Paradoxical glucagon response after stimulation with glucose and arginine in isolated pancreatic sand rat islets.


:Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.






Ziegler M,Hahn HJ,Ziegler B,Köhler E,Fiedler H




Has Abstract


1975-02-01 00:00:00












  • Treatment of diabetes mellitus.

    abstract::New treatment strategies for subjects with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus are being developed. Pilot studies utilising insulin itself have been reported to prevent Type 1 diabetes in subjects likely, by immunogenetic and physiologic criteria, to develop clinically overt...


    pub_type: 杂志文章,评审


    authors: Robertson RP,Klein DJ

    更新日期:1992-12-01 00:00:00

  • SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion.

    abstract:AIMS:The gene SLC2A2 encodes GLUT2, which is found predominantly in pancreas, liver, kidney and intestine. In mice, GLUT2 is the major glucose transporter into pancreatic beta cells, and biallelic Slc2a2 inactivation causes lethal neonatal diabetes. The role of GLUT2 in human beta cells is controversial, and biallelic ...


    pub_type: 杂志文章


    authors: Sansbury FH,Flanagan SE,Houghton JA,Shuixian Shen FL,Al-Senani AM,Habeb AM,Abdullah M,Kariminejad A,Ellard S,Hattersley AT

    更新日期:2012-09-01 00:00:00

  • Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice.

    abstract:AIMS/HYPOTHESIS:High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormonal responses, particularly glucose-dependent...


    pub_type: 杂志文章


    authors: Keyhani-Nejad F,Irmler M,Isken F,Wirth EK,Beckers J,Birkenfeld AL,Pfeiffer AF

    更新日期:2015-02-01 00:00:00

  • Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L.

    abstract:AIMS/HYPOTHESIS:We previously reported that exposure to antibodies neutralising serpin B13, a protease inhibitor expressed in exocrine pancreatic ducts, promotes beta cell proliferation, underscoring the importance of a functional relationship between exocrine and endocrine pancreas. The aim of the present study was to...


    pub_type: 杂志文章


    authors: Lo CW,Kryvalap Y,Sheu TJ,Chang CH,Czyzyk J

    更新日期:2019-05-01 00:00:00

  • Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...


    pub_type: 杂志文章


    authors: Lutgers HL,Gerrits EG,Graaff R,Links TP,Sluiter WJ,Gans RO,Bilo HJ,Smit AJ

    更新日期:2009-05-01 00:00:00

  • The direct effect of hypoglycaemic sulphonylureas on myocardial contractile force and arterial blood pressure.

    abstract::The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sul...


    pub_type: 杂志文章


    authors: Pogátsa G,Dubecz E

    更新日期:1977-09-01 00:00:00

  • Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.

    abstract:AIMS/HYPOTHESIS:The mechanisms by which transcription factor 7-like 2 (TCF7L2) regulates the pathways that are important in the pathogenesis of type 2 diabetes are unknown. We therefore examined the role of TCF7L2 in hepatic glucose production (HGP) in vitro and characterised the whole-genome chromatin occupancy of TCF...


    pub_type: 杂志文章


    authors: Norton L,Fourcaudot M,Abdul-Ghani MA,Winnier D,Mehta FF,Jenkinson CP,Defronzo RA

    更新日期:2011-12-01 00:00:00

  • Insulin receptor substrate-1 gene mutations in NIDDM; implications for the study of polygenic disease.

    abstract::Variations in the coding regions of the insulin receptor substrate-1 (IRS-1) gene have recently been suggested to contribute to the susceptibility of non-insulin-dependent diabetes mellitus (NIDDM). The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) an...


    pub_type: 杂志文章


    authors: Hitman GA,Hawrami K,McCarthy MI,Viswanathan M,Snehalatha C,Ramachandran A,Tuomilehto J,Tuomilehto-Wolf E,Nissinen A,Pedersen O

    更新日期:1995-04-01 00:00:00

  • Elevated von Willebrand factor antigen predicts deterioration in diabetic peripheral nerve function.

    abstract::We have studied the temporal relationship of plasma von Willebrand Factor (vWF), a marker of endothelial damage, with the development of complications in 63 young diabetic patients (56 of whom were insulin-dependent) who took part in a prospective study. Results are presented from baseline to follow-up. In the group a...


    pub_type: 杂志文章


    authors: Plater ME,Ford I,Dent MT,Preston FE,Ward JD

    更新日期:1996-03-01 00:00:00

  • Reduction of plasma 1,5-anhydroglucitol (1-deoxyglucose) concentration in diabetic patients.

    abstract::The plasma concentration of 1,5-anhydro-D-glucitol(AG)(1-deoxyglucose) is known to decrease in diabetic patients. In order to evaluate the usefulness of this polyol as a diabetic marker, we examined the specificity of the plasma AG reduction in various diseases: the plasma AG level was determined in 108 newly diagnose...


