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  • Depression as a risk factor for dementia in older people with type 2 diabetes and the mediating effect of inflammation.

    abstract:AIMS/HYPOTHESIS:We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. METHODS:The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05301-6

    authors: Carr AL,Sluiman AJ,Grecian SM,Forster R,McLachlan S,Strachan MWJ,Price JF

    更新日期:2021-02-01 00:00:00

  • Brain JNK and metabolic disease.

    abstract::Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05327-w

    authors: Nogueiras R,Sabio G

    更新日期:2021-02-01 00:00:00

  • Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial.

    abstract:AIMS/HYPOTHESIS:Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune response actions on ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05376-1

    authors: Assfalg R,Knoop J,Hoffman KL,Pfirrmann M,Zapardiel-Gonzalo JM,Hofelich A,Eugster A,Weigelt M,Matzke C,Reinhardt J,Fuchs Y,Bunk M,Weiss A,Hippich M,Halfter K,Hauck SM,Hasford J,Petrosino JF,Achenbach P,Bonifacio E,

    更新日期:2021-01-30 00:00:00

  • Heterogeneity in insulin-stimulated glucose uptake among different muscle groups in healthy lean people and people with obesity.

    abstract:AIMS/HYPOTHESIS:It has been proposed that muscle fibre type composition and perfusion are key determinants of insulin-stimulated muscle glucose uptake, and alterations in muscle fibre type composition and perfusion contribute to muscle, and consequently whole-body, insulin resistance in people with obesity. The goal of...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-021-05383-w

    authors: Koh HE,van Vliet S,Meyer GA,Laforest R,Gropler RJ,Klein S,Mittendorfer B

    更新日期:2021-01-29 00:00:00

  • Hypoxia and hypoxia-inducible factors in diabetes and its complications.

    abstract::Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hypergly...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-021-05380-z

    authors: Catrina SB,Zheng X

    更新日期:2021-01-26 00:00:00

  • Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy.

    abstract:AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05352-9

    authors: Karlsson P,Gylfadottir SS,Kristensen AG,Ramirez JD,Cruz P,Le N,Shillo PR,Tesfaye S,Rice ASC,Tankisi H,Finnerup NB,Nyengaard JR,Jensen TS,Bennett DLH,Themistocleous AC

    更新日期:2021-01-23 00:00:00

  • The promise of stem cell-derived islet replacement therapy.

    abstract::Present-day treatments for people that are insulin dependent require multiple insulin injections, sometimes with an insulin pump, coupled with regular blood glucose monitoring. The availability of modified insulins, each with peaks of activity at varying times, has improved diabetes management. On the other hand, ther...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05367-2

    authors: Melton D

    更新日期:2021-01-16 00:00:00

  • Association between diabetes and haematological malignancies: a population-based study.

    abstract:AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observation...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05338-7

    authors: Gong IY,Cheung MC,Read S,Na Y,Lega IC,Lipscombe LL

    更新日期:2021-01-06 00:00:00

  • A prospective study of endometriosis and risk of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazard...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05347-6

    authors: Farland LV,Degnan WJ,Harris HR,Tobias DK,Missmer SA

    更新日期:2021-01-05 00:00:00

  • The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis.

    abstract:AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05295-1

    authors: Bock PM,Telo GH,Ramalho R,Sbaraini M,Leivas G,Martins AF,Schaan BD

    更新日期:2021-01-01 00:00:00

  • Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

    abstract::Available evidence provides arguments both for and against a primary pathogenic role for T cells in human type 1 diabetes. Genetic susceptibility linked to HLA Class II lends strong support. Histopathology documents HLA Class I hyperexpression and islet infiltrates dominated by CD8+ T cells. While both hallmarks are n...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05298-y

    authors: Carré A,Richardson SJ,Larger E,Mallone R

    更新日期:2021-01-01 00:00:00

  • Vitreous metabolomics profiling of proliferative diabetic retinopathy.

    abstract:AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05309-y

    authors: Tomita Y,Cagnone G,Fu Z,Cakir B,Kotoda Y,Asakage M,Wakabayashi Y,Hellström A,Joyal JS,Talukdar S,Smith LEH,Usui Y

