Abstract:
AIMS/HYPOTHESIS:The euglycaemic-hyperinsulinaemic clamp is the gold-standard method for measuring insulin sensitivity, but is less suitable for large clinical trials. Thus, several indices have been developed for evaluating insulin sensitivity from the oral glucose tolerance test (OGTT). However, most of them yield values different from those obtained by the clamp method. The aim of this study was to develop a new index to predict clamp-derived insulin sensitivity (M value) from the OGTT-derived oral glucose insulin sensitivity index (OGIS). METHODS:We analysed datasets of people that underwent both a clamp and an OGTT or meal test, thereby allowing calculation of both the M value and OGIS. The population was divided into a training and a validation cohort (n = 359 and n = 154, respectively). After a stepwise selection approach, the best model for M value prediction was applied to the validation cohort. This cohort was also divided into subgroups according to glucose tolerance, obesity category and age. RESULTS:The new index, called PREDIcted M (PREDIM), was based on OGIS, BMI, 2 h glucose during OGTT and fasting insulin. Bland-Altman analysis revealed a good relationship between the M value and PREDIM in the validation dataset (only 9 of 154 observations outside limits of agreement). Also, no significant differences were found between the M value and PREDIM (equivalence test: p < 0.0063). Subgroup stratification showed that measured M value and PREDIM have a similar ability to detect intergroup differences (p < 0.02, both M value and PREDIM). CONCLUSIONS/INTERPRETATION:The new index PREDIM provides excellent prediction of M values from OGTT or meal data, thereby allowing comparison of insulin sensitivity between studies using different tests.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Tura A,Chemello G,Szendroedi J,Göbl C,Færch K,Vrbíková J,Pacini G,Ferrannini E,Roden Mdoi
10.1007/s00125-018-4568-4subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1135-1141issue
5eissn
0012-186Xissn
1432-0428pii
10.1007/s00125-018-4568-4journal_volume
61pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:We evaluated the secular trend of glycaemic control in individuals with type 2 diabetes in developing countries, where data are limited. METHODS:The International Diabetes Management Practices Study provides real-world evidence of patient profiles and diabetes care practices in developing countries in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05078-3
更新日期:2020-04-01 00:00:00
abstract::The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (GLUT 4) level in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00429089
更新日期:1992-08-01 00:00:00
abstract::The human insulin receptor exists in two isoforms (HIR-A alpha-subunit 719 amino acids and HIR-B alpha-subunit 731 amino acids) which are generated by alternative splicing of a small exon and display distinct patterns of tissue-specific expression. Using the polymerase chain reaction we have recently shown that skelet...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404072
更新日期:1993-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Beta cells situated in the islet of Langerhans respond more vigorously to glucose than do dissociated beta cells. Mechanisms for this discrepancy were studied by comparing insulin-producing MIN6 cells aggregated into pseudoislets with MIN6 monolayer cells and mouse and human islets. METHODS:MIN6 monola...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2903-3
更新日期:2013-07-01 00:00:00
abstract::Recent studies have suggested an association between a deletion (D) variant of the angiotensin-converting-enzyme (ACE) gene and diabetic nephropathy. However, this finding has not been confirmed by all investigators. Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050662
更新日期:1997-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Growth factor imbalance and endothelial progenitor cell dysfunction are well-known elements of the inappropriate response to injury in human and experimental diabetes. We hypothesised that in diabetes the outgrowth of myofibroblast progenitor cells (MFPCs) is also altered and that this relates to aberra...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0172-0
更新日期:2006-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:In order to identify type 2 diabetes disease susceptibility gene(s) in a Japanese population, we applied a region-wide case-control association test to the 20.4 Mb region between D3S1293 and D3S2319 on chromosome 3p24.3-22.1, supported by linkage to type 2 diabetes and its related traits in Japanese and...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-007-0631-2
更新日期:2007-06-01 00:00:00
abstract::We have studied the temporal relationship of plasma von Willebrand Factor (vWF), a marker of endothelial damage, with the development of complications in 63 young diabetic patients (56 of whom were insulin-dependent) who took part in a prospective study. Results are presented from baseline to follow-up. In the group a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418350
更新日期:1996-03-01 00:00:00
abstract::Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050805
更新日期:1997-10-01 00:00:00
abstract::Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whethe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050907
更新日期:1998-03-01 00:00:00
abstract::The effect of the alpha-glucosidase inhibitor acarbose on postprandial hyperglycaemia was explored in the spontaneously diabetic BB/W-rat. Acarbose-treatment (5 mg.kg body weight-1.day-1) of diabetic BB/W-rats maintained on small doses of insulin, was associated with a 40% reduction in the 24-h glucose area compared t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00401199
更新日期:1992-04-01 00:00:00
abstract::This study analyses 2848 primary major lower limb amputations in diabetic individuals during the period 1982-1993. The male:female sex ratio (mean 1.18) increased, while the mean age at the primary amputation was constant (70.96 years) during the period. The incidence uniformly decreased for both men and women by 0.96...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250050622
更新日期:1996-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in well-categorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. METHODS:A longitudinal observational study was undertaken involving 1291 part...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4127-9
