Family-based mitochondrial association study of traits related to type 2 diabetes and the metabolic syndrome in adolescents.

abstract：AIMS/HYPOTHESIS:Fetal growth is influenced by genetic factors as well as the intra-uterine environment. We hypothesised that some genetic factors may alter fetal insulin secretion and insulin action. SUBJECTS, MATERIALS AND METHODS:To assess this, we analysed plasma insulin concentration in umbilical cord blood from 6...

journal_title：Diabetologia

authors： Shields BM,Knight B,Turner M,Wilkins-Wall B,Shakespeare L,Powell RJ,Hannemann M,Clark PM,Yajnik CS,Hattersley AT

更新日期：2006-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fractal analysis of the retinal vasculature provides a global measure of the complexity and density of retinal vessels summarised as a single variable: the fractal dimension. We investigated fractal dimensions as long-term predictors of microvasculopathy in type 1 diabetes. METHODS:We included 180 pati...

journal_title：Diabetologia

authors： Broe R,Rasmussen ML,Frydkjaer-Olsen U,Olsen BS,Mortensen HB,Peto T,Grauslund J

更新日期：2014-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with traditional cardiovascular risk factors and incident cardiovascular events in older people with type 2 diabetes. METHODS:In the prospective phase of the Edinburgh Type 2 Diabetes Study,...

journal_title：Diabetologia

authors： Price AH,Welsh P,Weir CJ,Feinkohl I,Robertson CM,Morling JR,McLachlan S,Strachan MW,Sattar N,Price JF

更新日期：2014-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:This multicentre randomised double-blind placebo-controlled clinical trial assessed the efficacy and safety of a methionine aminopeptidase 2 (MetAP2) inhibitor, beloranib, in individuals with obesity (BMI ≥30 kg/m2) and type 2 diabetes (HbA1c 53-97 mmol/mol [7-11%] and fasting glucose <15.6 mmol/l). ME...

journal_title：Diabetologia

authors： Proietto J,Malloy J,Zhuang D,Arya M,Cohen ND,de Looze FJ,Gilfillan C,Griffin P,Hall S,Nathow T,Oldfield GS,O'Neal DN,Roberts A,Stuckey BGA,Yue D,Taylor K,Kim D

更新日期：2018-09-01 00:00:00

abstract：:Plasma insulin and growth hormone levels were measured during morning and afternoon oral glucose tolerance tests performed on 12 young men at three monthly intervals in the Antarctic. No diurnal or seasonal differences in growth hormone levels were found. However there were diurnal and seasonal variations in the blood...

journal_title：Diabetologia

authors： Campbell IT,Jarrett RJ,Rutland P,Stimmler L

更新日期：1975-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Beta cells situated in the islet of Langerhans respond more vigorously to glucose than do dissociated beta cells. Mechanisms for this discrepancy were studied by comparing insulin-producing MIN6 cells aggregated into pseudoislets with MIN6 monolayer cells and mouse and human islets. METHODS:MIN6 monola...

journal_title：Diabetologia

authors： Chowdhury A,Dyachok O,Tengholm A,Sandler S,Bergsten P

更新日期：2013-07-01 00:00:00

abstract：:A method has been developed for the purification of single A, B and D cells and for the isolation of coupled islet cells. Isolated rat islets were dissociated by repeated pipetting in the presence of trypsin and ethylene glycol bis (beta-aminoethyl ether) N,N' tetra-acetic acid (EGTA), and then filtered through nylon ...

journal_title：Diabetologia

authors： Pipeleers DG,Pipeleers-Marichal MA

更新日期：1981-06-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI3-kinase) plays a crucial role in insulin signal transduction. We studied the molecular mechanism of the insulin-induced activation of PI3-kinase in rat hepatoma Fao cells using an antibody against the 110-kDa catalytic subunit (p110) and two against the 85-kDa regulatory subunit (p85 alph...

journal_title：Diabetologia

authors： Hayashi T,Okamoto M,Yoshimasa Y,Inoue G,Yamada K,Kono S,Shigemoto M,Suga J,Kuzuya H,Nakao K

更新日期：1996-05-01 00:00:00

abstract：:Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18-24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight non-diabetic subjects aged 23-35 years in ...

journal_title：Diabetologia

authors： George E,Harris N,Bedford C,Macdonald IA,Hardisty CA,Heller SR

更新日期：1995-10-01 00:00:00

abstract：:The characteristics, progressivity and reversibility of the changes in glucose homeostasis brought about by chronic protein-calorie malnutrition were studied in the rat. Four-week-old male rats received a control diet (15% protein) or a low-protein diet (5% protein) until the age of 28 weeks. Other rats received the l...

journal_title：Diabetologia

authors： Okitolonda W,Brichard SM,Henquin JC

更新日期：1987-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impaired fibrinolysis and insulin clearance. We examined the association between plasminogen activato...

journal_title：Diabetologia

authors： Lee CC,Lorenzo C,Haffner SM,Wagenknecht LE,Festa A,Goodarzi MO,Stefanovski D,Olson NC,Norris JM,Rewers MJ,Hanley AJ

更新日期：2013-01-01 00:00:00

abstract：:The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (ser...

journal_title：Diabetologia

authors： Sasaki A

更新日期：1981-03-01 00:00:00

abstract：:Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may...

journal_title：Diabetologia

authors： Köbberling J,Brüggeboes B

更新日期：1980-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axo...

