解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05327-w
更新日期:2021-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. METHODS:The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05301-6
更新日期:2021-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune response actions on ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05376-1
更新日期:2021-01-30 00:00:00
abstract:AIMS/HYPOTHESIS:It has been proposed that muscle fibre type composition and perfusion are key determinants of insulin-stimulated muscle glucose uptake, and alterations in muscle fibre type composition and perfusion contribute to muscle, and consequently whole-body, insulin resistance in people with obesity. The goal of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-021-05383-w
更新日期:2021-01-29 00:00:00
abstract::Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hypergly...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-021-05380-z
更新日期:2021-01-26 00:00:00
abstract:AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05352-9
更新日期:2021-01-23 00:00:00
abstract::Present-day treatments for people that are insulin dependent require multiple insulin injections, sometimes with an insulin pump, coupled with regular blood glucose monitoring. The availability of modified insulins, each with peaks of activity at varying times, has improved diabetes management. On the other hand, ther...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05367-2
更新日期:2021-01-16 00:00:00
abstract:AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observation...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05338-7
更新日期:2021-01-06 00:00:00
abstract:AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazard...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05347-6
更新日期:2021-01-05 00:00:00
abstract:AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05295-1
更新日期:2021-01-01 00:00:00
abstract:AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05307-0
更新日期:2021-01-01 00:00:00
abstract::Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are n...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05298-y
更新日期:2021-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05309-y
更新日期:2021-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05305-2
更新日期:2021-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Abnormal gut microbiota and blood metabolome profiles have been reported both in children and adults with uncomplicated type 1 diabetes as well as in adults with type 1 diabetes and advanced stages of diabetic nephropathy. In this study we aimed to investigate the gut microbiota and a panel of targeted ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05260-y
更新日期:2020-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05332-z
更新日期:2020-11-26 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this work was to examine the progression to type 1 and type 2 diabetes after gestational diabetes mellitus (GDM) in a 23 year follow-up study. METHODS:We carried out a cohort study of 391 women with GDM diagnosed by an OGTT or the use of insulin treatment during pregnancy, and 391 age- and p...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05215-3
更新日期:2020-10-01 00:00:00
abstract::It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05176-7
更新日期:2020-10-01 00:00:00
abstract::Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points for mature islet functionality, understanding biological variatio...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05159-8
更新日期:2020-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. METHODS:The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international pro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05242-0
更新日期:2020-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of this study was to provide deeper insight into the complex network of molecular and cellular c...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05218-0
更新日期:2020-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05212-6
更新日期:2020-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between geneticall...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05190-9
更新日期:2020-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this work was to examine the associations of average weight and weight velocity in three growth periods from birth through adolescence with type 2 diabetes incidence. METHODS:Child participants were selected from a 43 year longitudinal study of American Indians to represent three growth peri...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05165-w
更新日期:2020-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05147-y
更新日期:2020-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05116-5
更新日期:2020-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05115-6
更新日期:2020-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Tenascin-C (TN-C) is an extracellular matrix glycoprotein highly expressed in inflammatory and cardiovascular (CV) diseases. Serum TN-C has not yet been specifically studied in individuals with type 2 diabetes, a condition associated with chronic low-grade inflammation and increased CV disease risk. In ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05108-5
更新日期:2020-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05099-3
更新日期:2020-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited. METHODS:The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05078-3
更新日期:2020-04-01 00:00:00
abstract::The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05104-9
更新日期:2020-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05047-w
更新日期:2020-03-01 00:00:00
abstract::Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts of the world, diabetes is more prevalent in men than in women, especially in middle-aged populations. In line with this, considering almost all animal models, males are more likely to d...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-019-05040-3
更新日期:2020-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05029-y
更新日期:2020-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is an autosomal recessive disorder characterised by lipodystrophy and insulin resistance. BSCL2 is caused by loss-of-function mutations in the Seipin gene (also known as Bscl2). Deletion of this gene in mice induces insulin resistance, glucose in...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05038-x
更新日期:2020-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05017-2
更新日期:2020-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Rapid and adequate islet revascularisation and restoration of the islet-extracellular matrix (ECM) interaction are significant factors influencing islet survival and function of the transplanted islets in individuals with type 1 diabetes. Because the ECM encapsulating the islets is degraded during islet...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05018-1
更新日期:2020-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to low-doses of ultraviolet radiation (UVR) reduced weight gain and signs of diabetes in male mice fed a high-fat diet, in part via release of nitric oxide from skin. He...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05022-5
更新日期:2020-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The workplace is a potentially important arena for prevention of type 2 diabetes and the first step is to identify occupations where the disease is common and/or risk is high. Therefore, our aim was to analyse incidence and prevalence of type 2 diabetes across all occupational groups in Sweden. METHODS...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-04997-5
更新日期:2020-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Sphingolipid metabolism regulates beta cell biology and inflammation and is abnormal at the onset of type 1 diabetes. Fenofibrate, a regulator of sphingolipid metabolism, is known to prevent diabetes in NOD mice. Here, we aimed to investigate the effects of fenofibrate on the pancreatic lipidome, pancre...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-04973-z
更新日期:2019-12-01 00:00:00