当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Hyperuricemia as a trigger of immune response in hypertension and chronic kidney disease.

Hyperuricemia as a trigger of immune response in hypertension and chronic kidney disease.

Abstract：

:Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the development of hypertension and chronic kidney disease. A 2-hit model has been proposed to explain the role of urate in hypertension. The first hit entails activation of the renin-angiotensin system and inhibition of nitric oxide synthesis, which promote endothelial dysfunction, proliferation of vascular smooth muscle cells, and sodium reabsorption, leading to a moderate but consistent increase in systemic blood pressure. The second hit involves the immune system. Uric acid released in response to hypertension-induced damage can be recognized as a danger molecule by pattern-recognition receptors, the sentinels of the innate immunity. Downstream signaling from these receptors leads to dendritic cell maturation and activation of resting T cells, but it can also trigger the inflammasome and induce the secretion of proinflammatory cytokines. This proinflammatory milieu concurs in expanding the extracellular fluid volume and in increasing vascular resistances, which further promote systemic hypertension. Through similar mechanisms, hyperuricemia may also cause vascular and tubulointerstitial lesions that favor the development and progression of chronic kidney disease. To counteract these actions, xanthine oxidase inhibitors and uricosuric agents have been advocated as logical candidates to decrease the serum levels of uric acid. However, despite a clear rationale for using hypouricemic drugs in patients with chronic kidney disease, there is currently a lack of robust evidence that lowering uric acid may slow the progression of renal disease.

journal_name

Kidney Int

journal_title

Kidney international

authors

Ponticelli C,Podestà MA,Moroni G

doi

10.1016/j.kint.2020.05.056

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1149-1159

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(20)30804-8

journal_volume

98

pub_type

杂志文章,评审

相关文献

KIDNEY INTERNATIONAL文献大全
  • Acidifying defect induced by amphotericin B: comparison of bicarbonate and hydrogen ion permeabilities.

    abstract：:The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1977.39

    authors： Finn JT,Cohen LH,Steinmetz PR

    更新日期：1977-04-01 00:00:00

  • Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease-Improving Global Outcomes (KDIGO) Controversies Conference.

    abstract：:Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the care of such patients is very limited. Some treatments have been assessed in randomized trials, but most such trials have been too small to detect treatment ef...

    journal_title：Kidney international

    pub_type：

    doi：10.1016/j.kint.2017.04.019

    authors： Baigent C,Herrington WG,Coresh J,Landray MJ,Levin A,Perkovic V,Pfeffer MA,Rossing P,Walsh M,Wanner C,Wheeler DC,Winkelmayer WC,McMurray JJV,KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephr

    更新日期：2017-08-01 00:00:00

  • The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane.

    abstract：BACKGROUND:Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy (RRT), concerns remain regarding the bioincompatible nature of standard PD fluid. In order to evaluate whether a newly formulated fluid of neutral pH, and containing low levels of glucose degradation products (GDP), resu...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1523-1755.2004.00747.x

    authors： Williams JD,Topley N,Craig KJ,Mackenzie RK,Pischetsrieder M,Lage C,Passlick-Deetjen J,Euro Balance Trial Group.

    更新日期：2004-07-01 00:00:00

  • Predicting long-term kidney allograft outcomes: pitfalls and progress.

    abstract：:Early identification of kidney transplant recipients at risk of progressive allograft dysfunction may allow clinicians to provide closer monitoring and more aggressive risk factor modification. In this issue, Raynaud et al. presented a latent class model that clustered kidney transplant recipients into 8 risk categori...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2020.07.031

    authors： Dinh A,McCulloch CE,Ku E

    更新日期：2021-01-01 00:00:00

  • Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats.

    abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000076

    authors： Tian Y,Riazi S,Khan O,Klein JD,Sugimura Y,Verbalis JG,Ecelbarger CA

    更新日期：2006-01-01 00:00:00

  • Strict blood pressure control associates with decreased mortality risk by APOL1 genotype.

