Effects of L-leucine on the insulin production, oxidative metabolism and mitochondrial ultrastructure of isolated mouse pancreatic islets in tissue culture.

abstract：:The insulin receptor has been proposed as a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus and we therefore studied three restriction fragment length polymorphic sites, two revealed with the enzyme Sst1 and one by Rsa1, using two insulin receptor cDNA probes in 131 Caucasia...

journal_title：Diabetologia

authors： Oelbaum RS,Bouloux PM,Li SR,Baroni MG,Stocks J,Galton DJ

更新日期：1991-04-01 00:00:00

abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...

journal_title：Diabetologia

authors： Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

更新日期：1984-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Identifying the metabolite profile of individuals with normal fasting glucose (NFG [<5.55 mmol/l]) who progressed to type 2 diabetes may give novel insights into early type 2 diabetes disease interception and detection. METHODS:We conducted a population-based prospective study among 1150 Framingham Hea...

journal_title：Diabetologia

authors： Merino J,Leong A,Liu CT,Porneala B,Walford GA,von Grotthuss M,Wang TJ,Flannick J,Dupuis J,Levy D,Gerszten RE,Florez JC,Meigs JB

更新日期：2018-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...

journal_title：Diabetologia

authors： Ferdaoussi M,Bergeron V,Zarrouki B,Kolic J,Cantley J,Fielitz J,Olson EN,Prentki M,Biden T,MacDonald PE,Poitout V

更新日期：2012-10-01 00:00:00

abstract：:Plasma immunoreactive secretin and insulin concentrations were measured in fasting normal humans after intraduodenal infusions of hydrochloric acid, isotonic or hypertonic glucose. The effect of intraduodenal acidification or intravenous bolus injections of secretin on plasma insulin concentrations during infusions of...

journal_title：Diabetologia

authors： Fahrenkrug J,Schaffalitzky de Muckadell OB,Kühl C

更新日期：1978-04-01 00:00:00

abstract：:Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by pos...

journal_title：Diabetologia

authors： Geldermans CA,Terpstra J,Krans HM

更新日期：1975-10-01 00:00:00

abstract：:The role of B lymphocytes in the pathogenesis of type 1 diabetes in humans is not entirely evident. These cells are presumed to be important, but this assumption is largely based on animal models of autoimmune diabetes, where compelling evidence for the contribution of both B lymphocytes and insulin-specific autoantib...

journal_title：Diabetologia

authors： Bloem SJ,Roep BO

更新日期：2017-07-01 00:00:00

abstract：:Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated insulin secretion in beta cells. K(ATP) channels are also highly expressed in glucagon-producing alpha cells, where their function remains unresolved. Under hypoglycaemic conditions, K(ATP) channels are open in alpha ce...

journal_title：Diabetologia

authors： Rorsman P,Ramracheya R,Rorsman NJ,Zhang Q

更新日期：2014-09-01 00:00:00

abstract：UNLABELLED:AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associate...

journal_title：Diabetologia

authors： Weets I,Van Autreve J,Van der Auwera BJ,Schuit FC,Du Caju MV,Decochez K,De Leeuw IH,Keymeulen B,Mathieu C,Rottiers R,Dorchy H,Quartier E,Gorus FK,Belgian Diabetes Registry.

更新日期：2001-01-01 00:00:00

abstract：:Non-insulin adjunct therapies in type 1 diabetes have been proposed as a means of improving glycaemic control and reducing risk of hypoglycaemia. Evidence to support this approach is, however, scant and few pharmacological agents have proved effective enough to become part of routine clinical care. Recent short-term P...

journal_title：Diabetologia

authors： McCrimmon RJ,Henry RR

更新日期：2018-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The benefits of moderate alcohol consumption for type 2 diabetes have been postulated to involve a mechanism of improved insulin sensitivity. Fetuin-A, which is known to inhibit insulin signalling, has emerged as a biomarker for diabetes risk. Alcohol consumption may influence circulating fetuin-A conce...

journal_title：Diabetologia

authors： Ley SH,Sun Q,Jimenez MC,Rexrode KM,Manson JE,Jensen MK,Rimm EB,Hu FB

更新日期：2014-01-01 00:00:00

abstract：:Stroke incidence, case fatality and mortality in diabetic patients were compared to non-diabetic subjects in a 35-74-year-old population in northern Sweden (target population 241,000). During an 8-year period, 1,544 stroke events in diabetic patients and 4,826 events in non-diabetic subjects were recorded. The crude i...

journal_title：Diabetologia

authors： Stegmayr B,Asplund K

更新日期：1995-09-01 00:00:00

abstract：:Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on va...

journal_title：Diabetologia

authors： Dean BM,Walker R,Bone AJ,Baird JD,Cooke A

更新日期：1985-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Circulating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes. This study investigated the relationship of plasma FGF21 levels with cardiovascular events in patients with type 2 diabetes. METHODS:Plasma FGF21 levels were meas...

journal_title：Diabetologia

authors： Ong KL,Januszewski AS,O'Connell R,Jenkins AJ,Xu A,Sullivan DR,Barter PJ,Hung WT,Scott RS,Taskinen MR,Keech AC,Rye KA

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...

journal_title：Diabetologia

authors： Clarke PM,Gray AM,Briggs A,Stevens RJ,Matthews DR,Holman RR,UKPDS 72 United Kingdom Prospective Diabetes Study.

