Abstract:
AIMS/HYPOTHESIS:Among diabetic patients, glucose homeostasis may be affected by abnormal gastrointestinal motility and autonomic neuropathy. This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis. MATERIALS AND METHODS:Oesophageal manometry and gastric emptying scintigraphy were performed in 20 diabetic patients. Heart-rate variation during deep breathing (expiration/inspiration [E/I] ratio) and continuous subcutaneous glucose concentrations for a period of 72 h were also monitored in the same patients. RESULTS:Oesophageal dysmotility was found in eight of 14 patients. Eleven of 20 patients had delayed gastric emptying (abnormal gastric emptying half-time [T (50)]) and nine of 18 had an abnormal E/I ratio. Complaints of abdominal fullness were predictive of delayed gastric emptying. A low peristaltic speed of the oesophagus was associated with impaired T (50) (r ( s )=-0.67; p=0.02). One hour after breakfast, subcutaneous glucose levels decreased in patients with delayed gastric emptying but continued to rise in those with normal emptying. Consequently, the median glucose level 2.5 h after breakfast was lower in the former (9.1 [4.2-12.5] vs 14.3 [11.2-17.7] mmol/l; p<0.05). Glucose fluctuations during the 72 h were significantly higher in patients with an abnormal E/I ratio than in those with a normal E/I ratio (coefficient of variation: 41 [46-49] vs 28 [27-34]%; p=0.008). CONCLUSIONS/INTERPRETATION:Abdominal fullness predicted delayed gastric emptying that was associated with diminished glucose uptake after breakfast. Low oesophageal peristaltic speed was associated with slow gastric emptying whereas parasympathetic neuropathy was associated with increased glucose variations.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Ohlsson B,Melander O,Thorsson O,Olsson R,Ekberg O,Sundkvist Gdoi
10.1007/s00125-006-0354-9subject
Has Abstractpub_date
2006-09-01 00:00:00pages
2010-4issue
9eissn
0012-186Xissn
1432-0428journal_volume
49pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract::Epigenetics encapsulates a group of molecular mechanisms including DNA methylation, histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk of adverse perinatal outcomes and is associated with future offspring risk of obesity and type 2 diabetes. It has been hypothesised that epigene...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-019-05011-8
更新日期:2019-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether components of the renin-angiotensin system and semicarbazide-sensitive amine oxidase (SSAO) are associated with the development of pre-eclampsia in women with type 1 diabetes. METHODS:This was an observational study of 107 consecutive pregnant women with...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2087-7
更新日期:2011-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes is characterised by excessive hepatic glucose production and frequently leads to systemic vascular complications. We therefore analysed the relationship between the gene expression profile in the liver and the pathophysiology of Type 2 diabetes. METHODS:Liver biopsy samples were obtaine...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1366-y
更新日期:2004-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2650-x
更新日期:2012-10-01 00:00:00
abstract::Glomerular basement membrane thickness (GBMT) has been measured in streptozotocin diabetic rats treated with insulin. The study included 3 groups of 8 rats each: 1) a 'well-controlled' group of diabetic rats under insulin treatment with a plasma glucose level reasonable close to normal values, 2) a 'poorly-controlled'...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223621
更新日期:1979-05-01 00:00:00
abstract::Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) dia...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-002-0975-6
更新日期:2002-12-01 00:00:00
abstract::Using 3H-thymidine labeling techniques, we found that rates of DNA synthesis in islet cells doubled when mouse pancreatic islets were cultured for 1 week with 10 mmol/l nicotinamide, a potent poly(ADP-ribose) synthetase inhibitor. Culture with nicotinamide partially inhibited glucose-stimulated insulin release, wherea...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02427093
更新日期:1986-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy. METHODS:PubMed, EMBASE and Web of Science were searched for articles assessing the association between genes and diabetic nephropathy. All genetic variants statistically associated w...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析
doi:10.1007/s00125-010-1996-1
更新日期:2011-03-01 00:00:00
abstract::The damaging effects of glucose on the cells which contribute to the development of diabetic complications are ill-understood. There are three major hypotheses - the sorbitol pathway, non-enzymatic glycation of proteins and increased oxidative stress - and many examples illustrate inter-connections between the three. ...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250051439
更新日期:1999-11-01 00:00:00
abstract::The accumulation of noradrenaline in constricted sciatic nerves was measured in 6 month diabetic rats (streptozotocin 35 mg/kg) and 4 day diabetic rats (streptozotocin 70 mg/kg) together with two groups of age-matched control animals. There was no alteration in the amount of noradrenaline accumulated in the nerves of ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00283753
更新日期:1982-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus. METHODS:We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents It(o), IK, Iss and IK1 in enzymaticall...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050013
更新日期:2000-01-01 00:00:00
