believed to be responsible for glomerular basement membrane thickening and spikes. We studied experimental MN in rats (passive Heymann nephritis, PHN) at 5, 10 and 30 days. PHN rats exhibited a marked increase in GEC immuno...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Shankland SJ,Pippin J,Pichler RH,Gordon KL,Friedman S,Gold LI,Johnson RJ,Couser WG

    更新日期:1996-07-01 00:00:00

  • Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg.

    abstract:UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

    更新日期:2003-07-01 00:00:00

  • Effect of calcium and phosphate on bicarbonate and fluid transport by proximal tubules in vitro.

    abstract::Previous studies in living animals have suggested that variations in the serum concentrations of calcium and phosphate directly affect renal tubular bicarbonate transport. To examine this area more directly, we measured the bicarbonate and the fluid transport in isolated rabbit proximal convoluted and straight tubules...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: McKinney TD,Myers P

    更新日期:1982-03-01 00:00:00

  • Effect of Schiff base formation on the function of the calcitriol receptor.

    abstract::The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. We have shown that the interaction of VDRs with VDREs is inhibited by uremic toxins. We hypothesize that uremic toxins form Schiff bases with the lysine re...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Patel SR,Koenig RJ,Hsu CH

    更新日期:1996-11-01 00:00:00

  • Vitamin D: a new hope for chronic kidney disease?

    abstract::Vitamin D analogs may slow the progression of chronic kidney disease. Tan et al. report that paricalcitol has additive effects with an angiotensin-converting enzyme inhibitor (ACEI) in suppressing extracellular matrix expression, interstitial inflammation, and myofibroblast activation in obstructive nephropathy. Paric...

    journal_title:Kidney international

    pub_type: 评论,杂志文章,评审


    authors: Li M,Batuman V

    更新日期:2009-12-01 00:00:00

  • The intensity of acidosis differentially alters the pathways of ammoniagenesis in LLC-PK1 cells.

    abstract::Utilizing [5-15N] and [2-15N]-labeled glutamine and gas chromatography mass spectrometry methodology, we examined the pathways of ammoniagenesis under basal and acute acidotic conditions of pH 7.0 and pH 6.8, respectively. LLC-PK1 cultures were incubated for one hour with gentle rocking in a bicarbonate buffer of pH 7...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Nissim I,Sahai A,Sandler RS,Tannen RL

    更新日期:1994-04-01 00:00:00

  • Immunological quantification of advanced glycosylation end-products in the serum of patients on hemodialysis or CAPD.

    abstract::We have developed an immunological procedure for measuring advanced glycosylation end-products (AGEs) in serum. Using this method, we measured AGEs in healthy volunteers, patients with diabetes, renal failure without treatment and in patients with renal failure, treated with hemodialysis (HD) or continuous ambulatory ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Papanastasiou P,Grass L,Rodela H,Patrikarea A,Oreopoulos D,Diamandis EP

    更新日期:1994-07-01 00:00:00

  • L-carnitine is an osmotic agent suitable for peritoneal dialysis.

    abstract::Excessive intraperitoneal absorption of glucose during peritoneal dialysis has both local cytotoxic and systemic metabolic effects. Here we evaluate peritoneal dialysis solutions containing L-carnitine, an osmotically active compound that induces fluid flow across the peritoneum. In rats, L-carnitine in the peritoneal...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Bonomini M,Pandolfi A,Di Liberato L,Di Silvestre S,Cnops Y,Di Tomo P,D'Arezzo M,Monaco MP,Giardinelli A,Di Pietro N,Devuyst O,Arduini A

    更新日期:2011-09-01 00:00:00

  • Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress.

    abstract::Kallistatin is a serine protease inhibitor with anti-inflammatory, anti-angiogenic, and anti-oxidative properties. Since oxidative stress plays a critical role in the pathogenesis of diabetic nephropathy, we studied the effect and mechanisms of action of kallistatin superinduction. Using ultrasound-microbubble-mediate...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Yiu WH,Wong DW,Wu HJ,Li RX,Yam I,Chan LY,Leung JC,Lan HY,Lai KN,Tang SC

    更新日期:2016-02-01 00:00:00

  • A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression.

    abstract:UNLABELLED:A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression. BACKGROUND:The expression of inducible nitric oxide synthase (iNOS) is subject to strict tissue-specific transcriptional control. In mouse renal epithelium, an interferon-gamma (IFN-gamma)-induced signaling protei...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Amoah-Apraku B,Fang MZ,Guzman NJ

