当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance.

Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance.

Abstract：

AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D. METHODS:At baseline, participants aged 35-56 years without known type 2 diabetes were examined using OGTTs, 25(OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8-10 years later were selected as cases; these were then age- and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men. RESULTS:Men but not women in the highest quartile of 25(OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline. In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D. A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men. CONCLUSIONS/INTERPRETATION:High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in terms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

doi

10.1007/s00125-012-2529-x

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

1668-78

issue

6

eissn

0012-186X

issn

1432-0428

journal_volume

55

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Complications in IDDM are caused by elevated blood glucose level: the Stockholm Diabetes Intervention Study (SDIS) at 10-year follow up.

    abstract：:Blood glucose values close to normal reduce the microvascular complications of insulin-dependent diabetes mellitus. The Stockholm study of this effect continued after the initial 7.5-year period in order to see what happened when intensively treated patients were left to control their own treatment while treatment was...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s001250050602

    authors： Reichard P,Pihl M,Rosenqvist U,Sule J

    更新日期：1996-12-01 00:00:00

  • Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas.

    abstract：:In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00420977

    authors： Gotfredsen CF

    更新日期：1976-08-01 00:00:00

  • Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry.

    abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. METHODS:Islets were isolated from C57BL/6J mice and used either directly or after exposu...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1661-7

    authors： Ahmed M,Bergsten P

    更新日期：2005-03-01 00:00:00

  • Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.

    abstract：AIMS/HYPOTHESIS:Mutations in the islet amyloid polypeptide ( IAPP) gene may play a potential role in the abnormal regulation or expression of the peptide. The aim of this study was to determine the functional role of the -132 G/A mutation reported in the promoter region of the IAPP gene in a population of Spanish Type ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1439-y

    authors： Novials A,Mato E,Lucas M,Franco C,Rivas M,Santisteban P,Gomis R

    更新日期：2004-07-01 00:00:00

  • Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease.

    abstract：AIMS/HYPOTHESIS:Chemokines are chemotactic cytokines controlling the recruitment of leukocytes from the blood by regulating integrin adhesiveness. It has been shown that the migration of CD4+Th1 and CD4+Th2 cells is governed by specific chemokines. Increasing evidence suggests that the CD4+Th1 cheomoattractant chemokin...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0879-5

    authors： Nicoletti F,Conget I,Di Mauro M,Di Marco R,Mazzarino MC,Bendtzen K,Messina A,Gomis R

    更新日期：2002-08-01 00:00:00

  • The metabolic response to hyperglycaemic clamping in insulin-dependent diabetes.

    abstract：:The metabolic and hormonal effects of stable hyperglycaemia (10-12 mmol/l) have been examined in five insulin-dependent diabetics and compared with the results of 8 h (1200 to 2000 h) normoglycaemic (5-6 mmol/l) clamping. Glucose levels were maintained using a glucose controlled insulin infusion system. Mean blood lac...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00262012

    authors： Nosadini R,Noy GA,Alberti KG,Hodson A,Orskoy H

    更新日期：1981-02-01 00:00:00

  • Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats.

    abstract：:Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400353

    authors： Fong Y,Edelstein D,Wang EA,Brownlee M

    更新日期：1993-09-01 00:00:00

  • Differential binding of sulphated insulin to adipocytes and hepatocytes.

    abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00273803

    authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

    更新日期：1984-08-01 00:00:00

  • Immunoisolation of pancreatic B cells by microencapsulation. An in vitro study.

    abstract：:The selective permeability of alginate microcapsules, containing isolated rat islets of Langerhans or insulin secreting RINm5F cells, was investigated in vitro. An increase in insulin release was observed when microencapsulated islets were stimulated by glucose+theophylline, and when microencapsulated RINm5F cells wer...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00265027

    authors： Darquy S,Reach G

    更新日期：1985-10-01 00:00:00

  • Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora's box.

    abstract：:Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...

    journal_title：Diabetologia

    pub_type： 评论,杂志文章

    doi：10.1007/s00125-013-3159-7

    authors： Atkinson MA

    更新日期：2014-04-01 00:00:00

  • Non-neural tyrosine hydroxylase, via modulation of endocrine pancreatic precursors, is required for normal development of beta cells in the mouse pancreas.

    abstract：AIMS/HYPOTHESIS:Apart from transcription factors, little is known about the molecules that modulate the proliferation and differentiation of pancreatic endocrine cells. The early expression of tyrosine hydroxylase (TH) in a subset of glucagon(+) cells led us to investigate whether catecholamines have a role in beta cel...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-014-3341-6

    authors： Vázquez P,Robles AM,de Pablo F,Hernández-Sánchez C

    更新日期：2014-11-01 00:00:00

  • In vitro bioactivity of insulin analogues: lipogenic and anti-lipolytic potency and their interaction with the effect of native insulin.

