当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Leisure-time physical activity and type 2 diabetes during a 28 year follow-up in twins.

Leisure-time physical activity and type 2 diabetes during a 28 year follow-up in twins.

Abstract：

AIMS/HYPOTHESIS:The study aimed to investigate whether baseline physical activity protects against the occurrence of type 2 diabetes during a 28 year follow-up, after controlling for childhood environment and genetic predisposition. METHODS:At baseline in 1975 same-sex twin pairs born in Finland before 1958 were sent a questionnaire including questions on physical activity. The participants (20,487 individuals, including 8,182 complete twin pairs) were divided into quintiles by leisure-time physical activity metabolic equivalent (MET) index (MET h/day). Type 2 diabetes was determined from nationwide registers for the follow-up period (1 January 1976-31 December 2004). Individual and pairwise Cox proportional hazard models were used. RESULTS:During follow-up, 1,082 type 2 diabetes cases were observed. Among all individuals, participants in MET quintiles (Q) III-V had significantly decreased risk for type 2 diabetes compared with sedentary individuals (QI). The pairwise analysis on pairs discordant for physical activity showed that participants in MET QII to V had significantly lower hazard ratios (0.61, 0.59, 0.61, 0.61) compared with sedentary participants. These findings from the pairwise analysis persisted after adjusting for BMI. In the pairwise analysis, the BMI-adjusted hazard ratio for type 2 diabetes was lower for physically active members of twin pairs (combined QII-V) than for inactive co-twins (HR 0.54; 95% CI 0.37-0.78). Similar results were obtained for both dizygotic and monozygotic pairs, as well as for the subgroup of twin pairs defined as free of co-morbidities in 1981 (HR 0.36; 95% CI 0.17-0.76). CONCLUSIONS/INTERPRETATION:Leisure-time physical activity protects from type 2 diabetes after taking familial and genetic effects into account.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Waller K,Kaprio J,Lehtovirta M,Silventoinen K,Koskenvuo M,Kujala UM

doi

10.1007/s00125-010-1875-9

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

2531-7

issue

12

eissn

0012-186X

issn

1432-0428

journal_volume

53

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study.

    abstract：AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0017-2

    authors： Freedman BI,Hsu FC,Langefeld CD,Rich SS,Herrington DM,Carr JJ,Xu J,Bowden DW,Wagenknecht LE

    更新日期：2005-12-01 00:00:00

  • SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion.

    abstract：AIMS:The gene SLC2A2 encodes GLUT2, which is found predominantly in pancreas, liver, kidney and intestine. In mice, GLUT2 is the major glucose transporter into pancreatic beta cells, and biallelic Slc2a2 inactivation causes lethal neonatal diabetes. The role of GLUT2 in human beta cells is controversial, and biallelic ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2595-0

    authors： Sansbury FH,Flanagan SE,Houghton JA,Shuixian Shen FL,Al-Senani AM,Habeb AM,Abdullah M,Kariminejad A,Ellard S,Hattersley AT

    更新日期：2012-09-01 00:00:00

  • Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis.

    abstract：AIMS/HYPOTHESIS:We hypothesised that non-obese diabetic mice (NOD) mice have an autoimmune-mediated loss of islet sympathetic nerves and an impairment of sympathetically mediated glucagon responses. We aimed: (1) to determine whether diabetic NOD mice have an early impairment of the glucagon response to insulin-induced...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1494-5

    authors： Taborsky GJ Jr,Mei Q,Hackney DJ,Figlewicz DP,LeBoeuf R,Mundinger TO

    更新日期：2009-12-01 00:00:00

  • MAFA controls genes implicated in insulin biosynthesis and secretion.

    abstract：AIMS/HYPOTHESIS:Effects of the transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MAFA) on the regulation of beta cell gene expression and function were investigated. MATERIALS AND METHODS:INS-1 stable cell lines permitting inducible up- or downregulation of this transcription factor were...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0490-2

    authors： Wang H,Brun T,Kataoka K,Sharma AJ,Wollheim CB

    更新日期：2007-02-01 00:00:00

  • Hypoxia and hypoxia-inducible factors in diabetes and its complications.

    abstract：:Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hypergly...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-021-05380-z

    authors： Catrina SB,Zheng X

    更新日期：2021-01-26 00:00:00

  • ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

    abstract：:Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated insulin secretion in beta cells. K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, K(ATP) channels are open in alpha ce...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-014-3279-8

    authors： Rorsman P,Ramracheya R,Rorsman NJ,Zhang Q

    更新日期：2014-09-01 00:00:00

  • Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications.

    abstract：AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1710-x

    authors： Retnakaran R,Hanley AJ,Raif N,Hirning CR,Connelly PW,Sermer M,Kahn SE,Zinman B

    更新日期：2005-05-01 00:00:00

  • Abnormal increases in urinary albumin excretion during pregnancy in IDDM women with pre-existing microalbuminuria.

