Abstract：
:Urinary albumin excretion has been assessed in 585 newly-presenting Type 2 (non-insulin-dependent) diabetic patients (aged 53 (8) years, 67% male) at diagnosis with fasting plasma glucose 10.3 (3.2) mmol/l and over 3 years of dietary treatment. Urinary albumin at diagnosis, geometric mean (1 SD interval) corrected for dilution by regression on urine creatinine concentration of 10 mmol/l, was 17 (5-58) mg/l compared with 8 (3-18) mg/l in an age-matched non-diabetic reference population. Values greater than 50 mg/l were found in 17% of diabetic patients compared with 4% in the reference group. After diet therapy for 3 months, fasting plasma glucose decreased to 6.9 mmol/l and urinary albumin to 12 (4-31) mg/l (p < 0.0001). This suggests that increased urinary albumin excretion at diagnosis is in part functional, possibly secondary to glomerular hyperfiltration caused by hyperglycaemia and raised blood pressure. Over the next 3 years, mean fasting plasma glucose was 7.2 mmol/l, albumin excretion changed little, without significant increase either in patients with raised or normal albumin at diagnosis. Both at diagnosis and over 3 years, urinary albumin excretion was independently associated with fasting plasma glucose and triglyceride levels and with systolic blood pressure, but the combination of these factors only explained 10% of the total variance. This suggests the presence of additional pathological processes in patients with increased urinary albumin. Urinary albumin was not associated with other variables included in syndrome X, such as HDL cholesterol, fasting plasma insulin, obesity or central adiposity.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Diabetologiajournal_title
Diabetologiaauthors
subject
Has Abstractpub_date
1993-10-01 00:00:00pages
1021-9issue
10eissn
0012-186Xissn
1432-0428journal_volume
36pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract：AIMS/HYPOTHESIS:The Cost of Diabetes in Europe-Type II study is the first coordinated attempt to assess the total costs of Type II (non-insulin-dependent) diabetes mellitus in Europe. Although gaining a clearer understanding of the economics of diabetes was the goal of the study, a secondary objective was to consider t...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-002-0861-2
更新日期：2002-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the impact of birthweight on early-onset (age <40 years) type 2 diabetes. METHODS:A longitudinal study of American Indians, aged ≥5 years, was conducted from 1965 to 2007. Participants who had a recorded birthweight were followed until they developed diabetes or the...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-4899-9
更新日期：2019-09-01 00:00:00
abstract：:Vasoactive intestinal polypeptide is a pancreatic neurotransmitter which augments insulin release. To obtain more detailed information on its mode of action on the pancreatic beta cell we studied the effect of vasoactive intestinal polypeptide on 86Rb+ efflux, 45Ca2+ uptake, electrical activity and second messenger sy...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF02374473
更新日期：1993-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-009-1606-2
更新日期：2010-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Type 2 diabetes is a chronic, heterogeneous disease and a major risk factor for cardiovascular diseases. The underlying mechanisms leading to progression to type 2 diabetes are not fully understood and genetic tools may help to identify important pathways of glycaemic deterioration. METHODS:Using prosp...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-013-2988-8
更新日期：2013-10-01 00:00:00
abstract：:The accumulation of noradrenaline in constricted sciatic nerves was measured in 6 month diabetic rats (streptozotocin 35 mg/kg) and 4 day diabetic rats (streptozotocin 70 mg/kg) together with two groups of age-matched control animals. There was no alteration in the amount of noradrenaline accumulated in the nerves of ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00283753
更新日期：1982-03-01 00:00:00
abstract：:Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric aci...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00400920
更新日期：1992-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-05047-w
更新日期：2020-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:A common G to A polymorphism ( UCSNP-43) in the Calpain 10 gene was recently found to be associated with Type II (non-insulin-dependent) diabetes mellitus and variations in post-absorptive and insulin stimulated glucose metabolism in vivo. We aimed to study the influence of Calpain 10 polymorphism on in...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-001-0732-2
更新日期：2002-02-01 00:00:00
abstract：:Data are discussed which demonstrate that insulin plays an important role in sodium metabolism. The primary action of insulin on sodium balance is exerted on the kidney. Increases in plasma insulin concentration within the physiological range stimulate sodium reabsorption by the distal nephron segments and this effect...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/BF00252649
更新日期：1981-09-01 00:00:00
abstract：:Major histocompatibility complex-linked immune response genes are thought to influence susceptibility to induction of both human insulin-dependent diabetes and murine streptozotocin-induced diabetes. To clarify this relationship, we administered streptozotocin intravenously in two doses (120 and 240 mg/kg body weight)...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00275678
