Abstract:
AIMS/HYPOTHESIS:The aim of this study was to estimate absolute and relative mortality rates in patients with type 1 diabetes at the Steno Diabetes Centre relative to the general Danish background population. METHODS:Patients with type 1 diabetes (n = 4,821) were followed from 1 January 2002 until 1 January 2011, with death from any cause as the main outcome. Poisson regression was used to model mortality rates by age, diabetes duration and calendar time, according to sex. RESULTS:In the period 2002-2010, a total of 673 deaths (402 men, 271 women) occurred in the study population during 33,847 years of follow-up of type 1 diabetes. The predominant cause of death in patients with type 1 diabetes was cardiovascular disease. Mortality rates were highest among those with the lowest age at onset, particularly men. The mortality rate in the diabetic population decreased over that time period by 6.6% and 4.8% per year in men and women, respectively; this was substantially greater than the decrease in mortality rates in the background population. The decline in standard mortality rate was 4.3% per year in men and 2.6% per year in women. Patients who did not develop nephropathy had only slightly elevated mortality rates compared with the background population. CONCLUSIONS/INTERPRETATION:Despite advances in care, mortality rates in the past decade continue to be greater in patients with type 1 diabetes than in those without diabetes; however, the mortality rate in patients decreased over the study period faster than that of the background population. Nephropathy seems to be the main driver of the excess mortality.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Jørgensen ME,Almdal TP,Carstensen Bdoi
10.1007/s00125-013-3025-7subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2401-4issue
11eissn
0012-186Xissn
1432-0428journal_volume
56pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::Platelet aggregation in response to collagen, adenosine diphosphate and arachidonic acid was studied prospectively in 30 children with Type 1 (insulin-dependent) diabetes mellitus. The studies began on admission to hospital and continued throughout the two years following diagnosis. The results were compared with thos...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274532
更新日期:1989-10-01 00:00:00
abstract::The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD. Situations in which proteomics could be applied in clinical practice include the identif...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-016-4001-9
更新日期:2016-09-01 00:00:00
abstract::It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050644
更新日期:1997-01-01 00:00:00
abstract::The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219423
更新日期:1978-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:We investigated of the effects of fatty acid composition of the maternal diet on fetal and postnatal growth, morphology of the pancreas and glucose metabolism and muscle hexosamine concentrations in the adult offspring of rats. METHODS:High-fat diets enriched with either saturated or unsaturated fatty ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-002-0918-2
更新日期:2002-10-01 00:00:00
abstract::A recent report has shown an association between a specific Xba1 restriction fragment of the human HepG2-Erythrocyte glucose transporter gene and Type 2 (non-insulin dependent) diabetes. To further examine the significance of this finding we have studied Type 2 diabetic pedigrees for linkage between the Xba1 alleles o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00285296
更新日期:1989-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin enhances coronary vasodilation in healthy subjects. We tested whether insulin is able to induce coronary vasodilation in Type I (insulin-dependent) diabetic mellitus patients. Additionally, the effect of short-term hyperglycaemia on myocardial perfusion was studied. METHODS:Myocardial blood flo...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-002-0819-4
更新日期:2002-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 1 diabetes increases the risk of peripheral ischaemia and impairs recovery once ischaemia occurs, probably because the healing process is hampered by diabetes-induced endothelial dysfunction. In normoglycaemic mice subjected to limb ischaemia, blockade of nerve growth factor (NGF) compromises repar...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1424-5
更新日期:2004-06-01 00:00:00
abstract::The insulin-like growth factor I receptor and the activity of its associated tyrosine kinase activity were characterised in wheat germ agglutinin extracts from skeletal muscle biopsies from nine control and ten obese Type 2 (non-insulin-dependent) diabetic subjects, who had marked peripheral in vivo insulin resistance...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00265369
更新日期:1988-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Microvascular complications in the heart and kidney are strongly associated with an overall rise in inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory molecule that limits and resolves inflammation. In this study, we have used a bedside to bench approach to investigate: (1) ANXA1 levels...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4469-y
更新日期:2018-02-01 00:00:00
