Abstract:
:The authors have been made aware that the following sentence is incorrect: 'Like IIK7, both ramelteon and tasimelteon have a greater affinity for the MT2 receptor [162].'
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Forrestel AC,Miedlich SU,Yurcheshen M,Wittlin SD,Sellix MTdoi
10.1007/s00125-018-4577-3subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1237issue
5eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-018-4577-3journal_volume
61pub_type
杂志文章,已发布勘误相关文献
DIABETOLOGIA文献大全abstract::We have suggested that the order of cellular vascular perfusion within the islet is important in the regulation of islet hormone secretion. Anatomically, the A and D cells appear to be randomly dispersed throughout the mantle. Although islet capillary blood flow is known to be from the B-cell core to the A- and D-cell...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00265095
更新日期:1989-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:It has been proposed that muscle fibre type composition and perfusion are key determinants of insulin-stimulated muscle glucose uptake, and alterations in muscle fibre type composition and perfusion contribute to muscle, and consequently whole-body, insulin resistance in people with obesity. The goal of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-021-05383-w
更新日期:2021-01-29 00:00:00
abstract:AIMS/HYPOTHESIS:Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repair...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0556-1
更新日期:2007-03-01 00:00:00
abstract::To test the hypothesis that interaction between genetic, immunological, clinical and metabolic risk factors influences the outcome of Type II (non-insulin-dependent) diabetes mellitus, we examined which of the above factors present at baseline were associated with mortality in 134 Type II diabetic patients followed fo...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051062
更新日期:1998-11-01 00:00:00
abstract::Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM). A new class of drugs, the thiazolidinediones, have been shown to lower blood glucose levels without stimulating insulin secretion. We report the metabolic effect of the thiazolidinedione, darg...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/BF00401763
更新日期:1995-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mitochondrial dysfunction has been postulated to underlie muscular fat accumulation, leading to muscular insulin sensitivity and ultimately type 2 diabetes mellitus. Here we re-interpret previously published data on [(13)C]acetate recovery in breath gas obtained during exercise in type 2 diabetic patien...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1069-x
更新日期:2008-09-01 00:00:00
abstract::Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050805
更新日期:1997-10-01 00:00:00
abstract::Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given at high doses for a variety of therapeutic applications. It is currently in trial as a potential means of preventing the onset of Type I (insulin-dependent) diabetes mellitus in high-risk, first-degree relatives. Nicotinamid...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250051536
更新日期:2000-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The Cost of Diabetes in Europe-Type II study is the first coordinated attempt to assess the total costs of Type II (non-insulin-dependent) diabetes mellitus in Europe. Although gaining a clearer understanding of the economics of diabetes was the goal of the study, a secondary objective was to consider t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0861-2
更新日期:2002-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study aimed to explore the infancy growth trajectories of 'recent' and 'earlier' offspring of mothers with gestational diabetes mellitus (OGDM), each compared with the same control infants, and investigate whether 'recent' OGDM still exhibit a classical phenotype, with macrosomia and increased adip...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4970-6
更新日期:2019-11-01 00:00:00
abstract::Little is known about the immunological impact of insulin administration other than it can boost insulin autoantibody levels. In particular, while the subcutaneous administration of a soluble foreign antigen (without adjuvant) is generally only weakly immunogenic in a naive animal, it is unknown what effect the subcut...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050896
更新日期:1998-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Recent studies have demonstrated that pioglitazone (PIO) has beneficial effects on insulin sensitivity compared with placebo in patients with type 2 diabetes. The effects of PIO and gliclazide (GLIC)-based therapy on insulin sensitivity have not previously been directly compared. This analysis aimed to ...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1007/s00125-004-1651-9
更新日期:2005-03-01 00:00:00
abstract::It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050644
更新日期:1997-01-01 00:00:00
abstract::In sham-operated rats, intravenous administration of 14C-very low density lipoprotein triglycerides (with labelled esterified fatty acids) caused an initial decrease and subsequent increase in plasma 14C-lipids of both very low density lipoproteins (VLDL) (density less than 1.006) and lipoproteins of density greater t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282718
更新日期:1983-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivit...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3269-x
更新日期:2014-08-01 00:00:00
abstract::Freshly isolated and primary cultured adult rat cardiomyocytes were used to elucidate the mechanism of action of the new oral antidiabetic agent (+/-)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethyl-chroman-2-yl-methoxy)benzyl]-2,4-thiazolidinedione (troglitazone) on the heart. Interaction with protein kinase C (PKC) and regul...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050509
更新日期:1996-07-01 00:00:00
abstract::A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the se...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02658499
更新日期:1996-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Improvements in islet transplantation require clinical series large enough to implement controlled new strategies. The goal of this study was to demonstrate the feasibility of a multicentre network for islet transplantation in Type I (insulin-dependent) diabetic patients. METHODS:The five centres (Besa...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s001250100571
更新日期:2001-07-01 00:00:00
abstract::Type 1 diabetes is an immune-mediated disease leading to almost total beta cell destruction and permanent exogenous insulin dependency. The appearance of clinical symptoms is preceded by an asymptomatic preclinical period, the duration of which is highly individual. The emergence of diabetes-associated autoantibodies ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4147-5
更新日期:2017-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1510-9
更新日期:2009-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes. SUBJECTS, MATERIALS AND METHODS:This was a single-centre, randomised, double-blind study in drug-naive patients with type 2 diabetes. Pa...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-006-0340-2
更新日期:2006-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Contemporary data on diabetic foot ulcer prevalence are scarce. Most studies were conducted in the 1990s, reporting incidence rates of 1.9-2.6%. Since then the prevalence of diabetes has doubled and the organisation of diabetes care has undergone major changes. Up-to-date data that quantify the occurren...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4274-7
更新日期:2017-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Advances in type 2 diabetes genetics have raised hopes that genetic testing will improve disease prediction, prevention and treatment. Little is known about current physician and patient views regarding type 2 diabetes genetic testing. We hypothesised that physician and patient views would differ regard...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1512-7
更新日期:2009-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-018-4677-0
更新日期:2018-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1618-y
更新日期:2010-03-01 00:00:00
abstract::The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400254
更新日期:1992-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:We hypothesised that non-obese diabetic mice (NOD) mice have an autoimmune-mediated loss of islet sympathetic nerves and an impairment of sympathetically mediated glucagon responses. We aimed: (1) to determine whether diabetic NOD mice have an early impairment of the glucagon response to insulin-induced...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1494-5
更新日期:2009-12-01 00:00:00
abstract:AIM/HYPOTHESIS:Diabetic neuropathy is accompanied by a range of positive (paresthaesia, dysesthaesia, pain) and negative (hypesthaesia, anesthaesia) neurological symptoms suggesting widespread alterations in axonal excitability. The nature and the mechanisms underlying these alterations in axonal excitability are not w...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-1026-z
更新日期:2003-02-01 00:00:00
abstract::In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02341509
更新日期:1988-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:To investigate whether proinsulin C peptide influences sympathetic nerve activity directly or indirectly through parasympathetic nerve activity. METHODS:The proliferative response of splenic lymphocytes to Concanavalin A (ConA response) which is known to be suppressed by subjection of rats to footshock...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051562
更新日期:2000-12-01 00:00:00