Effect of secretin on basal- and glucose-stimulated insulin secretion in man.

abstract：AIMS/HYPOTHESIS:Changes in kidney function in diabetes could be due to changes in the kidney basement membranes. Proteoglycans are important constituents of this kidney extracellular matrix. This study explored the possibility that advanced glycation end products affect proteoglycan synthesis in cultured kidney epithel...

journal_title：Diabetologia

authors： Borrebaek J,Prydz K,Fjeldstad K,Vuong TT,Berg TJ,Holkov C,Kolset SO

更新日期：2001-04-01 00:00:00

abstract：:The aim of this study was to compare the causes of death and parameters related to alcohol consumption, between subjects diagnosed as diabetic, clinically by their general practitioner, or glucose intolerant and in particular as diabetic, using the epidemiological criteria of an abnormal glucose level following an ora...

journal_title：Diabetologia

authors： Balkau B,Eschwège E,Fontbonne A,Claude JR,Warnet JM

更新日期：1992-01-01 00:00:00

abstract：:Use of monoclonal antibodies specific for rat lymphocyte subsets and an anti-insulin marker has allowed us to document the following sequence of events leading to the development of clinical diabetes in this animal model. The first change observed in the pancreas is increased expression of MHC class II molecules on va...

journal_title：Diabetologia

authors： Dean BM,Walker R,Bone AJ,Baird JD,Cooke A

更新日期：1985-07-01 00:00:00

abstract：:Human crude and recombinant interleukin 1 (IL-1) was found to dose- and time-dependently affect the biosynthesis of (pro)insulin in isolated rat islets of Langerhans. Incubation of rat islets with either 0.5 U/ml or 5 U/ml of crude IL-1 for 1 h had no detectable effect on (pro)insulin biosynthesis. After 24 hours of e...

journal_title：Diabetologia

authors： Spinas GA,Hansen BS,Linde S,Kastern W,Mølvig J,Mandrup-Poulsen T,Dinarello CA,Nielsen JH,Nerup J

更新日期：1987-07-01 00:00:00

abstract：AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...

journal_title：Diabetologia

authors： Kim YK,Joung KH,Ryu MJ,Kim SJ,Kim H,Chung HK,Lee MH,Lee SE,Choi MJ,Chang JY,Hong HJ,Kim KS,Lee SH,Kweon GR,Kim H,Lee CH,Kim HJ,Shong M

更新日期：2015-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...

journal_title：Diabetologia

authors： Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Enterovirus infections are among the environmental risk factors potentially contributing to the pathogenesis of Type 1 diabetes. The aim of this study was to evaluate virus-host interaction by analysing the enterovirus antibody levels in subjects carrying different HLA-DR alleles associated with either ...

journal_title：Diabetologia

authors： Sadeharju K,Knip M,Hiltunen M,Akerblom HK,Hyöty H

更新日期：2003-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data in...

journal_title：Diabetologia

authors： Dawed AY,Ali A,Zhou K,Pearson ER,Franks PW

更新日期：2017-11-01 00:00:00

abstract：:Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by pos...

journal_title：Diabetologia

authors： Geldermans CA,Terpstra J,Krans HM

更新日期：1975-10-01 00:00:00

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：:Pancreatic beta cells differ in terms of glucose responsiveness, insulin secretion and proliferative capacity; however, the molecular pathways that regulate this cellular heterogeneity are unknown. We have identified the Wnt-planar cell polarity (PCP) effector Flattop (FLTP) as a biomarker that identifies mature beta ...

journal_title：Diabetologia

authors： Migliorini A,Roscioni SS,Lickert H

更新日期：2016-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:As vascular endothelial growth factor (VEGF) plays a pivotal role in the development of diabetic retinopathy, inhibition of angiogenesis induced by VEGF is crucial to treat diabetic retinopathy. HGF (hepatocyte growth factor)/NK4, containing the N-terminal hairpin domain and the four subsequent kringle ...

journal_title：Diabetologia

authors： Nakabayashi M,Morishita R,Nakagami H,Kuba K,Matsumoto K,Nakamura T,Tano Y,Kaneda Y

更新日期：2003-01-01 00:00:00

abstract：:Vasoactive intestinal polypeptide is a pancreatic neurotransmitter which augments insulin release. To obtain more detailed information on its mode of action on the pancreatic beta cell we studied the effect of vasoactive intestinal polypeptide on 86Rb+ efflux, 45Ca2+ uptake, electrical activity and second messenger sy...

journal_title：Diabetologia

authors： Wahl MA,Straub SG,Ammon HP

更新日期：1993-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...

journal_title：Diabetologia

authors： Colhoun HM,Lee ET,Bennett PH,Lu M,Keen H,Wang SL,Stevens LK,Fuller JH

更新日期：2001-09-01 00:00:00

abstract：:Monolayer cell cultures from pancreatic islets of aging 129/J strain diabetes (db3J/db3J) and lean littermate control mice were tested for differences in glucagon and insulin secretion in either serum-free Eagle's minimal essential medium (MEM) or Dulbecco's modified minimal essential medium (DMEM). There was a highly...