    更新日期:2021-01-01 00:00:00

  • β-Hydroxybutyrate inhibits histone deacetylase 3 to promote claudin-5 generation and attenuate cardiac microvascular hyperpermeability in diabetes.

    abstract:AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05305-2

    authors: Li B,Yu Y,Liu K,Zhang Y,Geng Q,Zhang F,Li Y,Qi J

    更新日期:2021-01-01 00:00:00

  • Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity.

    abstract:AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05307-0

    authors: Rouault C,Marcelin G,Adriouch S,Rose C,Genser L,Ambrosini M,Bichet JC,Zhang Y,Marquet F,Aron-Wisnewsky J,Poitou C,André S,Dérumeaux G,Guerre-Millo M,Clément K

    更新日期:2021-01-01 00:00:00

  • Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria.

    abstract:AIMS/HYPOTHESIS:Abnormal gut microbiota and blood metabolome profiles have been reported both in children and adults with uncomplicated type 1 diabetes as well as in adults with type 1 diabetes and advanced stages of diabetic nephropathy. In this study we aimed to investigate the gut microbiota and a panel of targeted ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05260-y

    authors: Winther SA,Henriksen P,Vogt JK,Hansen TH,Ahonen L,Suvitaival T,Hein Zobel E,Frimodt-Møller M,Hansen TW,Hansen T,Parving HH,Legido-Quigley C,Rossing P,Pedersen O

    更新日期:2020-12-01 00:00:00

  • Altered hormonal and autonomic nerve responses to hypo- and hyperglycaemia are found in overweight and insulin-resistant individuals and may contribute to the development of type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05332-z

    authors: Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

    更新日期:2020-11-26 00:00:00

  • Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of IRS2 in the liver of ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05212-6

    authors: Krause C,Geißler C,Tackenberg H,El Gammal AT,Wolter S,Spranger J,Mann O,Lehnert H,Kirchner H

    更新日期:2020-10-01 00:00:00

  • Type 1 and type 2 diabetes after gestational diabetes: a 23 year cohort study.

    abstract:AIMS/HYPOTHESIS:The aim of this work was to examine the progression to type 1 and type 2 diabetes after gestational diabetes mellitus (GDM) in a 23 year follow-up study. METHODS:We carried out a cohort study of 391 women with GDM diagnosed by an OGTT or the use of insulin treatment during pregnancy, and 391 age- and p...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05215-3

    authors: Auvinen AM,Luiro K,Jokelainen J,Järvelä I,Knip M,Auvinen J,Tapanainen JS

    更新日期:2020-10-01 00:00:00

  • The metabolic syndrome in pregnancy and its association with child telomere length.

    abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age. METHODS:The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international pro...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05242-0

    authors: McAninch D,Bianco-Miotto T,Gatford KL,Leemaqz SY,Andraweera PH,Garrett A,Plummer MD,Dekker GA,Roberts CT,Smithers LG,Grieger JA

    更新日期:2020-10-01 00:00:00

  • Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy.

    abstract:AIMS/HYPOTHESIS:Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Despite recent advances, our understanding of its pathophysiology remains incomplete. The aim of this study was to provide deeper insight into the complex network of molecular and cellular c...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05218-0

    authors: Van Hove I,De Groef L,Boeckx B,Modave E,Hu TT,Beets K,Etienne I,Van Bergen T,Lambrechts D,Moons L,Feyen JHM,Porcu M

    更新日期:2020-10-01 00:00:00

  • Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

    abstract::It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve both the autoimmune aggressors and their beta cell targets, which engage in a conflicting dialogue within and possibly outside the pancreas. Indeed, autoimmune CD8+ T cells, which are the final mediators of beta cell destruction, ...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05176-7

    authors: Mallone R,Eizirik DL

    更新日期:2020-10-01 00:00:00

  • Molecular and functional profiling of human islets: from heterogeneity to human phenotypes.

