Abstract:
:Type I diabetes mellitus may represent a heterogeneous disorder with a distinct pathogenesis in patients with young and adult onset of the disease. To investigate whether serological markers directed to different autoantigens have the potential to distinguish acute onset from slowly progressive Type I diabetes we analysed antibodies to tyrosine phosphatases IA-2/ICA512 (IA-2A) and IA-2beta/phogrin (IA2betaA), antibodies to GAD65 (GADA) and cytoplasmic islet cell antibodies (ICA) in a non-selected group of diabetic patients clinically classified as having Type I or Type II diabetes at diagnosis. Both IA-2A and IA-2betaBA were found to be positively associated with onset before the age of 20 years and the presentation of classical features of Type I diabetes. In Type I diabetes 56 % (112/200) of patients were positive for IA-2A and 38 % (76/200) for IA-2betaA. In contrast, only 1 of 785 (0.1 %) patients with Type II diabetes had IA-2A and all of them were negative for IA-2betaA (p < 0.001). Among the patients with Type II diabetes 7.6% (n = 60) were ICA positive and 2.8% (n = 22) had GADA suggesting the presence of slowly progressive Type I diabetes. GADA were found in 8 of 60 (13.3 %) ICA positive subjects which was lower than the percentage detected in patients with acute onset of diabetes (115/157 73.2%) (p < 0.001). Blocking of double antibody positive sera showed that only 3 of 8 (37.5 %) patients with slowly progressive diabetes had ICA restricted to GAD or IA-2 whereas ICA were completely inhibited in 12 of 20 (60.0 %) patients with Type I diabetes. Among 193 patients with Type II diabetes available for follow-up, 35 % of ICA positives, 58 % of GADA positives and 60 % of those positive for both markers required insulin by 3 years. However, using strict criteria for the switch to insulin treatment the corresponding sensitivity of each marker was only low (9%, 10% and 5%). We show that clinical subtypes of Type I diabetes are associated with distinct humoral autoimmunity. IA-2A and GADA were associated with classical features of Type I diabetes whereas GADA and an uncharacterized ICA subspecificity indicate slowly progressive disease.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Seissler J,de Sonnaville JJ,Morgenthaler NG,Steinbrenner H,Glawe D,Khoo-Morgenthaler UY,Lan MS,Notkins AL,Heine RJ,Scherbaum WAdoi
10.1007/s001250051004subject
Has Abstractpub_date
1998-08-01 00:00:00pages
891-7issue
8eissn
0012-186Xissn
1432-0428journal_volume
41pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:The process of islet isolation can cause chemical and mechanical injury to beta cells. In addition, hyperglycaemia after islet transplantation can compromise beta cell function. The aim of this experiment was to evaluate changes in gene expression in endogenous islets using laser-capture microdissection...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0536-5
更新日期:2007-02-01 00:00:00
abstract::The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (ser...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00252627
更新日期:1981-03-01 00:00:00
abstract::Using a prospective randomised double-blind crossover design, the effect of the angiotensin converting enzyme inhibitor enalapril compared to a placebo was studied in 18 normotensive, normoalbuminuric Type 1 (insulin-dependent) diabetic children. Each patient had a high normal or clearly elevated glomerular filtration...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00285294
更新日期:1989-04-01 00:00:00
abstract::Overall D-glucose metabolism and 3-0-methylglucose transport were measured in the perfused heart preparation of lean and genetically obese (fa/fa) rats. Absolute values of basal and insulin-stimulated glucose metabolism were decreased in hearts of 15-week-old obese rats when compared to lean age-matched controls. Basa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00284464
更新日期:1983-12-01 00:00:00
abstract::To study the effect of E. Coli L-asparaginase on glucose tolerance and insulin release, 6 patients with neoplastic disease were subjected to 3 hour oral glucose tolerance tests with simultaneous measurement of serum immunoreactive insulin (IRI) levels before and following the intravenous administration of 5000 I. U. L...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00422255
更新日期:1978-08-01 00:00:00
abstract::In sham-operated rats, intravenous administration of 14C-very low density lipoprotein triglycerides (with labelled esterified fatty acids) caused an initial decrease and subsequent increase in plasma 14C-lipids of both very low density lipoproteins (VLDL) (density less than 1.006) and lipoproteins of density greater t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282718
更新日期:1983-04-01 00:00:00
abstract::We examined changes in guanosine triphosphate-dependent signal transduction mechanisms in the retina from the early stages of the streptozotocin-diabetic rat, a model for Type 1 (insulin-dependent) diabetes mellitus. Guanosine triphosphate binding, guanosine triphosphatase activity, and binding of (azido) guanosine tr...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400253
更新日期:1992-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mitochondrial dysfunction has been postulated to underlie muscular fat accumulation, leading to muscular insulin sensitivity and ultimately type 2 diabetes mellitus. Here we re-interpret previously published data on [(13)C]acetate recovery in breath gas obtained during exercise in type 2 diabetic patien...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1069-x
更新日期:2008-09-01 00:00:00
abstract::The immune response of diabetic patients to influenza vaccination was examined in 31 patients, 10 with Type 1 (insulin-dependent) diabetes and 21 with Type 2 (non-insulin-dependent diabetes), and in 19 normal subjects. Each received a single intramuscular injection of the 3 virus strains (A/Chile,A/Philippines,B/USSR)...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00870139
更新日期:1986-12-01 00:00:00
