Abstract：
:The incidence of malnutrition disorders in chronic kidney disease (CKD) appears unchanged over time, whereas patient-care and dialysis techniques continue to progress. Despite some evidence for cost-effective treatments, there are numerous caveats to applying these research findings on a daily care basis. There is a sustained generation of data confirming metabolic improvement when patients control their protein intake, even at early stages of CKD. A recent protein-energy wasting nomenclature allows a simpler approach to the diagnosis and causes of malnutrition. During maintenance dialysis, optimal protein and energy intakes have been recently challenged, and there is no longer an indication to control hyperphosphatemia through diet restriction. Recent measurements of energy expenditure in dialysis patients confirm very low physical activity, which affects energy requirements. Finally, inflammation, a common state during CKD, acts on both nutrient intake and catabolism, but is not a contraindication to a nutritional intervention, as patients do respond and improve their survival as well as do noninflamed patients.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Fouque D,Pelletier S,Mafra D,Chauveau Pdoi
10.1038/ki.2011.118subject
Has Abstractpub_date
2011-08-01 00:00:00pages
348-57issue
4eissn
0085-2538issn
1523-1755pii
S0085-2538(15)55046-1journal_volume
80pub_type
杂志文章,评审abstract：:The soluble receptor of advanced glycation end product (sRAGE) prevents vascular damage in experimental animal models, and observational studies in the general population support the hypothesis that sRAGE may exert a protective role on the vasculature. To test this in patients with chronic kidney disease, we determine...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2009.419
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. MET...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1999.00433.x
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening. In the present study, we explored the possible involvement of the kinin-kallikrein system in the development of this renal vascula...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1999.00574.x
更新日期：1999-08-01 00:00:00
abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1983.105
更新日期：1983-06-01 00:00:00
abstract：:This very brief summary of the various possible contributions of PG to normal and abnormal renal function should highlight the problem of assigning a specific role to PG in overall renal physiology and pathophysiology. PG produced in specific segments of the nephron will affect specific functions occurring in this seg...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.1986.13
更新日期：1986-01-01 00:00:00
abstract：:We studied binding and degradation of vasoactive intestinal peptide (VIP) by highly purified brush border and basolateral membranes from rabbit kidney cortex. Brush border and basolateral membranes were capable of 73 and 49% degradation of VIP after 20 minutes, and the degradation was totally prevented by bacitracin. ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.32
更新日期：1991-02-01 00:00:00
abstract：:With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major health problem worldwide. Approximately, 80% of kidney stones are composed of calcium and hypercalciuria is found in up to 40% of stone-formers. Although the mechanisms resulting in precipitation and growth of calcium crystals in...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002441
更新日期：2007-11-01 00:00:00
abstract：:Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, inhibition of nitric oxide synthase causes hypertension, renal dysfunction and damage. We hypoth...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.02.020
更新日期：2020-08-01 00:00:00
abstract：:Cultures of human proximal tubule cells were exposed to elevated concentrations of glucose and dome formation was assessed over a 22 day period of growth. Cultures grown on 5.5 mM glucose formed five domes per microscopic field while those exposed to elevated glucose concentrations (11.0 mM to 27.5 mM) formed only two...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1989.5
更新日期：1989-01-01 00:00:00
abstract：:Females across their lifespan and certain male populations are susceptible to urinary tract infections (UTI). The influence of female vs. male sex on UTI is incompletely understood, in part because preclinical modeling has been performed almost exclusively in female mice. Here, we employed established and new mouse mo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.04.023
更新日期：2018-09-01 00:00:00
abstract：:Mechanisms responsible for renal hemodynamic alterations were studied in jaundiced (by bile-duct ligation) rabbits (BDL) 10 days after ligation of the biliary tract, in comparison with sham-operated rabbits (SO). Arterial hematocrit, plasma volume, blood pressure, abdominal inferior vena cava pressure, and heart rate ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1980.25
更新日期：1980-02-01 00:00:00
abstract：BACKGROUND:Acute renal allograft rejection with intimal arteritis is designated by the widely used Banff 97 classification as type 2A or 2B depending on the extent of arteritis, without regard to interstitial inflammation or tubulitis. We examined whether the distinction between type 2A and 2B is relevant to short- and...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00254.x
更新日期：2002-04-01 00:00:00
abstract：:The structure of the duodenal mucosa was evaluated in duodenal biopsy samples obtained from patients with moderate renal failure (MRF) and in dialysis patients (HD) in an effort to examine the possibility that changes in duodenal mucosa may contribute to the impaired calcium absorption in renal failure (RF). The effec...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1981.23