    abstract::Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points for mature islet functionality, understanding biological variatio...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05159-8

    authors: Arrojo E Drigo R,Roy B,MacDonald PE

    更新日期:2020-10-01 00:00:00

  • Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex.

    abstract:AIMS/HYPOTHESIS:Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This stu...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05147-y

    authors: Che D,Fang Z,Yan L,Du J,Li F,Xie J,Feng J,Yin P,Qi W,Yang Z,Ma J,Yang X,Gao G,Zhou T

    更新日期:2020-09-01 00:00:00

  • Weight tracking in childhood and adolescence and type 2 diabetes risk.

    abstract:AIMS/HYPOTHESIS:The aim of this work was to examine the associations of average weight and weight velocity in three growth periods from birth through adolescence with type 2 diabetes incidence. METHODS:Child participants were selected from a 43 year longitudinal study of American Indians to represent three growth peri...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05165-w

    authors: Olaiya MT,Knowler WC,Sinha M,Kobes S,Nelson RG,Baier LJ,Muller YL,Hanson RL

    更新日期:2020-09-01 00:00:00

  • IGF-1 and cardiometabolic diseases: a Mendelian randomisation study.

    abstract:AIMS/HYPOTHESIS:Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between geneticall...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05190-9

    authors: Larsson SC,Michaëlsson K,Burgess S

    更新日期:2020-09-01 00:00:00

  • Transition of metabolic phenotypes and risk of subclinical atherosclerosis according to BMI: a prospective study.

    abstract:AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05116-5

    authors: Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

    更新日期:2020-07-01 00:00:00

  • Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis.

    abstract:AIMS/HYPOTHESIS:It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS:Immunohistological analysis was used to determine the distribution of proinsulin and insulin in t...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05115-6

    authors: Leete P,Oram RA,McDonald TJ,Shields BM,Ziller C,TIGI study team.,Hattersley AT,Richardson SJ,Morgan NG

    更新日期:2020-06-01 00:00:00

  • Preserved C-peptide secretion is associated with fewer low-glucose events and lower glucose variability on flash glucose monitoring in adults with type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05099-3

    authors: Gibb FW,McKnight JA,Clarke C,Strachan MWJ

    更新日期:2020-05-01 00:00:00

  • Serum tenascin-C is independently associated with increased major adverse cardiovascular events and death in individuals with type 2 diabetes: a French prospective cohort.

    abstract:AIMS/HYPOTHESIS:Tenascin-C (TN-C) is an extracellular matrix glycoprotein highly expressed in inflammatory and cardiovascular (CV) diseases. Serum TN-C has not yet been specifically studied in individuals with type 2 diabetes, a condition associated with chronic low-grade inflammation and increased CV disease risk. In ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-020-05108-5

    authors: Gellen B,Thorin-Trescases N,Thorin E,Gand E,Sosner P,Brishoual S,Rigalleau V,Montaigne D,Javaugue V,Pucheu Y,Gatault P,Piguel X,Hadjadj S,Saulnier PJ,SURDIAGENE Study group.

    更新日期:2020-05-01 00:00:00

  • Persistent poor glycaemic control in individuals with type 2 diabetes in developing countries: 12 years of real-world evidence of the International Diabetes Management Practices Study (IDMPS).

    abstract:AIMS/HYPOTHESIS:We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited. METHODS:The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in ...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05078-3

    authors: Aschner P,Gagliardino JJ,Ilkova H,Lavalle F,Ramachandran A,Mbanya JC,Shestakova M,Chantelot JM,Chan JCN

    更新日期:2020-04-01 00:00:00

  • Neuronal control of peripheral nutrient partitioning.

    abstract::The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-020-05104-9

    authors: Manceau R,Majeur D,Alquier T

    更新日期:2020-04-01 00:00:00

  • Sex differences in metabolic regulation and diabetes susceptibility.

    abstract::Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts of the world, diabetes is more prevalent in men than in women, especially in middle-aged populations. In line with this, considering almost all animal models, males are more likely to d...

