Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring.

abstract：AIMS/HYPOTHESIS:We assessed secular trends of cardiovascular outcomes following first diagnosis of myocardial infarction (MI) or diabetes in an unselected population. METHODS:All Danish residents aged > or = 30 years without prior diabetes or MI were identified by individual-level linkage of nationwide registers. Indi...

journal_title：Diabetologia

authors： Norgaard ML,Andersen SS,Schramm TK,Folke F,Jørgensen CH,Hansen ML,Andersson C,Bretler DM,Vaag A,Køber L,Torp-Pedersen C,Gislason GH

更新日期：2010-08-01 00:00:00

abstract：:The aim of the study was to evaluate an acute decrease in NEFA levels during an oral glucose tolerance test and its effects on glucose tolerance, muscle glucose uptake and muscle indirect calorimetry in ten lean non-insulin-dependent diabetic subjects. Two 75-g oral glucose tolerance tests were performed in random ord...

journal_title：Diabetologia

authors： Piatti PM,Monti LD,Davis SN,Conti M,Brown MD,Pozza G,Alberti KG

更新日期：1996-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...

journal_title：Diabetologia

authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

更新日期：2012-01-01 00:00:00

abstract：:Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

journal_title：Diabetologia

authors： Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin resistance is recognised as the core factor in the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus, hypertension and atherosclerosis. Several studies indicate the possible role of mutations of the insulin receptor substrate-1 (IRS-1) gene in the pathogenesis of insulin-resistan...

journal_title：Diabetologia

authors： Baroni MG,Arca M,Sentinelli F,Buzzetti R,Capici F,Lovari S,Vitale M,Romeo S,Di Mario U

更新日期：2001-03-01 00:00:00

abstract：:The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic hormones were studied in 10 diphenylhydantoin-treated epileptic patients and 15 geriatric patients. Their mean serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 de...

journal_title：Diabetologia

authors： Nyomba BL,Auwerx J,Bormans V,Peeters TL,Pelemans W,Reynaert J,Bouillon R,Vantrappen G,De Moor P

更新日期：1986-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to determine the role of fatty acid signalling in islet beta cell compensation for insulin resistance in the Zucker fatty fa/fa (ZF) rat, a genetic model of severe obesity, hyperlipidaemia and insulin resistance that does not develop diabetes. MATERIALS AND METHODS:NEFA augmen...

journal_title：Diabetologia

authors： Nolan CJ,Leahy JL,Delghingaro-Augusto V,Moibi J,Soni K,Peyot ML,Fortier M,Guay C,Lamontagne J,Barbeau A,Przybytkowski E,Joly E,Masiello P,Wang S,Mitchell GA,Prentki M

更新日期：2006-09-01 00:00:00

abstract：:We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...

journal_title：Diabetologia

authors： Ma Z,Westermark GT,Li ZC,Engström U,Westermark P

更新日期：1997-07-01 00:00:00

abstract：:An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin-allergy. No differences were observed between normal perso...

journal_title：Diabetologia

authors： Nakagawa S,Saito N,Nakayama H,Sasaki T,Watanabe T,Aoki S

更新日期：1978-01-14 00:00:00

abstract：:Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric aci...

journal_title：Diabetologia

authors： Hartmann H,Meyer-Alber A,Braulke T

更新日期：1992-03-01 00:00:00

abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

journal_title：Diabetologia

authors： Gill GV,Yudkin JS,Keen H,Beran D

更新日期：2011-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...

journal_title：Diabetologia

authors： Camastra S,Gastaldelli A,Mari A,Bonuccelli S,Scartabelli G,Frascerra S,Baldi S,Nannipieri M,Rebelos E,Anselmino M,Muscelli E,Ferrannini E

更新日期：2011-08-01 00:00:00

abstract：AIM/HYPOTHESIS:Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key...

journal_title：Diabetologia

authors： Wang L,Ishihara T,Ibayashi Y,Tatsushima K,Setoyama D,Hanada Y,Takeichi Y,Sakamoto S,Yokota S,Mihara K,Kang D,Ishihara N,Takayanagi R,Nomura M

更新日期：2015-10-01 00:00:00

abstract：:Muscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients. We scanned the GYS1 gene for mutation by single strand conformational polymorphism in 244 non-obese Japanese NIDD...

journal_title：Diabetologia

authors： Shimomura H,Sanke T,Ueda K,Hanabusa T,Sakagashira S,Nanjo K

更新日期：1997-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Rewers MJ,Haffner SM

更新日期：2014-07-01 00:00:00

abstract：:Hepatic microsomal glucose-6-phosphatase activity levels and the hepatic output of glucose are increased in diabetes. We have used protein chemistry and immunological techniques to determine the mechanism by which the activity levels of the glucose-6-phosphatase system are increased in streptozotocin-induced diabetic ...

