The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats.

abstract：AIMS/HYPOTHESIS:We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations. METHODS:Eighty-four non-diabetic women of Caucasian origin and 61 years of age, of whom 48 had normal glucose tolerance (NGT) and 36 had IGT, underwent a 75 g OGTT and a hyperinsuli...

journal_title：Diabetologia

authors： Ahrén B,Larsson H

更新日期：2001-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The Ca2+/calmodulin-dependent protein kinase II (CaMK II) is highly expressed in pancreatic islets and associated with insulin secretion vesicles. The suppression of CaMK II disturbs insulin secretion and insulin gene expression. There are four isoforms of CaMK II, alpha to delta, that are expressed fro...

journal_title：Diabetologia

authors： Rochlitz H,Voigt A,Lankat-Buttgereit B,Göke B,Heimberg H,Nauck MA,Schiemann U,Schatz H,Pfeiffer AF

更新日期：2000-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. METHODS:We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle ce...

journal_title：Diabetologia

authors： Matthews VB,Aström MB,Chan MH,Bruce CR,Krabbe KS,Prelovsek O,Akerström T,Yfanti C,Broholm C,Mortensen OH,Penkowa M,Hojman P,Zankari A,Watt MJ,Bruunsgaard H,Pedersen BK,Febbraio MA

更新日期：2009-07-01 00:00:00

abstract：:Screening and diagnostic criteria for gestational diabetes (GDM) are inconsistent across Europe, and the development of a uniform GDM screening strategy is necessary. Such a strategy would create opportunities for more women to receive timely treatment for GDM. Developing a consensus on screening for GDM in Europe is ...

journal_title：Diabetologia

authors： Benhalima K,Mathieu C,Damm P,Van Assche A,Devlieger R,Desoye G,Corcoy R,Mahmood T,Nizard J,Savona-Ventura C,Dunne F

更新日期：2015-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperproinsulinaemia reflects both beta cell dysfunction and insulin resistance in cross-sectional studies, but it is not known whether changes in proinsulin concentrations are related to insulin resistance over time. As trans10cis12 (t10c12)-conjugated linoleic acid (CLA) supplementation induces insuli...

journal_title：Diabetologia

authors： Risérus U,Vessby B,Arner P,Zethelius B

更新日期：2004-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:In order to identify type 2 diabetes disease susceptibility gene(s) in a Japanese population, we applied a region-wide case-control association test to the 20.4 Mb region between D3S1293 and D3S2319 on chromosome 3p24.3-22.1, supported by linkage to type 2 diabetes and its related traits in Japanese and...

journal_title：Diabetologia

authors： Moritani M,Nomura K,Tanahashi T,Osabe D,Fujita Y,Shinohara S,Yamaguchi Y,Keshavarz P,Kudo E,Nakamura N,Yoshikawa T,Ichiishi E,Takata Y,Yasui N,Shiota H,Kunika K,Inoue H,Itakura M

更新日期：2007-06-01 00:00:00

abstract：:To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibodies and high titre...

journal_title：Diabetologia

authors： Betterle C,Presotto F,Pedini B,Moro L,Slack RS,Zanette F,Zanchetta R

更新日期：1987-05-01 00:00:00

abstract：:Kwashiorkor, the human disease of protein-energy malnutrition, has been implicated in the aetiology of malnutrition-related diabetes mellitus, a form of diabetes not uncommon in developing countries. We have previously demonstrated that temporary protein-energy malnutrition in young rats causes a persisting impairment...

journal_title：Diabetologia

authors： Swenne I,Borg LA,Crace CJ,Schnell Landström A

更新日期：1992-10-01 00:00:00

abstract：:Mild hypoglycaemia was induced using an artificial pancreas in five normal subjects (from 5.00 +/- 0.15 to 2.83 +/- 0.15 mmol/l) by infusing 28 mU/m2 per min soluble insulin for 60 min. Six Type 1 (insulin-dependent) diabetic patients were stabilized for 14h using an artificial pancreas. They were then rendered hypogl...

journal_title：Diabetologia

authors： Bolli G,Calabrese G,De Feo P,Compagnucci P,Zega G,Angeletti G,Cartechini MG,Santeusanio F,Brunetti P

更新日期：1982-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...

journal_title：Diabetologia

authors： Drivsholm T,de Fine Olivarius N,Nielsen AB,Siersma V

更新日期：2005-02-01 00:00:00

abstract：AIM/HYPOTHESIS:Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key...

journal_title：Diabetologia

authors： Wang L,Ishihara T,Ibayashi Y,Tatsushima K,Setoyama D,Hanada Y,Takeichi Y,Sakamoto S,Yokota S,Mihara K,Kang D,Ishihara N,Takayanagi R,Nomura M

更新日期：2015-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Assessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 d...

journal_title：Diabetologia

authors： Lytvyn Y,Xiao F,Kennedy CR,Perkins BA,Reich HN,Scholey JW,Cherney DZ,Burger D

更新日期：2017-03-01 00:00:00

abstract：:We examined the origin of hypermethioninaemia in streptozotocin-diabetic rats. In rats administered streptozotocin over a range from 55 to 75 mg/kg, the dose of drug injected correlated directly with the plasma methionine concentration and inversely with the plasma insulin level. Although insulin administration preven...

journal_title：Diabetologia

authors： Glanville NT,Anderson GH

更新日期：1984-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...

journal_title：Diabetologia

authors： Keyhani-Nejad F,Irmler M,Isken F,Wirth EK,Beckers J,Birkenfeld AL,Pfeiffer AF

更新日期：2015-02-01 00:00:00

abstract：:Oral (o.GTT) and intravenous glucose tolerance tests (i.v. GTT) were carried out on 492 patients of both sexes, aged from 5 to 78 years. Three hundred and fifty-nine non-diabetics in all were suspected clinically of reduced carbohydrate tolerance leaving 133 patients for comparison (controls). In 102 obesity was noted...