journal_title：Diabetologia

authors： Glawe JD,Mijalis EM,Davis WC,Barlow SC,Gungor N,McVie R,Kevil CG

更新日期：2013-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The paucity of information on the epigenetic barriers that are blocking reprogramming protocols, and on what makes a beta cell unique, has hampered efforts to develop novel beta cell sources. Here, we aimed to identify enhancers in pancreatic islets, to understand their developmental ontologies, and to ...

journal_title：Diabetologia

authors： Tennant BR,Robertson AG,Kramer M,Li L,Zhang X,Beach M,Thiessen N,Chiu R,Mungall K,Whiting CJ,Sabatini PV,Kim A,Gottardo R,Marra MA,Lynn FC,Jones SJ,Hoodless PA,Hoffman BG

更新日期：2013-03-01 00:00:00

abstract：:We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurif...

journal_title：Diabetologia

authors： Grasso G,Frittitta L,Anello M,Russo P,Sesti G,Trischitta V

更新日期：1995-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Clinical trials are in progress to test thiazolidinediones in neurodegenerative diseases such as Alzheimer's disease that involve deficiencies in brain glucose metabolism. While thiazolidinediones enhance glucose uptake in non-cerebral tissues, their impact on brain energy metabolism has not been invest...

journal_title：Diabetologia

authors： Galea E,Feinstein DL,Lacombe P

更新日期：2006-09-01 00:00:00

abstract：:Forearm perfusion studies were carried out to determine the responsiveness to insulin of the superficial forearm tissues in non-obese Type 2 (non-insulin-dependent) diabetics, and the interrelationships among plasma concentrations of glucose, insulin and non-esterified fatty acids (NEFA), tissue uptake of glucose and ...

journal_title：Diabetologia

authors： Kalant N,Leibovici D,Fukushima N,Kuyumjian J,Ozaki S

更新日期：1982-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on...

journal_title：Diabetologia

authors： Favaro E,Carpanetto A,Caorsi C,Giovarelli M,Angelini C,Cavallo-Perin P,Tetta C,Camussi G,Zanone MM

更新日期：2016-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. METHODS:Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphen...

journal_title：Diabetologia

authors： Ukropec J,Radikova Z,Huckova M,Koska J,Kocan A,Sebokova E,Drobna B,Trnovec T,Susienkova K,Labudova V,Gasperikova D,Langer P,Klimes I

更新日期：2010-05-01 00:00:00

abstract：:The effect of human growth hormone on arterial basement membrane-like (BM) material was studied. BM-like material was obtained from the cell layer of cultured aortic myomedial cells using a sonication-differential centrifugation technique. After the addition of small amounts of growth hormone (1 ng/ml) to the cultures...

journal_title：Diabetologia

authors： Ledet T,Heickendorff L

更新日期：1985-12-01 00:00:00

abstract：:Diabetic patients exhibit a higher incidence of post-surgical sepsis, as well as a higher rate of mortality from sepsis, than their non-diabetic counterparts. This may be a result of cardiovascular deterioration associated with diabetes mellitus. This study was designed to characterize the cardiovascular sequelae asso...

journal_title：Diabetologia

authors： Law WR,Moriarty MT,McLane MP

更新日期：1991-10-01 00:00:00

abstract：:Human crude and recombinant interleukin 1 (IL-1) was found to dose- and time-dependently affect the biosynthesis of (pro)insulin in isolated rat islets of Langerhans. Incubation of rat islets with either 0.5 U/ml or 5 U/ml of crude IL-1 for 1 h had no detectable effect on (pro)insulin biosynthesis. After 24 hours of e...

journal_title：Diabetologia

authors： Spinas GA,Hansen BS,Linde S,Kastern W,Mølvig J,Mandrup-Poulsen T,Dinarello CA,Nielsen JH,Nerup J

更新日期：1987-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes. METHODS:A cross-sectional nested case-control study of the foll...

journal_title：Diabetologia

authors： Schram MT,Chaturvedi N,Schalkwijk CG,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

更新日期：2005-02-01 00:00:00

abstract：:Hyperglycaemia has been shown to play a central part in diabetic vascular disease, which is also influenced by individual background. Hyperglycaemia initiates the pathogenetic sequence through a series of interrelated biochemical abnormalities, including increased flux through the polyol and hexosamine pathways, oxida...

journal_title：Diabetologia

authors： Di Mario U,Pugliese G

更新日期：2001-06-01 00:00:00

abstract：:The NOD mouse, which shows many features of human IDDM, is extensively used to evaluate the role of T lymphocytes in the pathogenesis of autoimmune diabetes. The development of diabetes in this model appears to be controlled by a finely tuned immunoregulatory balance between autoaggressive T cells and regulatory immun...

journal_title：Diabetologia

authors： Sempé P,Richard MF,Bach JF,Boitard C

更新日期：1994-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...

journal_title：Diabetologia

authors： Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

更新日期：2009-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentrations are characteristic for subjects with insulin resistance and could contribute to the increased cardiovascular risk in this state. In this study, we investigated the effect of troglitazone, a ligand of the nuclear receptor peroxisom...

journal_title：Diabetologia

authors： Gottschling-Zeller H,Röhrig K,Hauner H

更新日期：2000-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...

journal_title：Diabetologia

authors： Huang CJ,Butler AE,Moran A,Rao PN,Wagner JE,Blazar BR,Rizza RA,Manivel JC,Butler PC

更新日期：2011-05-01 00:00:00

abstract：:QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...

journal_title：Diabetologia

authors： Ewing DJ,Boland O,Neilson JM,Cho CG,Clarke BF

更新日期：1991-03-01 00:00:00