更新日期：1984-07-01 00:00:00
abstract：:The involvement of the CNS in pancreatic hormone release has been studied. 1.) It has been shown that one source of vagal efferent fibers capable of facilitating insulin secretion originated in the rostral half of the nucleus ambiguus. 2.) Acute lesions of the ventromedial hypothalamus resulted in hyperinsulinaemia th...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00254511
更新日期：1981-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:The transcription factor upstream stimulatory factor 1 (USF1) regulates the expression of genes involved in glucose and lipid metabolism and has been associated with familial combined hyperlipidaemia. USF1 is located on chromosome 1q22-23, a region with evidence for linkage to type 2 diabetes and variou...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-005-1914-0
更新日期：2005-10-01 00:00:00
abstract：AIM/HYPOTHESIS:The aim of this study was to investigate the association between processed and other meat intake and incidence of Type 2 diabetes in a large cohort of women. METHODS:Incident cases of Type 2 diabetes were identified during 8 years of follow-up in a prospective cohort study of 91246 U.S. women aged 26 to...
journal_title：Diabetologia
pub_type： 杂志文章,多中心研究
doi：10.1007/s00125-003-1220-7
更新日期：2003-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture. METHODS:The study population consisted of 35,444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250051248
更新日期：1999-08-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this work was to examine the associations of average weight and weight velocity in three growth periods from birth through adolescence with type 2 diabetes incidence. METHODS:Child participants were selected from a 43 year longitudinal study of American Indians to represent three growth peri...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-020-05165-w
更新日期：2020-09-01 00:00:00
abstract：:Weaning onto chow diets causes the highest incidence of diabetes in the BB rat. Changes in gut development and absorption of nutrients in the diabetes prone rat and the subsequent effect on pancreatic function may play a role in the ultimate development of the disease. BB diabetes prone (dp) and BB normal (n) dams wer...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050762
更新日期：1997-08-01 00:00:00
abstract：AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-017-4222-6
更新日期：2017-05-01 00:00:00
abstract：AIMS/HYPOTHESIS:Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS:Sixty-three...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-017-4437-6
更新日期：2017-12-01 00:00:00
abstract：:The aim of the present study was to determine whether short-term appropriate insulinization of Type 1 (insulin-dependent) diabetic patients in long-term poor glycaemic control (HbA1C > 9.5%) was associated with an adaptive regulation of the activity and gene expression of key proteins in muscle glycogen storage and gl...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00428782
更新日期：1994-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS:A case-cohort study within the European Pros...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-04978-8
更新日期：2019-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-012-2506-4
更新日期：2012-06-01 00:00:00
abstract：:The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00276966
更新日期：1984-12-01 00:00:00
abstract：:The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular cells by means of ...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/BF00304849
更新日期：1984-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-011-2071-2
更新日期：2011-05-01 00:00:00
abstract：:Plasma glucose control and arterial pressure were assessed in 28 Type 1 (insulin-dependent) diabetic patients with different degrees of micro-albuminuria. They were divided into two groups according to their urinary albumin excretion rate: a low micro-albuminuria group (n = 16) with albumin excretion ranging between 1...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00262209
更新日期：1984-06-01 00:00:00
abstract：AIMS/HYPOTHESIS:We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. METHODS:The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-011-2395-y
更新日期：2012-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Osmotic and oxidative stress is associated with the progression and advancement of diabetic cataract. In the present study, we used a cDNA microarray method to analyse gene expression patterns in streptozotocin-induced diabetic rats and galactose-fed cataractous lenses. In addition, we investigated the ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-005-1687-5
更新日期：2005-04-01 00:00:00
abstract：:Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18-24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight non-diabetic subjects aged 23-35 years in ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00422367
更新日期：1995-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus. METHODS:We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents It(o), IK, Iss and IK1 in enzymaticall...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050013
更新日期：2000-01-01 00:00:00
