Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.

abstract：AIMS/HYPOTHESIS:We determined the effects of 6 years of lifestyle intervention in persons with impaired glucose tolerance (IGT) on the development of retinopathy, nephropathy and neuropathy over a 20 year period. METHODS:In 1986, 577 adults with IGT from 33 clinics in Da Qing, China were randomly assigned by clinic to...

journal_title：Diabetologia

authors： Gong Q,Gregg EW,Wang J,An Y,Zhang P,Yang W,Li H,Li H,Jiang Y,Shuai Y,Zhang B,Zhang J,Gerzoff RB,Roglic G,Hu Y,Li G,Bennett PH

更新日期：2011-02-01 00:00:00

abstract：:Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after...

journal_title：Diabetologia

authors： Krentz AJ,Clark PM,Cox L,Williams AC,Nattrass M

更新日期：1992-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...

journal_title：Diabetologia

authors： Lin L,Zhang J,Jiang L,Du R,Hu C,Lu J,Wang T,Li M,Zhao Z,Xu Y,Xu M,Bi Y,Ning G,Wang W,Chen Y

更新日期：2020-07-01 00:00:00

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin converting enzyme inhibitor (ACEI). METHODS:We examined the effects of olmesartan, an ARB, on primary compo...

journal_title：Diabetologia

authors： Imai E,Chan JC,Ito S,Yamasaki T,Kobayashi F,Haneda M,Makino H,ORIENT study investigators.

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim was to conduct a systematic review and meta-analysis of randomised controlled clinical trials assessing the effect of probiotic, prebiotic or synbiotic supplementation on gut microbiota and glucose control and lipid levels in individuals with diabetes. METHODS:MEDLINE, EMBASE and the Cochrane L...

journal_title：Diabetologia

authors： Bock PM,Telo GH,Ramalho R,Sbaraini M,Leivas G,Martins AF,Schaan BD

更新日期：2021-01-01 00:00:00

abstract：:In the isolated perfused rat pancreas various sulfonylurea drugs were tested with a basal glucose level of 1 mg/ml in the perfusion buffer and were found to cause a biphasic insulin response. NOVOCS 476, a new and potent sulfonylurea, and glibenclamide qualitatively differed from tolbutamide, glibornuride, glipizide, ...

journal_title：Diabetologia

authors： Gotfredsen CF

更新日期：1976-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to assess the risk factors for diabetes mellitus, by age and sex in Canada and to recommend prevention and control strategies. METHODS:This study was based on the Canadian 1996-1997 National Population Health Survey which comprised 69 494 participants aged 12 years and over. The prevalence of ...

journal_title：Diabetologia

authors： Choi BC,Shi F

更新日期：2001-10-01 00:00:00

abstract：:AbstractIn Table 1 the data for age group, sex and Townsend index were incorrectly identified as mean ± SD instead of n (%). The table is corrected here. ...

journal_title：Diabetologia

authors： Nirantharakumar K,Mohammed N,Toulis KA,Thomas GN,Narendran P

更新日期：2018-07-01 00:00:00

abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

journal_title：Diabetologia

authors： Pyke DA

更新日期：1979-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 ...

journal_title：Diabetologia

authors： Yang X,Li M,Haghiac M,Catalano PM,O'Tierney-Ginn P,Hauguel-de Mouzon S

更新日期：2016-11-01 00:00:00

abstract：:In the present study, human islets were isolated by collagenase digestion from the pancreases of three kidney donors. Maintainance of the islets in tissue culture enabled insulin release, glucose oxidation and Ca2+ -calmodulin-dependent protein phosphorylation to be determined using the same islets. Increasing glucose...

journal_title：Diabetologia

authors： Harrison DE,Christie MR,Gray DW

更新日期：1985-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...

journal_title：Diabetologia

authors： Gibb FW,McKnight JA,Clarke C,Strachan MWJ

更新日期：2020-05-01 00:00:00

abstract：:Oral glucose administration increased plasma noradrenaline concentration significantly in seven normal subjects (p less than 0.02), whereas in six young short-term Type 1 diabetic patients without complications plasma noradrenaline did not change. Basal plasma noradrenaline did not differ between the two groups. In th...

journal_title：Diabetologia

authors： Hegedüs L,Christensen NJ,Sestoft L

更新日期：1983-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Animal studies have indicated that disturbed diurnal rhythms of clock gene expression in adipose tissue can induce obesity and type 2 diabetes. The importance of the circadian timing system for energy metabolism is well established, but little is known about the diurnal regulation of (clock) gene expres...

journal_title：Diabetologia

authors： Stenvers DJ,Jongejan A,Atiqi S,Vreijling JP,Limonard EJ,Endert E,Baas F,Moerland PD,Fliers E,Kalsbeek A,Bisschop PH