journal_title：Diabetologia

authors： Schilling WH,Oberdisse K,Hüter KA,Blank H

更新日期：1966-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The gut hormone glucagon-like peptide-1 (GLP-1) decreases beta cell apoptosis in a protein kinase B (PKB)-dependent fashion, and increases islet cell mass and function in vivo. In contrast, cytokines induce beta cell apoptosis, leading to decreased islet mass and type 1 diabetes. In the present study we...

journal_title：Diabetologia

authors： Li L,El-Kholy W,Rhodes CJ,Brubaker PL

更新日期：2005-07-01 00:00:00

abstract：:498 diabetics were discovered in a survey of ischaemic heart disease in 10,059 men aged 40 years and over in Israel. -The diabetics were divided into previously known and newly diagnosed. -During a 5 year follow-up period, the incidence rates of fatal and non-fatal myocardial infarction and the incidence of intermitte...

journal_title：Diabetologia

authors： Herman JB,Medalie JH,Goldbourt U

更新日期：1977-05-01 00:00:00

abstract：:The impact of improved glycaemic control on renal function in newly-presenting Type 2 (non-insulin-dependent) diabetic patients has not been adequately researched. Consequently, glomerular filtration rate and effective renal plasma flow and urinary albumin excretion rates were determined in 76 subjects (age (mean (SD)...

journal_title：Diabetologia

authors： Vora JP,Dolben J,Williams JD,Peters JR,Owens DR

更新日期：1993-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and ...

journal_title：Diabetologia

authors： Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist G

更新日期：2006-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...

journal_title：Diabetologia

authors： van der Berg JD,Stehouwer CD,Bosma H,van der Velde JH,Willems PJ,Savelberg HH,Schram MT,Sep SJ,van der Kallen CJ,Henry RM,Dagnelie PC,Schaper NC,Koster A

更新日期：2016-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 2 diabetic patients we compared 9 months of combination therapy with insulin glargine and metformin with 9 months of NPH insulin combined with metformin. The primary focus was changes in HbA(1c); secondary focus was diurnal glucose profiles and symptomatic hypoglycaemia. METHODS:In this investi...

journal_title：Diabetologia

authors： Yki-Järvinen H,Kauppinen-Mäkelin R,Tiikkainen M,Vähätalo M,Virtamo H,Nikkilä K,Tulokas T,Hulme S,Hardy K,McNulty S,Hänninen J,Levänen H,Lahdenperä S,Lehtonen R,Ryysy L

更新日期：2006-03-01 00:00:00

abstract：:Blood glucose screening results, obtained using two different screening procedures, are reported from two occupational groups. Post-prandial blood glucose levels were measured in 3346 subjects aged 45 years or more employed by the Greater London Council/Inner London Education Authority. In women, mean blood glucose le...

journal_title：Diabetologia

authors： Jarrett RJ,Murrells TJ,Shipley MJ,Hall T

更新日期：1984-12-01 00:00:00

abstract：:The above discussion illustrating the multitude of variables which influence insulin sensitivity in normal subjects challenges the prevailing view that insulin sensitivity is genetically determined in patients with NIDDM. The lack of accurate quantitation of all determinants of insulin sensitivity in the cross-section...

journal_title：Diabetologia

authors： Yki-Järvinen H

更新日期：1995-12-01 00:00:00

abstract：:We aimed to assess prandial responses, basal glucose turnover and insulin action (euglycaemic clamp) in a very low-dose neonatal streptozotocin model of Type 2 (non-insulin-dependent) diabetes mellitus. Male Wistar rats were injected at 2 days of age with 45 mg/kg streptozotocin or vehicle (control). At 8 weeks, the g...

journal_title：Diabetologia

authors： Pascoe WS,Jenkins AB,Kusunoki M,Storlien LH

更新日期：1992-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix modulation. Here, we studied its role in high glucose-induced collagen elaboration by mesangial cells. METHODS:Primary rat mesangial cells were trea...

journal_title：Diabetologia

authors： Wu D,Peng F,Zhang B,Ingram AJ,Gao B,Krepinsky JC

更新日期：2007-09-01 00:00:00

abstract：:Pancreatic beta cells are clustered in islets of Langerhans together with alpha cells in an arrangement that facilitates the tight coordination of insulin and glucagon secretion at the source of their release. Other secretory cells, including somatostatin-secreting delta cells and pancreatic polypeptide cells, co-loca...

journal_title：Diabetologia

authors： Huising MO

更新日期：2015-06-01 00:00:00

abstract：:The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...

journal_title：Diabetologia

authors： Dietze G,Wicklmayr M,Mehnert H,Czempiel H,Henftling HG

更新日期：1978-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...

journal_title：Diabetologia

authors： Gysemans C,Stoffels K,Giulietti A,Overbergh L,Waer M,Lannoo M,Feige U,Mathieu C

更新日期：2003-08-01 00:00:00

abstract：AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...

journal_title：Diabetologia

authors： Hara M,Yamagata K,Tomino Y,Saito A,Hirayama Y,Ogasawara S,Kurosawa H,Sekine S,Yan K

更新日期：2012-11-01 00:00:00

abstract：:It has been shown that, in streptozotocin diabetic rats, protamine-retarded insulin administered in vivo stimulates intimal hyperplasia in balloon-injured carotid artery. The aim of this study was to evaluate the influence of protamine on cultured human vascular smooth muscle cells (h VSMC), by observing its effects o...

journal_title：Diabetologia

authors： Cavalot F,Russo I,Mattiello L,Anfossi G,Massucco P,Mularoni E,Hahn AW,Trovati M

更新日期：1997-01-01 00:00:00