journal_title：Diabetologia

authors： Leiter EH,Strack I,Eisenstein AB

更新日期：1980-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Rosiglitazone, an insulin sensitiser, not only improves insulin sensitivity but also enhances insulin secretory capacity by ameliorating gluco- and lipotoxicity in beta cells. Rosiglitazone can stimulate insulin secretion at basal and high glucose levels via a phosphatidylinositol 3-kinase (PI3K)-depend...

journal_title：Diabetologia

authors： Chang TJ,Chen WP,Yang C,Lu PH,Liang YC,Su MJ,Lee SC,Chuang LM

更新日期：2009-06-01 00:00:00

abstract：:Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...

journal_title：Diabetologia

authors： Chicheportiche D,Reach G

更新日期：1988-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular disease in diabetes is linked to increased risk of atherosclerosis, increased levels of triglyceride-rich lipoproteins and enhanced hepatic lipogenesis. The hepatic hexosamine pathway has been implicated in signalling for de novo lipogenesis by the liver. In this study, we assessed if dec...

journal_title：Diabetologia

authors： Babaei-Jadidi R,Karachalias N,Kupich C,Ahmed N,Thornalley PJ

更新日期：2004-12-01 00:00:00

abstract：:While the modest reduction in the primary composite outcome of myocardial infarction, stroke or cardiovascular death in the EMPA-REG Outcomes trial was welcome, the 30-40% reductions in heart failure hospitalisation (HFH) and cardiovascular and all-cause deaths in patients treated with empagliflozin were highly impres...

journal_title：Diabetologia

authors： Sattar N,McLaren J,Kristensen SL,Preiss D,McMurray JJ

更新日期：2016-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...

journal_title：Diabetologia

authors： Yajnik CS,Joglekar CV,Lubree HG,Rege SS,Naik SS,Bhat DS,Uradey B,Raut KN,Shetty P,Yudkin JS

更新日期：2008-01-01 00:00:00

abstract：:The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sul...

journal_title：Diabetologia

authors： Pogátsa G,Dubecz E

更新日期：1977-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adiponectin is an adipokine that exhibits insulin-sensitising, fat-burning and anti-inflammatory properties as well as modulatory effects on oxidative stress. We examined whether adiponectin could be induced in a non-adipose tissue, skeletal muscle, in response to metabolic or oxidative aggression both ...

journal_title：Diabetologia

authors： Delaigle AM,Senou M,Guiot Y,Many MC,Brichard SM

更新日期：2006-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated in type 2 diabetes, and Nupr1 has been implicated in cell proliferation and apoptosis cascades. We used Nupr1(-/-) mice to study the role of Nupr1 in glucose hom...

journal_title：Diabetologia

authors： Barbosa-Sampaio HC,Liu B,Drynda R,Rodriguez de Ledesma AM,King AJ,Bowe JE,Malicet C,Iovanna JL,Jones PM,Persaud SJ,Muller DS

更新日期：2013-11-01 00:00:00

abstract：:Islet allografts in insulin-dependent diabetic (IDDM) patients exhibit variable survival lengths and low rates of insulin-independence despite treatment with anti-T-cell antibodies and maintenance immunosuppression. Use of poorly characterized freshly isolated preparations makes it difficult to determine whether failu...

journal_title：Diabetologia

authors： Keymeulen B,Ling Z,Gorus FK,Delvaux G,Bouwens L,Grupping A,Hendrieckx C,Pipeleers-Marichal M,Van Schravendijk C,Salmela K,Pipeleers DG

更新日期：1998-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. SUBJECTS, MATERIALS AND METHODS:Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a ho...

journal_title：Diabetologia

authors： Simmons D,Shaw J,McKenzie A,Eaton S,Cameron AJ,Zimmet P

更新日期：2006-07-01 00:00:00

abstract：:We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a phosphatidylinositol-3 (PI) kinase dependent pathway in C2C12 myotubes. The aim of the present study was to identify the signalling path from the leptin receptor to the PI-3 kinase. We stimulated C2C12 myot...

journal_title：Diabetologia

authors： Kellerer M,Koch M,Metzinger E,Mushack J,Capp E,Häring HU

更新日期：1997-11-01 00:00:00

abstract：:Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...

journal_title：Diabetologia

authors： Rossing P,Hommel E,Smidt UM,Parving HH

更新日期：1994-05-01 00:00:00

abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...

journal_title：Diabetologia

authors： Pyke DA

更新日期：1979-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus. METHODS:We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents It(o), IK, Iss and IK1 in enzymaticall...

journal_title：Diabetologia

authors： Casis O,Gallego M,Iriarte M,Sánchez-Chapula JA

更新日期：2000-01-01 00:00:00

abstract：:Diabetes is an important risk factor for atherosclerosis but the mechanism of the risk is unknown. As endothelial injury is considered to be an early event in the development of atherosclerosis, the effect of glucose on endothelial cell replication was studied. Concentrations of glucose of 11.2, 16.8 and 22.4 mmol/l i...

journal_title：Diabetologia

authors： Stout RW

更新日期：1982-11-01 00:00:00