Tamm-Horsfall glycoprotein binds IgG with high affinity.

abstract：:Because of differences in case-mix across states, state-level case-mix-adjusted end-stage renal disease (ESRD) incident rates are reported in each United States Renal Data System Annual Data Report to make the across-state comparisons valid. The adjusted rates were estimated by the direct adjustment method, a widely u...

journal_title：Kidney international

authors： Liu J,Louis TA,Pan W,Ma JZ,Collins AJ

更新日期：2006-04-01 00:00:00

abstract：:The effects of acidosis on renal function and morphology were examined in the isolated perfused rat kidney (IPK). Kidneys were perfused with oxygenated Krebs-Henseleit-albumin medium for 60 minutes at pH 7.4 or pH 7.0. At the lower pH, GFR was reduced by 25%, TRNa by 32% and oxygen consumption by 41% as compared to pe...

journal_title：Kidney international

authors： Shanley PF,Shapiro JI,Chan L,Burke TJ,Johnson GC

更新日期：1988-12-01 00:00:00

abstract：:Incorporation in vivo of labeled orotate into RNA and total nucleotides was measured in isolated glomeruli and whole renal cortex. In 2-day diabetic animals, glomerular RNA was increased, and there was greater incorporation of orotate into total nucleotides and RNA as compared with controls. Insulin reversed the exagg...

journal_title：Kidney international

authors： Cortes P,Dumler F,Venkatachalam KK,Goldman J,Sastry KS,Venkatachalam H,Bernstein J,Levin NW

更新日期：1981-10-01 00:00:00

abstract：:Podocyte effacement and the reformation of foot processes and slit diaphragms can be induced within minutes experimentally. Therefore, it seems likely that the slit diaphragm proteins underlie orchestrated recycling mechanisms under the control of posttranslational modifiers. One of these modifiers, SUMO (small ubiqui...

journal_title：Kidney international

authors： Tossidou I,Himmelseher E,Teng B,Haller H,Schiffer M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Patients with thin basement membrane disease (TBMD) are often from families where hematuria segregates with the COL4A3 and COL4A4 genes. These genes also are affected in autosomal recessive Alport syndrome. The aim of this study was to demonstrate COL4A4 mutations in TBMD. METHODS:Forty-eight unrelated indi...

journal_title：Kidney international

authors： Buzza M,Dagher H,Wang YY,Wilson D,Babon JJ,Cotton RG,Savige J

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...

journal_title：Kidney international

authors： Rasch R,Nyengaard JR,Marcussen N,Meyer TW

更新日期：2002-08-01 00:00:00

abstract：:Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world, and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading to CKD after acute injury are limited by current animal models of AKI, which concurrently target v...

journal_title：Kidney international

authors： Grgic I,Campanholle G,Bijol V,Wang C,Sabbisetti VS,Ichimura T,Humphreys BD,Bonventre JV

更新日期：2012-07-01 00:00:00

abstract：:Proteinuric diabetic patients have an increased risk of cardiovascular disease and almost always have hypertension. In the early stages of diabetic renal disease (microalbuminuria) when renal function is well preserved, systemic arterial blood pressure is already elevated compared to insulin-dependent diabetic patient...

journal_title：Kidney international

authors： Earle K,Viberti GC

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Chronic oversecretion of parathyroid hormone (PTH) is associated with parathyroid hyperplasia, reflecting a disturbed balance between cell proliferation and apoptosis. This study addressed the unsolved issue of apoptosis in hyperparathyroidism. METHODS:Parathyroid glands from 19 patients with primary (1 deg...

journal_title：Kidney international

authors： Zhang P,Duchambon P,Gogusev J,Nabarra B,Sarfati E,Bourdeau A,Drüeke TB

更新日期：2000-02-01 00:00:00

abstract：:The inner medullary collecting duct (IMCD) is a major target site of atrial natriuretic peptide (ANP) for diuresis and natriuresis, and it is in a hypertonic condition made by the renal countercurrent multiplication system. We investigated the effects of hyperosmolality on ANP-stimulated cGMP generation in IMCD and gl...

journal_title：Kidney international

authors： Shinohara M,Nonoguchi H,Ujiie K,Terada Y,Owada A,Tomita K,Marumo F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Hypertension is a recognized complication of partial correction of anemia with recombinant human erythropoietin (epoetin) in hemodialysis patients. We used interdialytic ambulatory blood pressure (ABP) monitoring to study the effects of partially corrected anemia versus normal hematocrit (hct) on BP in hemod...