abstract::The incidence, sex, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus (j.i.d.m.) were studied retrospectively on one third of the Danish population 1970-1974. The j.i.d.m. incidence remained fairly constant during the study period, the average being 13.2 per 100000 per year. The ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01223266
更新日期:1977-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Knowledge of the within-subject variability of a parameter is required to properly design and calculate sample sizes for longitudinal studies. We sought to determine the day-to-day variability of measures of beta cell function derived from an OGTT. METHODS:Thirty-seven adults (13 with normal glucose to...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-007-0819-5
更新日期:2007-12-01 00:00:00
abstract::The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sul...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01234506
更新日期:1977-09-01 00:00:00
abstract::The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276965
更新日期:1984-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes is characterised by progressive loss of pancreatic beta cell mass and function. Therefore, it is of therapeutic interest to identify factors with the potential to improve beta cell proliferation and insulin secretion. Bone morphogenetic protein 4 (BMP4) expression is increased in diabeti...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3568-x
更新日期:2015-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:No previous studies on the association between salt intake and the risk of type 2 diabetes have been reported. The aim of this study was to assess whether high salt intake, measured by 24-h urinary sodium excretion, is an independent risk factor for type 2 diabetes. METHODS:We followed prospectively 93...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1824-1
更新日期:2005-08-01 00:00:00
abstract::Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused b...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00422820
更新日期:1975-02-01 00:00:00
abstract::Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051072
更新日期:1998-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Microvascular endothelial hyperpermeability, mainly caused by claudin-5 deficiency, is the initial pathological change that occurs in diabetes-associated cardiovascular disease. The ketone body β-hydroxybutyrate (BHB) exerts unique beneficial effects on the cardiovascular system, but the involvement of ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05305-2
更新日期:2021-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two trainin...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-007-0783-0
更新日期:2007-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Beta cells situated in the islet of Langerhans respond more vigorously to glucose than do dissociated beta cells. Mechanisms for this discrepancy were studied by comparing insulin-producing MIN6 cells aggregated into pseudoislets with MIN6 monolayer cells and mouse and human islets. METHODS:MIN6 monola...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2903-3
更新日期:2013-07-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) in the gut-brain-pancreatic axis are key players in the postprandial control of metabolism and food intake. A number of intestinally located receptors have been implicated in the chemo-detection of ingested nutrients, and in the pancreatic islets and nervous system GPCRs play essent...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-015-3825-z
更新日期:2016-02-01 00:00:00
abstract::The activation of glycogen synthase after addition of glucose to isolated hepatocytes became impaired in BB rats after the development of insulin-dependent diabetes. This defect was associated with a decreased hepatic synthase phosphatase activity. Both features correspond closely to previous observations on alloxan-d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00278757
更新日期:1988-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Although insulin resistance has been associated with accumulations of specific intramuscular fatty acids and altered subcellular localisation of lipid droplets, these concepts remain controversial. Therefore, we aimed to identify specific intramuscular fatty acids and subcellular lipid localisations ass...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3169-0
更新日期:2014-04-01 00:00:00
abstract::The effect of the alpha-glucosidase inhibitor acarbose on postprandial hyperglycaemia was explored in the spontaneously diabetic BB/W-rat. Acarbose-treatment (5 mg.kg body weight-1.day-1) of diabetic BB/W-rats maintained on small doses of insulin, was associated with a 40% reduction in the 24-h glucose area compared t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401199
更新日期:1992-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:It has been recently shown that glycated human haemoglobin induces endothelial dysfunction in rat vessels by generating superoxide anions that interfere with nitric oxide mediated responses. Our study analysed the effect of glycated human haemoglobin on the endothelium-dependent relaxations of human ves...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050011
更新日期:2000-01-01 00:00:00
abstract::Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00587632
更新日期:1991-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3423-5
更新日期:2015-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to compare developments in the utilisation of antihyperglycaemic drugs (AHGDs) in ten European countries. SUBJECTS AND METHODS:Data on the yearly utilisation of insulin and oral AHGDs were collected from public registers in Denmark, Finland, Norway, Sweden, Belgium, England, G...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0331-3
更新日期:2006-09-01 00:00:00
abstract::Glucose-induced insulin secretion is impaired in the presence of chronic hyperglycaemia. Insulin secretion was studied in a diabetic rat model prior to the beta cells becoming non-responsive to glucose in order to map out the sequence of changes that accompany chronic hyperglycaemia. In vitro pancreas perfusions were ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400800
更新日期:1993-12-01 00:00:00
abstract::Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050711
更新日期:1997-05-01 00:00:00