当前位置： SCI文献检索 > DIABETOLOGIA期刊下所有文献 > Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues.

Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues.

Abstract：

:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction in 86Rb efflux normally produced by the sugar. 3-O-methylglucose (20 mmol/l) provided complete protection against the alteration of 86Rb efflux and partial protection against the inhibition of insulin release. Immediately after alloxan treatment, glyceraldehyde, alpha-ketoisocaproic acid and tolbutamide still induced a rapid release of insulin, but the late phase normally stimulated by glyceraldehyde and alpha-ketoisocaproic acid was inhibited. If islets were exposed to glyceraldehyde or tolbutamide 15 min after alloxan treatment, the rapid insulin release was also markedly impaired. Alloxan failed, however, to affect the ability of these three stimuli to reduce 86Rb efflux from islet cells. Glucose oxidation and utilization were decreased in alloxan-treated islets and 3-O-methylglucose protected against this effect. The results show that the glucose recognition system in B-cells is the most rapidly and severely affected by alloxan. The drug also alters the response to other secretagogues, the insulin releasing properties of which can be impaired without alteration of their ability to reduce 86Rb efflux.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Henquin JC,Malvaux P,Lambert AE

doi

10.1007/BF01221952

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

253-60

issue

4

eissn

0012-186X

issn

1432-0428

journal_volume

16

pub_type

杂志文章

相关文献

DIABETOLOGIA文献大全
  • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.

    abstract：:The insulin receptor substrate proteins IRS1 and IRS2 are key targets of the insulin receptor tyrosine kinase and are required for hormonal control of metabolism. Tissues from insulin-resistant and diabetic humans exhibit defects in IRS-dependent signalling, implicating their dysregulation in the initiation and progre...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-012-2644-8

    authors： Copps KD,White MF

    更新日期：2012-10-01 00:00:00

  • Mitochondrial regulation of insulin production in rat pancreatic islets.

    abstract：AIMS/HYPOTHESIS:The study was designed to identify the key metabolic signals of glucose-stimulated proinsulin gene transcription and translation, focusing on the mechanism of succinate stimulation of insulin production. METHODS:Wistar rat islets were incubated in 3.3 mmol/l glucose with and without esters of different...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-1811-6

    authors： Leibowitz G,Khaldi MZ,Shauer A,Parnes M,Oprescu AI,Cerasi E,Jonas JC,Kaiser N

    更新日期：2005-08-01 00:00:00

  • Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

    abstract：AIMS/HYPOTHESIS:Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes i...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-007-0891-x

    authors： Florez JC,Jablonski KA,McAteer J,Sandhu MS,Wareham NJ,Barroso I,Franks PW,Altshuler D,Knowler WC,Diabetes Prevention Program Research Group.

    更新日期：2008-03-01 00:00:00

  • Central nervous system regulation of liver and adipose tissue metabolism.

    abstract：:Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：

    authors： Shimazu T

    更新日期：1981-03-01 00:00:00

  • Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2.

    abstract：AIMS/HYPOTHESIS:Islet autoantibodies are important in diabetes classification and risk assessment, and as endpoints in observational studies. The Diabetes Autoantibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report results for glut...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-008-0967-2

    authors： Törn C,Mueller PW,Schlosser M,Bonifacio E,Bingley PJ,Participating Laboratories.

    更新日期：2008-05-01 00:00:00

  • Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study.

    abstract：AIMS/HYPOTHESIS:Measurement of plasma apolipoprotein (Apo) B may improve prediction of cardiovascular risk, as it provides a measure of the total number of atherogenic particles. The aim of this population-based study was to compare the association of non-HDL-cholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascu...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-006-0195-6

    authors： Bruno G,Merletti F,Biggeri A,Bargero G,Prina-Cerai S,Pagano G,Cavallo-Perin P

    更新日期：2006-05-01 00:00:00

  • Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity.

