Abstract:
AIMS/HYPOTHESIS:Insulin clearance may decline as an early mechanism compensating for deteriorating insulin sensitivity. However, no previous studies have investigated the association between subclinical inflammation or impaired fibrinolysis and insulin clearance. We examined the association between plasminogen activator inhibitor (PAI)-1, C-reactive protein (CRP), TNF-α, leptin and fibrinogen and the progression of metabolic clearance rate of insulin (MCRI) over time. METHODS:We studied 784 non-diabetic white, Hispanic and African-American individuals in the Insulin Resistance Atherosclerosis Study (IRAS). Insulin sensitivity, acute insulin response and MCRI were determined from frequently sampled intravenous glucose tolerance tests at baseline and at 5-year follow-up. Inflammatory and fibrinolytic proteins were measured in fasting plasma at baseline. RESULTS:MCRI had declined significantly by 29% at the 5-year follow-up. We observed a significant association between higher plasma PAI-1 levels and the decline in MCRI in multivariable-adjusted regression models (β = -0.045 [95% CI -0.081, -0.0091]). Higher plasma CRP and leptin levels were associated with a decline in MCRI in unadjusted models, but these associations were non-significant after adjusting for BMI and waist circumference (β = -0.016 [95% CI -0.041, 0.0083] for CRP; β = -0.044 [95% CI -0.10, 0.011] for leptin). A higher plasma TNF-α concentration was associated with a decline in MCRI in unadjusted (β = -0.071 [95% CI -0.14, -0.00087]) but not in multivariable-adjusted (β = -0.056 [95% CI -0.13, 0.017]) models. Plasma fibrinogen level was not associated with the change in MCRI. CONCLUSIONS/INTERPRETATION:We identified that higher plasma PAI-1 (but not CRP, TNF-α, leptin or fibrinogen) levels independently predicted the progressive decline of insulin clearance in the multiethnic cohort of the IRAS.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Lee CC,Lorenzo C,Haffner SM,Wagenknecht LE,Festa A,Goodarzi MO,Stefanovski D,Olson NC,Norris JM,Rewers MJ,Hanley AJdoi
10.1007/s00125-012-2741-8subject
Has Abstractpub_date
2013-01-01 00:00:00pages
112-20issue
1eissn
0012-186Xissn
1432-0428journal_volume
56pub_type
杂志文章,多中心研究相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner. The PPARG proline for alanine substitution at position 12 (Pro12Al...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-007-0826-6
更新日期:2007-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-011-2312-4
更新日期:2012-01-01 00:00:00
abstract::The effect of acute lowering of arterial blood pressure upon kidney function in nephropathy was studied in 13 patients with long-term Type 1 (insulin-dependent) diabetes. Ten normal subjects (six normotensive and four hypertensive) and five short-term Type 1 diabetic patients without nephropathy served as controls. Re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276965
更新日期:1984-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield val...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4568-4
更新日期:2018-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to determine whether oral dosing with N-acetylcysteine (NAC) increases intraplatelet levels of the antioxidant, glutathione (GSH), and reduces platelet-monocyte conjugation in blood from patients with type 2 diabetes. METHODS:In this placebo-controlled randomised crossover stu...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-012-2685-z
更新日期:2012-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of anti-inflammatory molecules such as IL-4 and IL-13. While the actions of proinflammatory cytokines have ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4750-8
更新日期:2019-01-01 00:00:00
abstract::The validity of the new diagnostic criteria for diabetes mellitus for Japanese subjects was assessed by the long-term prognosis of 501 patients, found in an epidemiological survey of 6,681 people in a Japanese town. Ten-year relative survival rates were examined in relation to the 50 g oral glucose tolerance test (ser...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00252627
更新日期:1981-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The prevalence of diabetes and heart failure is increasing, and diabetes has been associated with an increased risk of heart failure. However, whether diabetes confers the same excess risk of heart failure in women and men is unknown. The aim of this study was to conduct a comprehensive systematic revie...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-019-4926-x
更新日期:2019-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051372
更新日期:2000-06-01 00:00:00
abstract::To study the effect of E. Coli L-asparaginase on glucose tolerance and insulin release, 6 patients with neoplastic disease were subjected to 3 hour oral glucose tolerance tests with simultaneous measurement of serum immunoreactive insulin (IRI) levels before and following the intravenous administration of 5000 I. U. L...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00422255
更新日期:1978-08-01 00:00:00
abstract::While the modest reduction in the primary composite outcome of myocardial infarction, stroke or cardiovascular death in the EMPA-REG Outcomes trial was welcome, the 30-40% reductions in heart failure hospitalisation (HFH) and cardiovascular and all-cause deaths in patients treated with empagliflozin were highly impres...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-016-3956-x
