Abstract:
AIMS/HYPOTHESIS:We aimed to study the incidence of Type I diabetes in 4 countries, Estonia, Latvia, Lithuania and Finland, during 1983-1998, focusing on the two separate periods of 1983-1990 and 1991-1998. METHODS:Population-based incidence data from nationwide diabetes registries were used. Crude and age-standardized incidence rates using the proportions of 39%, 32% and 29% for 5-year age groups (0-4, 5-9 and 10-14 years) were calculated. Yearly incidence was evaluated and the means between the two periods compared. RESULTS:Between 1983-1990 and 1991-1998 there was a statistically significant incidence increase in all 4 countries of Estonia, Lativia, Lithuania and Finland (relative risk 1.15, 95%-Confidence interval 1.10-1.19) and as well as in the 3 Baltic states of Estonia, Latvia, Lithuania (relative risk 1.13, 95%. Confidence interval 1.04-1.22). The crude incidence increased in Estonia from 10.1 (95%-Confidence interval 8.9-11.4) to 12.3 (11.0-13.8), in Latvia from 6.6 (5.8-7.3) to 7.4 (6.6-8.2) and in Lithuania from 6.8 (6.2-7.5) to 7.8 (7.1-8.5). In Finland the incidence rose from 34.6 (33.3-36.0) in 1983-1990 to 40.8 (39.4-42.2) in 1991-1998. In children under 5 years of a age a statistically important increase was seen in Estonia and Finland. The highest incidence for a single year was recorded for all participating countries in the late 1990 s. The highest annual incidence rate of childhood onset Type I diabetes in the world ever known was recorded in Finland in 1998 with 48.5 cases per 100 000 person-years. CONCLUSION/HYPOTHESIS:The incidence of Type I diabetes has increased since 1983 in the three Baltic states as well as in Finland. Long-term monitoring is needed for a better detection in changes in incidence.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Podar T,Solntsev A,Karvonen M,Padaiga Z,Brigis G,Urbonaite B,Viik-Kajander M,Reunanen A,Tuomilehto Jdoi
10.1007/pl00002947subject
Has Abstractpub_date
2001-10-01 00:00:00pages
B17-20eissn
0012-186Xissn
1432-0428journal_volume
44 Suppl 3pub_type
杂志文章,多中心研究相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:The relevance of the OGTT in predicting type 2 diabetes is unclear. We assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. METHODS:We studied 2,603 and 2,386 Europeans from the Botnia study and Malmö Prevention Project (MPP) cohorts with baseline OGTT data. Over a follow-u...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3390-x
更新日期:2015-01-01 00:00:00
abstract::Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223020
更新日期:1978-05-01 00:00:00
abstract::Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403323
更新日期:1990-05-01 00:00:00
abstract::An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281308
更新日期:1982-04-01 00:00:00
abstract::Amylin is a 37-amino acid pancreatic polypeptide, probably involved in the pathophysiology of Type 2 (non-insulin-dependent) diabetes mellitus. We have determined amylin in human plasma by extraction-based radioimmunoassay (Sep-Pak C18). Of 23 healthy control subjects plasma amylin was determined as 11.9 +/- 3.5 ng/l....
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404025
更新日期:1991-01-01 00:00:00
abstract::Type I diabetes mellitus may represent a heterogeneous disorder with a distinct pathogenesis in patients with young and adult onset of the disease. To investigate whether serological markers directed to different autoantigens have the potential to distinguish acute onset from slowly progressive Type I diabetes we anal...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051004
更新日期:1998-08-01 00:00:00
abstract::QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418273
更新日期:1991-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hypertension, obesity, impaired glucose tolerance and dyslipidaemia are metabolic abnormalities that often cluster together more often than expected by chance alone. Since these metabolic variables are highly heritable and are at least partially genetically determined, the clustering of defects in these...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0720-2
更新日期:2007-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Elevated circulating adipocyte fatty acid-binding protein (AFABP) levels have been found to correlate with diabetic nephropathy staging in cross-sectional studies. However, it remains unclear whether these higher serum levels reflect a role of AFABP in the development of diabetic kidney disease (DKD), o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4742-8
更新日期:2019-01-01 00:00:00
abstract::Screening and diagnostic criteria for gestational diabetes (GDM) are inconsistent across Europe, and the development of a uniform GDM screening strategy is necessary. Such a strategy would create opportunities for more women to receive timely treatment for GDM. Developing a consensus on screening for GDM in Europe is ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3615-7
更新日期:2015-07-01 00:00:00
abstract::The authors have been made aware that the following sentence is incorrect: 'Like IIK7, both ramelteon and tasimelteon have a greater affinity for the MT2 receptor [162].' ...