    abstract：AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-012-2506-4

    authors： Poungvarin N,Lee JK,Yechoor VK,Li MV,Assavapokee T,Suksaranjit P,Thepsongwajja JJ,Saha PK,Oka K,Chan L

    更新日期：2012-06-01 00:00:00

  • Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines.

    abstract：AIMS/HYPOTHESIS:Activin receptor-like kinase 7 (ALK7), a member of the type I receptor serine/threonine kinases of the TGF-beta superfamily, was recently reported to regulate cell proliferation and apoptosis. We hypothesised that ALK7 may play a role in modulating pancreatic beta cell proliferation and/or apoptosis. M...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-005-0095-1

    authors： Zhang N,Kumar M,Xu G,Ju W,Yoon T,Xu E,Huang X,Gaisano H,Peng C,Wang Q

    更新日期：2006-03-01 00:00:00

  • A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.

    abstract：:Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051026

    authors： Yagui K,Shimada F,Mimura M,Hashimoto N,Suzuki Y,Tokuyama Y,Nata K,Tohgo A,Ikehata F,Takasawa S,Okamoto H,Makino H,Saito Y,Kanatsuka A

    更新日期：1998-09-01 00:00:00

  • Anti-GAD antibodies in Chinese patients with youth and adult-onset IDDM and NIDDM.

    abstract：:An autoimmune basis for the pathogenesis of insulin-dependent diabetes mellitus (IDDM) is supported by the frequent presence of autoantibodies - islet cell antibodies (ICAs) and GAD antibodies (GADab). However, in Chinese patients with clinical IDDM, a low prevalence of ICAs was observed. In non-insulin-dependent diab...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250050845

    authors： Thai AC,Ng WY,Loke KY,Lee WR,Lui KF,Cheah JS

    更新日期：1997-12-01 00:00:00

  • Birthweight and early-onset type 2 diabetes in American Indians: differential effects in adolescents and young adults and additive effects of genotype, BMI and maternal diabetes.

    abstract：AIMS/HYPOTHESIS:The aim of this work was to estimate the impact of birthweight on early-onset (age <40 years) type 2 diabetes. METHODS:A longitudinal study of American Indians, aged ≥5 years, was conducted from 1965 to 2007. Participants who had a recorded birthweight were followed until they developed diabetes or the...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-019-4899-9

    authors： Olaiya MT,Wedekind LE,Hanson RL,Sinha M,Kobes S,Nelson RG,Baier LJ,Knowler WC

    更新日期：2019-09-01 00:00:00

  • Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity.

    abstract：AIMS/HYPOTHESIS:Hyperproinsulinaemia reflects both beta cell dysfunction and insulin resistance in cross-sectional studies, but it is not known whether changes in proinsulin concentrations are related to insulin resistance over time. As trans10cis12 (t10c12)-conjugated linoleic acid (CLA) supplementation induces insuli...

    journal_title：Diabetologia

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00125-004-1421-8

    authors： Risérus U,Vessby B,Arner P,Zethelius B

    更新日期：2004-06-01 00:00:00

  • Risk factors for diabetes mellitus by age and sex: results of the National Population Health Survey.

    abstract：AIMS/HYPOTHESIS:We aimed to assess the risk factors for diabetes mellitus, by age and sex in Canada and to recommend prevention and control strategies. METHODS:This study was based on the Canadian 1996-1997 National Population Health Survey which comprised 69 494 participants aged 12 years and over. The prevalence of ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250100648

    authors： Choi BC,Shi F

    更新日期：2001-10-01 00:00:00

  • Surface binding, internalization and degradation by cultured human fibroblasts of low density lipoproteins isolated from type 1 (insulin-dependent) diabetic patients: changes with metabolic control.

    abstract：:A previous study of low density lipoprotein metabolism by cultured cells focused on the metabolism of normal lipoproteins in vitro by fibroblasts isolated from diabetic patients. No abnormalities were found. We have followed the opposite approach. Using normal human fibroblasts as test cells we compared the metabolism...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00282585

    authors： Lopes-Virella MF,Sherer GK,Lees AM,Wohltmann H,Mayfield R,Sagel J,LeRoy EC,Colwell JA

