Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy.

abstract：:Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused b...

journal_title：Diabetologia

authors： Ziegler M,Hahn HJ,Ziegler B,Köhler E,Fiedler H

更新日期：1975-02-01 00:00:00

abstract：:The eyes, kidneys and pancreas of mice (SJL/J) infected with encephalomyocarditis virus were examined by light and electron microscopy. Diabetic mice with the longest duration (6 months) of diabetes showed marked renal and ocular alterations. Fasting blood glucose levels were 17.8-21.9 mmol/l and glycosuria was presen...

journal_title：Diabetologia

authors： Rodrigues M,Currier C,Yoon J

更新日期：1983-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impaired fibrinolysis and insulin clearance. We examined the association between plasminogen activato...

journal_title：Diabetologia

authors： Lee CC,Lorenzo C,Haffner SM,Wagenknecht LE,Festa A,Goodarzi MO,Stefanovski D,Olson NC,Norris JM,Rewers MJ,Hanley AJ

更新日期：2013-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Diabetic cardiomyopathy is a myocardial disease triggered by impaired insulin signalling, increased fatty acid uptake and diminished glucose utilisation. Liver X receptors (LXRs) are key transcriptional regulators of metabolic homeostasis. However, their effect in the diabetic heart is largely unknown. ...

journal_title：Diabetologia

authors： Cannon MV,Silljé HH,Sijbesma JW,Khan MA,Steffensen KR,van Gilst WH,de Boer RA

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:The prognostic importance of the ankle-brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes. METHODS:The ABI was measured at baseline in ...

journal_title：Diabetologia

authors： Cardoso CRL,Melo JV,Salles GC,Leite NC,Salles GF

更新日期：2018-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Leptin resistance is generally considered a consequence of obesity. We postulated that leptin resistance is associated with diminished hypothalamic leptin signalling capacity and that leptin resistance is causal to obesity. We assessed maximal leptin-mediated binding of the transcription factor signal t...

journal_title：Diabetologia

authors： Scarpace PJ,Matheny M,Tümer N,Cheng KY,Zhang Y

更新日期：2005-06-01 00:00:00

abstract：:Developmental changes in the plasma insulin response to milk ingestion have been determined in neonatal lambs fed by bottle and in naturally suckled infant rabbits. In lambs at 4 days of age and older plasma insulin increased within 5 min of suckling and declined again before increasing to a second peak 60 to 120 min ...

journal_title：Diabetologia

authors： Porter RJ,Bassett JM

更新日期：1979-03-01 00:00:00

abstract：:Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...

journal_title：Diabetologia

authors： Rosenstock J,Loizou SA,Brajkovich IE,Mashiter K,Joplin GF

更新日期：1982-03-01 00:00:00

abstract：:Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...

journal_title：Diabetologia

authors： Comi G,Galardi G,Amadio S,Bianchi E,Secchi A,Martinenghi S,Caldara R,Pozza G,Canal N

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:A reduction in retinal blood flow occurs early in diabetes and is likely to be involved in the development of diabetic retinopathy. We hypothesise that activation of the arginase pathway could have a role in the vascular dysfunction of diabetic retinopathy. METHODS:Experiments were performed using a mo...

journal_title：Diabetologia

authors： Elms SC,Toque HA,Rojas M,Xu Z,Caldwell RW,Caldwell RB

更新日期：2013-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is characterised by leucocyte infiltration of pancreatic islets and a progressive destruction of insulin-producing beta cells. As endothelial nitric oxide production is known to regulate adhesion molecule expression and leucocyte permeation, we examined the a...

journal_title：Diabetologia

authors： Suschek CV,Bonmann E,Kolb-Bachofen V

更新日期：1999-04-01 00:00:00

abstract：AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...

journal_title：Diabetologia

authors： Perrini S,Laviola L,Cignarelli A,Melchiorre M,De Stefano F,Caccioppoli C,Natalicchio A,Orlando MR,Garruti G,De Fazio M,Catalano G,Memeo V,Giorgino R,Giorgino F

更新日期：2008-01-01 00:00:00

abstract：AIMS:We compared the effects of continuous subcutaneous insulin infusion (CSII) with those of multiple daily insulin (MDI) injections on glycaemic control, risk of hypoglycaemic episodes, insulin requirements and adverse events in type 1 and type 2 diabetes mellitus. METHODS:The electronic databases MEDLINE, EMBASE an...

journal_title：Diabetologia

authors： Jeitler K,Horvath K,Berghold A,Gratzer TW,Neeser K,Pieber TR,Siebenhofer A

更新日期：2008-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...

journal_title：Diabetologia

authors： Kuwabara T,Mori K,Mukoyama M,Kasahara M,Yokoi H,Saito Y,Ogawa Y,Imamaki H,Kawanishi T,Ishii A,Koga K,Mori KP,Kato Y,Sugawara A,Nakao K

更新日期：2012-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. METHODS:The Outcome Reduction with an Initial Glargine Intervent...

journal_title：Diabetologia

authors： ORIGIN trial investigators.,Gilbert RE,Mann JF,Hanefeld M,Spinas G,Bosch J,Yusuf S,Gerstein HC

更新日期：2014-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Glutamic acid decarboxylase autoantibodies (GADA) are the most frequent beta-cell-specific autoantibodies in type 1 diabetes and in latent autoimmune diabetes in adults (LADA). The autoimmune attack on pancreatic islet cells is associated with a T helper 1 cell (T(h)1) response, mainly represented by Ig...