更新日期：2019-04-01 00:00:00

abstract：:Insulin secretion from pancreatic beta cells is dependent on membrane potential changes that result from the concerted regulation of multiple ion channels. Among the distinct K+ channels known to be expressed in beta cells, large conductance Ca(2+)-activated K+ channels have been suggested to play an important role in...

journal_title：Diabetologia

authors： Ferrer J,Wasson J,Salkoff L,Permutt MA

更新日期：1996-08-01 00:00:00

abstract：:Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncertain. We therefore studied the association between diabetes and dementia in the Rotterdam Study, a large populati...

journal_title：Diabetologia

authors： Ott A,Stolk RP,Hofman A,van Harskamp F,Grobbee DE,Breteler MM

更新日期：1996-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Subtyping GAD autoantibody (GADA) responses using affinity measurement allows the identification of GADA-positive children with a family history of type 1 diabetes who are at risk of developing diabetes. Here, we asked whether GADA affinity is a useful marker to stratify the risk of type 1 diabetes in G...

journal_title：Diabetologia

authors： Bender C,Schlosser M,Christen U,Ziegler AG,Achenbach P

更新日期：2014-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on th...

journal_title：Diabetologia

authors： Deleskog A,Hilding A,Brismar K,Hamsten A,Efendic S,Östenson CG

更新日期：2012-06-01 00:00:00

abstract：:The aim of this study was to compare the causes of death and parameters related to alcohol consumption, between subjects diagnosed as diabetic, clinically by their general practitioner, or glucose intolerant and in particular as diabetic, using the epidemiological criteria of an abnormal glucose level following an ora...

journal_title：Diabetologia

authors： Balkau B,Eschwège E,Fontbonne A,Claude JR,Warnet JM

更新日期：1992-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...

journal_title：Diabetologia

authors： Gysemans C,Stoffels K,Giulietti A,Overbergh L,Waer M,Lannoo M,Feige U,Mathieu C

更新日期：2003-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We have examined the effects of streptozotocin-induced type 1 diabetes on the expression and subcellular distribution of the classic sugar transporters (GLUT-1 to 5 and sodium-dependent glucose transporter-1 [SGLT-1]) in the endothelial cells of an en face preparation of septal coronary artery from Wist...

journal_title：Diabetologia

authors： Gaudreault N,Scriven DR,Moore ED

更新日期：2004-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Rewers MJ,Haffner SM

更新日期：2014-07-01 00:00:00

abstract：:A representative sample (n = 2140) of the Israeli Jewish population aged 40-70 (excluding known diabetic patients), whose body mass index had been measured 10 years earlier, underwent an oral glucose tolerance test and redetermination of body mass index. Irrespective of weight changes, high concurrent and high past bo...

journal_title：Diabetologia

authors： Modan M,Karasik A,Halkin H,Fuchs Z,Lusky A,Shitrit A,Modan B

更新日期：1986-02-01 00:00:00

abstract：:Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.0...

journal_title：Diabetologia

authors： Daneman D,Tsalikian E,Hengstenberg F,Becker DJ,Drash AL

更新日期：1980-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Chemokines are chemotactic cytokines controlling the recruitment of leukocytes from the blood by regulating integrin adhesiveness. It has been shown that the migration of CD4+Th1 and CD4+Th2 cells is governed by specific chemokines. Increasing evidence suggests that the CD4+Th1 cheomoattractant chemokin...

journal_title：Diabetologia

authors： Nicoletti F,Conget I,Di Mauro M,Di Marco R,Mazzarino MC,Bendtzen K,Messina A,Gomis R

更新日期：2002-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The first clinical manifestation of diabetes is polyuria. The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney. The purpose of this work was to study the contribution of EP3 to diabetic polyuria...

journal_title：Diabetologia

authors： Hassouneh R,Nasrallah R,Zimpelmann J,Gutsol A,Eckert D,Ghossein J,Burns KD,Hébert RL

更新日期：2016-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes. METHODS:Adult male Akita mice (12 weeks old) were treated with insu...

journal_title：Diabetologia

authors： Abdo S,Lo CS,Chenier I,Shamsuyarova A,Filep JG,Ingelfinger JR,Zhang SL,Chan JS

更新日期：2013-07-01 00:00:00

abstract：:The transcription factor SOX9 is regarded as a crucial player in pancreas development, both maintaining progenitors and later being required for beta cell differentiation. However, very little is known about the possible involvement of other SOX family members in such processes. In this issue, the work of Xu et al (DO...

journal_title：Diabetologia

authors： Grapin-Botton A,Seymour PA,Gradwohl G

更新日期：2015-05-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...

journal_title：Diabetologia

authors： Fernyhough P,Diemel LT,Tomlinson DR

更新日期：1998-03-01 00:00:00