    abstract：:We compared urinary albumin excretion during and after pregnancy in 30 insulin-dependent diabetic (IDDM) women with normoalbuminuria and in 12 IDDM women with microalbuminuria (> 15 micrograms.min-1) prior to conception. There was a 6.7-fold increase in the urinary albumin excretion up until the third trimester in the...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00400946

    authors： Biesenbach G,Zazgornik J,Stöger H,Grafinger P,Hubmann R,Kaiser W,Janko O,Stuby U

    更新日期：1994-09-01 00:00:00

  • In vivo assessment of isolated pancreatic islet viability using the streptozotocin-induced diabetic nude rat.

    abstract：:In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02341509

    authors： Lake SP,Chamberlain J,Husken P,Bell PR,James RF

    更新日期：1988-06-01 00:00:00

  • Differences in cardiovascular morbidity and mortality between previously known and newly diagnosed adult diabetics.

    abstract：:498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01219704

    authors： Herman JB,Medalie JH,Goldbourt U

    更新日期：1977-05-01 00:00:00

  • Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance.

    abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2529-x

    authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

    更新日期：2012-06-01 00:00:00

  • Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line.

    abstract：AIMS/HYPOTHESIS:To investigate the pathways by which cyclic AMP (cAMP) stimulates glucagon-like peptide-1 (GLP-1) secretion, using the GLUTag enteroendocrine cell line. MATERIALS AND METHODS:GLP-1 release from GLUTag cells was measured in response to agents that increase cAMP, and single cells were studied by fluoresc...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0750-9

    authors： Simpson AK,Ward PS,Wong KY,Collord GJ,Habib AM,Reimann F,Gribble FM

    更新日期：2007-10-01 00:00:00

  • An oxidative stress paradox: time for a conceptual change?

    abstract：:Oxidative stress has long been considered a key driving factor of many obesity-related health problems. However, recent work by Merry, Tran et al (Diabetologia DOI 10.1007/s00125-016-4084-3 ) challenges this idea with an interesting study using a hepatocyte-specific Gpx1-knockout (HGKO) mouse. GPX1 is an important det...

    journal_title：Diabetologia

    pub_type： 评论,社论

    doi：10.1007/s00125-016-4117-y

    authors： Haas JT,Staels B

    更新日期：2016-12-01 00:00:00

  • Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial.

    abstract：AIMS/HYPOTHESIS:Both obesity and genetics contribute to cardiovascular disease (CVD). We examined whether a genetic risk score (GRS) prospectively predicted cardiovascular morbidity and mortality among overweight/obese individuals with type 2 diabetes and whether behavioural weight loss could diminish this association....

    journal_title：Diabetologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00125-015-3610-z

    authors： Look AHEAD Research Group.

    更新日期：2015-08-01 00:00:00

  • Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?

    abstract：AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0556-1

    authors： Wägner AM,Cloos P,Bergholdt R,Boissy P,Andersen TL,Henriksen DB,Christiansen C,Christgau S,Pociot F,Nerup J

    更新日期：2007-03-01 00:00:00

  • Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations.

    abstract：AIMS/HYPOTHESIS:The study aimed to assess, in multiple populations, the role of HLA alleles on early and late age at onset of type 1 diabetes. METHODS:Stepwise linear regression models were used to determine which HLA class I and class II risk alleles to include. High-resolution genotyping data for patients from the T...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2608-z

    authors： Valdes AM,Erlich HA,Carlson J,Varney M,Moonsamy PV,Noble JA

    更新日期：2012-09-01 00:00:00

  • The glucose-lowering agent sodium tungstate increases the levels and translocation of GLUT4 in L6 myotubes through a mechanism associated with ERK1/2 and MEF2D.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the action of the glucose-lowering compound sodium tungstate on glucose transport in muscle myotubes and to unravel the molecular events underlying the effects observed. METHODS:We studied the effects of tungstate on 2-deoxy-D: -glucose uptake, levels and transl...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1003-2

    authors： Girón MD,Sevillano N,Vargas AM,Domínguez J,Guinovart JJ,Salto R

    更新日期：2008-07-01 00:00:00

  • Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents.

    abstract：AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-003-1154-0

    authors： Gysemans C,Stoffels K,Giulietti A,Overbergh L,Waer M,Lannoo M,Feige U,Mathieu C

    更新日期：2003-08-01 00:00:00

  • Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin.

    abstract：:Epidemiologic data suggest that having a parent with Type 2 (non-insulin-dependent) diabetes mellitus increases the risk for Type 1 (insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. This increase in risk is consistent with a shared genetic susceptibility between Type 1 diabetes and Type 2 diabetes...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00405008

    authors： Rich SS,Panter SS,Goetz FC,Hedlund B,Barbosa J

    更新日期：1991-05-01 00:00:00

  • Immunological heterogeneity in type I diabetes: presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease.