更新日期：2005-05-01 00:00:00

abstract：:The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies ...

journal_title：Diabetologia

authors： Hutton JC

更新日期：1994-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesit...

journal_title：Diabetologia

authors： Li H,Kilpeläinen TO,Liu C,Zhu J,Liu Y,Hu C,Yang Z,Zhang W,Bao W,Cha S,Wu Y,Yang T,Sekine A,Choi BY,Yajnik CS,Zhou D,Takeuchi F,Yamamoto K,Chan JC,Mani KR,Been LF,Imamura M,Nakashima E,Lee N,Fujisawa T,Ka

更新日期：2012-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:White adipose tissue (WAT) consists of various depots with different adipocyte functionality and immune cell composition. Knowledge of WAT-depot-specific differences in expandability and immune cell influx during the development of obesity is limited, therefore we aimed to characterise different WAT dep...

journal_title：Diabetologia

authors： van Beek L,van Klinken JB,Pronk AC,van Dam AD,Dirven E,Rensen PC,Koning F,Willems van Dijk K,van Harmelen V

更新日期：2015-07-01 00:00:00

abstract：:The microvascular permeability to small and large molecules was studied during good and poor metabolic regulation in ten short duration juvenile diabetics. The following variables were measured; daily urinary albumin and beta2-microglobulin-excretion rates, whole body transcapillary escape rate of albumin (TER), glome...

journal_title：Diabetologia

authors： Parving HH,Noer I,Deckert T,Evrin PE,Nielsen SL,Lyngsoe J,Mogensen CE,Rorth M,Svendsen PA,Trap-Jensen J,Lassen NA

更新日期：1976-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabetes living in Scotland. METHODS:Data from Scottish Care Information-Diabetes (SCI-Diabetes) were...

journal_title：Diabetologia

authors： Malik MO,Govan L,Petrie JR,Ghouri N,Leese G,Fischbacher C,Colhoun H,Philip S,Wild S,McCrimmon R,Sattar N,Lindsay RS,Scottish Diabetes Research Network Epidemiology Group.

更新日期：2015-04-01 00:00:00

abstract：:The above discussion illustrating the multitude of variables which influence insulin sensitivity in normal subjects challenges the prevailing view that insulin sensitivity is genetically determined in patients with NIDDM. The lack of accurate quantitation of all determinants of insulin sensitivity in the cross-section...

journal_title：Diabetologia

authors： Yki-Järvinen H

更新日期：1995-12-01 00:00:00

abstract：:The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD. Situations in which proteomics could be applied in clinical practice include the identif...

journal_title：Diabetologia

authors： Pena MJ,Mischak H,Heerspink HJ

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...

journal_title：Diabetologia

authors： Kuwabara T,Mori K,Mukoyama M,Kasahara M,Yokoi H,Saito Y,Ogawa Y,Imamaki H,Kawanishi T,Ishii A,Koga K,Mori KP,Kato Y,Sugawara A,Nakao K

更新日期：2012-08-01 00:00:00

abstract：:Severe microvascular disease exists at the stage of clinical diabetic neuropathy. A non-invasive test that will identify those diabetic subjects who will eventually develop neuropathy is essential for early intervention. Sural sensory conduction velocity was recorded (x3) in 12 non-neuropathic diabetic subjects, 15 di...

journal_title：Diabetologia

authors： Tesfaye S,Harris ND,Wilson RM,Ward JD

更新日期：1992-02-01 00:00:00

abstract：:Fifty-nine Type 1 (insulin-dependent) diabetic patients with (group I) and 59 patients without nephropathy (group II) pair-matched according to sex (30 males and 29 females), age (33 years, range 15-48) and diabetes duration (19 years, range 6-42) were followed for a period of 10 years from about 5 years before to 5 y...

journal_title：Diabetologia

authors： Jensen T,Borch-Johnsen K,Kofoed-Enevoldsen A,Deckert T

更新日期：1987-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by progressive loss of pancreatic beta cell mass and function. Therefore, it is of therapeutic interest to identify factors with the potential to improve beta cell proliferation and insulin secretion. Bone morphogenetic protein 4 (BMP4) expression is increased in diabeti...

journal_title：Diabetologia

authors： Christensen GL,Jacobsen ML,Wendt A,Mollet IG,Friberg J,Frederiksen KS,Meyer M,Bruun C,Eliasson L,Billestrup N

更新日期：2015-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...

journal_title：Diabetologia

authors： Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial. METHODS:In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous ...

journal_title：Diabetologia

authors： Gastaldelli A,Sironi AM,Ciociaro D,Positano V,Buzzigoli E,Giannessi D,Lombardi M,Mari A,Ferrannini E

更新日期：2005-10-01 00:00:00

abstract：:Recent studies have reported reduced endocrine and symptomatic responses to hypoglycaemia 18-24 h after antecedent hypoglycaemia in both non-diabetic subjects and those with insulin-dependent diabetes mellitus. We examined these and peripheral physiological responses in eight non-diabetic subjects aged 23-35 years in ...

journal_title：Diabetologia

authors： George E,Harris N,Bedford C,Macdonald IA,Hardisty CA,Heller SR

更新日期：1995-10-01 00:00:00

abstract：:Insulin action and insulin specific binding to erythrocytes were examined in ten recipients of a pancreatic segment and renal graft (Group 1), in nine non-diabetic kidney recipients (Group 2) and in ten age- and weight-matched healthy control subjects (Group 3). All transplant recipients were normoglycaemic without ne...

journal_title：Diabetologia

authors： Saudek F,Pelikánová T,Bartos V,Reneltová I,Kazdová L,Kovár J,Karasová L

更新日期：1991-08-01 00:00:00