Vitreous metabolomics profiling of proliferative diabetic retinopathy.

abstract：AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...

journal_title：Diabetologia

authors： Kuwabara T,Mori K,Mukoyama M,Kasahara M,Yokoi H,Saito Y,Ogawa Y,Imamaki H,Kawanishi T,Ishii A,Koga K,Mori KP,Kato Y,Sugawara A,Nakao K

更新日期：2012-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Elevated circulating adipocyte fatty acid-binding protein (AFABP) levels have been found to correlate with diabetic nephropathy staging in cross-sectional studies. However, it remains unclear whether these higher serum levels reflect a role of AFABP in the development of diabetic kidney disease (DKD), o...

journal_title：Diabetologia

authors： Lee CH,Cheung CYY,Woo YC,Lui DTW,Yuen MMA,Fong CHY,Chow WS,Xu A,Lam KSL

更新日期：2019-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Epithelium-mesenchyme interactions play a major role in pancreas development. Recently, we demonstrated that embryonic pancreatic mesenchyme enhanced progenitor cell proliferation but inhibited endocrine cell differentiation. Here, we investigated the role played by sulphated proteoglycans, which are kn...

journal_title：Diabetologia

authors： Zertal-Zidani S,Bounacer A,Scharfmann R

更新日期：2007-03-01 00:00:00

abstract：:In the present study the antepartum relationship between maternal diabetic glucose control and fetal hypoxaemia was examined in 44 Type 1 (insulin-dependent) diabetic and 23 non-diabetic control pregnancies. Maternal HbA1C was used to assess maternal integrated blood glucose control while fetal metabolic control was e...

journal_title：Diabetologia

authors： Widness JA,Teramo KA,Clemons GK,Voutilainen P,Stenman UH,McKinlay SM,Schwartz R

更新日期：1990-06-01 00:00:00

abstract：:In vitro and in vivo studies have suggested that metabolic deterioration can be induced by hyperglycaemia per se. The effect of 53 h of 2.2 mg glucose.kg ideal body weight-1.min-1 was examined in four normal male subjects. This produced overnight hyperglycaemia of 6.0 mmol/l on the two nights of the study compared wit...

journal_title：Diabetologia

authors： Flax H,Matthews DR,Levy JC,Coppack SW,Turner RC

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...

journal_title：Diabetologia

authors： Camastra S,Gastaldelli A,Mari A,Bonuccelli S,Scartabelli G,Frascerra S,Baldi S,Nannipieri M,Rebelos E,Anselmino M,Muscelli E,Ferrannini E

更新日期：2011-08-01 00:00:00

abstract：:Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 125I-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity added compared to ...

journal_title：Diabetologia

authors： Shemer J,Penhos JC,LeRoith D

更新日期：1986-05-01 00:00:00

abstract：:The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD. Situations in which proteomics could be applied in clinical practice include the identif...

journal_title：Diabetologia

authors： Pena MJ,Mischak H,Heerspink HJ

更新日期：2016-09-01 00:00:00

abstract：:QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...

journal_title：Diabetologia

authors： Ewing DJ,Boland O,Neilson JM,Cho CG,Clarke BF

更新日期：1991-03-01 00:00:00

abstract：:We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a phosphatidylinositol-3 (PI) kinase dependent pathway in C2C12 myotubes. The aim of the present study was to identify the signalling path from the leptin receptor to the PI-3 kinase. We stimulated C2C12 myot...

journal_title：Diabetologia

authors： Kellerer M,Koch M,Metzinger E,Mushack J,Capp E,Häring HU

更新日期：1997-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. Whether this downregulation is a cause or effect o...

journal_title：Diabetologia

authors： Hoeks J,Hesselink MK,Russell AP,Mensink M,Saris WH,Mensink RP,Schrauwen P

更新日期：2006-10-01 00:00:00

abstract：:Urinary albumin excretion has been assessed in 585 newly-presenting Type 2 (non-insulin-dependent) diabetic patients (aged 53 (8) years, 67% male) at diagnosis with fasting plasma glucose 10.3 (3.2) mmol/l and over 3 years of dietary treatment. Urinary albumin at diagnosis, geometric mean (1 SD interval) corrected for...

journal_title：Diabetologia

authors：

更新日期：1993-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The abnormal intrauterine milieu of intrauterine growth retardation (IUGR) permanently alters gene expression and function of pancreatic beta cells leading to the development of diabetes in adulthood. Expression of the pancreatic homeobox transcription factor Pdx1 is permanently reduced in IUGR islets s...

journal_title：Diabetologia

authors： Pinney SE,Jaeckle Santos LJ,Han Y,Stoffers DA,Simmons RA

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maturity onset diabetes of the young type 3 (MODY3) is a monogenic form of diabetes mellitus caused by mutations in the gene encoding for hepatocyte nuclear factor 1 alpha, HNF1 alpha. In this study we have examined the in vivo and in vitro effects of a mutation (L107I) outside the DNA binding and dimer...

journal_title：Diabetologia

authors： Cervin C,Orho-Melander M,Ridderstråle M,Lehto M,Barg S,Groop L,Cilio CM

更新日期：2002-12-01 00:00:00

abstract：:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

journal_title：Diabetologia

authors： Henquin JC,Malvaux P,Lambert AE

更新日期：1979-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:An increase in endogenous glucose production (EGP) is a major contributor to fasting morning hyperglycaemia in type 2 diabetes. This increase is dissipated with fasting, later in the day. To understand its origin, EGP, gluconeogenesis and hormones that regulate metabolism were measured over 24 h. We hyp...

