Abstract:
:The recently completed diabetes complications and control trial has highlighted the need for improvement of insulin delivery systems for treatment of insulin-dependent diabetes mellitus. Despite steady improvement in methods for islet and whole pancreas transplantation over the past three decades, the broad-scale applicability of these approaches remains uncertain due in part to the difficulty and expense associated with procurement of functional tissue. To address this concern, we and others have been using the tools of molecular biology to develop cell lines with regulated insulin secretion that might serve as a surrogate for primary islets or pancreas tissue in transplantation therapy. This article seeks to provide a brief summary of the current status of this growing field, with a particular emphasis on progress in producing cell lines with appropriate glucose-stimulated insulin secretion.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Newgard CB,Clark S,BeltrandelRio H,Hohmeier HE,Quaade C,Normington Kdoi
10.1007/s001250051398subject
Has Abstractpub_date
1997-07-01 00:00:00pages
S42-7eissn
0012-186Xissn
1432-0428journal_volume
40 Suppl 2pub_type
杂志文章,评审相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:To study if people with Type I (insulin-dependent) or Type II (non-insulin-dependent) diabetes mellitus have increased risk of hip fracture. METHODS:The study population consisted of 35,444 people 50 years of age and older, attending a health screening in a Norwegian county. They were followed up with ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051248
更新日期:1999-08-01 00:00:00
abstract::A diabetes prevalence study on an isolated urbanized Central Pacific Island has established a prevalence rate of 34.4% in individuals aged 15 years and over. Of these, 10.4% had previously known diabetes; in the others the diagnosis was made on the basis of a plasma glucose level of at least 160 mg/100 ml 2h after a 7...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00745137
更新日期:1977-04-01 00:00:00
abstract::A prominent feature of Type 2 (non-insulin-dependent) diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissue. In adipocytes from individuals with Type 2 diabetes, insulin resistance has been shown to be associated with a depletion of glucose transporters. Si...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400207
更新日期:1990-10-01 00:00:00
abstract::Many mutagenic nitroso compounds are also diabetogenic. Betel-nut (Areca catechu) chewing populations have an increased incidence of foregut cancers related to betel-nut nitrosamines which suggests that betel consumption could be diabetogenic. Young adult CD1 mice with a low spontaneous incidence of diabetes were fed ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00428777
更新日期:1994-01-01 00:00:00
abstract::The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970-1974. The j.i.d.m. incidence remained fairly constant during the study period, the average being 13.2 per 100000 per year. The ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223266
更新日期:1977-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone released from gut K cells. While the predominant form is GIP(1-42), a shorter form, GIP(1-30), is produced by pancreatic alpha cells and promotes insulin secretion in a paracrine manner. Here, we elucidated whether GIP(1-30) express...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3842-y
更新日期:2016-03-01 00:00:00
abstract::We describe a patient who had an anaphylactic reaction to highly purified pork insulin; he was not allergic however to beef insulin. The sensitivity to pork but not to beef insulin was confirmed by skin testing, radioallergosorbent test (RAST) and RAST inhibition. A scheme is suggested for the investigation of such pa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00253575
更新日期:1982-05-01 00:00:00
abstract::Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset between age 20 and 40 years (2.4) than before age 20 years (1.0); no age-or...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401060
更新日期:1993-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2211-8
更新日期:2011-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) acts as a cofactor for several nuclear hormone receptors in many tissues and organs implicated in blood pressure regulation. Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension f...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1567-4
更新日期:2004-11-01 00:00:00
abstract::Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050140
更新日期:1994-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1943-1
更新日期:2011-02-01 00:00:00
abstract::There is now evidence that a single bout of endurance (aerobic) or resistance exercise reduces 24 h post-exercise subcutaneous glucose profiles to the same extent in insulin-resistant humans with or without type 2 diabetes. However, it remains to be determined which group would benefit most from specific exercise prot...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2513-5
更新日期:2012-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1036-6
更新日期:2008-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Osmotic and oxidative stress is associated with the progression and advancement of diabetic cataract. In the present study, we used a cDNA microarray method to analyse gene expression patterns in streptozotocin-induced diabetic rats and galactose-fed cataractous lenses. In addition, we investigated the ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1687-5
更新日期:2005-04-01 00:00:00
abstract::Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400353
更新日期:1993-09-01 00:00:00
abstract::Highly purified insulins offer the possibility of reducing insulin antibody levels and insulin requirement. Those likely to respond cannot be predicted on clinical grounds and a simple laboratory test is recommended for this purpose. This is based on insulin binding capacity (IBC) of plasma and has been used to follow...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223271
更新日期:1977-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline. METHODS:Participants without dementia aged 55-90 years from the Cognition...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4778-9
更新日期:2019-03-01 00:00:00
abstract::An inconsistency has come to light between the conclusion of Lucassen et al. that IDDM2 (11p15.5) must lie within a 4.1 kilobase (kb) segment at the insulin (INS) locus and their own data showing statistically significant associations between insulin-dependent diabetes mellitus (IDDM) and markers beyond the boundaries...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403307
更新日期:1996-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Recruitment of the protein c-Cbl to the insulin receptor (IR) and its tyrosine phosphorylation via a pathway that is independent from phosphatidylinositol 3'-kinase is necessary for insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes. The activation of this pathway by insulin or exercise has yet...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1322-2
更新日期:2004-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes and eNAMPT immuno-neutralisation improves glucose tolerance i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05029-y
更新日期:2020-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes in vitreous metabo...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05309-y
更新日期:2021-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-007-0884-9
更新日期:2008-02-01 00:00:00
abstract::Islet allografts in insulin-dependent diabetic (IDDM) patients exhibit variable survival lengths and low rates of insulin-independence despite treatment with anti-T-cell antibodies and maintenance immunosuppression. Use of poorly characterized freshly isolated preparations makes it difficult to determine whether failu...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s001250050929
更新日期:1998-04-01 00:00:00
abstract::It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050644
更新日期:1997-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axo...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2978-x
更新日期:2013-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:The 1997 American Diabetes Association classification of diabetes mellitus included a subset of Type I diabetic patients who do not need insulin for several years but eventually progress to complete insulin deficiency i. e. atypical Type I diabetes mellitus. In Caucasian populations, most Type I diabeti...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250100028
更新日期:2001-12-01 00:00:00
abstract::The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00274254
更新日期:1989-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated in type 2 diabetes, and Nupr1 has been implicated in cell proliferation and apoptosis cascades. We used Nupr1(-/-) mice to study the role of Nupr1 in glucose hom...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3006-x
更新日期:2013-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to assess whether persistence of C-peptide secretion is associated with less glucose variability and fewer low-glucose events in adults with type 1 diabetes who use flash monitoring. METHODS:We performed a cross-sectional study of 290 adults attending a university teaching hospital diabetes cl...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05099-3
更新日期:2020-05-01 00:00:00