Abstract:
:Data are discussed which demonstrate that insulin plays an important role in sodium metabolism. The primary action of insulin on sodium balance is exerted on the kidney. Increases in plasma insulin concentration within the physiological range stimulate sodium reabsorption by the distal nephron segments and this effect is independent of changes in circulating metabolites or other hormones. Several clinical situations are reviewed: sodium wasting in poorly controlled diabetics, natriuresis of starvation, anti-natriuresis of refeeding and hypertension of obesity, in which insulin-mediated changes in sodium balance have been shown to play an important pathophysiological role.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
DeFronzo RAdoi
10.1007/BF00252649subject
Has Abstractpub_date
1981-09-01 00:00:00pages
165-71issue
3eissn
0012-186Xissn
1432-0428journal_volume
21pub_type
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