    更新日期：1982-06-01 00:00:00

  • Predicting risk of severe hypoglycaemia in type 2 diabetes.

    abstract：:For many, the extent to which blood glucose control can be lowered is limited by risk of hypoglycaemia. Hypoglycaemia is feared and carries fiscal, social and medical costs, with risk of death being associated with severe hypoglycaemia in patients with type 2 diabetes at high cardiovascular risk. In this issue of Diab...

    journal_title：Diabetologia

    pub_type： 评论,杂志文章

    doi：10.1007/s00125-015-3550-7

    authors： Neupane S,Evans ML

    更新日期：2015-06-01 00:00:00

  • Assessment of urinary microparticles in normotensive patients with type 1 diabetes.

    abstract：AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-016-4190-2

    authors： Lytvyn Y,Xiao F,Kennedy CR,Perkins BA,Reich HN,Scholey JW,Cherney DZ,Burger D

    更新日期：2017-03-01 00:00:00

  • Electron microscopy of renal and ocular changes in virus-induced diabetes mellitus in mice.

    abstract：:The eyes, kidneys and pancreas of mice (SJL/J) infected with encephalomyocarditis virus were examined by light and electron microscopy. Diabetic mice with the longest duration (6 months) of diabetes showed marked renal and ocular alterations. Fasting blood glucose levels were 17.8-21.9 mmol/l and glycosuria was presen...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00282717

    authors： Rodrigues M,Currier C,Yoon J

    更新日期：1983-04-01 00:00:00

  • Pancreatic secretion in man with subclinical vitamin D deficiency.

    abstract：:The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic hormones were studied in 10 diphenylhydantoin-treated epileptic patients and 15 geriatric patients. Their mean serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 de...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02427278

    authors： Nyomba BL,Auwerx J,Bormans V,Peeters TL,Pelemans W,Reynaert J,Bouillon R,Vantrappen G,De Moor P

    更新日期：1986-01-01 00:00:00

  • Immunological abnormalities in islets at diagnosis paralleled further deterioration of glycaemic control in patients with recent-onset Type I (insulin-dependent) diabetes mellitus.

    abstract：AIMS/HYPOTHESIS:To determine whether the clinical heterogeneity observed in the development of Type I (insulin-dependent) diabetes mellitus correlates with immunohistochemical differences observed at diagnosis. METHODS:Patients (n = 17) with recent-onset diabetes clinically considered to be insulin dependent (Type I),...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s001250051197

    authors： Imagawa A,Hanafusa T,Itoh N,Waguri M,Yamamoto K,Miyagawa J,Moriwaki M,Yamagata K,Iwahashi H,Sada M,Tsuji T,Tamura S,Kawata S,Kuwajima M,Nakajima H,Namba M,Matsuzawa Y

    更新日期：1999-05-01 00:00:00

  • Determination of peritoneal glucose kinetics in rats: implications for the peritoneal implantation of closed-loop insulin delivery systems.

    abstract：:Peritoneal glucose kinetics were evaluated in the anaesthetized rat, to assess whether the peritoneal cavity would be a suitable site for the implantation of membrane-protected islets of Langerhans (bioartificial pancreas) or the glucose sensor of an artificial B cell. Glucose was measured in peritoneal fluid samples ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00277254

    authors： Velho G,Froguel P,Reach G

    更新日期：1989-06-01 00:00:00

  • Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs.

    abstract：:Employing saline-impregnated cotton threads, an implanted-wick technique was adopted in dogs to obtain specimen from the subcutaneous interstitial compartment in order to estimate its glucose concentration. By measuring the protein, potassium and haemoglobin contents, the centrifuged wick fluid was shown to contain th...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00295878

    authors： Fischer U,Ertle R,Abel P,Rebrin K,Brunstein E,Hahn von Dorsche H,Freyse EJ