    abstract：:This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF01219650

    authors： Ellis MJ,Darby SC,Jones RH,Sönksen PH

    更新日期：1978-11-01 00:00:00

  • Individuals with only one allele for a functional insulin receptor have a tendency to hyperinsulinaemia but not to hyperglycaemia.

    abstract：:Recently, we described a leprechaun patient with a genetically transmitted severe insulin resistance due to the absence of functional insulin receptors as inferred from the loss of insulin binding to the patients' fibroblasts and the impaired autophosphorylation of the beta-chain of the receptor. This patient was homo...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00274534

    authors： Lekanne Deprez RH,Potter van Loon BJ,van der Zon GC,Möller W,Lindhout D,Klinkhamer MP,Krans HM,Maassen JA

    更新日期：1989-10-01 00:00:00

  • Adults with type 1 diabetes eat a high-fat atherogenic diet that is associated with coronary artery calcium.

    abstract：AIMS/HYPOTHESIS:Coronary heart disease is the leading cause of mortality among people with type 1 diabetes. Diet is an important lifestyle factor that relates to risk of CHD. The aim of this study was to examine how diet and adherence to dietary guidelines differ between adults with and without type 1 diabetes, and the...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1280-4

    authors： Snell-Bergeon JK,Chartier-Logan C,Maahs DM,Ogden LG,Hokanson JE,Kinney GL,Eckel RH,Ehrlich J,Rewers M

    更新日期：2009-05-01 00:00:00

  • C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men.

    abstract：AIMS/HYPOTHESIS:Low-grade inflammation has been implicated in the development of Type 2 diabetes and cardiovascular disease, but its role in the pathogenesis of the metabolic syndrome is unclear. We investigated the association between C-reactive protein (CRP) levels and the development of the metabolic syndrome and di...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1472-x

    authors： Laaksonen DE,Niskanen L,Nyyssönen K,Punnonen K,Tuomainen TP,Valkonen VP,Salonen R,Salonen JT

    更新日期：2004-08-01 00:00:00

  • A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs with basal insulin analogues detemir and glargine in type 2 diabetic patients. METHODS:Insulin-naive adults (n=582, HbA(1c) 7.5-1...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00125-007-0911-x

    authors： Rosenstock J,Davies M,Home PD,Larsen J,Koenen C,Schernthaner G

    更新日期：2008-03-01 00:00:00

  • Secular trend for mortality from breast cancer and the association between diabetes and breast cancer in Taiwan between 1995 and 2006.

    abstract：AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-1204-8

    authors： Tseng CH,Chong CK,Tai TY

    更新日期：2009-02-01 00:00:00

  • Effect of past and concurrent body mass index on prevalence of glucose intolerance and type 2 (non-insulin-dependent) diabetes and on insulin response. The Israel study of glucose intolerance, obesity and hypertension.

    abstract：:A representative sample (n = 2140) of the Israeli Jewish population aged 40-70 (excluding known diabetic patients), whose body mass index had been measured 10 years earlier, underwent an oral glucose tolerance test and redetermination of body mass index. Irrespective of weight changes, high concurrent and high past bo...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00456115

    authors： Modan M,Karasik A,Halkin H,Fuchs Z,Lusky A,Shitrit A,Modan B

    更新日期：1986-02-01 00:00:00

  • Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay.

    abstract：:Measurement of insulin autoantibodies (IAA) with a novel micro radiobinding assay which requires only 20 microl of serum was compared with that in a conventional radiobinding assay which uses 600 microl of serum. IAA were measured with both assays in samples from 94 new onset insulin-dependent diabetes mellitus (IDDM)...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050968

    authors： Naserke HE,Dozio N,Ziegler AG,Bonifacio E

    更新日期：1998-06-01 00:00:00

  • Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies.

    abstract：AIMS/HYPOTHESIS:Knowledge of the within-subject variability of a parameter is required to properly design and calculate sample sizes for longitudinal studies. We sought to determine the day-to-day variability of measures of beta cell function derived from an OGTT. METHODS:Thirty-seven adults (13 with normal glucose to...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00125-007-0819-5

    authors： Utzschneider KM,Prigeon RL,Tong J,Gerchman F,Carr DB,Zraika S,Udayasankar J,Montgomery B,Mari A,Kahn SE

    更新日期：2007-12-01 00:00:00

  • Assessment of an algorithm for the artificial B-cell using the normal insulin-glucose relationship in diabetic dogs and men.

