Abstract:
AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes TrialNet Pathway to Prevention participants with mAbs (n = 1815; age, 12.35 ± 9.39 years; range, 1-49 years) were analysed. Type 1 diabetes risk was assessed according to age, autoantibody type/number (insulin autoantibodies [IAA], glutamic acid decarboxylase autoantibodies [GADA], insulinoma-associated antigen-2 autoantibodies [IA-2A] or zinc transporter 8 autoantibodies [ZnT8A]) and Index60 (composite measure of fasting C-peptide, 60 min glucose and 60 min C-peptide). Cox regression and cumulative incidence curves were utilised in this cohort study. RESULTS:Age was inversely related to type 1 diabetes risk in those with mAbs (HR 0.97 [95% CI 0.96, 0.99]). Among participants with 2 autoantibodies, those with GADA had less risk (HR 0.35 [95% CI 0.22, 0.57]) and those with IA-2A had higher risk (HR 2.82 [95% CI 1.76, 4.51]) of type 1 diabetes. Those with IAA and GADA had only a 17% 5 year risk of type 1 diabetes. The risk was significantly lower for those with Index60 <1.0 (HR 0.23 [95% CI 0.19, 0.30]) vs those with Index60 values ≥1.0. Among the 12% (225/1815) ≥12.0 years of age with GADA positivity, IA-2A negativity and Index60 <1.0, the 5 year risk of type 1 diabetes was 8%. CONCLUSIONS/INTERPRETATION:Type 1 diabetes risk varies substantially according to age, autoantibody type and metabolic status in individuals screened for mAbs. An appreciable proportion of older children and adults with mAbs appear to have a low risk of progressing to type 1 diabetes at 5 years. With this knowledge, clinical trials of type 1 diabetes prevention can better target those most likely to progress.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Jacobsen LM,Bocchino L,Evans-Molina C,DiMeglio L,Goland R,Wilson DM,Atkinson MA,Aye T,Russell WE,Wentworth JM,Boulware D,Geyer S,Sosenko JMdoi
10.1007/s00125-019-05047-wsubject
Has Abstractpub_date
2020-03-01 00:00:00pages
588-596issue
3eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-019-05047-wjournal_volume
63pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. METHODS:Control and streptozotocin diabetic mice,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1837-2
更新日期:2010-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:This long-term study was designed to further characterise the retinal safety profile of insulin glargine and human neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes mellitus. METHODS:An open-label, 5 year, randomised (1:1), multicentre, stratified, parallel-group study conducted...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-009-1415-7
更新日期:2009-09-01 00:00:00
abstract::Aspects of the regulation of the glucose transport by perfused hearts of normal rats have been studied by measuring glucose transport (via the efflux of labelled 3-O-methyl-D-glucose) and glucose transporters (via the labelled cytochalasin B binding assay). Similarly to what is observed with insulin, increasing worklo...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00395557
更新日期:1988-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetic retinopathy is the most common complication of diabetes and a leading cause of blindness among working-age adults. Anatomical and functional changes occur in the retina and retinal pigment epithelium (RPE) prior to clinical symptoms of the disease. However, the molecular mechanisms responsible ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0991-2
更新日期:2008-06-01 00:00:00
abstract::A follow-up study was carried out to determine whether reduced fetal growth is associated with the development of impaired glucose tolerance in men and women aged 50 years. Standard oral glucose tolerance tests were carried out on 140 men and 126 women born in Preston (Lancashire, UK) between 1935 and 1943, whose size...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00399954
更新日期:1993-03-01 00:00:00
abstract::Blood glucose screening results, obtained using two different screening procedures, are reported from two occupational groups. Post-prandial blood glucose levels were measured in 3346 subjects aged 45 years or more employed by the Greater London Council/Inner London Education Authority. In women, mean blood glucose le...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276970
更新日期:1984-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes is a major risk factor for CHD. We hypothesised that diabetes genetic susceptibility variants might be associated with increased CHD risk. METHODS:We examined the individual and cumulative effect of 38 common genetic variants previously reported to be associated with type 2 diabetes on ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2206-5
更新日期:2011-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fat balance is critical in the aetiology of obesity and related diseases. Lipoprotein lipase is of major importance in lipid metabolism. The aim of this study was to investigate the long-term effects of the lipoprotein lipase activator, NO-1886, on substrate utilisation, adiposity and insulin action in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051464
更新日期:2000-07-01 00:00:00
abstract::Two sequential studies of life quality among pancreas transplant recipients are reported. The first study (n = 32) investigated symptoms of neuropathy, enteropathy and retinopathy, along with well-being post successful transplantation. Patients noted improvement in secondary complications, were satisfied with the proc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00587641
更新日期:1991-08-01 00:00:00
abstract::We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 1 1973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were greater than age 50 y...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279934
更新日期:1983-09-01 00:00:00
abstract::AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...
