Abstract:
:T cells taken from normal rats treated with an exogenous source of bacterial superantigen in vivo specifically failed to proliferate following re-stimulation with the same superantigen in vitro. Responsiveness was restored following the addition of an exogenous source of interleukin-2 indicating that the T cells had been made functionally tolerant and not deleted. While staphylococcal enterotoxin treatment of normal rats virtually abolished T-cell proliferation to the same enterotoxin in vitro, T cells from similarly treated diabetes-prone Biobreeding (BB-DP) rats were markedly resistant to this in vivo effect. Responses in BB-DP rats were never reduced by more than 50% even when a 4 times more effective dose of enterotoxin was employed. The resistance of BB-DP peripheral T cells to staphylococcal enterotoxin-induced tolerance could not be attributed to differences in T-cell receptor V beta chain family usage of BB-DP vs normal T cells but was associated with qualitative differences in the way in which BB-DP T cells responded to staphylococcal enterotoxins in vitro. While under optimal stimulatory conditions BB-DP T-cell proliferative responses to staphylococcal enterotoxins appeared comparable to those from non-diabetes-prone animals, under superoptimal conditions BB-DP, but not diabetes-resistant, donor T-cell proliferative responses to staphylococcal enterotoxins could be blocked in vitro with antibodies to CD4 antigens. In addition, BB-DP T-cell proliferative responses were more sensitive to suboptimal staphylococcal enterotoxin doses in vitro. We discuss ways in which abnormal BB-DP T-cell responses to superantigens in general and resistance to staphylococcal enterotoxin-mediated tolerance induction in particular may play a role in the generation of a peripheral T-cell repertoire prone to autoimmunity.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Sellins KS,Gold DP,Bellgrau Ddoi
10.1007/BF00400410subject
Has Abstractpub_date
1996-01-01 00:00:00pages
28-36issue
1eissn
0012-186Xissn
1432-0428journal_volume
39pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1149-x
更新日期:2003-08-01 00:00:00
abstract::We examined glomerular basement membrane anionic site distribution identified by cationic gold in seven patients with insulin-dependent and four patients with non-insulin-dependent diabetes mellitus, presenting a spectrum of clinical and glomerular changes. Anionic sites were investigated by pretreatment of tissue wit...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400607
更新日期:1995-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Endothelial-endocrine cell interactions and vascular endothelial growth factor (VEGF)-A signalling are deemed essential for maternal islet vascularisation, glucose control and beta cell expansion during mouse pregnancy. The aim of this study was to assess whether pregnancy-associated beta cell expansion...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4243-1
更新日期:2017-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased oxidative-nitrosative stress, poly(ADP-ribose) polymerase (PARP) activation and subsequent cellular damage play important roles in the complications of both diabetes mellitus and pregnancy. Our aim was to investigate nitrative stress and PARP activity levels during normal and gestational diabe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1435-3
更新日期:2009-09-01 00:00:00
abstract::The M variant of encephalomyocarditis virus (EMC) produces a disease similar to human insulin-dependent diabetes mellitus in some but not all strains of mice. This diabetogenic M variant was found to induce fivefold more interferon than non-diabetogenic strains of EMC in cultures of mouse L 929 fibroblasts. When inter...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00275945
更新日期:1983-01-01 00:00:00
abstract::Cyclic adenosine 5'diphosphate-ribose (cADPR) is thought to have a second messenger role in insulin secretion through mobilisation of Ca2+. As human lymphocyte antigen CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activity, it may be important in glucose-induced insulin secretion in islets. Thirty one randomly...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051026
更新日期:1998-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia during pregnancy are poorly understood. We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs l...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-011-2363-6
更新日期:2012-02-01 00:00:00
abstract::Five healthy volunteers and 6 diabetics were given a mixed test meal on two occasions--once with and once without 10 g guar flour. Addition of guar caused a 47% decrease in maximum post-prandial GIP levels, a 48% decrease in blood glucose and a 48% decrease in plasma insulin in normal subjects. In diabetics, addition ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01222207
更新日期:1979-08-01 00:00:00
abstract::Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 125I-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity added compared to ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00452070
更新日期:1986-05-01 00:00:00
abstract::The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell funct...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-015-3862-7
更新日期:2016-04-01 00:00:00
abstract::Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116-340 mg/100 ml) the kidney weight, protein content a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00745142
更新日期:1977-04-01 00:00:00
