Functional differences between aggregated and dispersed insulin-producing cells.

abstract：:This study aimed at evaluating the influence of furosemide upon insulin and glucagon responses to arginine in healthy subjects. For this purpose, six normal subjects received two consecutive arginine pulses (3 g), 60 min apart, before and after the administration of furosemide (40 mg, IV). The acute insulin response (...

journal_title：Diabetologia

authors： Giugliano D,Torella R,Sgambato S,D'Onofrio F

更新日期：1980-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Chronic hyperglycaemia in patients with Type II (non-insulin-dependent) diabetes mellitus often leads to a decline in glucose-responsive insulin secretion from pancreatic beta cells, a phenomenon called glucose toxicity. Upon hyperglycaemia, glycation reaction occurs in the beta cells and induces oxidat...

journal_title：Diabetologia

authors： Kajimoto Y,Matsuoka T,Kaneto H,Watada H,Fujitani Y,Kishimoto M,Sakamoto K,Matsuhisa M,Kawamori R,Yamasaki Y,Hori M

更新日期：1999-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). METHODS:The stud...

journal_title：Diabetologia

authors： Cho YM,Kim TH,Lim S,Choi SH,Shin HD,Lee HK,Park KS,Jang HC

更新日期：2009-02-01 00:00:00

abstract：:T cells taken from normal rats treated with an exogenous source of bacterial superantigen in vivo specifically failed to proliferate following re-stimulation with the same superantigen in vitro. Responsiveness was restored following the addition of an exogenous source of interleukin-2 indicating that the T cells had b...

journal_title：Diabetologia

authors： Sellins KS,Gold DP,Bellgrau D

更新日期：1996-01-01 00:00:00

abstract：:Measurement of insulin autoantibodies (IAA) with a novel micro radiobinding assay which requires only 20 microl of serum was compared with that in a conventional radiobinding assay which uses 600 microl of serum. IAA were measured with both assays in samples from 94 new onset insulin-dependent diabetes mellitus (IDDM)...

journal_title：Diabetologia

authors： Naserke HE,Dozio N,Ziegler AG,Bonifacio E

更新日期：1998-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to assess the risk factors for diabetes mellitus, by age and sex in Canada and to recommend prevention and control strategies. METHODS:This study was based on the Canadian 1996-1997 National Population Health Survey which comprised 69 494 participants aged 12 years and over. The prevalence of ...

journal_title：Diabetologia

authors： Choi BC,Shi F

更新日期：2001-10-01 00:00:00

abstract：:Immunoelectrophoresis of glomerular basement membrane antigens in the urine of 20 Type 1 (insulin-dependent) diabetic and 10 healthy children was performed. In 10 of the diabetic children, there was altered alpha-1-mobility, while the other diabetic and normal children showed alpha-2-mobility. After incubation with gl...

journal_title：Diabetologia

authors： Schober E,Pollak A,Coradello H,Lubec G

更新日期：1982-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to assess the predictive role of autonomic reactivity in body weight loss induced by gastric bypass. METHODS:A group of 22 morbidly obese subjects, who were due to undergo a gastric bypass, were submitted, before surgery, to a euglycaemic-hyperinsulinaemic clamp, during which ...

journal_title：Diabetologia

authors： Bobbioni-Harsch E,Sztajzel J,Barthassat V,Lehmann TN,Sievert K,Chassot G,Huber O,Morel P,Golay A,Assimacopoulos-Jeannet F

更新日期：2005-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes. METHODS:We used data from the Nurses' Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazard...

journal_title：Diabetologia

authors： Farland LV,Degnan WJ,Harris HR,Tobias DK,Missmer SA

更新日期：2021-01-05 00:00:00

abstract：AIMS/HYPOTHESIS:An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not pro...

journal_title：Diabetologia

authors： Finken MJ,Keijzer-Veen MG,Dekker FW,Frölich M,Hille ET,Romijn JA,Wit JM,Dutch POPS-19 Collaborative Study Group.

更新日期：2006-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. METHOD...

journal_title：Diabetologia

authors： Nakajou K,Horiuchi S,Sakai M,Haraguchi N,Tanaka M,Takeya M,Otagiri M

更新日期：2005-02-01 00:00:00

abstract：:We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurif...

journal_title：Diabetologia

authors： Grasso G,Frittitta L,Anello M,Russo P,Sesti G,Trischitta V

更新日期：1995-01-01 00:00:00

abstract：:Using 3H-thymidine labeling techniques, we found that rates of DNA synthesis in islet cells doubled when mouse pancreatic islets were cultured for 1 week with 10 mmol/l nicotinamide, a potent poly(ADP-ribose) synthetase inhibitor. Culture with nicotinamide partially inhibited glucose-stimulated insulin release, wherea...

journal_title：Diabetologia

authors： Sandler S,Andersson A

更新日期：1986-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Measurement of plasma apolipoprotein (Apo) B may improve prediction of cardiovascular risk, as it provides a measure of the total number of atherogenic particles. The aim of this population-based study was to compare the association of non-HDL-cholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascu...

journal_title：Diabetologia

authors： Bruno G,Merletti F,Biggeri A,Bargero G,Prina-Cerai S,Pagano G,Cavallo-Perin P

更新日期：2006-05-01 00:00:00

abstract：:The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulin-dependent) diabetes mellitus over the period 1968-1982. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. ...

journal_title：Diabetologia

authors： Ostbye T,Welby TJ,Prior IA,Salmond CE,Stokes YM

更新日期：1989-08-01 00:00:00

abstract：:Insulin release and 86Rb efflux were studied in perifused rat islets exposed in vitro to alloxan (2 mmol/l) for 5 min. At a low glucose concentration, alloxan transiently increased 86Rb efflux. Alloxan immediately and completely abolished the secretory response to glucose (15 mmol/l) and markedly delayed the reduction...

