Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

abstract：:Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...

journal_title：Diabetologia

authors： Fernyhough P,Diemel LT,Tomlinson DR

更新日期：1998-03-01 00:00:00

abstract：:Progressive capillary occlusion often leads to severe retinopathy within 15-20 years of the onset of Type 1 (insulin-dependent) diabetes mellitus. Lipoprotein(a), a complex formed by apolipoprotein(a), apo B-100 and lipids, is considered an independent, genetically determined, predictor of cardiovascular disease. It m...

journal_title：Diabetologia

authors： Maioli M,Tonolo G,Pacifico A,Ciccarese M,Brizzi P,Kohner EM,Porta M

更新日期：1993-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...

journal_title：Diabetologia

authors： Villegas R,Gao YT,Yang G,Li HL,Elasy T,Zheng W,Shu XO

更新日期：2008-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

journal_title：Diabetologia

authors： Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

更新日期：2020-11-26 00:00:00

abstract：AIMS/HYPOTHESIS:Thickening of the basement membrane and selective loss of pericytes occur early in diabetic retinopathy. As we showed previously that pericyte adhesion is impaired on extracellular matrix produced by endothelial cells in high hexose concentrations, we aimed to verify if altered adhesion could influence ...

journal_title：Diabetologia

authors： Beltramo E,Buttiglieri S,Pomero F,Allione A,D'Alù F,Ponte E,Porta M

更新日期：2003-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...

journal_title：Diabetologia

authors： Tomita Y,Cagnone G,Fu Z,Cakir B,Kotoda Y,Asakage M,Wakabayashi Y,Hellström A,Joyal JS,Talukdar S,Smith LEH,Usui Y

更新日期：2021-01-01 00:00:00

abstract：:In liver perfusion from sucrose-fed, streptozotocin-diabetic rats there was in comparison with normal animals, a decrease in very low density lipoprotein concentration in the perfusion medium (38.6 +/- 6.3 versus 64.4 +/- 8.4 microgram . g liver -1 3 h-1, p less than 0.05) and an increase in high density lipoprotein c...

journal_title：Diabetologia

authors： Berry EM,Ziv E,Bar-On H

更新日期：1981-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for...

journal_title：Diabetologia

authors： Egan AM,Vellinga A,Harreiter J,Simmons D,Desoye G,Corcoy R,Adelantado JM,Devlieger R,Van Assche A,Galjaard S,Damm P,Mathiesen ER,Jensen DM,Andersen L,Lapolla A,Dalfrà MG,Bertolotto A,Mantaj U,Wender-Ozegowska E,Zawi

更新日期：2017-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We compared metabolic gene expression in adipose tissue and skeletal muscle from patients with type 2 diabetes and from well-matched healthy control subjects. We hypothesised that gene expression would be discordantly regulated when comparing the two groups. Our secondary aim was to determine the effect...

journal_title：Diabetologia

authors： Carey AL,Petersen EW,Bruce CR,Southgate RJ,Pilegaard H,Hawley JA,Pedersen BK,Febbraio MA

更新日期：2006-05-01 00:00:00

abstract：:Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes,...

journal_title：Diabetologia

authors： Grønbaek H,Nielsen B,Osterby R,Harris A,Orskov H,Flyvbjerg A

更新日期：1995-02-01 00:00:00

abstract：:To examine differences among pregnant diabetic and nondiabetic subjects, serum glucose, and immunoreactivity of C-peptide, free and total insulin were measured at hourly intervals during a 24--h third trimester metabolic ward evaluation. Six normals, three mild, and four juvenile-onset type diabetics were studied. Die...

journal_title：Diabetologia

authors： Lewis SB,Wallin JD,Kuzuya H,Murray WK,Coustan DR,Daane TA,Rubenstein AH

更新日期：1976-08-01 00:00:00

abstract：:The plasma concentration of 1,5-anhydro-D-glucitol(AG)(1-deoxyglucose) is known to decrease in diabetic patients. In order to evaluate the usefulness of this polyol as a diabetic marker, we examined the specificity of the plasma AG reduction in various diseases: the plasma AG level was determined in 108 newly diagnose...

journal_title：Diabetologia

authors： Yamanouchi T,Akanuma H,Nakamura T,Akaoka I,Akanuma Y

更新日期：1988-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...

journal_title：Diabetologia

authors： Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

更新日期：2009-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated of the effects of fatty acid composition of the maternal diet on fetal and postnatal growth, morphology of the pancreas and glucose metabolism and muscle hexosamine concentrations in the adult offspring of rats. METHODS:High-fat diets enriched with either saturated or unsaturated fatty ...

journal_title：Diabetologia

authors： Siemelink M,Verhoef A,Dormans JA,Span PN,Piersma AH

更新日期：2002-10-01 00:00:00

abstract：:The antiprotozoal drug, pentamidine, has been reported to induce hypoglycaemia associated with inappropriately high plasma insulin concentrations, followed by insulin-dependent diabetes mellitus. It has been suggested that this drug can be toxic to the islet B cell, inducing early cytolytic release of insulin leading ...

journal_title：Diabetologia

authors： Saï P,Boillot D,Boitard C,Debray-Sachs M,Reach G,Assan R

更新日期：1983-11-01 00:00:00

abstract：UNLABELLED:125I-insulin binding and receptor-mediated insulin degradation were studied in isolated human fat cells from subcutaneous tissue. A high albumin concentration during cell isolation and incubation protected the fragile human adipocyte from lysis. Binding of tracer was pH dependent with an optimum between 7.4 ...