    更新日期:2000-01-01 00:00:00

  • Nature of glomerular dysfunction in pre-eclampsia.

    abstract:BACKGROUND:Pre-eclampsia is characterized by hypertension, proteinuria and edema. Simultaneous studies of kidney function and structure have not been reported. We wished to explore the degree and nature of glomerular dysfunction in pre-eclampsia. METHODS:Physiologic techniques were used to estimate glomerular filtrati...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lafayette RA,Druzin M,Sibley R,Derby G,Malik T,Huie P,Polhemus C,Deen WM,Myers BD

    更新日期:1998-10-01 00:00:00

  • Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus.

    abstract:BACKGROUND:Many studies have reported that blocking the renin-angiotensin-system (RAS) with an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker in the patient with diabetes mellitus leads to an increase in renal plasma flow (RPF), no change in glomerular filtration rate (GFR), and a fall...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章


    authors: Hollenberg NK,Price DA,Fisher ND,Lansang MC,Perkins B,Gordon MS,Williams GH,Laffel LM

    更新日期:2003-01-01 00:00:00

  • The hypercalcemia of malignancy.

    abstract::The hypercalcemia of malignancy is mediated by complex and heterogeneous mechanisms. Once thought of as a simple paraneoplastic syndrome mediated by the effects of tumor production of PTH, it is now clear that multiple mechanisms are involved and that these mechanisms involve abnormalities in calcium transport in bone...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Mundy GR

    更新日期:1987-01-01 00:00:00

  • Effects of contrast media and mannitol on renal medullary blood flow and red cell aggregation in the rat kidney.

    abstract::Hemodynamic factors may play a role in the development of acute renal failure following administration of contrast media (CM). In this study the effect of intravenous injection of contrast media and mannitol on red blood cell velocity (VRBC) and red blood cell aggregation in renal medullary vessels was studied in 58 r...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Liss P,Nygren A,Olsson U,Ulfendahl HR,Erikson U

    更新日期:1996-05-01 00:00:00

  • Higher body mass index is associated with incident diabetes and chronic kidney disease independent of genetic confounding.

    abstract::It is unknown whether the association between body mass index (BMI) and chronic kidney disease (CKD) is mediated by genetic confounding or obesity-associated diabetes. We investigated the association between BMI and incident CKD in 29,136 Swedish twins with no history of CKD or diabetes, first using traditional Cox re...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Xu H,Kuja-Halkola R,Chen X,Magnusson PKE,Svensson P,Carrero JJ

    更新日期:2019-05-01 00:00:00

  • Acidosis and hypoxic medullary injury in the isolated perfused kidney.

    abstract::The effects of acidosis on renal function and morphology were examined in the isolated perfused rat kidney (IPK). Kidneys were perfused with oxygenated Krebs-Henseleit-albumin medium for 60 minutes at pH 7.4 or pH 7.0. At the lower pH, GFR was reduced by 25%, TRNa by 32% and oxygen consumption by 41% as compared to pe...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Shanley PF,Shapiro JI,Chan L,Burke TJ,Johnson GC

    更新日期:1988-12-01 00:00:00

  • Lp(a) and LDL induce apoptosis in human endothelial cells and in rabbit aorta: role of oxidative stress.

    abstract:BACKGROUND:Atherogenic lipoproteins cause injury to the vascular wall in the early phase of atherogenesis. We assessed the effects of native (nLDL) and oxidized (oxLDL) low-density lipoprotein (LDL) and lipoprotein (a) [Lp(a)] on O2- formation and cell death in cultured human umbilical vein endothelial cells (HUVECs) a...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Galle J,Schneider R,Heinloth A,Wanner C,Galle PR,Conzelmann E,Dimmeler S,Heermeier K

    更新日期:1999-04-01 00:00:00

  • Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase.

    abstract:BACKGROUND:The rat renal proximal tubule cells contain a large amount of monoamine oxidase, which catalyzes the oxidative deamination of catecholamines such as dopamine (DA). The aim of this study is to investigate the potential role of hydrogen peroxide (H2O2) produced by monoamine oxidase (MAO) isoform on regulation ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Vindis C,Séguélas MH,Lanier S,Parini A,Cambon C

    更新日期:2001-01-01 00:00:00

  • Interaction between variants of two glycosyltransferase genes in IgA nephropathy.

    abstract::Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

    更新日期:2009-07-01 00:00:00