Calcium and phosphate concentrations and future development of type 2 diabetes: the Insulin Resistance Atherosclerosis Study.

abstract：AIMS/HYPOTHESIS:The study was designed to identify the key metabolic signals of glucose-stimulated proinsulin gene transcription and translation, focusing on the mechanism of succinate stimulation of insulin production. METHODS:Wistar rat islets were incubated in 3.3 mmol/l glucose with and without esters of different...

journal_title：Diabetologia

authors： Leibowitz G,Khaldi MZ,Shauer A,Parnes M,Oprescu AI,Cerasi E,Jonas JC,Kaiser N

更新日期：2005-08-01 00:00:00

abstract：AIM/HYPOTHESIS:Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key...

journal_title：Diabetologia

authors： Wang L,Ishihara T,Ibayashi Y,Tatsushima K,Setoyama D,Hanada Y,Takeichi Y,Sakamoto S,Yokota S,Mihara K,Kang D,Ishihara N,Takayanagi R,Nomura M

更新日期：2015-10-01 00:00:00

abstract：:Plasma glucose control and arterial pressure were assessed in 28 Type 1 (insulin-dependent) diabetic patients with different degrees of micro-albuminuria. They were divided into two groups according to their urinary albumin excretion rate: a low micro-albuminuria group (n = 16) with albumin excretion ranging between 1...

journal_title：Diabetologia

authors： Wiseman M,Viberti G,Mackintosh D,Jarrett RJ,Keen H

更新日期：1984-06-01 00:00:00

abstract：:The presence of immunoreactive insulin in saliva and its relationship to plasma immunoreactive insulin was investigated in healthy subjects, newly diagnosed non-obese Type 2 (non-insulin-dependent) diabetic patients and obese non-diabetic subjects, basally and after an oral glucose tolerance test. The mean +/- SEM fas...

journal_title：Diabetologia

authors： Marchetti P,Benzi L,Masoni A,Cecchetti P,Giannarelli R,Di Cianni G,Ciccarone AM,Navalesi R

更新日期：1986-10-01 00:00:00

abstract：:The human insulin receptor exists in two isoforms (HIR-A alpha-subunit 719 amino acids and HIR-B alpha-subunit 731 amino acids) which are generated by alternative splicing of a small exon and display distinct patterns of tissue-specific expression. Using the polymerase chain reaction we have recently shown that skelet...

journal_title：Diabetologia

authors： Kellerer M,Sesti G,Seffer E,Obermaier-Kusser B,Pongratz DE,Mosthaf L,Häring HU

更新日期：1993-07-01 00:00:00

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) i...

journal_title：Diabetologia

authors： Rees MG,Wincovitch S,Schultz J,Waterstradt R,Beer NL,Baltrusch S,Collins FS,Gloyn AL

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:High sodium (HS) effects on hypertension are well established. Recent evidence implicates a relationship between HS intake and insulin resistance, even in the absence of hypertension. The aim of the current study was to determine whether loss of the vascular actions of insulin may be the driving factor ...

journal_title：Diabetologia

authors： Premilovac D,Richards SM,Rattigan S,Keske MA

更新日期：2014-12-01 00:00:00

abstract：AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...

journal_title：Diabetologia

authors： Perrini S,Laviola L,Cignarelli A,Melchiorre M,De Stefano F,Caccioppoli C,Natalicchio A,Orlando MR,Garruti G,De Fazio M,Catalano G,Memeo V,Giorgino R,Giorgino F

更新日期：2008-01-01 00:00:00

abstract：:In order to characterize pancreatic beta cell function in Geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. The initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) ...

journal_title：Diabetologia

authors： Rabinovitch A,Gutzeit A,Kikuchi M,Cerasi E,Renold AE

更新日期：1975-10-01 00:00:00

abstract：:Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...

journal_title：Diabetologia

authors： Sakura H,Ashcroft FM

更新日期：1997-05-01 00:00:00

abstract：:In this study, we found that the ratio of proinsulin to total immunoreactive insulin was much higher in 22 patients with Type 2 (non-insulin-dependent) diabetes mellitus than in 28 non-diabetic control subjects of similar age and adiposity (32 +/- 3 vs 15 +/- 1%, p less than 0.001). In addition, the arginine-induced a...

journal_title：Diabetologia

authors： Ward WK,LaCava EC,Paquette TL,Beard JC,Wallum BJ,Porte D Jr

更新日期：1987-09-01 00:00:00

abstract：:It has been proposed that the development of diabetic complications may involve a depletion of cellular myo-inositol due to an increase in polyol (sorbitol) formation. We therefore initially examined the effect of diabetes on levels of these metabolites in isolated cerebral microvessels. Compared with microvessels fro...

journal_title：Diabetologia

authors： Sussman I,Carson MP,Schultz V,Wu XP,McCall AL,Ruderman NB,Tornheim K

更新日期：1988-10-01 00:00:00

abstract：:Zinc transporter 8 (ZnT8), a protein highly specific to pancreatic insulin-producing beta cells, is vital for the biosynthesis and secretion of insulin. ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies. In combination with autoantibodies to several other i...