    更新日期：1987-12-01 00:00:00

  • Effect of glucagon antibodies on plasma glucose, insulin and somatostatin in the fasting and fed rat.

    abstract：:A potent high-titre glucagon antibody pool was used to induce a state of acute glucagon deficiency in order to investigate the importance of glucagon in maintaining euglycaemia in the fed and fasted anaesthetised rat. Binding characteristics of the antiserum and evidence of its neutralisation of the biological effects...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00280887

    authors： Tan K,Tsiolakis D,Marks V

    更新日期：1985-07-01 00:00:00

  • The insulin dilemma in resource-limited countries. A way forward?

    abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-010-1897-3

    authors： Gill GV,Yudkin JS,Keen H,Beran D

    更新日期：2011-01-01 00:00:00

  • Glucokinase is not the pancreatic B-cell glucoreceptor.

    abstract：:A series of recent experimental findings are reviewed to indicate that glucokinase does not represent the pancreatic B-cell glucoreceptor. Whether in liver, pancreatic islet or insulin-producing tumoral cell homogenates, glucokinase fails to yield a higher reaction velocity with alpha-than beta-D-glucose. At a high gl...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00281986

    authors： Malaisse WJ,Sener A

    更新日期：1985-08-01 00:00:00

  • Islet-intrinsic effects of CFTR mutation.

    abstract：:Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cysti...

    journal_title：Diabetologia

    pub_type： 杂志文章,评审

    doi：10.1007/s00125-016-3936-1

    authors： Koivula FNM,McClenaghan NH,Harper AGS,Kelly C

    更新日期：2016-07-01 00:00:00

  • Paternal insulin resistance and its association with umbilical cord insulin concentrations.

    abstract：AIMS/HYPOTHESIS:Fetal growth is influenced by genetic factors as well as the intra-uterine environment. We hypothesised that some genetic factors may alter fetal insulin secretion and insulin action. SUBJECTS, MATERIALS AND METHODS:To assess this, we analysed plasma insulin concentration in umbilical cord blood from 6...

    journal_title：Diabetologia

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00125-006-0282-8

    authors： Shields BM,Knight B,Turner M,Wilkins-Wall B,Shakespeare L,Powell RJ,Hannemann M,Clark PM,Yajnik CS,Hattersley AT

    更新日期：2006-11-01 00:00:00

  • Mast cells and type VIII collagen in human diabetic nephropathy.

    abstract：:Renal injury in diabetes mellitus is associated with progressive interstitial fibrosis and extracellular matrix accumulation. However, the phenotypes of cells forming the interstitial infiltrate in diabetic nephropathy have not been precisely defined. There is increasing evidence for the association of mast cells with...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF02658509

    authors： Rüger BM,Hasan Q,Greenhill NS,Davis PF,Dunbar PR,Neale TJ

    更新日期：1996-10-01 00:00:00

  • Tropical pancreatic diabetes in South India: heterogeneity in clinical and biochemical profile.

    abstract：:Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tro...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00282238

    authors： Mohan V,Mohan R,Susheela L,Snehalatha C,Bharani G,Mahajan VK,Ramachandran A,Viswanathan M,Kohner EM

    更新日期：1985-04-01 00:00:00

  • The ultrastructure of polyploid B-cells in the islets of normal mice.

    abstract：:Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, so...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/BF00428985

    authors： Bowen RE,Swartz FJ

    更新日期：1976-05-01 00:00:00

  • Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease.

    abstract：AIMS/HYPOTHESIS:Type 2 diabetes is a major risk factor for CHD. We hypothesised that diabetes genetic susceptibility variants might be associated with increased CHD risk. METHODS:We examined the individual and cumulative effect of 38 common genetic variants previously reported to be associated with type 2 diabetes on ...

    journal_title：Diabetologia

    pub_type： 杂志文章

    doi：10.1007/s00125-011-2206-5

    authors： Pfister R,Barnes D,Luben RN,Khaw KT,Wareham NJ,Langenberg C

    更新日期：2011-09-01 00:00:00