Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment.

abstract：:Lithium exerts an inhibitory effect on glucose-induced insulin release. Lithium (5 mmol/l) added 30 min prior to glucose stimulation or together with glucose (16.7 mmol/l) failed to affect first phase, but reduced second phase glucose-induced insulin release by 35%. Similar results were obtained when islets isolated f...

journal_title：Diabetologia

authors： Fontela T,Garcia Hermida O,Gómez-Acebo J

更新日期：1987-03-01 00:00:00

abstract：:The effect of early antihypertensive treatment on survival of patients with diabetic nephropathy was evaluated by studying two cohorts of Type 1 (insulin-dependent) diabetic patients developing persistent proteinuria in I: 1957-1973 (late treatment group n = 49) and II: 1979-1983 (early treatment group n = 71). At ons...

journal_title：Diabetologia

authors： Mathiesen ER,Borch-Johnsen K,Jensen DV,Deckert T

更新日期：1989-12-01 00:00:00

abstract：:Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, so...

journal_title：Diabetologia

authors： Bowen RE,Swartz FJ

更新日期：1976-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between geneticall...

journal_title：Diabetologia

authors： Larsson SC,Michaëlsson K,Burgess S

更新日期：2020-09-01 00:00:00

abstract：:The effect of a five day pretreatment with phenformin (3 X 50 mg daily) on hepatic metabolism was studied in six healthy volunteers. Arterial and hepatic venous concentrations of substrates and hepatic blood flow were estimated during a basal period and during a low-dose lactate infusion (0,03 mmol . kg-1 . min-1). Th...

journal_title：Diabetologia

authors： Dietze G,Wicklmayr M,Mehnert H,Czempiel H,Henftling HG

更新日期：1978-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes. METHODS:A total of 21 men with Type 1 diabetes were investigated, including 9 men with background retinopathy and 12 men without retinopathy. In addition, 12 non-diabet...

journal_title：Diabetologia

authors： Sundell J,Janatuinen T,Rönnemaa T,Raitakari OT,Toikka J,Nuutila P,Knuuti J

更新日期：2004-04-01 00:00:00

abstract：AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...

journal_title：Diabetologia

authors： Perrini S,Laviola L,Cignarelli A,Melchiorre M,De Stefano F,Caccioppoli C,Natalicchio A,Orlando MR,Garruti G,De Fazio M,Catalano G,Memeo V,Giorgino R,Giorgino F

更新日期：2008-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Paraoxonase is a member of a multigene family of three genes. Paraoxonase2 gene polymorphisms have been associated with coronary heart disease in non-diabetic patients and with an increased fasting glycaemia in patients with Type II (non-insulin-dependent) diabetes mellitus. We tested the hypothesis of ...

journal_title：Diabetologia

authors： Pinizzotto M,Castillo E,Fiaux M,Temler E,Gaillard RC,Ruiz J

更新日期：2001-01-01 00:00:00

abstract：:Insulin resistance of the skeletal muscle plays a key role in the development of the metabolic endocrine syndrome and its further progression to non-insulin dependent diabetes (NIDDM). Available data suggest that insulin resistance is caused by an impaired signal from the insulin receptor to the glucose transport syst...

journal_title：Diabetologia

authors： Häring HU,Kellerer M,Mosthaf L

更新日期：1994-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to compare glycaemic control and maternal-fetal outcomes in women with type 1 diabetes managed on insulin pumps compared with multiple daily injections of insulin (MDI). METHODS:In a retrospective study, glycaemic control and outcomes of 387 consecutive pregnancies in women wi...

journal_title：Diabetologia

authors： Kallas-Koeman MM,Kong JM,Klinke JA,Butalia S,Lodha AK,Lim KI,Duan QM,Donovan LE

更新日期：2014-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes is associated with a high incidence of ischaemic disease and impaired nitric oxide responses. Therefore, the aim of the present study was to assess the effect of nitric oxide on ischaemia/reperfusion (I/R)-induced microvascular responses in an experimental model of diabetes. METHODS:Leucocyte-...

journal_title：Diabetologia

authors： Salas A,Panés J,Rosenbloom CL,Elizalde JI,Anderson DC,Granger DN,Piqué JM

更新日期：1999-11-01 00:00:00

abstract：:N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis, a free radical scavenger and an inhibitor of tumour necrosis factor alpha (TNF). Because these functions might be beneficial in diabetic complications, in this study we examined whether NAC inhibits peripheral neuropathy. Motor nerve conduction velo...

journal_title：Diabetologia

authors： Sagara M,Satoh J,Wada R,Yagihashi S,Takahashi K,Fukuzawa M,Muto G,Muto Y,Toyota T

更新日期：1996-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT(2)R) may modulate key processes linked to atherosclerosis. The aim of this study was to...

journal_title：Diabetologia

authors： Koïtka A,Cao Z,Koh P,Watson AM,Sourris KC,Loufrani L,Soro-Paavonen A,Walther T,Woollard KJ,Jandeleit-Dahm KA,Cooper ME,Allen TJ