journal_title：Diabetologia

authors： Hillman M,Törn C,Thorgeirsson H,Landin-Olsson M

更新日期：2004-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thia...

journal_title：Diabetologia

authors： Tanaka T,Itoh H,Doi K,Fukunaga Y,Hosoda K,Shintani M,Yamashita J,Chun TH,Inoue M,Masatsugu K,Sawada N,Saito T,Inoue G,Nishimura H,Yoshimasa Y,Nakao K

更新日期：1999-06-01 00:00:00

abstract：:Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5-5.5 years (mean +/- SD: 3.2 +/- 1.6 years), 26 out of 50 patients...

journal_title：Diabetologia

authors： Ludvigsson J

更新日期：1984-02-01 00:00:00

abstract：:The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...

journal_title：Diabetologia

authors： Cavallo-Perin P,Chiambretti A,Calefato V,Tomalino M,Urbino R,Cecchini G,Pagano G

更新日期：1991-11-01 00:00:00

abstract：:Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene polymorphisms were analysed in 40 North Indian Asian Type 1 diabetic patients and 63 control subjects. A 5.5 kilobase gene fragment was significantly increased a...

journal_title：Diabetologia

authors： Jenkins D,Penny MA,Mijovic CH,Jacobs KH,Fletcher J,Barnett AH

更新日期：1991-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Activation of the G protein-coupled receptor (GPR)40 by long-chain fatty acids potentiates glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells, and GPR40 agonists are in clinical development for type 2 diabetes therapy. GPR40 couples to the G protein subunit Gα(q/11) but the signallin...

journal_title：Diabetologia

authors： Ferdaoussi M,Bergeron V,Zarrouki B,Kolic J,Cantley J,Fielitz J,Olson EN,Prentki M,Biden T,MacDonald PE,Poitout V

更新日期：2012-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin resistance are unclear. To determine factors that may cause insulin resistance, we have performed a detailed time-course study in mice fed a high-fat diet (HFD). MET...

journal_title：Diabetologia

authors： Turner N,Kowalski GM,Leslie SJ,Risis S,Yang C,Lee-Young RS,Babb JR,Meikle PJ,Lancaster GI,Henstridge DC,White PJ,Kraegen EW,Marette A,Cooney GJ,Febbraio MA,Bruce CR

更新日期：2013-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of the study was to evaluate the relationship between insulin sensitivity, beta cell function and glucose tolerance, and its dependence on variants in the newly identified Type 2 diabetes susceptibility gene, calpain-10 ( CAPN10). METHODS:We studied 203 men of the same age but with varying degr...

journal_title：Diabetologia

authors： Tripathy D,Eriksson KF,Orho-Melander M,Fredriksson J,Ahlqvist G,Groop L

更新日期：2004-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...

journal_title：Diabetologia

authors： Hinkle SN,Buck Louis GM,Rawal S,Zhu Y,Albert PS,Zhang C

更新日期：2016-12-01 00:00:00

abstract：:Free-radical scavengers and inhibitors of tumour necrosis factor-alpha (TNF-alpha) such as N-acetylcysteine and pentoxifylline have been shown to inhibit the development of peripheral neuropathy in streptozotocin(STZ)-induced diabetic rats. In this study we examined the effect of troglitazone, an anti-diabetic thiazol...

journal_title：Diabetologia

authors： Qiang X,Satoh J,Sagara M,Fukuzawa M,Masuda T,Sakata Y,Muto G,Muto Y,Takahashi K,Toyota T

更新日期：1998-11-01 00:00:00

abstract：:Treatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes,...

journal_title：Diabetologia

authors： Grønbaek H,Nielsen B,Osterby R,Harris A,Orskov H,Flyvbjerg A

更新日期：1995-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We assessed secular trends of cardiovascular outcomes following first diagnosis of myocardial infarction (MI) or diabetes in an unselected population. METHODS:All Danish residents aged > or = 30 years without prior diabetes or MI were identified by individual-level linkage of nationwide registers. Indi...

journal_title：Diabetologia

authors： Norgaard ML,Andersen SS,Schramm TK,Folke F,Jørgensen CH,Hansen ML,Andersson C,Bretler DM,Vaag A,Køber L,Torp-Pedersen C,Gislason GH

更新日期：2010-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is characterised by excessive hepatic glucose production and frequently leads to systemic vascular complications. We therefore analysed the relationship between the gene expression profile in the liver and the pathophysiology of Type 2 diabetes. METHODS:Liver biopsy samples were obtaine...

journal_title：Diabetologia

authors： Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S

更新日期：2004-04-01 00:00:00

abstract：:The ability of the amino acid leucine and its keto acid, alpha-ketoisocaproate, to induce insulin release, to initiate phosphoinositide hydrolysis, and to amplify the subsequent insulin secretory response to glucose was assessed. In islets whose inositol-containing lipids were prelabelled with myo[2-3H]inositol, the a...

journal_title：Diabetologia

authors： Zawalich WS

更新日期：1988-07-01 00:00:00

abstract：:The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular cells by means of ...

journal_title：Diabetologia

authors： Rabkin R,Ryan MP,Duckworth WC

更新日期：1984-09-01 00:00:00