journal_title：Diabetologia

authors： Pedersen O,Hjøllund E,Beck-Nielsen H,Lindskov HO,Sonne O,Gliemann J

更新日期：1981-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pancreatic islet transplantation (PIT) offers a physiological treatment for type 1 diabetes, but the failure of islet engraftment hinders its application. The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftm...

journal_title：Diabetologia

authors： Liu S,Kilic G,Meyers MS,Navarro G,Wang Y,Oberholzer J,Mauvais-Jarvis F

更新日期：2013-02-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the extracellular matrix. As the actual mechanisms by which glucose induces VSMC dysfunction remain unclear, the aim of this study was to assess the potential role ...

journal_title：Diabetologia

authors： Sharpe PC,Yue KK,Catherwood MA,McMaster D,Trimble ER

更新日期：1998-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the action of the glucose-lowering compound sodium tungstate on glucose transport in muscle myotubes and to unravel the molecular events underlying the effects observed. METHODS:We studied the effects of tungstate on 2-deoxy-D: -glucose uptake, levels and transl...

journal_title：Diabetologia

authors： Girón MD,Sevillano N,Vargas AM,Domínguez J,Guinovart JJ,Salto R

更新日期：2008-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated spinal and peripheral kappa opioid systems in diabetic rats. MATERIALS AND METHODS:Dynorphin A, N-methyl-D-aspartate (NMDA) and kappa opioid receptor (KOR) were measured in spinal cord, dorsal root ganglia, peripheral nerves and foot skin of control and streptozotocin-induced diabetic r...

journal_title：Diabetologia

authors： Jolivalt CG,Jiang Y,Freshwater JD,Bartoszyk GD,Calcutt NA

更新日期：2006-11-01 00:00:00

abstract：:We have studied the epidemiologic characteristics of insulin-dependent (Type 1) diabetic patients aged 0-19 in a city (San Diego, southern California, USA) characterized by an impressive racial diversity and especially mild and constant climatic conditions. Ascertainment was through retrospective review of medical rec...

journal_title：Diabetologia

authors： Lorenzi M,Cagliero E,Schmidt NJ

更新日期：1985-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Rapid and adequate islet revascularisation and restoration of the islet-extracellular matrix (ECM) interaction are significant factors influencing islet survival and function of the transplanted islets in individuals with type 1 diabetes. Because the ECM encapsulating the islets is degraded during islet...

journal_title：Diabetologia

authors： Nilsson J,Fardoos R,Hansen L,Lövkvist H,Pietras K,Holmberg D,Schmidt-Christensen A

更新日期：2020-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

journal_title：Diabetologia

authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

更新日期：2007-09-01 00:00:00

abstract：:A recent report has shown an association between a specific Xba1 restriction fragment of the human HepG2-Erythrocyte glucose transporter gene and Type 2 (non-insulin dependent) diabetes. To further examine the significance of this finding we have studied Type 2 diabetic pedigrees for linkage between the Xba1 alleles o...

journal_title：Diabetologia

authors： O'Rahilly S,Patel P,Wainscoat JS,Turner RC

更新日期：1989-04-01 00:00:00

abstract：:Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...

journal_title：Diabetologia

authors： Comi G,Galardi G,Amadio S,Bianchi E,Secchi A,Martinenghi S,Caldara R,Pozza G,Canal N

更新日期：1991-08-01 00:00:00

abstract：:The incorporation of [35S]sulfate into heart proteoglycans has been studied in normal and alloxan-diabetic rats by perfusion and in vivo administration of the isotope; in the latter situation, comparison was also made of radiolabeled sulfate utilization by several other tissues (kidney, liver, lung, muscle, testes and...

journal_title：Diabetologia

authors： Spiro MJ

更新日期：1987-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. However, the impact of the disease on the acute metabolic response is less clear. To this end, we investigated the effect of type 2 diabetes on exercise-induced plasma metabolite changes and the muscu...

journal_title：Diabetologia

authors： Hansen JS,Zhao X,Irmler M,Liu X,Hoene M,Scheler M,Li Y,Beckers J,Hrabĕ de Angelis M,Häring HU,Pedersen BK,Lehmann R,Xu G,Plomgaard P,Weigert C

更新日期：2015-08-01 00:00:00

abstract：:A nationwide mumps-measles-rubella vaccination was introduced in 1982 in Finland to children aged 1.5 to 6 years and since then mumps has virtually disappeared in the country. We investigated whether this rapid epidemiological change had any impact on antibody activity against mumps virus in Type 1 (insulin-dependent)...

journal_title：Diabetologia

authors： Hyöty H,Hiltunen M,Reunanen A,Leinikki P,Vesikari T,Lounamaa R,Tuomilehto J,Akerblom HK

更新日期：1993-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...

journal_title：Diabetologia

authors： Jacobsen LM,Bocchino L,Evans-Molina C,DiMeglio L,Goland R,Wilson DM,Atkinson MA,Aye T,Russell WE,Wentworth JM,Boulware D,Geyer S,Sosenko JM

更新日期：2020-03-01 00:00:00

abstract：:Freshly isolated and primary cultured adult rat cardiomyocytes were used to elucidate the mechanism of action of the new oral antidiabetic agent (+/-)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethyl-chroman-2-yl-methoxy)benzyl]-2,4-thiazolidinedione (troglitazone) on the heart. Interaction with protein kinase C (PKC) and regul...

journal_title：Diabetologia

authors： Bähr M,Spelleken M,Bock M,von Holtey M,Kiehn R,Eckel J

更新日期：1996-07-01 00:00:00