journal_title：Diabetologia

authors： Radziuk J,Pye S

更新日期：2006-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Defective beta cell function during lipid oversupply and type 2 diabetes is associated with dysregulation of lysosomal function and autophagy. Whether this dysregulation represents augmentation or inhibition is unclear because of technical limitations in assaying autophagy. The current aim was to determ...

journal_title：Diabetologia

authors： Chu KY,O'Reilly L,Ramm G,Biden TJ

更新日期：2015-09-01 00:00:00

abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

journal_title：Diabetologia

authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

更新日期：1984-08-01 00:00:00

abstract：:Mortality among 4740 diabetic men and women aged 35-55 years participating in the WHO Multinational Study of Vascular Disease in Diabetics has been studied. Ten of the original centres (Warsaw, Berlin, Havana, Arizona, Oklahoma, Hong Kong, Switzerland, London, Tokyo, Zagreb) were able to identify the life/death status...

journal_title：Diabetologia

authors： Head J,Fuller JH

更新日期：1990-08-01 00:00:00

abstract：:We have studied the epidemiologic characteristics of insulin-dependent (Type 1) diabetic patients aged 0-19 in a city (San Diego, southern California, USA) characterized by an impressive racial diversity and especially mild and constant climatic conditions. Ascertainment was through retrospective review of medical rec...

journal_title：Diabetologia

authors： Lorenzi M,Cagliero E,Schmidt NJ

更新日期：1985-10-01 00:00:00

abstract：:Oral (o.GTT) and intravenous glucose tolerance tests (i.v. GTT) were carried out on 492 patients of both sexes, aged from 5 to 78 years. Three hundred and fifty-nine non-diabetics in all were suspected clinically of reduced carbohydrate tolerance leaving 133 patients for comparison (controls). In 102 obesity was noted...

journal_title：Diabetologia

authors： Schilling WH,Oberdisse K,Hüter KA,Blank H

更新日期：1966-04-01 00:00:00

abstract：:Highly purified insulins offer the possibility of reducing insulin antibody levels and insulin requirement. Those likely to respond cannot be predicted on clinical grounds and a simple laboratory test is recommended for this purpose. This is based on insulin binding capacity (IBC) of plasma and has been used to follow...

journal_title：Diabetologia

authors： Mustaffa BE,Daggett PR,Nabarro JD

更新日期：1977-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Urinary orosomucoid excretion rate is increased in a substantial proportion of patients with Type II (non-insulin-dependent) diabetes mellitus and normal urinary albumin excretion rate. The aim of this study was to determine whether increased urinary orosomucoid excretion rate is predictive of increased...

journal_title：Diabetologia

authors： Christiansen MS,Hommel E,Magid E,Feldt-Rasmussen B

更新日期：2002-01-01 00:00:00

abstract：:Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J-+/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of r...

journal_title：Diabetologia

authors： Chang AY,Gilchrist BJ,Wyse BM

更新日期：1983-12-01 00:00:00

abstract：:The presence of immunoreactive insulin in saliva and its relationship to plasma immunoreactive insulin was investigated in healthy subjects, newly diagnosed non-obese Type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects, basally and after an oral glucose tolerance test. The mean +/- SEM fas...

journal_title：Diabetologia

authors： Marchetti P,Benzi L,Masoni A,Cecchetti P,Giannarelli R,Di Cianni G,Ciccarone AM,Navalesi R

更新日期：1986-10-01 00:00:00

abstract：:Fifty-nine Type 1 (insulin-dependent) diabetic patients with (group I) and 59 patients without nephropathy (group II) pair-matched according to sex (30 males and 29 females), age (33 years, range 15-48) and diabetes duration (19 years, range 6-42) were followed for a period of 10 years from about 5 years before to 5 y...

journal_title：Diabetologia

authors： Jensen T,Borch-Johnsen K,Kofoed-Enevoldsen A,Deckert T

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The Ca2+/calmodulin-dependent protein kinase II (CaMK II) is highly expressed in pancreatic islets and associated with insulin secretion vesicles. The suppression of CaMK II disturbs insulin secretion and insulin gene expression. There are four isoforms of CaMK II, alpha to delta, that are expressed fro...

journal_title：Diabetologia

authors： Rochlitz H,Voigt A,Lankat-Buttgereit B,Göke B,Heimberg H,Nauck MA,Schiemann U,Schatz H,Pfeiffer AF

更新日期：2000-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified analyses. METHODS:Wom...

journal_title：Diabetologia

authors： d'Emden MC,Jenkins AJ,Li L,Zannino D,Mann KP,Best JD,Stuckey BG,Park K,Saltevo J,Keech AC,FIELD Study Investigators.

更新日期：2014-11-01 00:00:00

abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

journal_title：Diabetologia

authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

更新日期：1992-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:In this study we investigated whether chronic fetal hypoxia, as indicated by amniotic fluid erythropoietin levels, is associated with perinatal morbidity in type 1 diabetic pregnancies. METHODS:A total of 331 women with type 1 diabetes had at least one childbirth between 1995 and 2000. The amniotic flu...

journal_title：Diabetologia

authors： Teramo K,Kari MA,Eronen M,Markkanen H,Hiilesmaa V

更新日期：2004-10-01 00:00:00