journal_title：Diabetologia

authors： Henquin JC,Malvaux P,Lambert AE

更新日期：1979-04-01 00:00:00

abstract：:Zinc transporter 8 (ZnT8), a protein highly specific to pancreatic insulin-producing beta cells, is vital for the biosynthesis and secretion of insulin. ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies. In combination with autoantibodies to several other i...

journal_title：Diabetologia

authors： Williams CL,Long AE

更新日期：2019-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

journal_title：Diabetologia

authors： Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

更新日期：2020-11-26 00:00:00

abstract：:Forearm perfusion studies were carried out to determine the responsiveness to insulin of the superficial forearm tissues in non-obese Type 2 (non-insulin-dependent) diabetics, and the interrelationships among plasma concentrations of glucose, insulin and non-esterified fatty acids (NEFA), tissue uptake of glucose and ...

journal_title：Diabetologia

authors： Kalant N,Leibovici D,Fukushima N,Kuyumjian J,Ozaki S

更新日期：1982-04-01 00:00:00

abstract：:Rat pups delivered by caesarian section one day before term, either remained attached to (experimental group) or were separated from their placenta (control group). Both groups were transferred into an incubator and their metabolic parameters studied. In the control group, plasma amino acid concentration fell from 11....

journal_title：Diabetologia

authors： Sodoyez-Goffaux F,Sodoyez JC,De Vos CJ

更新日期：1981-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Somatostatin from islet delta cells inhibits insulin and glucagon secretion, but knowledge of the regulation of pancreatic somatostatin release is limited. Some insulin secretagogues stimulate somatostatin secretion, and here we investigated whether delta cell secretory responses are indirectly regulate...

journal_title：Diabetologia

authors： Hauge-Evans AC,Anderson RL,Persaud SJ,Jones PM

更新日期：2012-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetes promotes cerebral neovascularisation via increased vascular endothelial growth factor (VEGF) angiogenic signalling. Roundabout-4 (ROBO4) protein is an endogenous inhibitor of VEGF signalling that stabilises the vasculature. Yet, how diabetes affects ROBO4 function remains unknown. We hypothesis...

journal_title：Diabetologia

authors： Abdelsaid M,Coucha M,Hafez S,Yasir A,Johnson MH,Ergul A

更新日期：2017-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:White cell count has been shown to predict incident type 2 diabetes, but differential white cell count has received scant attention. We examined the risk of developing diabetes associated with differential white cell count and neutrophil:lymphocyte ratio and the effect of insulin sensitivity and subclin...

journal_title：Diabetologia

authors： Lorenzo C,Hanley AJ,Haffner SM

更新日期：2014-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most other global populations. The aim of the present study was to assess the...

journal_title：Diabetologia

authors： Hanson RL,Safabakhsh S,Curtis JM,Hsueh WC,Jones LI,Aflague TF,Duenas Sarmiento J,Kumar S,Blackburn NB,Curran JE,Mahkee D,Baier LJ,Knowler WC,Nelson RG

更新日期：2019-09-01 00:00:00

abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...

journal_title：Diabetologia

authors： Humphriss DB,Stewart MW,Berrish TS,Barriocanal LA,Trajano LR,Ashworth LA,Brown MD,Miller M,Avery PJ,Alberti KG,Walker M

更新日期：1997-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. METHODS:Male par...

journal_title：Diabetologia

authors： Broekhuizen LN,Lemkes BA,Mooij HL,Meuwese MC,Verberne H,Holleman F,Schlingemann RO,Nieuwdorp M,Stroes ES,Vink H

更新日期：2010-12-01 00:00:00

abstract：:High levels of gluconeogenic precursors have been reported in patients with long-term diabetes secondary to total pancreatectomy. In the present study, blood concentrations of alanine, lactate and pyruvate were measured in six patients undergoing total pancreatectomy and in nine control subjects undergoing major abdom...

journal_title：Diabetologia

authors： Del Prato S,Vigili de Kreutzenberg S,Trevisan R,Duner E,Avogaro A,Nosadini R,Baccaglini U,Tremolada C,Tiengo A

更新日期：1985-05-01 00:00:00

abstract：:The prevalence of diabetes mellitus in 3,145 Tanzanian Africans living in three different areas of the country was studied. Fasting capillary blood glucose concentrations were measured by Dextrometer and if the levels were greater than or equal to 5.5 mmol/l an oral glucose tolerance test was performed. When using the...

journal_title：Diabetologia

authors： Ahrén B,Corrigan CB

更新日期：1984-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with traditional cardiovascular risk factors and incident cardiovascular events in older people with type 2 diabetes. METHODS:In the prospective phase of the Edinburgh Type 2 Diabetes Study,...

journal_title：Diabetologia

authors： Price AH,Welsh P,Weir CJ,Feinkohl I,Robertson CM,Morling JR,McLachlan S,Strachan MW,Sattar N,Price JF

更新日期：2014-12-01 00:00:00

abstract：AIM/HYPOTHESIS:Single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase 1B gene (PTPN1) have been reported to be associated with type 2 diabetes in white subjects, and insulin sensitivity and fasting glucose levels in Hispanic Americans. In this study, we determined whether SNPs in PTPN1 also have a r...

journal_title：Diabetologia

authors： Traurig M,Hanson RL,Kobes S,Bogardus C,Baier LJ

更新日期：2007-05-01 00:00:00