更新日期：2010-03-01 00:00:00

abstract：:Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

journal_title：Diabetologia

authors： Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

更新日期：2016-03-01 00:00:00

abstract：:Gender and biological sex impact the pathogenesis of numerous diseases, including metabolic disorders such as diabetes. In most parts of the world, diabetes is more prevalent in men than in women, especially in middle-aged populations. In line with this, considering almost all animal models, males are more likely to d...

journal_title：Diabetologia

authors： Tramunt B,Smati S,Grandgeorge N,Lenfant F,Arnal JF,Montagner A,Gourdy P

更新日期：2020-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:We have examined the effects of streptozotocin-induced type 1 diabetes on the expression and subcellular distribution of the classic sugar transporters (GLUT-1 to 5 and sodium-dependent glucose transporter-1 [SGLT-1]) in the endothelial cells of an en face preparation of septal coronary artery from Wist...

journal_title：Diabetologia

authors： Gaudreault N,Scriven DR,Moore ED

更新日期：2004-12-01 00:00:00

abstract：:The ultrastructure of myocardium was examined in short-term diabetic rats. Morphometric analysis showed the volume of myocytic mitochondria, sarcoplasmic reticulum and lipid droplets to be significantly increased compared with those of control animals. Further measurements of mitochondria and sarcoplasmic reticulum in...

journal_title：Diabetologia

authors： Reinilä A,Akerblom HK

更新日期：1984-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...

journal_title：Diabetologia

authors： Lammi N,Moltchanova E,Blomstedt PA,Tuomilehto J,Eriksson JG,Karvonen M

更新日期：2009-03-01 00:00:00

abstract：:Monolayer cell cultures from pancreatic islets of aging 129/J strain diabetes (db3J/db3J) and lean littermate control mice were tested for differences in glucagon and insulin secretion in either serum-free Eagle's minimal essential medium (MEM) or Dulbecco's modified minimal essential medium (DMEM). There was a highly...

journal_title：Diabetologia

authors： Leiter EH,Strack I,Eisenstein AB

更新日期：1980-07-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...

journal_title：Diabetologia

authors： Miele C,Beguinot F

更新日期：2012-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The effect of renin inhibition on type 2 diabetes is still unclear. The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes. METHODS:Groups of db/db mice, w...

journal_title：Diabetologia

authors： Dong YF,Liu L,Kataoka K,Nakamura T,Fukuda M,Tokutomi Y,Nako H,Ogawa H,Kim-Mitsuyama S

更新日期：2010-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin...

journal_title：Diabetologia

authors： Niersmann C,Carstensen-Kirberg M,Maalmi H,Holleczek B,Roden M,Brenner H,Herder C,Schöttker B

更新日期：2020-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS:We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneou...

journal_title：Diabetologia

authors： Medina A,Parween S,Ullsten S,Vishnu N,Siu YT,Quach M,Bennet H,Balhuizen A,Åkesson L,Wierup N,Carlsson PO,Ahlgren U,Lernmark Å,Fex M

更新日期：2018-04-01 00:00:00

abstract：:Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...

journal_title：Diabetologia

authors： Sakura H,Ashcroft FM

更新日期：1997-05-01 00:00:00

abstract：:For many, the extent to which blood glucose control can be lowered is limited by risk of hypoglycaemia. Hypoglycaemia is feared and carries fiscal, social and medical costs, with risk of death being associated with severe hypoglycaemia in patients with type 2 diabetes at high cardiovascular risk. In this issue of Diab...

journal_title：Diabetologia

authors： Neupane S,Evans ML

更新日期：2015-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Fetal growth is influenced by genetic factors as well as the intra-uterine environment. We hypothesised that some genetic factors may alter fetal insulin secretion and insulin action. SUBJECTS, MATERIALS AND METHODS:To assess this, we analysed plasma insulin concentration in umbilical cord blood from 6...

journal_title：Diabetologia

authors： Shields BM,Knight B,Turner M,Wilkins-Wall B,Shakespeare L,Powell RJ,Hannemann M,Clark PM,Yajnik CS,Hattersley AT

更新日期：2006-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The intestine is the main site for glucose absorption and it has been suggested that it exhibits insulin resistance. Bariatric surgery has been shown to reverse insulin resistance and type 2 diabetes, but its effects on human intestinal metabolism are unknown. Our aim was to evaluate the effects of insu...

journal_title：Diabetologia

authors： Mäkinen J,Hannukainen JC,Karmi A,Immonen HM,Soinio M,Nelimarkka L,Savisto N,Helmiö M,Ovaska J,Salminen P,Iozzo P,Nuutila P

更新日期：2015-05-01 00:00:00

abstract：:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

journal_title：Diabetologia

authors： Henquin JC,Malvaux P,Lambert AE

更新日期：1979-04-01 00:00:00

abstract：:The purpose of this study was to investigate whether young insulin-dependent diabetic patients still develop peripheral nerve dysfunction when using modern multiple insulin injection therapy and to elucidate if this correlated with various disease parameters. Seventy-five patients, 7 to 20 years old with a duration of...

journal_title：Diabetologia

authors： Hyllienmark L,Brismar T,Ludvigsson J

更新日期：1995-06-01 00:00:00

abstract：:The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...

journal_title：Diabetologia

authors： Jones PM,Persaud SJ,Bjaaland T,Pearson JD,Howell SL

更新日期：1992-11-01 00:00:00