    journal_title:Diabetologia

    pub_type: 杂志文章,评审

    doi:10.1007/s00125-019-05040-3

    authors: Tramunt B,Smati S,Grandgeorge N,Lenfant F,Arnal JF,Montagner A,Gourdy P

    更新日期:2020-03-01 00:00:00

  • The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.

    abstract:AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05047-w

    authors: Jacobsen LM,Bocchino L,Evans-Molina C,DiMeglio L,Goland R,Wilson DM,Atkinson MA,Aye T,Russell WE,Wentworth JM,Boulware D,Geyer S,Sosenko JM

    更新日期:2020-03-01 00:00:00

  • Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes.

    abstract:AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05017-2

    authors: Niersmann C,Carstensen-Kirberg M,Maalmi H,Holleczek B,Roden M,Brenner H,Herder C,Schöttker B

    更新日期:2020-02-01 00:00:00

  • Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

    abstract:AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05029-y

    authors: Sayers SR,Beavil RL,Fine NHF,Huang GC,Choudhary P,Pacholarz KJ,Barran PE,Butterworth S,Mills CE,Cruickshank JK,Silvestre MP,Poppitt SD,McGill AT,Lavery GG,Hodson DJ,Caton PW

    更新日期:2020-02-01 00:00:00

  • Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARγ expression.

    abstract:AIMS/HYPOTHESIS:Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is an autosomal recessive disorder characterised by lipodystrophy and insulin resistance. BSCL2 is caused by loss-of-function mutations in the Seipin gene (also known as Bscl2). Deletion of this gene in mice induces insulin resistance, glucose in...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05038-x

    authors: Xiong J,Sun P,Wang Y,Hua X,Song W,Wang Y,Wu J,Yu W,Liu G,Chen L

    更新日期:2020-02-01 00:00:00

  • Incidence and prevalence of type 2 diabetes by occupation: results from all Swedish employees.

    abstract:AIMS/HYPOTHESIS:The workplace is a potentially important arena for prevention of type 2 diabetes and the first step is to identify occupations where the disease is common and/or risk is high. Therefore, our aim was to analyse incidence and prevalence of type 2 diabetes across all occupational groups in Sweden. METHODS...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-04997-5

    authors: Carlsson S,Andersson T,Talbäck M,Feychting M

    更新日期:2020-01-01 00:00:00

  • Recruited fibroblasts reconstitute the peri-islet membrane: a longitudinal imaging study of human islet grafting and revascularisation.

    abstract:AIMS/HYPOTHESIS:Rapid and adequate islet revascularisation and restoration of the islet-extracellular matrix (ECM) interaction are significant factors influencing islet survival and function of the transplanted islets in individuals with type 1 diabetes. Because the ECM encapsulating the islets is degraded during islet...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05018-1

    authors: Nilsson J,Fardoos R,Hansen L,Lövkvist H,Pietras K,Holmberg D,Schmidt-Christensen A

    更新日期:2020-01-01 00:00:00

  • Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue.

    abstract:AIMS/HYPOTHESIS:Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to low-doses of ultraviolet radiation (UVR) reduced weight gain and signs of diabetes in male mice fed a high-fat diet, in part via release of nitric oxide from skin. He...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-05022-5

    authors: Dhamrait GK,Panchal K,Fleury NJ,Abel TN,Ancliffe MK,Crew RC,Croft K,Fernandez BO,Minnion M,Hart PH,Lucas RM,Mark PJ,Feelisch M,Weller RB,Matthews V,Gorman S

    更新日期:2020-01-01 00:00:00

  • Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice.

    abstract:AIMS/HYPOTHESIS:Sphingolipid metabolism regulates beta cell biology and inflammation and is abnormal at the onset of type 1 diabetes. Fenofibrate, a regulator of sphingolipid metabolism, is known to prevent diabetes in NOD mice. Here, we aimed to investigate the effects of fenofibrate on the pancreatic lipidome, pancre...

    journal_title:Diabetologia

    pub_type: 杂志文章

    doi:10.1007/s00125-019-04973-z

    authors: Holm LJ,Haupt-Jorgensen M,Giacobini JD,Hasselby JP,Bilgin M,Buschard K

    更新日期:2019-12-01 00:00:00

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