journal_title：Diabetologia

authors： Williams CL,Long AE

更新日期：2019-11-01 00:00:00

abstract：:Previous studies have suggested that nerve regeneration may be defective in patients with diabetic polyneuropathy. Since insulin-like growth factor I (IGF-I) has been shown to stimulate nerve regeneration, and IGF binding protein-1 is acutely regulated by plasma insulin we have investigated the relationships between p...

journal_title：Diabetologia

authors： Crosby SR,Tsigos C,Anderton CD,Gordon C,Young RJ,White A

更新日期：1992-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar effect in other ethnic groups is unknown. The aim of this study was to investigate the effect o...

journal_title：Diabetologia

authors： Hu C,Zhang R,Wang C,Ma X,Wang C,Fang Q,Bao Y,Xiang K,Jia W

更新日期：2009-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...

journal_title：Diabetologia

authors： Pundziute-Lyckå A,Urbonaite B,Dahlquist G

更新日期：2000-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...

journal_title：Diabetologia

authors： Golicki DT,Golicka D,Groele L,Pankowska E

更新日期：2008-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes. This study investigated the relationship of plasma FGF21 levels with cardiovascular events in patients with type 2 diabetes. METHODS:Plasma FGF21 levels were meas...

journal_title：Diabetologia

authors： Ong KL,Januszewski AS,O'Connell R,Jenkins AJ,Xu A,Sullivan DR,Barter PJ,Hung WT,Scott RS,Taskinen MR,Keech AC,Rye KA

更新日期：2015-03-01 00:00:00

abstract：:Patients with Type II (non-insulin-dependent) diabetes mellitus manifest abnormalities in insulin action and insulin secretion. It is widely accepted that insulin resistance is an early finding, evident before the onset of hyperglycaemia and predictive of the subsequent development of diabetes. Whether abnormalities i...

journal_title：Diabetologia

authors： Pratley RE,Weyer C

更新日期：2001-08-01 00:00:00

abstract：:This study was performed to evaluate whether L-leucine is able to relieve the structural and functional alterations previously described in pancreatic islets exposed in vitro for a prolonged time to a subnormal glucose concentration (3.3 mM). It was found that both the impairment of secretion and the decreased rate of...

journal_title：Diabetologia

authors： Andersson A,Höiriis-Nielsen J,Borg LA

更新日期：1977-01-01 00:00:00

abstract：:We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thro...

journal_title：Diabetologia

authors： Ishizuka T,Taniguchi O,Yamamoto M,Kajita K,Nagashima T,Takeda N,Inouye H,Yasuda K,Miura K

更新日期：1994-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The transcription factor upstream stimulatory factor 1 (USF1) regulates the expression of genes involved in glucose and lipid metabolism and has been associated with familial combined hyperlipidaemia. USF1 is located on chromosome 1q22-23, a region with evidence for linkage to type 2 diabetes and variou...

journal_title：Diabetologia

authors： Ng MC,Miyake K,So WY,Poon EW,Lam VK,Li JK,Cox NJ,Bell GI,Chan JC

更新日期：2005-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Experimental studies have suggested that ghrelin, a novel gastrointestinal peptide hormone, could play a role in glucose homeostasis. In addition, ghrelin has been associated with beneficial haemodynamic effects in experimental settings. Since the Arg51Gln mutation changes the carboxyterminal amino acid...

journal_title：Diabetologia

authors： Pöykkö S,Ukkola O,Kauma H,Savolainen MJ,Kesäniemi YA

更新日期：2003-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...

journal_title：Diabetologia

authors： Karlsson P,Gylfadottir SS,Kristensen AG,Ramirez JD,Cruz P,Le N,Shillo PR,Tesfaye S,Rice ASC,Tankisi H,Finnerup NB,Nyengaard JR,Jensen TS,Bennett DLH,Themistocleous AC

更新日期：2021-01-23 00:00:00

abstract：:In healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyperinsulinaemic (100 mU.m-2.min-1) (a) hypoglycaemia (2.5 mmol/l) and (b) euglycaemia (4.5 mmol/l) in insulin-d...

journal_title：Diabetologia

authors： Maggs DG,Macdonald IA,Tattersall RB

更新日期：1994-07-01 00:00:00

abstract：:Structural alterations in arterial extracellular matrix components have been suggested to play a role in the development of arterial disease among patients with diabetes mellitus. This study examines the quantity and quality of collagenous components in aortas from diabetic patients. In order to obtain data about the ...

journal_title：Diabetologia

authors： Rasmussen LM,Ledet T

更新日期：1993-05-01 00:00:00

abstract：:We have previously reported that oxygen free radical scavengers protect rat islet cells from damage by cytokines and we interpreted these findings as suggesting the involvement of oxygen free radicals but did not directly measure indices of free radical activity. In this study, we report on malondialdehyde, an end pro...

journal_title：Diabetologia

authors： Rabinovitch A,Suarez WL,Thomas PD,Strynadka K,Simpson I

更新日期：1992-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enterovirus (e.g. Coxsackie B virus serotypes [CVBs]) infections may be associated with development of type 1 diabetes. Studies conducted in several European countries have, however, shown an inverse correlation between the incidence of type 1 diabetes and the prevalence of enterovirus infections. These...

journal_title：Diabetologia

authors： Larsson PG,Lakshmikanth T,Svedin E,King C,Flodström-Tullberg M

更新日期：2013-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...

journal_title：Diabetologia

authors： Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

更新日期：2009-05-01 00:00:00