更新日期:2016-07-01 00:00:00
abstract::Vascular smooth muscle cell (VSMC) dysfunction plays a role in diabetic macrovasculopathy and this may include abnormalities in growth characteristics and the extracellular matrix. As the actual mechanisms by which glucose induces VSMC dysfunction remain unclear, the aim of this study was to assess the potential role ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051054
更新日期:1998-10-01 00:00:00
abstract::The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF02221676
更新日期:1992-11-01 00:00:00
abstract::Islet allografts in insulin-dependent diabetic (IDDM) patients exhibit variable survival lengths and low rates of insulin-independence despite treatment with anti-T-cell antibodies and maintenance immunosuppression. Use of poorly characterized freshly isolated preparations makes it difficult to determine whether failu...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s001250050929
更新日期:1998-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of baroreflex sensitivity. We studied the determinants of these measures obtained from cardiovascular autonomic function tests in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051344
更新日期:2000-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia during pregnancy are poorly understood. We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs l...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-011-2363-6
更新日期:2012-02-01 00:00:00
abstract::Glycogen phosphorylase regulates the breakdown of glycogen into glucose, but as previous studies have demonstrated, the control of glycogen metabolism becomes deregulated in diabetes mellitus. Messenger RNA levels encoding several different proteins are altered in skeletal muscle biopsies of patients with insulin-depe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403961
更新日期:1996-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:To assess whether self-monitoring of blood glucose (SMBG) is an independent predictor of improved outcome in a community-based cohort of type 2 diabetic patients. MATERIALS AND METHODS:We used longitudinal data from (1) 1,280 type 2 diabetic participants in the observational Fremantle Diabetes Study (F...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0581-0
更新日期:2007-03-01 00:00:00
abstract::Weaning onto chow diets causes the highest incidence of diabetes in the BB rat. Changes in gut development and absorption of nutrients in the diabetes prone rat and the subsequent effect on pancreatic function may play a role in the ultimate development of the disease. BB diabetes prone (dp) and BB normal (n) dams wer...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050762
更新日期:1997-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data in...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4404-2
更新日期:2017-11-01 00:00:00
abstract::Amylin is a 37-amino acid pancreatic polypeptide, probably involved in the pathophysiology of Type 2 (non-insulin-dependent) diabetes mellitus. We have determined amylin in human plasma by extraction-based radioimmunoassay (Sep-Pak C18). Of 23 healthy control subjects plasma amylin was determined as 11.9 +/- 3.5 ng/l....
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404025
更新日期:1991-01-01 00:00:00
abstract::Clinical and biochemical studies were carried out in 33 patients with diabetes secondary to chronic calcific, non-alcoholic pancreatitis (tropical pancreatic diabetes) and in 35 Type 2 (non-insulin-dependent) diabetic patients and 35 non-diabetic subjects. Despite lower body mass indices, only 25% of patients with tro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00282238
更新日期:1985-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4222-6
更新日期:2017-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1710-x
更新日期:2005-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1625-y
更新日期:2005-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The role of infections in the aetiology of Type I diabetes is controversial. Certain enteroviral infections might be involved in triggering the beta-cell destruction but insufficient exposure to early infections might increase the risk. We studied how the number of infections experienced during several ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051517
更新日期:2000-10-01 00:00:00
abstract::Nicotinamide, the amide derivative of nicotinic acid, has over the past forty years been given at high doses for a variety of therapeutic applications. It is currently in trial as a potential means of preventing the onset of Type I (insulin-dependent) diabetes mellitus in high-risk, first-degree relatives. Nicotinamid...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250051536
更新日期:2000-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:In the current study, the effect of a highly specific peptide inhibitor of glycogen synthase kinase 3 (GSK3) (L803-mts) on glucose metabolism and BP was examined in a high-fat (HF) fed mouse model of diabetes. METHODS:C57/BL6J mice were placed on an HF diet for 3 months and treated with L803-mts for 20...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0552-5
更新日期:2007-02-01 00:00:00
abstract::IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulo-interstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403374
更新日期:1994-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1894-0
更新日期:2005-10-01 00:00:00