journal_title：Kidney international

authors： Berns JS,Rudnick MR,Cohen RM,Bower JD,Wood BC

更新日期：1999-07-01 00:00:00

abstract：:In this mini review, we would like to challenge the well-established 'fact' that lead exposure causes chronic renal failure (CRF). Even though only scarce evidence exists of the relationship between lead and renal failure, a World Health Organization Environmental Health Criteria document summarizes that 'Lead has bee...

journal_title：Kidney international

authors： Evans M,Elinder CG

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Cisplatin (CP) induced polyuria in rats is associated with a reduction in medullary hypertonicity, normally generated by the thick ascending limb (TAL) salt transporters, and the collecting duct urea transporters (UT). To investigate the molecular basis of this abnormality, we determined the protein abundanc...

journal_title：Kidney international

authors： Ecelbarger CA,Sands JM,Doran JJ,Cacini W,Kishore BK

更新日期：2001-12-01 00:00:00

abstract：:Progressive renal fibrosis is the final common pathway leading to renal failure irrespective of the initiating cause. Clinical studies of renal fibrosis found that prominent mast cell accumulation correlated with worse outcomes. Mast cells are pluripotent innate immune cells that synthesize and secrete profibrotic med...

journal_title：Kidney international

authors： Summers SA,Gan PY,Dewage L,Ma FT,Ooi JD,O'Sullivan KM,Nikolic-Paterson DJ,Kitching AR,Holdsworth SR

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Autosomal-dominant medullary cystic kidney disease type 2 (MCKD2) is a tubulointerstitial nephropathy that causes renal salt wasting, hyperuricemia, gout, and end-stage renal failure in the fifth decade of life. The chromosomal locus for MCKD2 was localized on chromosome 16p12. Within this chromosomal region...

journal_title：Kidney international

authors： Wolf MT,Mucha BE,Attanasio M,Zalewski I,Karle SM,Neumann HP,Rahman N,Bader B,Baldamus CA,Otto E,Witzgall R,Fuchshuber A,Hildebrandt F

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:It is currently impossible to reliably predict which diabetic patients will develop nephropathy and progress to kidney failure. Microalbuminuria, often regarded as a predictor of overt diabetic renal disease is, in fact, an indicator of established glomerular damage. We have shown that glomerular expression ...

journal_title：Kidney international

authors： Riser BL,Cortes P,DeNichilo M,Deshmukh PV,Chahal PS,Mohammed AK,Yee J,Kahkonen D

更新日期：2003-08-01 00:00:00

abstract：:Anecdotal reports of complement component deficiencies in patients with immune complex disease led to a systematic study of the levels of seven complement components in serum specimens from 178 patients with glomerulonephritis and 163 normal subjects. Deficiencies were found with significantly higher frequency (22.7%)...

journal_title：Kidney international

authors： Coleman TH,Forristal J,Kosaka T,West CD

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:A need exists for a therapy that lowers parathyroid hormone (PTH) without increasing calcium x phosphorus in patients with secondary hyperparathyroidism. The calcimimetic AMG 073 increases the sensitivity of the parathyroid calcium-sensing receptor to extracellular calcium, thereby reducing PTH secretion. Co...

journal_title：Kidney international

authors： Lindberg JS,Moe SM,Goodman WG,Coburn JW,Sprague SM,Liu W,Blaisdell PW,Brenner RM,Turner SA,Martin KJ

更新日期：2003-01-01 00:00:00

abstract：:Development of physiologically relevant cellular models with strong translatability to human pathophysiology is critical for identification and validation of novel therapeutic targets. Herein we describe a detailed protocol for generation of an advanced 3-dimensional kidney cellular model using induced pluripotent ste...

journal_title：Kidney international

authors： Boreström C,Jonebring A,Guo J,Palmgren H,Cederblad L,Forslöw A,Svensson A,Söderberg M,Reznichenko A,Nyström J,Patrakka J,Hicks R,Maresca M,Valastro B,Collén A

更新日期：2018-12-01 00:00:00

abstract：:Chronic cyclosporine (CsA) nephrotoxicity is a major complication of heart, bone marrow, and renal transplantation, and is characterized in humans by striped interstitial fibrosis, tubular dilatation and atrophy, and hyalinization of hilar arterioles. This last feature is highly specific for cyclosporine injury and ha...

journal_title：Kidney international

authors： Young BA,Burdmann EA,Johnson RJ,Andoh T,Bennett WM,Couser WG,Alpers CE

更新日期：1995-08-01 00:00:00

abstract：:The pathogenesis of the multiple structural lesions in diabetic nephropathy remains debated, and likely is multifactorial. The uniform thickening of the renal basement membranes lining the glomerular and tubular elements appears to be a consequence of the metabolic perturbations which are directly related to hyperglyc...