更新日期:2017-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional s...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4612-4
更新日期:2018-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thia...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250051218
更新日期:1999-06-01 00:00:00
abstract::Insulin secretion from pancreatic beta cells is dependent on membrane potential changes that result from the concerted regulation of multiple ion channels. Among the distinct K+ channels known to be expressed in beta cells, large conductance Ca(2+)-activated K+ channels have been suggested to play an important role in...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00403907
更新日期:1996-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Reactive oxygen species (ROS) contribute to diabetes-induced glomerular injury and endoplasmic reticulum (ER) stress-induced beta cell dysfunction, but the source of ROS has not been fully elucidated. Our aim was to determine whether p47(phox)-dependent activation of NADPH oxidase is responsible for hyp...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2586-1
更新日期:2012-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Elevated circulating adipocyte fatty acid-binding protein (AFABP) levels have been found to correlate with diabetic nephropathy staging in cross-sectional studies. However, it remains unclear whether these higher serum levels reflect a role of AFABP in the development of diabetic kidney disease (DKD), o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-018-4742-8
更新日期:2019-01-01 00:00:00
abstract::Obesity and Type 2 diabetes mellitus are associated with abnormal regulation of glucocorticoid metabolism that are highlighted by clinical similarities between the sequelae of insulin resistance and Cushing's syndrome, as well as glucocorticoids' functional antagonism to insulin. 11beta-hydroxysteroid dehydrogenase ty...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-003-1284-4
更新日期:2004-01-01 00:00:00
abstract::Potassium homeostasis during a 50-g oral glucose tolerance test was studied in 14 newly diagnosed, untreated Type 2 (non-insulin-dependent) diabetics. They showed a rise in plasma potassium from a mean +/- SEM basal of 3.9 +/- 0.1 to 4.4 +/- 0.1 mmol/l at 60 min and to 4.6 +/- 0.1 mmol/l at 90 min (p less than 0.01), ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00283750
更新日期:1982-03-01 00:00:00
abstract::Oxidative stress has long been considered a key driving factor of many obesity-related health problems. However, recent work by Merry, Tran et al (Diabetologia DOI 10.1007/s00125-016-4084-3 ) challenges this idea with an interesting study using a hepatocyte-specific Gpx1-knockout (HGKO) mouse. GPX1 is an important det...
journal_title:Diabetologia
pub_type: 评论,社论
doi:10.1007/s00125-016-4117-y
更新日期:2016-12-01 00:00:00
abstract::A rapid chromatography method for separating glycosylated protein from non-glycosylated protein, using a boronate-agarose affinity medium which selectively binds the cis-diol groups of glycoproteins, was used to quantitate plasma glycoprotein as well as glycohaemoglobin. The results were found to be independent of: (1...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00253503
更新日期:1984-07-01 00:00:00
abstract::The aim of this study was to compare the causes of death and parameters related to alcohol consumption, between subjects diagnosed as diabetic, clinically by their general practitioner, or glucose intolerant and in particular as diabetic, using the epidemiological criteria of an abnormal glucose level following an ora...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00400850
更新日期:1992-01-01 00:00:00
abstract::The glycaemic control of infants and of their mothers was studied at delivery and on day 7 after birth in 11 control and 20 insulin-dependent diabetic women. At delivery, venous blood glucose was lower in infants of diabetic mothers compared with control infants (p less than 0.02). Seven days after birth, no significa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00276966
更新日期:1984-12-01 00:00:00
abstract::The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neuroph...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/BF00283137
更新日期:1985-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes is characterised by progressive loss of pancreatic beta cell mass and function. Therefore, it is of therapeutic interest to identify factors with the potential to improve beta cell proliferation and insulin secretion. Bone morphogenetic protein 4 (BMP4) expression is increased in diabeti...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3568-x
更新日期:2015-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Pancreatic islet transplantation (PIT) offers a physiological treatment for type 1 diabetes, but the failure of islet engraftment hinders its application. The female hormone 17β-oestradiol (E2) favours islet survival and stimulates angiogenesis, raising the possibility that E2 may enhance islet engraftm...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2764-1
更新日期:2013-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Epithelium-mesenchyme interactions play a major role in pancreas development. Recently, we demonstrated that embryonic pancreatic mesenchyme enhanced progenitor cell proliferation but inhibited endocrine cell differentiation. Here, we investigated the role played by sulphated proteoglycans, which are kn...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0571-2
更新日期:2007-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:In the current study, the effect of a highly specific peptide inhibitor of glycogen synthase kinase 3 (GSK3) (L803-mts) on glucose metabolism and BP was examined in a high-fat (HF) fed mouse model of diabetes. METHODS:C57/BL6J mice were placed on an HF diet for 3 months and treated with L803-mts for 20...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0552-5
更新日期:2007-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Depression and glucose intolerance commonly co-occur among non-pregnant individuals; however, the temporal relationship between gestational diabetes (GDM) and depression during pregnancy and the postpartum period is less understood. Our objective was to assess longitudinal associations between depressio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4086-1
更新日期:2016-12-01 00:00:00