    abstract：:Although APOL1 high-risk genotype partially accounts for the increased susceptibility of blacks to chronic kidney disease (CKD), whether APOL1 associates differentially with mortality risk remains controversial. Here we evaluate the association between APOL1 genotype and risk of death and determine whether APOL1 statu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.09.033

    authors： Ku E,Lipkowitz MS,Appel LJ,Parsa A,Gassman J,Glidden DV,Smogorzewski M,Hsu CY

    更新日期：2017-02-01 00:00:00

  • Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation.

    abstract：:Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by dysregulated complement activation. Clinically, aHUS is effectively treated by an anti-C5 monoclonal antibody (mAb) but whether the disease is mediated by the C5a receptor (C5aR) or C5b-9 pathway, or both, is unknown. Her...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.01.009

    authors： Ueda Y,Miwa T,Ito D,Kim H,Sato S,Gullipalli D,Zhou L,Golla M,Song D,Dunaief JL,Palmer MB,Song WC

    更新日期：2019-07-01 00:00:00

  • Albumin interaction with the glomerular capillary wall in vitro.

    abstract：:The binding of albumin to the glomerular capillary wall was studied using albumin-gold in perfused kidneys, the interaction of [3H]albumin with isolated glomeruli at 37 degrees C and 4 degrees C and the interaction at [3H]albumin with purified basement membrane. The albumin-gold was found to bind predominantly to the ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.149

    authors： Adal Y,Smit MF,Osicka TM,Comper WD

    更新日期：1995-04-01 00:00:00

  • Cyclosporine A attenuates the natriuretic action of loop diuretics by inhibition of renal COX-2 expression.

    abstract：BACKGROUND:It is known that inhibition of cyclooxygenase (COX) impairs the renal actions of loop diuretics. Recently, we found that cyclosporine A (CsA) inhibits renal COX-2 expression. Therefore, we examined the interferences of CsA with the renal actions of loop diuretics. METHOD:We investigated the renal effects of...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00627.x

    authors： Höcherl K,Kees F,Krämer BK,Kurtz A

    更新日期：2004-06-01 00:00:00

  • Late progression of renal pathology and cyst enlargement is reduced by rapamycin in a mouse model of nephronophthisis.

    abstract：:Because the size of renal cysts in the native kidneys of patients with ADPKD who have been transplanted was found to be reduced when rapamycin was the immunosuppressant, we tested the involvement of the mTOR pathway in cyst enlargement. Here, male pcy mice, with mutation in one of the nephronophthisis genes, were trea...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.147

    authors： Gattone VH 2nd,Sinders RM,Hornberger TA,Robling AG

    更新日期：2009-07-01 00:00:00

  • Proton-pump inhibitor use is associated with low serum magnesium concentrations.

    abstract：:Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia (<1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce gastric acid, or use of...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.452

    authors： Danziger J,William JH,Scott DJ,Lee J,Lehman LW,Mark RG,Howell MD,Celi LA,Mukamal KJ

    更新日期：2013-04-01 00:00:00

  • A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome.

    abstract：:Diabetic kidney disease is the leading cause of kidney failure. However, studies of molecular mechanisms of early kidney damage are lacking. Here we examined for possible linkage between transcriptional regulation and quantitative structural damage in early diabetic kidney disease in Pima Indians with type 2 diabetes....

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.08.013

    authors： Nair V,Komorowsky CV,Weil EJ,Yee B,Hodgin J,Harder JL,Godfrey B,Ju W,Boustany-Kari CM,Schwarz M,Lemley KV,Nelson PJ,Nelson RG,Kretzler M

    更新日期：2018-02-01 00:00:00

  • Hemoglobin is inversely related to flow-mediated dilatation in chronic kidney disease.

    abstract：:The microcirculation is regulated by oxygen gradients and by endothelial release of nitric oxide, which can react with hemoglobin to form S-nitroso derivatives. Here we induced flow-mediated dilatation of the brachial artery in response to ischemia in 141 non-diabetic patients with stage 3-4 chronic kidney disease who...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.63

    authors： Yilmaz MI,Sonmez A,Saglam M,Gulec M,Kilic S,Eyileten T,Caglar K,Oguz Y,Vural A,Yenicesu M,Zoccali C

