Awakening the Bowman: inhibition of CXCL12 signaling activates parietal epithelial cells.

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：:Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Here we provide evidence ...

journal_title：Kidney international

authors： Rashmi P,Colussi G,Ng M,Wu X,Kidwai A,Pearce D

更新日期：2017-05-01 00:00:00

abstract：:Vascular calcification (VC) is an important reason for the high burden of vascular disease among chronic dialysis patients. Chronic kidney disease (CKD) is associated with increased promoters and decreased inhibitors of VC. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the c...

journal_title：Kidney international

authors： Mehrotra R

更新日期：2007-07-01 00:00:00

abstract：:Levels of prepro epidermal growth factor (EGF) mRNA in renal cortical tissue and urinary EGF excretion have been determined during cisplatin and ischemia-induced acute renal failure in the rat. Northern analysis of polyadenylated RNAs of kidney cortical tissue showed diminished renal preproEGF mRNA in rats injected wi...

journal_title：Kidney international

authors： Safirstein R,Zelent AZ,Price PM

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Regular monitoring of dialysis grafts is recommended, but the value of dialysis graft blood flow monitoring and venous pressures in predicting subsequent outcomes are controversial. METHODS:Over a period of one month, we performed simultaneous flow and venous pressure monitoring in 71 dialysis patients with...

journal_title：Kidney international

authors： McDougal G,Agarwal R

更新日期：2001-08-01 00:00:00

abstract：:Regardless of the source of injury, an imbalance in the control of mesangial cell proliferation appears to play a direct role in the degree of progressive renal injury and glomerulosclerosis. Some of the regulatory mechanisms include specific soluble or non-soluble extracellular factors and a complex array of receptor...

journal_title：Kidney international

authors： Schöcklmann HO,Lang S,Sterzel RB

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:We have recently found evidence for increased reactive oxygen species (ROS) in rats with lead-induced hypertension. We hypothesized that increased ROS activity may contribute to hypertension by enhancing inactivation of nitric oxide (NO) in this model. METHODS:Rats were treated for 12 weeks with either lead...

journal_title：Kidney international

authors： Vaziri ND,Liang K,Ding Y

更新日期：1999-10-01 00:00:00

abstract：:The candidacidal activity of kidneys, liver, and spleen's phagocytic systems was studied in mouse. Different strains of mice were inoculated intravenously (i.v.) with 1 to 2.6 x 10(4) viable Candida albicans. Elimination of the microorganisms from the kidneys, liver, and spleen were evaluated by enumeration of colony ...

journal_title：Kidney international

authors： Baghian A,Lee KW

更新日期：1991-09-01 00:00:00

abstract：:Recent decades have witnessed the revelation of expanding roles of the vitamin D endocrine system beyond calcium and phosphorus metabolism. Along with these non-calcemic or non-classic actions of vitamin D are newly discovered therapeutic actions of vitamin D analogs in a number of pathological conditions, including k...

journal_title：Kidney international

authors： Li YC

更新日期：2010-07-01 00:00:00

abstract：:Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normox...

journal_title：Kidney international

authors： Haase VH

更新日期：2011-02-01 00:00:00

abstract：:In membranous nephropathy (MN) overproduction of matrix by glomerular epithelial cells (GEC) is believed to be responsible for glomerular basement membrane thickening and spikes. We studied experimental MN in rats (passive Heymann nephritis, PHN) at 5, 10 and 30 days. PHN rats exhibited a marked increase in GEC immuno...

journal_title：Kidney international

authors： Shankland SJ,Pippin J,Pichler RH,Gordon KL,Friedman S,Gold LI,Johnson RJ,Couser WG

更新日期：1996-07-01 00:00:00

abstract：:The impact of dialysis on cognitive trends is uncertain. Kurella Tamura et al. evaluated cognitive trajectories in 212 participants from the Chronic Renal Insufficiency Cohort study and found that dialysis initiation was associated with a decline in executive function. This is consistent with a cerebrovascular basis f...

journal_title：Kidney international

authors： Iyasere O,Brown EA

更新日期：2017-04-01 00:00:00

abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...

journal_title：Kidney international

authors： Sipos A,Toma I,Kang JJ,Rosivall L,Peti-Peterdi J

更新日期：2007-11-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：:In studying the metabolic effects of diet potassium (K+) variation in normal humans, we noted that varying diet K+ within its normal range influenced inorganic phosphorus (Pi) homeostasis and serum calcitriol (1,25-dihydroxyvitamin D) levels. In six men who ingested a constant whole-foods diet containing (per 70 kg bo...

journal_title：Kidney international

authors： Sebastian A,Hernandez RE,Portale AA,Colman J,Tatsuno J,Morris RC Jr

更新日期：1990-05-01 00:00:00

abstract：:Orskov and colleagues demonstrate the impact of birth weight on the mean age of end-stage renal disease (ESRD) in a large Danish ADPKD cohort. Each kilogram of birth weight extended the mean age of ESRD onset by 1.7 years. Placental insufficiency, activation of the renin-angiotensin-aldosterone system, increased fetal...

journal_title：Kidney international

authors： Chapman AB

更新日期：2012-05-01 00:00:00

abstract：:While it is known that risk of death from sepsis is higher in patients with pre-existing chronic kidney disease its mechanism is unknown. To study this we established a two-stage mouse model where renal disease was first induced by folic acid injection followed by sub-lethal cecal ligation and puncture to induce sepsi...

journal_title：Kidney international

authors： Doi K,Leelahavanichkul A,Hu X,Sidransky KL,Zhou H,Qin Y,Eisner C,Schnermann J,Yuen PS,Star RA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening. In the present study, we explored the possible involvement of the kinin-kallikrein system in the development of this renal vascula...