abstract::A follow-up study was carried out to determine whether reduced fetal growth is associated with the development of impaired glucose tolerance in men and women aged 50 years. Standard oral glucose tolerance tests were carried out on 140 men and 126 women born in Preston (Lancashire, UK) between 1935 and 1943, whose size...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00399954
更新日期:1993-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05017-2
更新日期:2020-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS:In this single-centre, double-blind, placebo-controlled, ...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-017-4289-0
更新日期:2017-08-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) in the gut-brain-pancreatic axis are key players in the postprandial control of metabolism and food intake. A number of intestinally located receptors have been implicated in the chemo-detection of ingested nutrients, and in the pancreatic islets and nervous system GPCRs play essent...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-015-3825-z
更新日期:2016-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1510-9
更新日期:2009-11-01 00:00:00
abstract::Type I diabetes mellitus may represent a heterogeneous disorder with a distinct pathogenesis in patients with young and adult onset of the disease. To investigate whether serological markers directed to different autoantigens have the potential to distinguish acute onset from slowly progressive Type I diabetes we anal...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051004
更新日期:1998-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. Whether this downregulation is a cause or effect o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0369-2
更新日期:2006-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Sympathetic nerves influence islet hormone levels in the circulation. Insights into islet sympathetic innervation and its remodelling in diabetes may impact future therapeutics. However, standard immunohistochemistry and microtome-based microscopy cannot provide an integral view of the islet neurovascul...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2699-6
更新日期:2012-12-01 00:00:00
abstract::In order to establish a model for the in vivo assessment of islet function we have used the Rowett nude rat with transplantation of allogeneic and xenogeneic (mouse) islets into the renal subcapsular space following a minimal period of diabetic induction. Thirty-one nude rats were given streptozotocin and 30 became di...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02341509
更新日期:1988-06-01 00:00:00
abstract::There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-013-2929-6
更新日期:2013-09-01 00:00:00
abstract::The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219423
更新日期:1978-04-01 00:00:00
abstract::The concentration of biologically active insulin was measured by the isolated fat cell method in serum and urine from healthy subjects and compared with the concentration of immunoreactive insulin. In both urine and serum the values obtained by the two methods correlated closely; In addition, there was a close correla...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219518
更新日期:1976-10-01 00:00:00
abstract::Diabetic nephropathy is the main cause of increased mortality and morbidity in IDDM patients. The effect of antihypertensive treatment on the progression of the nephropathy is highly variable. The aim of this study was to evaluate putative predictors of the progression in diabetic nephropathy during long-term antihyp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050140
更新日期:1994-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:We assessed secular trends of cardiovascular outcomes following first diagnosis of myocardial infarction (MI) or diabetes in an unselected population. METHODS:All Danish residents aged > or = 30 years without prior diabetes or MI were identified by individual-level linkage of nationwide registers. Indi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1783-z
更新日期:2010-08-01 00:00:00
abstract:AIMS/OBJECTIVE:Nephropathy, a major complication of diabetes, is the leading cause of end-stage renal disease. Recent studies have demonstrated that podocyte injury is involved in the onset of and progression to renal insufficiency. Here, we describe a novel, highly sensitive ELISA for detecting urinary podocalyxin, a ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2661-7
更新日期:2012-11-01 00:00:00
abstract::Immunoelectrophoresis of glomerular basement membrane antigens in the urine of 20 Type 1 (insulin-dependent) diabetic and 10 healthy children was performed. In 10 of the diabetic children, there was altered alpha-1-mobility, while the other diabetic and normal children showed alpha-2-mobility. After incubation with gl...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00254295
更新日期:1982-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with in...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05116-5
更新日期:2020-07-01 00:00:00
abstract::Microencapsulation has been proposed to protect islets of Langerhans against immune rejection in xenogenic transplantation. However, to achieve glucose homeostasis in human diabetic patients, insulin release by microencapsulated islets must increase in response to a glucose load. We microencapsulated isolated rat isle...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00279134
更新日期:1988-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The benefits of moderate alcohol consumption for type 2 diabetes have been postulated to involve a mechanism of improved insulin sensitivity. Fetuin-A, which is known to inhibit insulin signalling, has emerged as a biomarker for diabetes risk. Alcohol consumption may influence circulating fetuin-A conce...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-3077-8
更新日期:2014-01-01 00:00:00