    pub_type: 杂志文章


    authors: Yamanouchi T,Akanuma H,Nakamura T,Akaoka I,Akanuma Y

    更新日期:1988-01-01 00:00:00

  • A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.

    abstract:AIMS/HYPOTHESIS:HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) have been associated with type 1 diabetes...


    pub_type: 杂志文章


    authors: Howson JM,Dunger DB,Nutland S,Stevens H,Wicker LS,Todd JA

    更新日期:2007-04-01 00:00:00

  • The effects of a specific growth hormone antagonist on overnight insulin requirements and insulin sensitivity in young adults with Type 1 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:Growth hormone hypersecretion in Type 1 diabetes could exacerbate insulin resistance and contribute to declining glycaemic control. Our aim was to determine the effects of specific growth hormone blockade on insulin sensitivity and lipolysis in young adults with Type 1 diabetes. METHODS:We studied the ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Williams RM,Amin R,Shojaee-Moradie F,Umpleby AM,Acerini CL,Dunger DB

    更新日期:2003-09-01 00:00:00

  • Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells.

    abstract:AIMS/HYPOTHESIS:A common G to A polymorphism ( UCSNP-43) in the Calpain 10 gene was recently found to be associated with Type II (non-insulin-dependent) diabetes mellitus and variations in post-absorptive and insulin stimulated glucose metabolism in vivo. We aimed to study the influence of Calpain 10 polymorphism on in...


    pub_type: 杂志文章


    authors: Hoffstedt J,Rydén M,Löfgren P,Orho-Melander M,Groop L,Arner P

    更新日期:2002-02-01 00:00:00

  • A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker.

    abstract:AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...


    pub_type: 杂志文章


    authors: Flamez D,Roland I,Berton A,Kutlu B,Dufrane D,Beckers MC,De Waele E,Rooman I,Bouwens L,Clark A,Lonneux M,Jamar JF,Goldman S,Maréchal D,Goodman N,Gianello P,Van Huffel C,Salmon I,Eizirik DL

    更新日期:2010-07-01 00:00:00

  • Lipoprotein-associated phospholipase A(2) and future risk of subclinical disease and cardiovascular events in individuals with type 2 diabetes: the Cardiovascular Health Study.

    abstract:AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...


    pub_type: 杂志文章


    authors: Nelson TL,Kamineni A,Psaty B,Cushman M,Jenny NS,Hokanson J,Furberg C,Mukamal KJ

    更新日期:2011-02-01 00:00:00

  • Tubular lesions in streptozotocin-diabetic rats.

    abstract::Renal tubular lesions have been studied in streptozotocin-diabetic rats after 50 days of diabetes and compared with age-matched controls. The kidney weight increased by 67% in the diabetic animals and the length of the proximal tubules increased by 22%, but no abnormalities were found. The length of the distal tubules...


    pub_type: 杂志文章


    authors: Rasch R

    更新日期:1984-07-01 00:00:00

  • The high prevalence of diabetes mellitus on a Central Pacific Island.

    abstract::A diabetes prevalence study on an isolated urbanized Central Pacific Island has established a prevalence rate of 34.4% in individuals aged 15 years and over. Of these, 10.4% had previously known diabetes; in the others the diagnosis was made on the basis of a plasma glucose level of at least 160 mg/100 ml 2h after a 7...


    pub_type: 杂志文章


    authors: Zimmet P,Taft P,Guinea A,Guthrie W,Thoma K

    更新日期:1977-04-01 00:00:00

  • Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity.

    abstract:AIMS/HYPOTHESIS:This study was aimed at the elucidation of the pathogenesis of glucotoxicity, i.e. the mechanism whereby hyperglycaemia damages pancreatic beta cells. The identification of pathways in the process may help identify targets for beta cell-protective therapy. Carbohydrate response element-binding protein (...


    pub_type: 杂志文章


    authors: Poungvarin N,Lee JK,Yechoor VK,Li MV,Assavapokee T,Suksaranjit P,Thepsongwajja JJ,Saha PK,Oka K,Chan L

    更新日期:2012-06-01 00:00:00

  • Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two trainin...


    pub_type: 杂志文章,随机对照试验


    authors: Eriksen L,Dahl-Petersen I,Haugaard SB,Dela F

    更新日期:2007-11-01 00:00:00

  • Effect of advanced glycation end products on oxidative stress in endothelial cells in culture: a warning on the use of cells studied in serum-free media.

    abstract:AIMS/HYPOTHESIS:Alterations in vascular permeability and oxidative stress are characteristics of endothelial dysfunction in diabetic vascular disease. Since AGE-proteins have been hypothesized to mediate these effects, we studied the effects of AGE-bovine serum albumin on endothelial monolayer permeability and intracel...


    pub_type: 杂志文章


    authors: Hui YY,McAmis WC,Baynes JW,Schaeffer RC Jr,Wolf MB

    更新日期:2001-10-01 00:00:00

  • Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids.