abstract::A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051139
更新日期:1999-02-01 00:00:00
abstract::Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00399934
更新日期:1992-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:White adipose tissue (WAT) consists of various depots with different adipocyte functionality and immune cell composition. Knowledge of WAT-depot-specific differences in expandability and immune cell influx during the development of obesity is limited, therefore we aimed to characterise different WAT dep...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3594-8
更新日期:2015-07-01 00:00:00
abstract::Freshly isolated and primary cultured adult rat cardiomyocytes were used to elucidate the mechanism of action of the new oral antidiabetic agent (+/-)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethyl-chroman-2-yl-methoxy)benzyl]-2,4-thiazolidinedione (troglitazone) on the heart. Interaction with protein kinase C (PKC) and regul...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050509
更新日期:1996-07-01 00:00:00
abstract::The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1897-3
更新日期:2011-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The first clinical manifestation of diabetes is polyuria. The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney. The purpose of this work was to study the contribution of EP3 to diabetic polyuria...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-3916-5
更新日期:2016-06-01 00:00:00
abstract::Over a century ago, inquisitive physicians made remarkable discoveries regarding pancreatic pathology in individuals with diabetes, including those who were likely afflicted with the type 1 (autoimmune) form of the disease. Those studies of post-mortem tissues noted unique anatomical changes in islet architecture as w...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-013-3159-7
更新日期:2014-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0891-x
更新日期:2008-03-01 00:00:00
abstract::The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250051439
更新日期:1999-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051647
更新日期:2001-04-01 00:00:00
abstract::The 10-year follow-up of the Munich General Practitioner Project was designed as a long-term prospective study to evaluate factors predicting macrovascular and overall mortality in a random cohort of non-insulin-dependent diabetic (NIDDM) patients. Of the original 290 patients (103 males, 187 females, median age 65 ye...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050612
更新日期:1996-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes. METHODS:Within the Europe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3074-y
更新日期:2014-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association ...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-006-0435-9
更新日期:2006-11-01 00:00:00
abstract::Barium x-ray patterns of ketonuric diabetic Chinese hamsters displayed marked dilatation of the stomach, small and large intestine. Hypomotility was manifested by flocculation of barium in the small and large bowel. Impaired transit time was further characterized by prolonged emptying of the stomach (mean 570 min diab...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01222975
更新日期:1979-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Several investigations have shown that the renal medulla has a greater capacity to generate nitric oxide than the renal cortex. To further evaluate the changes of nitric oxide synthesis in the kidney, particularly in the outer medulla, in disorders involving fluid and electrolyte imbalances, we sought t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051354
更新日期:2000-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:The initial stages of type 1 diabetes are characterised by an aberrant islet inflammation that is in part regulated by the interaction between type 1 diabetes susceptibility genes and environmental factors. Chromosome 16p13 is associated with type 1 diabetes and CLEC16A is thought to be the aetiological...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4782-0
更新日期:2019-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to study the incidence of Type I diabetes in 4 countries, Estonia, Latvia, Lithuania and Finland, during 1983-1998, focusing on the two separate periods of 1983-1990 and 1991-1998. METHODS:Population-based incidence data from nationwide diabetes registries were used. Crude and age-standardized...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/pl00002947
更新日期:2001-10-01 00:00:00
abstract::The aim of the present study was to determine whether short-term appropriate insulinization of Type 1 (insulin-dependent) diabetic patients in long-term poor glycaemic control (HbA1C > 9.5%) was associated with an adaptive regulation of the activity and gene expression of key proteins in muscle glycogen storage and gl...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00428782
更新日期:1994-01-01 00:00:00
abstract::Muscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients. We scanned the GYS1 gene for mutation by single strand conformational polymorphism in 244 non-obese Japanese NIDD...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050772
更新日期:1997-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-4834-0
更新日期:2019-05-01 00:00:00