Cost-utility analyses of intensive blood glucose and tight blood pressure control in type 2 diabetes (UKPDS 72).

abstract：:The obese Zucker rat represents a model of obesity combined with insulin resistance and hyperlipidaemia, which over a period of several months develops spontaneous glomerulosclerosis. The present study addressed the question as to whether glomerular sclerosis was associated with alterations in the degradation of matri...

journal_title：Diabetologia

authors： Schaefer L,Han X,August C,Matzkies F,Lorenz T,Schaefer RM

更新日期：1997-09-01 00:00:00

abstract：:498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...

journal_title：Diabetologia

authors： Herman JB,Medalie JH,Goldbourt U

更新日期：1977-05-01 00:00:00

abstract：:In 1971, 107 newly diagnosed black diabetics admitted to Harare Central Hospital, Rhodesia, were studied. Nine died before discharge. In 1977, 93 of the 98 patients discharged alive were traced but of these 38 (41%) had since died. Of 18 autopsies performed the cause of death was hypoglycaemia in 8 patients and hyperg...

journal_title：Diabetologia

authors： Castle WM,Wicks AC

更新日期：1980-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...

journal_title：Diabetologia

authors： Yanagimachi T,Fujita Y,Takeda Y,Honjo J,Atageldiyeva KK,Takiyama Y,Abiko A,Makino Y,Kieffer TJ,Haneda M

更新日期：2016-03-01 00:00:00

abstract：:MODY is an early-onset monogenic form of diabetes. Correctly identifying MODY is of considerable importance as diagnosing the specific genetic subtype can inform the optimal treatment, with many patients being able to discontinue unnecessary insulin treatment. Diagnostic molecular genetic testing to confirm MODY is ex...

journal_title：Diabetologia

authors： Shields B,Colclough K

更新日期：2017-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the i...

journal_title：Diabetologia

authors： Karlsson MG,Lawesson SS,Ludvigsson J

更新日期：2000-06-01 00:00:00

abstract：:Diabetic retinopathy was found to be present in 12 out of a group of 67 diabetic patients supervised by us during 92 pregnancies, and 3 further pregnant diabetics were referred to us because of retinopathy. The mean duration of diabetes was 13 years (range 3--25 years). Nine patients had minimal retinopathy, 2 had bac...

journal_title：Diabetologia

authors： Cassar J,Kohner EM,Hamilton AM,Gordon H,Joplin GF

更新日期：1978-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maternal Type I (insulin-dependent) diabetes mellitus is associated with an increased risk for fetal malformations and spontaneous abortions. Although the pathogenic mechanism is not fully understood, reactive oxygen species have been shown to contribute to the pathogenesis in experimental studies. By m...

journal_title：Diabetologia

authors： Cederberg J,Basu S,Eriksson UJ

更新日期：2001-06-01 00:00:00

abstract：:A copy deoxyribonucleic acid (cDNA) clone of the immediate early growth response gene, egr-1 (Krox-24, Zif268, NGFI-1), was isolated through subtractive hybridization screening to identify glucose-induced genes in pancreatic beta cells. Glucose rapidly and transiently induced egr-1 mRNA in the SV40-transformed murine ...

journal_title：Diabetologia

authors： Josefsen K,Sørensen LR,Buschard K,Birkenbach M

更新日期：1999-02-01 00:00:00

abstract：:The in vivo radioautographic method has been applied to elucidate the mechanism of direct peptide hormone "feedback" action in the CNS. Using this method we have identified the circumventricular organs of the brain as general endocrine target tissues for a variety of blood-borne polypeptide hormones, including insulin...

journal_title：Diabetologia

authors： van Houten M,Posner BI

更新日期：1981-03-01 00:00:00

abstract：:The recently completed diabetes complications and control trial has highlighted the need for improvement of insulin delivery systems for treatment of insulin-dependent diabetes mellitus. Despite steady improvement in methods for islet and whole pancreas transplantation over the past three decades, the broad-scale appl...

journal_title：Diabetologia

authors： Newgard CB,Clark S,BeltrandelRio H,Hohmeier HE,Quaade C,Normington K

更新日期：1997-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular hyperfiltration is a well-established phenomenon occurring early in some patients with type 1 diabetes. However, there is no consistent answer regarding whether hyperfiltration predicts later development of nephropathy. We performed a systematic review and meta-analysis of observational studi...

journal_title：Diabetologia

authors： Magee GM,Bilous RW,Cardwell CR,Hunter SJ,Kee F,Fogarty DG

更新日期：2009-04-01 00:00:00

abstract：:The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...

journal_title：Diabetologia

authors： Chiu KC,Province MA,Dowse GK,Zimmet PZ,Wagner G,Serjeantson S,Permutt MA

更新日期：1992-07-01 00:00:00

abstract：:Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...

journal_title：Diabetologia

authors： Sakura H,Ashcroft FM

更新日期：1997-05-01 00:00:00

abstract：:The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate c...

journal_title：Diabetologia

authors： Jeppesen J,Zhou MY,Chen YD,Reaven GM

更新日期：1994-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:White adipose tissue (WAT) consists of various depots with different adipocyte functionality and immune cell composition. Knowledge of WAT-depot-specific differences in expandability and immune cell influx during the development of obesity is limited, therefore we aimed to characterise different WAT dep...

journal_title：Diabetologia

authors： van Beek L,van Klinken JB,Pronk AC,van Dam AD,Dirven E,Rensen PC,Koning F,Willems van Dijk K,van Harmelen V

