Abstract：
:The effect of human growth hormone on arterial basement membrane-like (BM) material was studied. BM-like material was obtained from the cell layer of cultured aortic myomedial cells using a sonication-differential centrifugation technique. After the addition of small amounts of growth hormone (1 ng/ml) to the cultures, we observed a 26% increased incorporation of amino acids into BM-like material (2p less than 0.005). However, further increase in the incorporation was not observed using either 3 ng or 10 ng growth hormone per ml. Growth hormone inhibited removal/degradation of BM-like material by 16% (2p less than 0.01). However, pinocytosis rate and activity of major lysosomal enzymes: cathepsin D, acid phosphatase and beta-N-acetyl-glucosaminidase were unchanged. Incorporation of glycosaminoglycans as evaluated by [35SO4]-labelling was reduced by 8% when cells were exposed to growth hormone (2p less than 0.01). The present study demonstrates an effect of growth hormone on the turnover and composition of BM-like material in cultured arterial myomedial cells.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Ledet T,Heickendorff Ldoi
10.1007/BF00703138subject
Has Abstractpub_date
1985-12-01 00:00:00pages
922-7issue
12eissn
0012-186Xissn
1432-0428journal_volume
28pub_type
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