A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes.

abstract：:The liver has a central role in the regulation of systemic glucose and lipid fluxes during feeding and fasting and also relies on these substrates for its own energy needs. These parallel requirements are met by coordinated control of carbohydrate and lipid fluxes into and out of the Krebs cycle, which is highly tuned...

journal_title：Diabetologia

authors： Jones JG

更新日期：2016-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with ty...

journal_title：Diabetologia

authors： Eliasson B,Möller-Goede D,Eeg-Olofsson K,Wilson C,Cederholm J,Fleck P,Diamant M,Taskinen MR,Smith U

更新日期：2012-04-01 00:00:00

abstract：:The oscillatory potential of the electroretinogram and the initial 2-min phase of dark-adaptation were studied in seven newly diagnosed Type 1 (insulin-dependent) diabetic patients before and during initial insulin treatment. Strict metabolic control was achieved in all seven patients using multiple subcutaneous injec...

journal_title：Diabetologia

authors： Frost-Larsen K,Christiansen JS,Parving HH

更新日期：1983-03-01 00:00:00

abstract：:Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in...

journal_title：Diabetologia

authors： Weber HE,Menahan LA,Chaudhuri SN,Shipp JC

更新日期：1977-04-01 00:00:00

abstract：:Barium x-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation of the stomach, small and large intestine. Hypomotility was manifested by flocculation of barium in the small and large bowel. Impaired transit time was further characterized by prolonged emptying of the stomach (mean 570 min diab...

journal_title：Diabetologia

authors： Diani AR,Grogan DM,Yates ME,Risinger DL,Gerritsen GC

更新日期：1979-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The newly identified liver- and fat-derived hormone, betatrophin, has recently been linked to insulin resistance and pancreatic beta cell growth in mice. These preclinical findings have suggested betatrophin as a potential candidate for novel glucose-lowering treatment concepts involving beta cell regen...

journal_title：Diabetologia

authors： Fenzl A,Itariu BK,Kosi L,Fritzer-Szekeres M,Kautzky-Willer A,Stulnig TM,Kiefer FW

更新日期：2014-06-01 00:00:00

abstract：:Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabso...

journal_title：Diabetologia

authors： Abdulkadir J,Mengesha B,Welde Gebriel Z,Keen H,Worku Y,Gebre P,Bekele A,Urga K,Taddesse AS

更新日期：1990-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...

journal_title：Diabetologia

authors： Ahmed N,Babaei-Jadidi R,Howell SK,Beisswenger PJ,Thornalley PJ

更新日期：2005-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...

journal_title：Diabetologia

authors： Poungvarin N,Lee JK,Yechoor VK,Li MV,Assavapokee T,Suksaranjit P,Thepsongwajja JJ,Saha PK,Oka K,Chan L

更新日期：2012-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes. Here, oral insulin was given as antigen-specific immunotherapy before the onset of autoimmunity in children from age 6 months to assess its safety and immune response actions on ...

journal_title：Diabetologia

authors： Assfalg R,Knoop J,Hoffman KL,Pfirrmann M,Zapardiel-Gonzalo JM,Hofelich A,Eugster A,Weigelt M,Matzke C,Reinhardt J,Fuchs Y,Bunk M,Weiss A,Hippich M,Halfter K,Hauck SM,Hasford J,Petrosino JF,Achenbach P,Bonifacio E,

更新日期：2021-01-30 00:00:00

abstract：:The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. ...

journal_title：Diabetologia

authors： Ostbye T,Welby TJ,Prior IA,Salmond CE,Stokes YM

更新日期：1989-08-01 00:00:00

abstract：:The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated ...

journal_title：Diabetologia

authors： Sima AA,Brown MB,Prashar A,Chakrabarti S,Laudadio C,Greene DA

更新日期：1992-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although the variable number tandem repeat (VNTR) minisatellite 5' to the insulin gene is among the most studied polymorphisms in diabetes, the relationships between VNTR variation, diabetes-related traits and predisposition to type 2 diabetes remain unclear. Since inadequate sample size is likely to ha...

journal_title：Diabetologia

authors： Bennett A,Sovio U,Ruokonen A,Martikainen H,Pouta A,Taponen S,Hartikainen AL,Franks S,Peltonen L,Elliott P,Järvelin MR,McCarthy MI

更新日期：2005-05-01 00:00:00

abstract：:In a population-based survey of 2,930 subjects, prevalence rates for obesity, Type 2 (non-insulin-dependent) diabetes mellitus, impaired glucose tolerance, hypertension, hypertriglyceridaemia, and hypercholesterolaemia were 54.3, 9.3, 11.1, 9.8, 10.3 and 9.2%, respectively. The prevalence, however, of each of these co...

journal_title：Diabetologia

authors： Ferrannini E,Haffner SM,Mitchell BD,Stern MP

更新日期：1991-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...

journal_title：Diabetologia

authors： Seghieri M,Rebelos E,Gastaldelli A,Astiarraga BD,Casolaro A,Barsotti E,Pocai A,Nauck M,Muscelli E,Ferrannini E

更新日期：2013-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Microvascular complications in the heart and kidney are strongly associated with an overall rise in inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory molecule that limits and resolves inflammation. In this study, we have used a bedside to bench approach to investigate: (1) ANXA1 levels...

