Abstract:
:Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in liver. Glucagon administered in vivo to normal rats caused an increase in the activity ratio and a decrease in total protein kinase activity in liver. The changes are similar to those in diabetes. A decrease in the ratio of insulin to glucagon in diabetes may account for the changes in protein kinase observed.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Weber HE,Menahan LA,Chaudhuri SN,Shipp JCdoi
10.1007/BF00745144subject
Has Abstractpub_date
1977-04-01 00:00:00pages
153-7issue
2eissn
0012-186Xissn
1432-0428journal_volume
13pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Glutamic acid decarboxylase autoantibodies (GADA) are the most frequent beta-cell-specific autoantibodies in type 1 diabetes and in latent autoimmune diabetes in adults (LADA). The autoimmune attack on pancreatic islet cells is associated with a T helper 1 cell (T(h)1) response, mainly represented by Ig...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1558-5
更新日期:2004-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Empagliflozin (EMPA), an inhibitor of the renal sodium-glucose cotransporter (SGLT) 2, reduces the risk of cardiovascular death in patients with type 2 diabetes. The underlying mechanism of this effect is unknown. Elevated cardiac cytoplasmic Na+ ([Na+]c) and Ca2+ ([Ca2+]c) concentrations and decreased ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4134-x
更新日期:2017-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The SMXA-5 mouse is one of the SMXA recombinant inbred substrains established from the non-diabetic SM/J and A/J strains, and is a model for polygenic type 2 diabetes, characterised by moderately impaired glucose tolerance and hyperinsulinaemia. These diabetic traits are worsened by feeding a high-fat d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0121-3
更新日期:2006-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabetes living in Scotland. METHODS:Data from Scottish Care Information-Diabetes (SCI-Diabetes) were...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3492-0
更新日期:2015-04-01 00:00:00
abstract::The authors have been made aware that the following sentence is incorrect: 'Like IIK7, both ramelteon and tasimelteon have a greater affinity for the MT2 receptor [162].' ...
journal_title:Diabetologia
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00125-018-4577-3
更新日期:2018-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Subtyping GAD autoantibody (GADA) responses using affinity measurement allows the identification of GADA-positive children with a family history of type 1 diabetes who are at risk of developing diabetes. Here, we asked whether GADA affinity is a useful marker to stratify the risk of type 1 diabetes in G...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3294-9
更新日期:2014-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar effect in other ethnic groups is unknown. The aim of this study was to investigate the effect o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1241-3
更新日期:2009-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1717-3
更新日期:2005-05-01 00:00:00
abstract:AIM/HYPOTHESIS:Oxidative stress was shown to selectively induce impaired metabolic response to insulin, raising the possible involvement of alterations in Insulin-Receptor-Substrate (IRS) proteins. This study was conducted to assess whether oxidative stress induced IRS protein degradation and enhanced serine phosphoryl...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1097-5
更新日期:2003-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Osmotic and oxidative stress is associated with the progression and advancement of diabetic cataract. In the present study, we used a cDNA microarray method to analyse gene expression patterns in streptozotocin-induced diabetic rats and galactose-fed cataractous lenses. In addition, we investigated the ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1687-5
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of this study was to assess whether pregnancy-associated beta cell expansion...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4243-1
更新日期:2017-06-01 00:00:00
abstract::Barium x-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation of the stomach, small and large intestine. Hypomotility was manifested by flocculation of barium in the small and large bowel. Impaired transit time was further characterized by prolonged emptying of the stomach (mean 570 min diab...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01222975
更新日期:1979-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-012-2685-z
更新日期:2012-11-01 00:00:00
abstract::The aim of the present study was to elucidate the pathophysiologic significance of circulating ouabain as a link between insulin resistance (IR) and hypertension (HT) in NIDDM. Euglycaemic (4.5 mmol/l) hyperinsulinaemic (360-580 pmol/l) clamping was performed using an artificial endocrine pancreas. Plasma ouabain-like...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050354
更新日期:1995-07-01 00:00:00
abstract::A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00257436
更新日期:1981-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Cre-loxP systems are frequently used in mouse genetics as research tools for studying tissue-specific functions of numerous genes/proteins. However, the expression of Cre recombinase in a tissue-specific manner often produces undesirable changes in mouse biology that can confound data interpretation whe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4643-x
更新日期:2018-08-01 00:00:00
abstract::We examined the origin of hypermethioninaemia in streptozotocin-diabetic rats. In rats administered streptozotocin over a range from 55 to 75 mg/kg, the dose of drug injected correlated directly with the plasma methionine concentration and inversely with the plasma insulin level. Although insulin administration preven...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00273913
更新日期:1984-10-01 00:00:00
abstract::Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cysti...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-016-3936-1
更新日期:2016-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Cerebral oedema complicating diabetic ketoacidosis (DKA) remains the major cause of morbidity and mortality in children with type 1 diabetes, but its aetiology remains unknown. Our objective was to determine the impact of baseline biochemical factors and of treatment-related variables on risk of the dev...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0363-8
更新日期:2006-09-01 00:00:00
abstract::People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-009-1454-0
更新日期:2009-10-01 00:00:00
abstract::QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418273
更新日期:1991-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1625-y
更新日期:2005-02-01 00:00:00
abstract::There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-013-2929-6
更新日期:2013-09-01 00:00:00
abstract::Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050907
更新日期:1998-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Alterations in vascular permeability and oxidative stress are characteristics of endothelial dysfunction in diabetic vascular disease. Since AGE-proteins have been hypothesized to mediate these effects, we studied the effects of AGE-bovine serum albumin on endothelial monolayer permeability and intracel...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250100646
更新日期:2001-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Identifying the metabolite profile of individuals with normal fasting glucose (NFG [<5.55 mmol/l]) who progressed to type 2 diabetes may give novel insights into early type 2 diabetes disease interception and detection. METHODS:We conducted a population-based prospective study among 1150 Framingham Hea...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4599-x
更新日期:2018-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1510-9
更新日期:2009-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaem...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3636-2
更新日期:2015-08-01 00:00:00
abstract::The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276965
更新日期:1984-12-01 00:00:00
abstract::Plasma immunoreactive secretin and insulin concentrations were measured in fasting normal humans after intraduodenal infusions of hydrochloric acid, isotonic or hypertonic glucose. The effect of intraduodenal acidification or intravenous bolus injections of secretin on plasma insulin concentrations during infusions of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219421
更新日期:1978-04-01 00:00:00