Abstract：
:Long-term complications of continuous immunosuppression still remain a serious threat and are currently drawing the attention of transplant physicians. Wimmer et al. show that malignancy occurs approximately fourfold more frequently in renal-transplant recipients than in a normal control population. Besides immunosuppression, viruses probably play an important oncogenic role in transplant recipients. The retrospective analysis by Wimmer et al. suggests that mTOR inhibitors and interleukin-2 receptor antibodies are promising immunosuppressive drugs to reduce the risk of cancer after transplantation. These preliminary results must be confirmed in large, prospective, randomized, controlled trials, with long follow-up, designed to evaluate the incidence of de novo malignancy in transplant recipients.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Bosmans JL,Verpooten GAdoi
10.1038/sj.ki.5002306subject
Has Abstractpub_date
2007-06-01 00:00:00pages
1197-9issue
12eissn
0085-2538issn
1523-1755pii
S0085-2538(15)52311-9journal_volume
71pub_type
评论,杂志文章abstract：:Tubular atrophy and interstitial fibrosis, important in progression of renal diseases, including diabetic (D) and cyclosporine-induced (CSA) nephropathy, have been considered irreversible. Normoglycemia for 10 years following pancreas transplantation alone (PTA) reversed D glomerulopathy lesions. This study quantified...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000153
更新日期：2006-03-01 00:00:00
abstract：:The International Pediatric Peritonitis Registry (IPPR) was created to assess and evaluate the validity of the pediatric peritonitis treatment guidelines issued by the International Society for Peritoneal Dialysis. The study by Schaefer et al., one of the first to emerge from the IPPR, describes regional variability i...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5002529
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Studies in animal models have shown that the alternative pathway of complement is activated in the kidney after ischemia/reperfusion. In addition, mice deficient in complement factor B, a necessary component of the alternative pathway, are protected from ischemic acute renal failure. The purpose of this stud...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.67109.x
更新日期：2005-02-01 00:00:00
abstract：:Only some individuals carrying the high-risk APOL1 genotype go on to develop kidney disease phenotypes. In this issue of Kidney International, Nadkarni and colleagues report the associations of several biomarkers with renal outcomes in individuals with high-risk APOL1 genotypes. In the era of precision medicine, these...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2018.03.005
更新日期：2018-06-01 00:00:00
abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) transforms endogenous glucocorticoids to their respective "biologically inert" 11-dehydro derivatives. A decrease in enzyme activity allows glucocorticoids to induce mineralocorticoid-like renal sodium retention. Since positive sodium balance is required for optimum ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.91
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:C-peptide has been reported to have biological effects on renal function early in the course of diabetes. This investigation was initiated to elucidate and amplify these findings with respect to protein leakage, hyperfiltration and renal functional reserve in diabetic rats. METHODS:Acute effects of 140 minu...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1998.00074.x
更新日期：1998-09-01 00:00:00
abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is associated with a urine-concentrating defect attributed to renal cystic changes. As PKD genes are expressed in the brain, altered central release of arginine vasopressin could also play a role. In order to help determine this we measured central and nephrogenic c...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.225
更新日期：2012-11-01 00:00:00
abstract：:Previously, uremic toxins were sometimes regarded as a large, mysterious, but also anonymous group of factors potentially contributing to morbidity and mortality in end-stage renal disease. By identifying the protein-bound solute p-cresol as a risk factor for mortality in dialysis patients, Bammens and colleagues for ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5000236
更新日期：2006-03-01 00:00:00
abstract：:Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.77
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2002.kid565.x
更新日期：2002-10-01 00:00:00
abstract：:Progression of diabetic nephropathy appears directly related to renal tubulointerstitial injury, but the involved genes are incompletely delineated. To identify such genes, DNA microarray analysis was performed with RNA from renal proximal tubules (RPTs) of streptozotocin-induced diabetic Wistar rats, spontaneously di...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000206
更新日期：2006-03-01 00:00:00
abstract：:Previous studies have demonstrated that dietary potassium deprivation in healthy human subjects eating diets otherwise containing normal quantities of NaCl is accompanied by an increase in urinary calcium excretion. This increase in urinary Ca excretion occurs in association with reductions in urinary Na and Cl excret...