    abstract：:Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order a...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00290484

    authors： Fischer U,Jutzi E,Bombor H,Freyse EJ,Salzieder E,Albrecht G,Besch W,Bruns W

    更新日期：1980-01-01 00:00:00

  • FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.

    abstract：AIMS/HYPOTHESIS:Fibroblast growth factor 21 (FGF21) is considered to be a promising therapeutic candidate for the treatment of type 2 diabetes. However, as FGF21 levels are elevated in obese and diabetic conditions we aimed to test if exogenous FGF21 is sufficient to prevent diabetes and beta cell loss in New Zealand o...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-017-4389-x

    authors： Laeger T,Baumeier C,Wilhelmi I,Würfel J,Kamitz A,Schürmann A

    更新日期：2017-11-01 00:00:00

  • Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:We examined the acute postprandial effects of meals containing unsaturated fatty acids on flow-mediated dilation (FMD) of the brachial artery and triacylglycerols in individuals with type 2 diabetes. We hypothesised that consumption of omega-3 fatty acids would enhance vascular function. Saturated fat r...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-004-1600-7

    authors： West SG,Hecker KD,Mustad VA,Nicholson S,Schoemer SL,Wagner P,Hinderliter AL,Ulbrecht J,Ruey P,Kris-Etherton PM

    更新日期：2005-01-01 00:00:00

  • Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young.

    abstract：AIMS/HYPOTHESIS:Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by pancreatic beta-cell dysfunction. Splice site mutations represent approximately 10% of reported HNF-1 alpha mutations. No studies to date have investig...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-002-0919-1

    authors： Bulman MP,Harries LW,Hansen T,Shepherd M,Kelly WF,Hattersley AT,Ellard S

    更新日期：2002-10-01 00:00:00

  • Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes.

    abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-006-0240-5

    authors： Højlund K,Frystyk J,Levin K,Flyvbjerg A,Wojtaszewski JF,Beck-Nielsen H

    更新日期：2006-06-01 00:00:00

  • Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.

    abstract：:Glucose-induced insulin secretion is impaired in the presence of chronic hyperglycaemia. Insulin secretion was studied in a diabetic rat model prior to the beta cells becoming non-responsive to glucose in order to map out the sequence of changes that accompany chronic hyperglycaemia. In vitro pancreas perfusions were ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00400800

    authors： Leahy JL,Bumbalo LM,Chen C

    更新日期：1993-12-01 00:00:00

  • Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes.

    abstract：AIMS/HYPOTHESIS:Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT(2)R) may modulate key processes linked to atherosclerosis. The aim of this study was to...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-009-1619-x

    authors： Koïtka A,Cao Z,Koh P,Watson AM,Sourris KC,Loufrani L,Soro-Paavonen A,Walther T,Woollard KJ,Jandeleit-Dahm KA,Cooper ME,Allen TJ

    更新日期：2010-03-01 00:00:00

  • Heterogeneity of the haemoglobin-A1c-band in isoelectric focussing.

    abstract：:A double HbA1c-band was demonstrated in isoelectric focussing of blood from diabetics with a fasting blood glucose above 11 mmol/l. The same band-doubling was also demonstrated after incubation of erythrocytes in glucose/saline solutions. This finding may reflect the presence of the initial condensation product betwee...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00281827

    authors： Welinder BS,Svendsen PA

    更新日期：1980-11-01 00:00:00

  • Serum tenascin-C is independently associated with increased major adverse cardiovascular events and death in individuals with type 2 diabetes: a French prospective cohort.

    abstract：AIMS/HYPOTHESIS:Tenascin-C (TN-C) is an extracellular matrix glycoprotein highly expressed in inflammatory and cardiovascular (CV) diseases. Serum TN-C has not yet been specifically studied in individuals with type 2 diabetes, a condition associated with chronic low-grade inflammation and increased CV disease risk. In ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-020-05108-5

    authors： Gellen B,Thorin-Trescases N,Thorin E,Gand E,Sosner P,Brishoual S,Rigalleau V,Montaigne D,Javaugue V,Pucheu Y,Gatault P,Piguel X,Hadjadj S,Saulnier PJ,SURDIAGENE Study group.

    更新日期：2020-05-01 00:00:00

  • Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2.

    abstract：AIMS/HYPOTHESIS:Islet autoantibodies are important in diabetes classification and risk assessment, and as endpoints in observational studies. The Diabetes Autoantibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report results for glut...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-0967-2

    authors： Törn C,Mueller PW,Schlosser M,Bonifacio E,Bingley PJ,Participating Laboratories.

    更新日期：2008-05-01 00:00:00