    更新日期：2009-06-01 00:00:00

  • Quantitative analysis of renal medullary anatomy in rats and rabbits.

    abstract：:The mean renal tubular diameters, number of tubules per unit of cross-sectional area, and fraction of the total volume occupied by each medullary structure were determined at various levels of the renal medulla of the rat and rabbit. Statistical estimates of anatomic variables were made using spatial sampling techniqu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1977.118

    authors： Knepper MA,Danielson RA,Saidel GM,Post RS

    更新日期：1977-11-01 00:00:00

  • The clot thickens.

    abstract：:Vascular sclerosis has been linked to many risk factors, including smoking, family history, low birth weight, and hypertension. In interesting studies, Goforth et al. show an increased rate of mutations in thrombophilic molecules in patients with vascular sclerosis in renal biopsies, suggesting yet another mechanism. ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5001721

    authors： Fogo AB

    更新日期：2006-08-01 00:00:00

  • Transplantation of developing metanephroi into adult rats.

    abstract：BACKGROUND:Transplantation of developing metanephroi into adult hosts has been proposed as a means to augment host renal function. METHODS:We implanted whole metanephroi from embryonic day 15 (E15) rats subcapsularly in kidneys or into the omentum of non-immunosupressed adult rat hosts. At the time of implantation, so...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00971.x

    authors： Rogers SA,Lowell JA,Hammerman NA,Hammerman MR

    更新日期：1998-07-01 00:00:00

  • Effect of antibody charge and concentration on deposition of antibody to glomerular basement membrane.

    abstract：:Fixed anionic sites within the glomerular capillary wall influence the permeation of serum proteins, the localization of various antigens, and the deposition of antibody in the subepithelial space. In anti-GBM nephritis antibody deposition occurs very rapidly to antigenic sites located relatively proximal in the glome...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1984.188

    authors： Madaio MP,Salant DJ,Adler S,Darby C,Couser WG

    更新日期：1984-10-01 00:00:00

  • Changes in cancer incidence and outcomes among kidney transplant recipients in the United States over a thirty-year period.

    abstract：:Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.10.018

    authors： Blosser CD,Haber G,Engels EA

    更新日期：2020-11-04 00:00:00

  • Primary outcomes of the Monitoring in Dialysis Study indicate that clinically significant arrhythmias are common in hemodialysis patients and related to dialytic cycle.

    abstract：:Sudden death is one of the more frequent causes of death for hemodialysis patients, but the underlying mechanisms, contribution of arrhythmia, and associations with serum chemistries or the dialysis procedure are incompletely understood. To study this, implantable loop recorders were utilized for continuous cardiac rh...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.kint.2017.11.019

    authors： Roy-Chaudhury P,Tumlin JA,Koplan BA,Costea AI,Kher V,Williamson D,Pokhariyal S,Charytan DM,MiD investigators and committees.

    更新日期：2018-04-01 00:00:00

  • Activation of innate immune defense mechanisms contributes to polyomavirus BK-associated nephropathy.

    abstract：:Polyomavirus-associated nephropathy (PVAN) is a significant complication after kidney transplantation, often leading to premature graft loss. In order to identify antiviral responses of the renal tubular epithelium, we studied activation of the viral DNA and the double-stranded RNA (dsRNA) sensors Toll-like receptor 3...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.311

    authors： Ribeiro A,Wörnle M,Motamedi N,Anders HJ,Gröne EF,Nitschko H,Kurktschiev P,Debiec H,Kretzler M,Cohen CD,Gröne HJ,Schlöndorff D,Schmid H

    更新日期：2012-01-01 00:00:00

  • Malignancy after kidney transplantation: still a challenge.