journal_title：Kidney international

authors： Ziyadeh FN

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Hemodialysis access thrombosis is a significant cause of morbidity for hemodialysis patients and results from decreased access flow caused by venous outflow tract stenosis. Ultrasound dilution (UD) is a practical, noninvasive, and reliable indicator of access flow and is effective in predicting venous stenos...

journal_title：Kidney international

authors： Goldstein SL,Allsteadt A

更新日期：2001-06-01 00:00:00

abstract：:Idiopathic retroperitoneal fibrosis (IRF) is a rare disease often causing obstructive uropathy. We evaluated the clinicopathologic features of 24 patients with IRF to characterize the histopathology of the disease and to provide a framework for the differential diagnosis with other retroperitoneal fibrosing conditions...

journal_title：Kidney international

authors： Corradi D,Maestri R,Palmisano A,Bosio S,Greco P,Manenti L,Ferretti S,Cobelli R,Moroni G,Dei Tos AP,Buzio C,Vaglio A

更新日期：2007-09-01 00:00:00

abstract：:Renal para-aminohippurate (PAH) clearances were predicted in 16 kidneys of eight hypertensive patients with renal artery stenosis, pyelonephritis, or obstructive nephropathy, without individual ureteral catheterization. Predictions of left or right kidney clearance (CL or CR) were based on roentgenographic renal front...

journal_title：Kidney international

authors： Gutkin M,Perl W,Das BN,Chin B,Modlinger RS

更新日期：1977-03-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase associated with numerous aspects of health and physiology. Overexpression of SIRT6 has emerged as a protector in cardiac tissues against pathologic cardiac hypertrophy. However, the mechanism of this protective effect is not fully understood. Here, both in vivo and in ...

journal_title：Kidney international

authors： Li Z,Xu K,Zhang N,Amador G,Wang Y,Zhao S,Li L,Qiu Y,Wang Z

更新日期：2018-04-01 00:00:00

abstract：:We examined the potential of in vivo linkage of plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) in the setting of endothelial injury and sclerosis following radiation injury in the rat. PAI-1 is a major physiological inhibitor of the plasminogen activator (PA)/plasmin system, a key regulator of f...

journal_title：Kidney international

authors： Oikawa T,Freeman M,Lo W,Vaughan DE,Fogo A

更新日期：1997-01-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphate-regulating hormone that acts primarily on the kidney and parathyroid. With declining kidney function there is an increase in circulating FGF23 levels, which is associated with vascular calcification and mortality in chronic kidney disease. Whether FGF23 exerts direct ...

journal_title：Kidney international

authors： Jimbo R,Kawakami-Mori F,Mu S,Hirohama D,Majtan B,Shimizu Y,Yatomi Y,Fukumoto S,Fujita T,Shimosawa T

更新日期：2014-05-01 00:00:00

abstract：:Erythropoietin (EPO) therapy in hemodialysis patients may be associated with an enhanced risk of vascular access and extracorporeal thrombosis. Assessment of blood coagulation and fibrinolysis was performed monthly on a group of 21 hemodialysis patients treated with EPO, and on four iron-deficient hemodialysis patient...

journal_title：Kidney international

authors： Taylor JE,Belch JJ,McLaren M,Henderson IS,Stewart WK

更新日期：1993-07-01 00:00:00

abstract：:Effect of insulin-like growth factor-1 (IGF) on the synthesis of glomerular proteoglycans (PGs) in an ex vivo recirculating organ perfusion system was investigated. Kidneys were perfused with a medium (approximately 80 ml) containing [35S]-sulfate (250 microCi/ml) and IGF (62.5 to 625 ng/ml). After radiolabeling, a sm...

journal_title：Kidney international

authors： Watanabe Y,Kashihara N,Makino H,Kanwar YS

更新日期：1992-05-01 00:00:00

abstract：:Nephropathia epidemica (NE) caused by Puumala hantavirus is one type of hemorrhagic fever with renal syndrome (HFRS). There is considerable variability in the clinical severity of NE. Many infections are subclinical but the disease can even be fatal. We questioned whether the wide spectrum in the outcome of NE is depe...

journal_title：Kidney international

authors： Mustonen J,Partanen J,Kanerva M,Pietilä K,Vapalahti O,Pasternack A,Vaheri A

更新日期：1996-01-01 00:00:00