    abstract：:Type I diabetes mellitus may represent a heterogeneous disorder with a distinct pathogenesis in patients with young and adult onset of the disease. To investigate whether serological markers directed to different autoantigens have the potential to distinguish acute onset from slowly progressive Type I diabetes we anal...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051004

    authors： Seissler J,de Sonnaville JJ,Morgenthaler NG,Steinbrenner H,Glawe D,Khoo-Morgenthaler UY,Lan MS,Notkins AL,Heine RJ,Scherbaum WA

    更新日期：1998-08-01 00:00:00

  • Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet.

    abstract：AIMS/HYPOTHESIS:Cre-loxP systems are frequently used in mouse genetics as research tools for studying tissue-specific functions of numerous genes/proteins. However, the expression of Cre recombinase in a tissue-specific manner often produces undesirable changes in mouse biology that can confound data interpretation whe...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-018-4643-x

    authors： Al Batran R,Gopal K,Martin MD,Ho KL,Almutairi M,Aburasayn H,Eaton F,Campbell JE,Ussher JR

    更新日期：2018-08-01 00:00:00

  • A simulation model of the cost of the incidence of IDDM in Spain.

    abstract：:This study estimates the direct health care costs of the incidence of insulin-dependent diabetes mellitus (IDDM) in Spain. A discrete event simulation model was developed to approximate the natural history of a cohort of newly diagnosed patients in a given year and used to calculate the average costs which would accum...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050680

    authors： Hart WM,Espinosa C,Rovira J

    更新日期：1997-03-01 00:00:00

  • Evidence for a placento-insular axis in the rat fetus.

    abstract：:Rat pups delivered by caesarian section one day before term, either remained attached to (experimental group) or were separated from their placenta (control group). Both groups were transferred into an incubator and their metabolic parameters studied. In the control group, plasma amino acid concentration fell from 11....

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00252766

    authors： Sodoyez-Goffaux F,Sodoyez JC,De Vos CJ

    更新日期：1981-05-01 00:00:00

  • Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.

    abstract：AIMS/HYPOTHESIS:The Ca2+/calmodulin-dependent protein kinase II (CaMK II) is highly expressed in pancreatic islets and associated with insulin secretion vesicles. The suppression of CaMK II disturbs insulin secretion and insulin gene expression. There are four isoforms of CaMK II, alpha to delta, that are expressed fro...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051330

    authors： Rochlitz H,Voigt A,Lankat-Buttgereit B,Göke B,Heimberg H,Nauck MA,Schiemann U,Schatz H,Pfeiffer AF

    更新日期：2000-04-01 00:00:00

  • Absence of telomere shortening and oxidative DNA damage in the young adult offspring of women with pre-gestational type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:The offspring of mothers with pre-gestational type 1 diabetes (PGDM) may be at increased risk of glucose intolerance and cardiovascular disease in childhood. The underlying causes of these observations, and whether they persist into adulthood, are unknown. The aim of the present study was to test the hy...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1207-5

    authors： Cross JA,Brennan C,Gray T,Temple RC,Dozio N,Hughes JC,Levell NJ,Murphy H,Fowler D,Hughes DA,Sampson MJ

    更新日期：2009-02-01 00:00:00

  • Genetic variation of the platelet- surface integrin GPIIb-IIIa (PIA1/A2-SNP) shows a high association with Type 2 diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:The gene encoding the beta(3)-subunit (GPIIIa) of the platelet alpha(2)beta(3)-integrin (fibrinogen receptor) shows a polymorphism PlA1/A2 with the A2 allele putatively associated with an increased risk of acute ischaemic events. This study investigated whether Type 2 diabetes as a particular macrovascu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-003-1132-6

    authors： Tschoepe D,Menart B,Ferber P,Altmann C,Haude M,Haastert B,Roesen P

    更新日期：2003-07-01 00:00:00

  • Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis.

    abstract：AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

    journal_title：Diabetologia

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00125-007-0884-9

    authors： Golicki DT,Golicka D,Groele L,Pankowska E

    更新日期：2008-02-01 00:00:00

  • Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model.

    abstract：AIMS/HYPOTHESIS:The receptor tyrosine kinase, c-Kit, and its ligand, stem cell factor, control a variety of cellular processes, including pancreatic beta cell survival and differentiation as revealed in c-Kit ( Wv ) mice, which have a p...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2566-5

    authors： Feng ZC,Li J,Turco BA,Riopel M,Yee SP,Wang R

    更新日期：2012-08-01 00:00:00

  • NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.

    abstract：:Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertriglyceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and accelerated atherosclerosis (metabolic syndrome X). Since a similar dyslipidaemia occurs with the acute-phase response, we investigated whether elevated...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050822

    authors： Pickup JC,Mattock MB,Chusney GD,Burt D

    更新日期：1997-11-01 00:00:00

  • Central nervous system regulation of liver and adipose tissue metabolism.

    abstract：:Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：

    authors： Shimazu T

    更新日期：1981-03-01 00:00:00