journal_title：Diabetologia

authors： Purvis GSD,Chiazza F,Chen J,Azevedo-Loiola R,Martin L,Kusters DHM,Reutelingsperger C,Fountoulakis N,Gnudi L,Yaqoob MM,Collino M,Thiemermann C,Solito E

更新日期：2018-02-01 00:00:00

abstract：:A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...

journal_title：Diabetologia

authors： Pipeleers DG,Pipeleers-Marichal MA

更新日期：1981-06-01 00:00:00

abstract：:A double HbA1c-band was demonstrated in isoelectric focussing of blood from diabetics with a fasting blood glucose above 11 mmol/l. The same band-doubling was also demonstrated after incubation of erythrocytes in glucose/saline solutions. This finding may reflect the presence of the initial condensation product betwee...

journal_title：Diabetologia

authors： Welinder BS,Svendsen PA

更新日期：1980-11-01 00:00:00

abstract：:AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...

journal_title：Diabetologia

authors： Nirantharakumar K,Mohammed N,Toulis KA,Thomas GN,Narendran P

更新日期：2018-07-01 00:00:00

abstract：:The effect of interference with diacylglycerol metabolism was investigated in pancreatic mouse islets. In the presence of the diacylglycerol lipase inhibitor RHC 80,267, glucose-induced insulin secretion was reduced 50-60%; whereas carbacholin-induced insulin secretion was unaffected. Addition of the diacylglycerol ki...

journal_title：Diabetologia

authors： Capito K,Hansen SE,Hedeskov CJ,Thams P

更新日期：1989-02-01 00:00:00

abstract：:The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...

journal_title：Diabetologia

authors： Sugden MC,Ashcroft SJ

更新日期：1977-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Statins and niacin (nicotinic acid) reduce circulating LDL-cholesterol (LDL-C) levels by different mechanisms. Yet, both increase the risk of diabetes mellitus. Our objective was to relate blood LDL-C concentrations and a genetic risk score (GRS) for LDL-C to the risk of incident diabetes in individuals...

journal_title：Diabetologia

authors： Andersson C,Lyass A,Larson MG,Robins SJ,Vasan RS

更新日期：2015-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our aim was to compare the therapeutic effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. METHODS:Male Holtzman rats of 6 to 8 weeks of age and weighing 170+/-30 g were randomly divided into four groups: control ( n=13), untreated ...

journal_title：Diabetologia

authors： Bosco AA,Lerario AC,Santos RF,Wajchenberg BL

更新日期：2003-12-01 00:00:00

abstract：:A rapid chromatography method for separating glycosylated protein from non-glycosylated protein, using a boronate-agarose affinity medium which selectively binds the cis-diol groups of glycoproteins, was used to quantitate plasma glycoprotein as well as glycohaemoglobin. The results were found to be independent of: (1...

journal_title：Diabetologia

authors： Willey DG,Rosenthal MA,Caldwell S

更新日期：1984-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes. METHODS:We conducted a population-based observation...

journal_title：Diabetologia

authors： Gong IY,Cheung MC,Read S,Na Y,Lega IC,Lipscombe LL

更新日期：2021-01-06 00:00:00

abstract：AIM/HYPOTHESIS:Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice. In humans, potential links with obesity comorbidities are poorly ...

journal_title：Diabetologia

authors： Rouault C,Marcelin G,Adriouch S,Rose C,Genser L,Ambrosini M,Bichet JC,Zhang Y,Marquet F,Aron-Wisnewsky J,Poitou C,André S,Dérumeaux G,Guerre-Millo M,Clément K

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women. MATERIALS AND METHODS:The women were divided into insulin-sensitive and -resistant groups based on their median whole-body insulin sensitivity (8.7+/-0.4 vs 4.2+/-0.3 mg kg(-1) min(-1) for insuli...

journal_title：Diabetologia

authors： Westerbacka J,Cornér A,Kannisto K,Kolak M,Makkonen J,Korsheninnikova E,Nyman T,Hamsten A,Fisher RM,Yki-Järvinen H

更新日期：2006-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aims of this work were to assess glycaemic control in metformin users receiving their first add-on glucose-lowering therapy and to examine the real-life effectiveness of different add-on drugs. METHODS:We carried out a population-based cohort study using healthcare databases in northern Denmark dur...

journal_title：Diabetologia

authors： Thomsen RW,Baggesen LM,Søgaard M,Pedersen L,Nørrelund H,Buhl ES,Haase CL,Johnsen SP

更新日期：2015-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...

journal_title：Diabetologia

authors： Sundell J,Laine H,Nuutila P,Rönnemaa T,Luotolahti M,Raitakari O,Knuuti J

更新日期：2002-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several investigations have shown that the renal medulla has a greater capacity to generate nitric oxide than the renal cortex. To further evaluate the changes of nitric oxide synthesis in the kidney, particularly in the outer medulla, in disorders involving fluid and electrolyte imbalances, we sought t...

journal_title：Diabetologia

authors： Shin SJ,Lai FJ,Wen JD,Hsiao PJ,Hsieh MC,Tzeng TF,Chen HC,Guh JY,Tsai JH

更新日期：2000-05-01 00:00:00