journal_title:Diabetologia
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00125-018-4620-4
更新日期:2018-07-01 00:00:00
abstract::Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282238
更新日期:1985-04-01 00:00:00
abstract::Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.0...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281820
更新日期:1980-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with ty...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-011-2447-3
更新日期:2012-04-01 00:00:00
abstract::Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of aut...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00262215
更新日期:1984-06-01 00:00:00
abstract::The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429089
更新日期:1992-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Neuronal dorsal root ganglion (DRG) cells seem to be vulnerable in diabetes. The aim of this study was to determine whether the p75 neurotrophin receptor stimulates perikaryal shrinkage and neuronal death, and further accelerates neuronal DRG cell loss after axotomy in a mouse model of diabetes. METHOD...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1504-6
更新日期:2004-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1204-8
更新日期:2009-02-01 00:00:00
abstract::Non-obese diabetic mice aged 30 to 60 days were treated orally with Cyclosporin at doses of 25, 15 and 2.5 mg/kg every 2 days until 160 days of age. Diabetes developed in 12 out of 18 oil-treated mice (67%), with partial to complete Langerhans' islet destruction associated with lymphocytic infiltration. The non-obese ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00454884
更新日期:1986-04-01 00:00:00
abstract::The effect of metergoline on insulin secretion has been evaluated in normal subjects and in patients with chemical diabetes. The repeated administration of metergoline, 2 mg at four-hour intervals to give a total of 24 mg, has enhanced insulin secretion in response to i.v. glucose in normal subjects but not in chemica...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429842
更新日期:1975-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopathy. ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-001-0769-2
更新日期:2002-03-01 00:00:00
abstract::Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM). A new class of drugs, the thiazolidinediones, have been shown to lower blood glucose levels without stimulating insulin secretion. We report the metabolic effect of the thiazolidinedione, darg...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/BF00401763
更新日期:1995-11-01 00:00:00
abstract::Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/BF01236266
更新日期:1979-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1244-0
更新日期:2009-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Experimental studies have suggested that ghrelin, a novel gastrointestinal peptide hormone, could play a role in glucose homeostasis. In addition, ghrelin has been associated with beneficial haemodynamic effects in experimental settings. Since the Arg51Gln mutation changes the carboxyterminal amino acid...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1058-z
更新日期:2003-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1810-7
更新日期:2005-08-01 00:00:00
abstract::The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes. Diabetic blood p50 was higher (29.79 +/- 1...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00260950
更新日期:1982-11-01 00:00:00
abstract::Human crude and recombinant interleukin 1 (IL-1) was found to dose- and time-dependently affect the biosynthesis of (pro)insulin in isolated rat islets of Langerhans. Incubation of rat islets with either 0.5 U/ml or 5 U/ml of crude IL-1 for 1 h had no detectable effect on (pro)insulin biosynthesis. After 24 hours of e...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279615
更新日期:1987-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Platelet activation, endothelial dysfunction and inflammation may be involved in early stages of diabetic microangiopathy. We therefore investigated patients with Type 1 diabetes mellitus, without ( n=19) and with ( n=20) microangiopathy, matched for glycaemic control and duration of disease, and matche...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1352-4
更新日期:2004-03-01 00:00:00
abstract:UNLABELLED:AIMS/HYPOTHESIS; The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiov...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s001250051229
更新日期:1999-07-01 00:00:00