abstract::Hyperglycaemia may enhance insulin resistance typical of non-insulin dependent diabetes mellitus, as well as insulin dependent diabetes mellitus, and thus initiate a vicious pathogenetic cycle. We sought to test the hypothesis that reduction in chronic hyperglycaemia in the diabetic dog by methods that do not employ i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00290590
更新日期:1988-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of the study was to identify surface bio-markers and corresponding antibody tools that can be used for the imaging and immunoisolation of the pancreatic beta cell and its progenitors. This may prove essential to obtain therapeutic grade human beta cells via stem cell differentiation. METHODS:Us...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2295-1
更新日期:2012-01-01 00:00:00
abstract::Using an antiserum raised to a recombinant coxsackie virus B 3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and panc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403323
更新日期:1990-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quan...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-020-05352-9
更新日期:2021-01-23 00:00:00
abstract::Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05327-w
更新日期:2021-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Empagliflozin (EMPA), an inhibitor of the renal sodium-glucose cotransporter (SGLT) 2, reduces the risk of cardiovascular death in patients with type 2 diabetes. The underlying mechanism of this effect is unknown. Elevated cardiac cytoplasmic Na+ ([Na+]c) and Ca2+ ([Ca2+]c) concentrations and decreased ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4134-x
更新日期:2017-03-01 00:00:00
abstract::It is hoped that information garnered from studies on population genetics will one day be translated into a form in which it meaningfully improves the prediction, prevention or treatment of type 2 diabetes. Type 2 diabetes genetics researchers have made extraordinary progress in identifying common genetic variants tha...
journal_title:Diabetologia
pub_type: 评论,杂志文章
doi:10.1007/s00125-012-2683-1
更新日期:2012-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Experimental studies have suggested that ghrelin, a novel gastrointestinal peptide hormone, could play a role in glucose homeostasis. In addition, ghrelin has been associated with beneficial haemodynamic effects in experimental settings. Since the Arg51Gln mutation changes the carboxyterminal amino acid...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1058-z
更新日期:2003-04-01 00:00:00
abstract::Rat pups delivered by caesarian section one day before term, either remained attached to (experimental group) or were separated from their placenta (control group). Both groups were transferred into an incubator and their metabolic parameters studied. In the control group, plasma amino acid concentration fell from 11....
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00252766
更新日期:1981-05-01 00:00:00
abstract::The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02221676
更新日期:1992-11-01 00:00:00
abstract::It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were evaluated in isolated dog adipocytes. The bradykinin receptor binding s...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400672
更新日期:1996-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Cerebral oedema complicating diabetic ketoacidosis (DKA) remains the major cause of morbidity and mortality in children with type 1 diabetes, but its aetiology remains unknown. Our objective was to determine the impact of baseline biochemical factors and of treatment-related variables on risk of the dev...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0363-8
更新日期:2006-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates. METHODS:The study was performed within the Hoorn Study, a population-based study of glucose metabolism in indi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2864-6
更新日期:2013-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1308-9
更新日期:2009-05-01 00:00:00
abstract::In diabetic nephropathy, expression of glycosaminoglycan side chains of heparan sulphate proteoglycan in the glomerular basement membrane is reduced proportionally to the degree of proteinuria. We performed a cross-sectional study to evaluate whether non-vascular basement membranes also show a decrease in heparan sulp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050989
更新日期:1998-07-01 00:00:00
abstract::Light and electron microscopic studies of diploid, tetraploid and octaploid B-cells in the islets of normal C57BL/KsJ mice revealed that polyploid cells were characterized by a wider range of granulated states than diploid B-cells. The maximum granule densities were similar for polyploid and diploid cells; however, so...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00428985
更新日期:1976-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentrations are characteristic for subjects with insulin resistance and could contribute to the increased cardiovascular risk in this state. In this study, we investigated the effect of troglitazone, a ligand of the nuclear receptor peroxisom...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050057
更新日期:2000-03-01 00:00:00
abstract::Regeneration of neonatal beta cells after streptozotocin (STZ)-induced destruction may be due to either replication from pre-existing intra-islet beta cells or extra-islet precursor cells. To further investigate this issue, beta-cell growth was analysed in normal and streptozotocin-treated newborn rats (100 micrograms...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418372
更新日期:1994-11-01 00:00:00
abstract::Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400276
更新日期:1991-08-01 00:00:00