journal_title：Diabetologia

authors： Burchell A,Cain DI

更新日期：1985-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised cont...

journal_title：Diabetologia

authors： Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S

更新日期：2014-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The initial stages of type 1 diabetes are characterised by an aberrant islet inflammation that is in part regulated by the interaction between type 1 diabetes susceptibility genes and environmental factors. Chromosome 16p13 is associated with type 1 diabetes and CLEC16A is thought to be the aetiological...

journal_title：Diabetologia

authors： Dos Santos RS,Marroqui L,Velayos T,Olazagoitia-Garmendia A,Jauregi-Miguel A,Castellanos-Rubio A,Eizirik DL,Castaño L,Santin I

更新日期：2019-03-01 00:00:00

abstract：:Peritoneal glucose kinetics were evaluated in the anaesthetized rat, to assess whether the peritoneal cavity would be a suitable site for the implantation of membrane-protected islets of Langerhans (bioartificial pancreas) or the glucose sensor of an artificial B cell. Glucose was measured in peritoneal fluid samples ...

journal_title：Diabetologia

authors： Velho G,Froguel P,Reach G

更新日期：1989-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

journal_title：Diabetologia

authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

更新日期：2007-09-01 00:00:00

abstract：:A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...

journal_title：Diabetologia

authors： Josefsen K,Sørensen LR,Buschard K,Birkenbach M

更新日期：1999-02-01 00:00:00

abstract：:The effect of the alpha-glucosidase inhibitor acarbose on postprandial hyperglycaemia was explored in the spontaneously diabetic BB/W-rat. Acarbose-treatment (5 mg.kg body weight-1.day-1) of diabetic BB/W-rats maintained on small doses of insulin, was associated with a 40% reduction in the 24-h glucose area compared t...

journal_title：Diabetologia

authors： Sima AA,Chakrabarti S

更新日期：1992-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:A shift towards younger age at onset of diabetes in susceptible people has been suggested as a possible explanation for the increasing temporal trend in incidence of type 1 diabetes. We aimed to test this hypothesis by assessing trends in incidence rates in the period 1984-2004 in children and young adu...

journal_title：Diabetologia

authors： Bruno G,Novelli G,Panero F,Perotto M,Monasterolo F,Bona G,Perino A,Rabbone I,Cavallo-Perin P,Cerutti F,Piedmont Study Group for Diabetes Epidemiology.

更新日期：2009-12-01 00:00:00

abstract：:A radioreceptor-assay for glucagon was developed employing pig liver plasma membranes isolated by means of an aqueous two-phase polymer system. The assay is simple, precise, and has a detection limit of 40 pg/ml. Acid-ethanol extracts of porcine intestinal mucosa and entero-glucagon purified by affinity chromatography...

journal_title：Diabetologia

authors： Holst JJ

更新日期：1975-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Mitochondrial oxidative phosphorylation (OXPHOS) plays an important role in the pathophysiology of type 2 diabetes. Genes involved in OXPHOS have been reported to be down-regulated in skeletal muscle from patients with type 2 diabetes; however, hepatic regulation is unknown. MATERIALS AND METHODS:We an...

journal_title：Diabetologia

authors： Misu H,Takamura T,Matsuzawa N,Shimizu A,Ota T,Sakurai M,Ando H,Arai K,Yamashita T,Honda M,Yamashita T,Kaneko S

更新日期：2007-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental functio...

journal_title：Diabetologia

authors： Salbaum JM,Kruger C,Zhang X,Delahaye NA,Pavlinkova G,Burk DH,Kappen C

更新日期：2011-07-01 00:00:00

abstract：:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

journal_title：Diabetologia

authors： Henquin JC,Malvaux P,Lambert AE

更新日期：1979-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Prolactin, a multifunctional hormone, is involved in regulating insulin sensitivity and glucose homeostasis in experimental studies. However, whether circulating concentrations of prolactin are associated with risk of type 2 diabetes remains uncertain. METHODS:We analysed the prospective relationship b...

journal_title：Diabetologia

authors： Li J,Rice MS,Huang T,Hankinson SE,Clevenger CV,Hu FB,Tworoger SS

更新日期：2018-12-01 00:00:00

abstract：:46Sc-and 99mTc-labelled microspheres were used to measure the effects of noradrenaline infusion on cardiac output and its regional distribution in 10 control and 10 streptozotocin-diabetic pithed rats. Plasma noradrenaline concentrations during the infusion were similar in both groups. Pressor responses were significa...

journal_title：Diabetologia

authors： Lucas PD

更新日期：1985-02-01 00:00:00

abstract：:Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased a...

journal_title：Diabetologia

authors： Jenkins D,Penny MA,Mijovic CH,Jacobs KH,Fletcher J,Barnett AH

更新日期：1991-08-01 00:00:00