    abstract：:Long-term complications of continuous immunosuppression still remain a serious threat and are currently drawing the attention of transplant physicians. Wimmer et al. show that malignancy occurs approximately fourfold more frequently in renal-transplant recipients than in a normal control population. Besides immunosupp...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5002306

    authors： Bosmans JL,Verpooten GA

    更新日期：2007-06-01 00:00:00

  • Assessing dialysis adequacy and dietary intake in the individual hemodialysis patient.

    abstract：BACKGROUND:Urea kinetic modeling (UKM) and food records are widely used to assess the dialysis adequacy. Clinicians use these methods in individual patients to decide whether the dialysis prescription should be adjusted. We determined the variation in UKM parameters and dietary intake within individual patients in orde...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1046/j.1523-1755.1999.00412.x

    authors： Kloppenburg WD,Stegeman CA,Hooyschuur M,van der Ven J,de Jong PE,Huisman RM

    更新日期：1999-05-01 00:00:00

  • Rac1 activation in podocytes induces the spectrum of nephrotic syndrome.

    abstract：:Hyper-activation of Rac1, a small GTPase, in glomerular podocytes has been implicated in the pathogenesis of familial proteinuric kidney diseases. However, the role of Rac1 in acquired nephrotic syndrome is unknown. To gain direct insights into this, we generated a transgenic mouse model expressing a doxycycline-induc...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.03.010

    authors： Robins R,Baldwin C,Aoudjit L,Côté JF,Gupta IR,Takano T

    更新日期：2017-08-01 00:00:00

  • Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury.

    abstract：:Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal i...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.07.019

    authors： Cao Q,Wang R,Wang Y,Niu Z,Chen T,Wang C,Jin L,Huang Q,Li Q,Wang XM,Azmi F,Lee VWS,Wang YM,Zheng G,Alexander SI,Harris DCH

    更新日期：2020-01-01 00:00:00

  • Proteinase 3 gene polymorphisms and Wegener's granulomatosis.

    abstract：BACKGROUND:Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00430.x

    authors： Gencik M,Meller S,Borgmann S,Fricke H

    更新日期：2000-12-01 00:00:00

  • Role of vascular endothelial growth factor in the regulation of angiogenesis.

    abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.1999.00610.x

    authors： Ferrara N

    更新日期：1999-09-01 00:00:00

  • Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells.

    abstract：BACKGROUND:Clinical studies have shown that the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor antagonists decrease proteinuria and slow the progression of nephropathy in diabetes, indicating that Ang II plays an important role in the development of nephropathy. We have previously re...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00271.x

    authors： Zhang SL,Filep JG,Hohman TC,Tang SS,Ingelfinger JR,Chan JS

    更新日期：1999-02-01 00:00:00

  • Direct antigen binding to glomerular immune complex deposits.

    abstract：:We evaluated the contribution of intrarenal factors in the increased renal accumulation of bovine serum albumin (BSA) in chronic serum sickness (CSS). Renal transplantation was used to study 125I BSA uptake (single and paired label techniques) in normal and CSS kidneys exposed to the same immunologic milieu. In CSS, t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.244

    authors： Ward DM,Lee S,Wilson CB

    更新日期：1986-11-01 00:00:00

  • Disposition of total and unbound prednisolone in renal transplant patients receiving anticonvulsants.

    abstract：:Kidney transplant patients receiving phenytoin or phenobarbital may have decreased graft survival. These drugs have been shown to enhance the metabolism of glucocorticoids. We determined the disposition of total and unbound prednisolone in six stable kidney transplant patients receiving prednisone for immunosuppressio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1984.17

    authors： Gambertoglio JG,Holford NH,Kapusnik JE,Nishikawa R,Saltiel M,Stanik-Lizak P,Birnbaum JL,Hau T,Amend WJ Jr

    更新日期：1984-01-01 00:00:00

  • Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome.

    abstract：:Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.06.040

    authors： Liu X,Ducasa GM,Mallela SK,Kim JJ,Molina J,Mitrofanova A,Wilbon SS,Ge M,Fontanella A,Pedigo C,Santos JV,Nelson RG,Drexler Y,Contreras G,Al-Ali H,Merscher S,Fornoni A

    更新日期：2020-11-01 00:00:00