Abstract:
BACKGROUND:Although renal protective effect of interrupting the inflammatory process is well established, it is still controversial if it also prevents the glomerular hemodynamic disturbances that initiate renal injury. We investigated the effects of suppressing inflammation with mycophenolate mofetil (MMF) on glomerular hemodynamics, arteriolar structural changes, and renal histologic injury in rats with subtotal renal ablation METHODS:Micropuncture studies were performed 30 days after 5/6 nephrectomy in rats untreated and treated with MMF (30 mg/kg/day). Renal histology, immunohistochemistry for lymphocytes, macrophages and inducible nitric oxide synthase (iNOS) expression, as well as afferent arteriolar (AA) morphometry was evaluated. RESULTS:Renal ablation significantly increased proteinuria (6.8 to 82.7 mg/day), mean arterial pressure (MAP) (120 to 166 mm Hg), single-nephron glomerular filtration rate (SNGFR) (34.8 to 56.3 nL/min), glomerular plasma flow (QA) (117.7 to 246.9 nL/min), and glomerular capillary pressure (PGC) (48.9 to 61.0 mm Hg). Afferent resistance (AR), efferent resistance, and ultrafiltration coefficient remained unchanged. Despite persisting arterial hypertension (152 mm Hg), MMF prevented proteinuria (13.3 mg/day), and significantly reduced SNGFR (44.4 nL/min), PGC (49.1 mm Hg), and QA (163.2 nL/min) due to a rise in AR (3.13 vs. 2.18 1010 dyn/sec/cm-5). Glomerular sclerosis, tubulointerstitial damage, lymphocyte and macrophage infiltration, and iNOS expression were significantly reduced by MMF, in addition hypertrophy of AA resistance evaluated by the media/lumen ratio was prevented (P < 0.001). CONCLUSIONS:Reduction in proteinuria, SNGFR, QA, and PGC, despite elevated MAP, indicate preservation of AA function. These results suggest that inflammation associated arteriolopathy of AA contributes to glomerular hemodynamic disturbances that participate in the progression of renal disease.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Tapia E,Franco M,Sánchez-Lozada LG,Soto V,Avila-Casado C,Santamaría J,Quiroz Y,Rodríguez-Iturbe B,Herrera-Acosta Jdoi
10.1046/j.1523-1755.2003.00811.xsubject
Has Abstractpub_date
2003-03-01 00:00:00pages
994-1002issue
3eissn
0085-2538issn
1523-1755pii
S0085-2538(15)48967-7journal_volume
63pub_type
杂志文章abstract::A study of dialysis costs in five major dialysis centers throughout the United States was conducted in 1973. When available, home, home training, limited care, satellite and in-hospital-full-care dialysis were included. The study's objective was to determine the cost per dialysis for each separate dialysis modality. A...
journal_title:Kidney international
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journal_title:Kidney international
pub_type: 杂志文章
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journal_title:Kidney international
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doi:10.1046/j.1523-1755.2000.00100.x
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pub_type: 评论,杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Kidney international
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journal_title:Kidney international
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doi:10.1038/ki.1995.301
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pub_type: 评论,杂志文章
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journal_title:Kidney international
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pub_type: 杂志文章,评审
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