更新日期：2015-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of anti-inflammatory molecules such as IL-4 and IL-13. While the actions of proinflammatory cytokines have ...

journal_title：Diabetologia

authors： Leslie KA,Russell MA,Taniguchi K,Richardson SJ,Morgan NG

更新日期：2019-01-01 00:00:00

abstract：:Oxidative stress has long been considered a key driving factor of many obesity-related health problems. However, recent work by Merry, Tran et al (Diabetologia DOI 10.1007/s00125-016-4084-3 ) challenges this idea with an interesting study using a hepatocyte-specific Gpx1-knockout (HGKO) mouse. GPX1 is an important det...

journal_title：Diabetologia

authors： Haas JT,Staels B

更新日期：2016-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain natriuretic peptide (BNP) is a potent vasorelaxing and natriuretic peptide that is secreted from the heart and has cardioprotective properties. We have previously generated hypotensive transgenic mice (BNP-Tg mice) that overproduce BNP in the liver, which is released into the circulation. Using th...

journal_title：Diabetologia

authors： Makino H,Mukoyama M,Mori K,Suganami T,Kasahara M,Yahata K,Nagae T,Yokoi H,Sawai K,Ogawa Y,Suga S,Yoshimasa Y,Sugawara A,Tanaka I,Nakao K

更新日期：2006-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fulminant type 1 diabetes, which is characterised by a markedly acute onset of diabetes and an absence of islet-related autoantibodies, accounts for 20% of type 1 diabetes in Japan. We aimed to clarify the contribution of the HLA subtype to fulminant type 1 diabetes in Japanese. METHODS:We determined t...

journal_title：Diabetologia

authors： Imagawa A,Hanafusa T,Uchigata Y,Kanatsuka A,Kawasaki E,Kobayashi T,Shimada A,Shimizu I,Maruyama T,Makino H

更新日期：2005-02-01 00:00:00

abstract：:The evolution of glucose assay methods has been central to the development of present therapies for diabetes mellitus. However, new blood glucose assay capabilities, such as convenient and truly continuous monitoring, are now needed to foster a new era of close blood glucose control. The principles and present status ...

journal_title：Diabetologia

authors： Gough DA,Armour JC,Baker DA

更新日期：1997-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:According to the foetal origins hypothesis, there is a relation between foetal nutrition and adult glucose intolerance. In adults, insulin resistance has been associated with dietary polyunsaturated fatty acids. We examined whether the availability of polyunsaturated fatty acids during foetal life, as i...

journal_title：Diabetologia

authors： Rump P,Popp-Snijders C,Heine RJ,Hornstra G

更新日期：2002-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to ...

journal_title：Diabetologia

authors： Mikus CR,Oberlin DJ,Libla J,Boyle LJ,Thyfault JP

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes. Recent genome-wide association (GWA) studies have identified multiple loci robustly associated with BMI and risk of obesity. However, information on their associations with type 2 diabetes is limited. Such information could help increase our understand...

journal_title：Diabetologia

authors： Li S,Zhao JH,Luan J,Langenberg C,Luben RN,Khaw KT,Wareham NJ,Loos RJ

更新日期：2011-04-01 00:00:00

abstract：:Restriction fragment length polymorphism of the human insulin receptor gene was analyzed with a 4.2 Kb cDNA probe in Japanese normal subjects and Type 2 (non-insulin-dependent) diabetic patients. Restriction endonuclease Rsa I digestion showed polymorphism of the human insulin receptor gene, with a band at 6.7 Kb, 6.2...

journal_title：Diabetologia

authors： Takeda J,Seino Y,Yoshimasa Y,Fukumoto H,Koh G,Kuzuya H,Imura H,Seino S

更新日期：1986-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...

journal_title：Diabetologia

authors： Poungvarin N,Lee JK,Yechoor VK,Li MV,Assavapokee T,Suksaranjit P,Thepsongwajja JJ,Saha PK,Oka K,Chan L

更新日期：2012-06-01 00:00:00

abstract：:Lithium exerts an inhibitory effect on glucose-induced insulin release. Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%. Similar results were obtained when islets isolated f...

journal_title：Diabetologia

authors： Fontela T,Garcia Hermida O,Gómez-Acebo J

更新日期：1987-03-01 00:00:00

abstract：:Hypoglycaemic sulphonamides stimulate net uptake of 45Ca++ and insulin release in isolated pancreatic islets. These effects are antagonized by organic calcium-antagonists (e.g. suloctidil). In an artificial system, hypoglycaemic sulphonamides, such as gliclazide, stimulate the translocation of calcium into or across a...

journal_title：Diabetologia

authors： Couturier E,Malaisse WJ

更新日期：1980-10-01 00:00:00

abstract：:Screening and diagnostic criteria for gestational diabetes (GDM) are inconsistent across Europe, and the development of a uniform GDM screening strategy is necessary. Such a strategy would create opportunities for more women to receive timely treatment for GDM. Developing a consensus on screening for GDM in Europe is ...

journal_title：Diabetologia

authors： Benhalima K,Mathieu C,Damm P,Van Assche A,Devlieger R,Desoye G,Corcoy R,Mahmood T,Nizard J,Savona-Ventura C,Dunne F

更新日期：2015-07-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hypergly...

journal_title：Diabetologia

authors： Catrina SB,Zheng X

更新日期：2021-01-26 00:00:00