Abstract:
:Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Ziegler M,Hahn HJ,Ziegler B,Köhler E,Fiedler Hdoi
10.1007/BF00422820subject
Has Abstractpub_date
1975-02-01 00:00:00pages
63-9issue
1eissn
0012-186Xissn
1432-0428journal_volume
11pub_type
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