    abstract:AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. Whether this downregulation is a cause or effect o...


    pub_type: 杂志文章


    authors: Hoeks J,Hesselink MK,Russell AP,Mensink M,Saris WH,Mensink RP,Schrauwen P

    更新日期:2006-10-01 00:00:00

  • Marine lipids normalize cholesteryl ester transfer in IDDM.

    abstract::Patients with insulin-dependent diabetes mellitus (IDDM) have a pathological increase in cholesteryl ester transfer (CET) that enriches the apolipoprotein B-containing lipoproteins with cholesteryl ester and increases their atherogenicity. Since we have shown earlier that omega-3 (n-3) fatty acids present in marine li...


    pub_type: 杂志文章


    authors: Bagdade JD,Ritter M,Subbaiah PV

    更新日期:1996-04-01 00:00:00

  • Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats.

    abstract:AIMS/HYPOTHESIS:Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS:We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneou...


    pub_type: 杂志文章


    authors: Medina A,Parween S,Ullsten S,Vishnu N,Siu YT,Quach M,Bennet H,Balhuizen A,Åkesson L,Wierup N,Carlsson PO,Ahlgren U,Lernmark Å,Fex M

    更新日期:2018-04-01 00:00:00

  • Increased energy expenditure in poorly controlled Type 1 (insulin-dependent) diabetic patients.

    abstract::The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042 +/- 62 kcal/24 h) was found to be significantly higher than the 1774 +/- 52 kcal/24 h predicted from their age, sex and body surface area (p less than 0.01). Intravenous insulin treatment significantly reduced ener...


    pub_type: 杂志文章


    authors: Nair KS,Halliday D,Garrow JS

    更新日期:1984-07-01 00:00:00

  • Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes.

    abstract:AIMS/HYPOTHESIS:This study aimed to elucidate the mechanism of increased proliferation of alpha cells in recent-onset type 1 diabetes. Pancreatic beta cells express GAD and produce γ-aminobutyric acid (GABA), which inhibits alpha cell secretion of glucagon. We explored the roles of GABA in alpha cell proliferation in c...


    pub_type: 杂志文章


    authors: Feng AL,Xiang YY,Gui L,Kaltsidis G,Feng Q,Lu WY

    更新日期:2017-06-01 00:00:00

  • Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats.

    abstract::Glycation of long-lived proteins is an inevitable consequence of aging that is accelerated in patients with diabetes mellitus. Treatment of demineralized bone matrix particles from 35-week-old normal Long-Evans rats with glycoaldehyde, a precursor of advanced glycation end-products, was used to assess the effects of b...


    pub_type: 杂志文章


    authors: Fong Y,Edelstein D,Wang EA,Brownlee M

    更新日期:1993-09-01 00:00:00

  • Markers of renal tubular dysfunction measured annually do not predict risk of microalbuminuria in the first few years after diagnosis of Type I diabetes.

    abstract:AIMS/HYPOTHESIS:Early detection of risk of microalbuminuria could prevent early renal damage. We investigated whether urine retinol binding protein and N-acetyl-glucosaminidase could predict the risk of microalbuminuria in a large cohort of children followed from diagnosis of Type I (insulin-dependent) diabetes mellitu...


    pub_type: 杂志文章


    authors: Schultz CJ,Dalton RN,Neil HA,Konopelska-Bahu T,Dunger DB,Oxford Regional Prospective Study Group.

    更新日期:2001-02-01 00:00:00

  • Effects of alloxan on glucose-stimulated insulin secretion, glucose metabolism, and cyclic adenosine 3', 5'-monophosphate levels in rat isolated islets of langerhans.

    abstract::Insulin secretion was stimulated and cyclic adenosine 3', 5'-monophosphate (cAMP) levels were elevated in isolated rat islets by 27.5 mmol/l glucose. Alloxan caused a dose-dependent decrease in both variables with complete obliteration of insulin release at a concentration of 1.25 mmol/l. D-glucose, in the presence or...


    pub_type: 杂志文章


    authors: Zawalich WS,Karl RC,Matschinsky FM

    更新日期:1979-02-01 00:00:00

  • Phosphoenolpyruvate in rat pancreatic islets: a possible intracellular trigger of insulin release?

    abstract::The content of phosphoenolpyruvate (PEP) has been measured in isolated rat islets of Langerhans incubated in vitro. Islet PEP was higher in islets incubated with 16.7 mmol/1 glucose than in islets incubated with zero or 2.8 mmol/1 glucose. Islet PEP content was also increased in islet incubated with 5 mmol/1 D-glycera...


    pub_type: 杂志文章


    authors: Sugden MC,Ashcroft SJ

    更新日期:1977-09-01 00:00:00

  • The insulin dilemma in resource-limited countries. A way forward?

    abstract::The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...


    pub_type: 杂志文章


    authors: Gill GV,Yudkin JS,Keen H,Beran D

    更新日期:2011-01-01 00:00:00