journal_title:Diabetologia
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00125-018-4577-3
更新日期:2018-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1625-y
更新日期:2005-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Coronary heart disease is the leading cause of mortality among people with type 1 diabetes. Diet is an important lifestyle factor that relates to risk of CHD. The aim of this study was to examine how diet and adherence to dietary guidelines differ between adults with and without type 1 diabetes, and the...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1280-4
更新日期:2009-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0865-z
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05332-z
更新日期:2020-11-26 00:00:00
abstract::The effect of pregnancy on pancreatic insulin content and relative B-cell volume has been studied in normoglycaemic Wistar rats treated with streptozotocin 14 days before mating. A single intravenous injection of streptozotocin (30 mg/kg body weight) caused a significant reduction of pancreatic insulin content and B-c...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00273867
更新日期:1985-03-01 00:00:00
abstract::We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050751
更新日期:1997-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0565-0
更新日期:2007-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The prognostic importance of the ankle-brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes. METHODS:The ABI was measured at baseline in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4709-9
更新日期:2018-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetes is induced by multiple low doses of streptozotocin (MLD-STZ) in male mice of susceptible strains. In this model beta-cell injury and T-cell-mediated inflammatory reactions are induced. Probably, reactive oxygen species (ROS) participate in the destruction of beta cells. The effects of ROS can b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050009
更新日期:2000-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1689-3
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Experimental studies have suggested that ghrelin, a novel gastrointestinal peptide hormone, could play a role in glucose homeostasis. In addition, ghrelin has been associated with beneficial haemodynamic effects in experimental settings. Since the Arg51Gln mutation changes the carboxyterminal amino acid...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1058-z
更新日期:2003-04-01 00:00:00
abstract::Insulin secretion from pancreatic beta cells is dependent on membrane potential changes that result from the concerted regulation of multiple ion channels. Among the distinct K+ channels known to be expressed in beta cells, large conductance Ca(2+)-activated K+ channels have been suggested to play an important role in...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403907
更新日期:1996-08-01 00:00:00
abstract::Major progress has been made over the last 10 years in understanding the immune mechanisms underlying autoimmune Type I (insulin-dependent) diabetes mellitus. It seems that immunotherapy is the best approach for preventing and/or arresting beta cell destruction. For immunotherapeutic approaches to be clinically applic...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250051658
更新日期:2001-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion. MATERIALS AND METHODS:We hypothesised that glucose concentratio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1860-x
更新日期:2005-09-01 00:00:00
abstract::Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5-5.5 years (mean +/- SD: 3.2 +/- 1.6 years), 26 out of 50 patients...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00281121
更新日期:1984-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in well-categorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. METHODS:A longitudinal observational study was undertaken involving 1291 part...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4127-9
更新日期:2017-01-01 00:00:00
abstract::Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051072
更新日期:1998-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Growth factor imbalance and endothelial progenitor cell dysfunction are well-known elements of the inappropriate response to injury in human and experimental diabetes. We hypothesised that in diabetes the outgrowth of myofibroblast progenitor cells (MFPCs) is also altered and that this relates to aberra...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0172-0
更新日期:2006-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fat balance is critical in the aetiology of obesity and related diseases. Lipoprotein lipase is of major importance in lipid metabolism. The aim of this study was to investigate the long-term effects of the lipoprotein lipase activator, NO-1886, on substrate utilisation, adiposity and insulin action in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051464
更新日期:2000-07-01 00:00:00