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Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors.

Abstract：

AIMS/HYPOTHESIS:This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS:A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. RESULTS:After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among men and women, but only among men if adjusted for total height. Adjustment for liver fat and triacylglycerols, adiponectin and C-reactive protein substantially attenuated associations between height and diabetes risk, particularly among women. CONCLUSIONS/INTERPRETATION:We observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Wittenbecher C,Kuxhaus O,Boeing H,Stefan N,Schulze MB

doi

10.1007/s00125-019-04978-8

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

2211-2221

issue

12

eissn

0012-186X

issn

1432-0428

pii

10.1007/s00125-019-04978-8

journal_volume

62

pub_type

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