Abstract:
:The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sulphonylureas develops without the mediation of glucagon, insulin or adrenaline. Contrary to the other investigated sulphonylureas, glibenclamide reduced myocardial contractile force and arterial blood pressure.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Pogátsa G,Dubecz Edoi
10.1007/BF01234506subject
Has Abstractpub_date
1977-09-01 00:00:00pages
515-9issue
5eissn
0012-186Xissn
1432-0428journal_volume
13pub_type
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