更新日期：1981-02-01 00:00:00
abstract：:Osteonectin (SPARC, culture shock protein, BM-40) is a widely distributed glycoprotein which binds calcium and several extracellular matrix proteins, including interstitial collagens and thrombospondin, but whose physiologic role remains undefined. In the present studies, we have demonstrated that immunoreactive osteo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.8
更新日期：1992-01-01 00:00:00
abstract：:The clinical value of biocompatible peritoneal dialysis solutions is uncertain because of inconsistent findings in randomized controlled trials. A systematic review by Cho et al. examining 20 such trials suggests a beneficial effect on residual renal function. However, the finding is not robust and may relate to decre...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2013.303
更新日期：2013-11-01 00:00:00
abstract：:Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome ...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2016.02.037
更新日期：2016-08-01 00:00:00
abstract：:Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of angiotensin II degradation. Here, we examined whether there is a kidney phenotype and any compensatory changes in other renin angiotensin system enzymes involved in the metabolism of angiotensin II associated with aminop...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.11.012
更新日期：2020-12-11 00:00:00
abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2014.70
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Various gene transfer vectors as well as delivery systems have been developed; however, many problems remain to be solved. We already achieved a technique to introduce genes into glomerular mesangial cells by hemagglutinating virus of Japan (HVJ) liposome-mediated gene transfer via renal artery. The main lim...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.0590041390.x
更新日期：2001-04-01 00:00:00
abstract：:The renal growth hormone--insulin-like growth factor-I system in acute ischemic renal failure. Recovery from acute tubular necrosis (ATN) is accelerated by IGF-I therapy. Furthermore, the local renal growth hormone-IGF-I system may participate in the natural repair. We examined the IGF-I system in rat kidneys subjecte...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.230
更新日期：1995-06-01 00:00:00
abstract：:We studied the adaptation to early (72 hr) and late (20 days) K loading (400 mmol/day, 4 equal meals every 6 hour) in six healthy humans. Throughout the study, each single K meal was followed by an acute transient rise in plasma K, aldosterone and kaliuresis. "K balance" (urinary K excretion approximately 80% of intak...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1990.295
更新日期：1990-11-01 00:00:00
abstract：:Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascul...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2008.644
更新日期：2009-05-01 00:00:00
abstract：:We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast medi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1975.11
更新日期：1975-02-01 00:00:00
abstract：:Whole-genome microarrays identify large numbers of gene expression changes that appear specifically related to disease states such as antineutrophil cytoplasmic autoantibody (ANCA) and systemic lupus erythematosus. Although understanding this enormous volume of esoteric data is difficult, a few basic concepts regardin...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5002492
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C>G) and plasma levels of vitamin B(12), folate, or total homocysteine. METHODS:In a cross-sectional study of 732 kidney allograft recipients, patients were categor...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00592.x
更新日期：2004-05-01 00:00:00
abstract：:Human transitional B cells express relatively high IL-10 and low TNF-α levels, which correlate with B regulatory activity in vitro. Herein, we aim to further define B regulatory phenotype and determine whether B regulatory activity can serve as a prognostic marker for renal allograft dysfunction (graft loss or 2-fold ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2016.08.028
更新日期：2017-01-01 00:00:00
abstract：:Prostaglandin E2 (PGE2) may be an important negative feedback modulator of endothelin-1 (ET-1)-stimulated mesangial cell proliferation and contraction. Recent studies suggest that ET-1 may induce prolonged mesangial cell PGE2 production, however the mechanism of this effect is unknown. The current study was undertaken...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.6
更新日期：1995-01-01 00:00:00
abstract：:Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the glomerular filtration rate. This study aimed to define the transporters involved in creatinine secretion, applying that knowledge to establish the mechanism for xe...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2014.66
更新日期：2014-08-01 00:00:00
abstract：:Previous studies have demonstrated that dietary potassium deprivation in healthy human subjects eating diets otherwise containing normal quantities of NaCl is accompanied by an increase in urinary calcium excretion. This increase in urinary Ca excretion occurs in association with reductions in urinary Na and Cl excret...
journal_title：Kidney international
pub_type： 临床试验,杂志文章
doi：10.1038/ki.1995.134
更新日期：1995-03-01 00:00:00
abstract：:Zhang et al. found that plasma concentrations of the thiamine antimetabolite oxythiamine are significantly increased in patients with end-stage renal disease. These investigators discuss the potential sources of oxythiamine and the consequences of its plasma elevation. This commentary addresses the significance of the...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2016.04.017
更新日期：2016-08-01 00:00:00