journal_title：Kidney international
pub_type： 临床试验,杂志文章
doi：10.1038/ki.1995.134
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:Cellular and molecular mechanisms responsible for cisplatin-induced nephrotoxicity to renal tubular epithelial cells are not well understood. Although caspases play a critical role in the execution of the cell death pathway, their specific role in toxic injury to renal tubular epithelial cells has not been e...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.00026.x
更新日期：2001-11-01 00:00:00
abstract：:The release of cytokines and prostaglandins (PG) by peritoneal macrophages (PM luminal diameter of) may influence the cytokine network controlling peritoneal inflammation and in the long-term the function of the peritoneum as a dialysis membrane. In the present study, an evaluation of the long-term effects of peritone...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.75
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Epidermal growth factor (EGF) plays an important role in renal tubular regeneration after ischemic injury in kidney. The present study reports the association between the renin-angiotensin system (RAS) and EGF, and the effect of angiotensin II blockade with losartan (LSRT) on EGF expression in an experimenta...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.060003847.x
更新日期：2001-09-01 00:00:00
abstract：:Thrombomodulin (TM), an endothelial receptor for thrombin, endowed with a powerful anticoagulant activity, plays an important role in the antithrombogenicity of the vascular endothelium. Its presence within the human renal glomerulus is already known but was thought to be only endothelial. We looked for TM expression ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.99
更新日期：1997-03-01 00:00:00
abstract：:This report describes the occurrence of immune complex glomerulonephritis in a patient with eosinophilic gastroenteritis and food hypersensitivity. A coincident allergen injection may have been a contributing factor in the sudden development of the nephrotic syndrome. Markedly elevated levels of circulating immune com...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1986.226
更新日期：1986-10-01 00:00:00
abstract：:The thick ascending limb of Henle's loop ( TAL ) develops a specific and consistent structural lesion during perfusion of the isolated rat kidney that progresses from mitochondrial swelling at 15 min to complete cellular disruption at 90 min. Because it seemed possible that damage localized to this metabolically activ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1984.9
更新日期：1984-01-01 00:00:00
abstract：:A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2013.38
更新日期：2013-05-01 00:00:00
abstract：:Erythropoietin (Epo) is essential for erythropoiesis and is mainly produced by the fetal liver and the adult kidney following hypoxic stimulation. Epo regulation is commonly studied in hepatoma cell lines, but differences in Epo regulation between kidney and liver limit the understanding of Epo dysregulation in polycy...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.08.043
更新日期：2019-02-01 00:00:00
abstract：:Electron microprobe analysis on freeze-dried cryosections was used to determine the effect of the loop diuretics torasemide and furosemide on intracellular electrolyte concentrations in individual cells of the outer and inner stripe of the outer medulla and on cell rubidium uptake, the latter a measure of basolateral ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.359
更新日期：1992-10-01 00:00:00
abstract：:To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.100
更新日期：1985-06-01 00:00:00
abstract：:Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase associated with numerous aspects of health and physiology. Overexpression of SIRT6 has emerged as a protector in cardiac tissues against pathologic cardiac hypertrophy. However, the mechanism of this protective effect is not fully understood. Here, both in vivo and in ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.10.021
更新日期：2018-04-01 00:00:00
abstract：:In rats undergoing renal mass reduction (RMR) oral supplementation with the nitric oxide (NO) precursor L-arginine increases glomerular filtration rate and ameliorates signs of glomerular injury, suggesting that chronic renal failure in the rats is a condition of low NO formation in the kidney. On the contrary, data a...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.317
更新日期：1997-07-01 00:00:00
abstract：:Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducibl...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.06.015
更新日期：2017-12-01 00:00:00
abstract：:In this study, we have evaluated 50 children (30 girls and 20 boys; mean age, 10.1 years) with a variety of renal diseases in whom renal biopsy specimens showed crescents in greater than or equal to 50% of glomeruli. Initial clinical features included edema in 61%; hypertension in 51%; gross hematuria in 73%; 3 to 4+ ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.30
更新日期：1985-02-01 00:00:00
abstract：:Most epidemiologic data, thus far, have focused on short-term outcomes of acute kidney injury (AKI). Lo et al. correlate AKI with long-term outcomes. The concept of 'uremic memory' sheds light on the importance of AKI and its permanent imprint. The focus of research should be on prevention of an episode of AKI, when p...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2009.314
更新日期：2009-10-01 00:00:00
abstract：:The ability to pursue gene therapy has been limited by the availability of an effective and safe system for gene delivery, especially to the kidney. Electroporation is an efficient method to transfer physiologically the gene to the cells without complicated preparation. Given that the systemic delivery of the function...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1046/j.1523-1755.2002.0610s1037.x
更新日期：2002-01-01 00:00:00
abstract：:In a variety of recent studies in animals with chronic renal diseases, investigators have found a tight correlation between the elevation in glomerular pressures and flows versus glomerular hypertrophy. To investigate a possible causal link between the glomerular hyperfunction and hypertrophy, we studied the functiona...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1989.35
更新日期：1989-02-01 00:00:00
abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis involves innate and adaptive immune cells in the induction of autoimmunity and in autoimmune effector responses. Most Fcγ receptors (FcγRs) activate immune cells, but FcγRIIB, found in humans and mice on B cells and innate cells, is an inhibitor...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2014.189
更新日期：2014-12-01 00:00:00