journal_title：Kidney international

authors： Tsuchida S,Miyazaki Y,Matsusaka T,Hunley TE,Inagami T,Fogo A,Ichikawa I

更新日期：1999-08-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) is a C-C chemokine with potent monocyte chemotactic and activating properties that may contribute to glomerular macrophage infiltration in anti-GBM Ab GN. We have previously reported increased glomerular steady state expression of MCP-1 mRNA relative to GAPDH mRNA in the hete...

journal_title：Kidney international

authors： Tang WW,Qi M,Warren JS

更新日期：1996-08-01 00:00:00

abstract：:Atherogenic lipoproteins and reactive oxygen species stimulate renin release from isolated juxtaglomerular (JG) cells. Here we assessed whether stimulation of renin release is mediated by formation of superoxide anion (O2-), and whether the effects of oxidized lipoproteins, like in many other biological systems, can b...

journal_title：Kidney international

authors： Galle J,Heinloth A,Schwedler S,Wanner C

更新日期：1997-01-01 00:00:00

abstract：:A strong influence of urinary kallikrein excretion on the salt sensitivity of blood pressure has been recently suggested in normotensive patients. To evaluate the relationship between kallikrein and salt sensitivity in essential hypertension, active kallikrein excretion, plasma renin activity, atrial natriuretic pepti...

journal_title：Kidney international

authors： Ferri C,Bellini C,Carlomagno A,Perrone A,Santucci A

更新日期：1994-09-01 00:00:00

abstract：:Intradialytic hypotension is a most frequent complication of hemodialysis and may contribute to cardiovascular events and high mortality. There is a hypothesis that an increase in adenosine generation during hemodialysis may cause vasodilation and a decrease in cardiac output, which results in systemic hypotension. We...

journal_title：Kidney international

authors： Imai E,Fujii M,Kohno Y,Kageyama H,Nakahara K,Hori M,Tsubakihara Y

更新日期：2006-03-01 00:00:00

abstract：:With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major health problem worldwide. Approximately, 80% of kidney stones are composed of calcium and hypercalciuria is found in up to 40% of stone-formers. Although the mechanisms resulting in precipitation and growth of calcium crystals in...

journal_title：Kidney international

authors： Devuyst O,Pirson Y

更新日期：2007-11-01 00:00:00

abstract：:Mutations in the MYH9 gene, coding for the non-muscle myosin heavy chain IIA (NMHC-IIA), are responsible for syndromes characterized by macrothrombocytopenia associated with deafness, cataracts, and severe glomerular disease. Electron microscopy of renal biopsies from these patients found glomerular abnormalities char...

journal_title：Kidney international

authors： Müller T,Rumpel E,Hradetzky S,Bollig F,Wegner H,Blumenthal A,Greinacher A,Endlich K,Endlich N

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure. METHODS:We performed meta-analysis of published reports on ARF after myeloa...

journal_title：Kidney international

authors： Parikh CR,McSweeney P,Schrier RW

更新日期：2005-05-01 00:00:00

abstract：:The beneficial effects of post-insult administration of pentoxifylline, a novel hemorheologic agent experimentally studied in various ischemic diseases, were evaluated in two models of acute renal failure (ARF): direct nephrotoxicity (mercuric chloride 4 mg/kg via femoral vein) and hemoglobinuria (glycerol 10 ml/kg i....

journal_title：Kidney international

authors： Vadiei K,Brunner LJ,Luke DR

更新日期：1989-09-01 00:00:00

abstract：:We studied the specific binding of radiolabeled bradykinin ([3H]BK) and vasopressin ([3H]AVP) to membrane preparations of bovine and porcine kidney medulla. [3H]BK reversibly labeled a single site (Kd = 1.06 nM) in bovine kidney medulla independently of [Mg2+]. The number of BK receptors in bovine kidney medulla, Bmax...

journal_title：Kidney international

authors： Howl J,Yarwood NJ,Davies AR,Wheatley M

更新日期：1996-08-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF)-D, a specific PDGF receptor β (PDGFR-β) ligand, mediates mesangial proliferation in vitro and in vivo. However, its role in renal development, physiology, and fibrosis is relatively unknown. In healthy murine kidneys, PDGF-D was found to be expressed on renal mesenchymal cells (me...

journal_title：Kidney international

authors： Buhl EM,Djudjaj S,Babickova J,Klinkhammer BM,Folestad E,Borkham-Kamphorst E,Weiskirchen R,Hudkins K,Alpers CE,Eriksson U,Floege J,Boor P

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Gene expression profiling of nephropathies may facilitate development of diagnostic strategies for complex renal diseases as well as provide insight into the molecular pathogenesis of kidney diseases. To test molecular based renal disease categorization, differential gene expression profiles were compared be...

journal_title：Kidney international

authors： Henger A,Kretzler M,Doran P,Bonrouhi M,Schmid H,Kiss E,Cohen CD,Madden S,Porubsky S,Gröne EF,Schlöndorff D,Nelson PJ,Gröne HJ

更新日期：2004-03-01 00:00:00

abstract：:IgA nephropathy (IgAN) often shows lesions morphologically identical with those of focal segmental glomerulosclerosis (FSGS). In order to determine the possible role of FSGS in IgAN lesions, we measured glomerular capsular adhesions, often the first step toward FSGS, in biopsies from 127 patients with IgAN, 100 with l...

journal_title：Kidney international

authors： Hill GS,Karoui KE,Karras A,Mandet C,Van Huyen JD,Nochy D,Bruneval P

更新日期：2011-03-01 00:00:00