Abstract：
AIMS/HYPOTHESIS:To assess whether self-monitoring of blood glucose (SMBG) is an independent predictor of improved outcome in a community-based cohort of type 2 diabetic patients. MATERIALS AND METHODS:We used longitudinal data from (1) 1,280 type 2 diabetic participants in the observational Fremantle Diabetes Study (FDS) who reported SMBG and diabetes treatment status at study entry (1993-1996), and (2) a subset of 531 participants who attended six or more annual assessments (referred to as the 5-year cohort). Diabetes-related morbidity, cardiac death and all-cause mortality were ascertained at each assessment, supplemented by linkage to the Western Australian Data Linkage System. RESULTS:At baseline, 70.2% (898 out of 1,280) of type 2 patients used SMBG. During 12,491 patient-years of follow-up (mean 9.8+/-3.5 years), 486 (38.0%) type 2 participants died (196 [15.3%] from cardiac causes). SMBG was significantly less prevalent in those who died during follow-up than in those who were still alive at the end of June 2006 (65.4 vs 73.0%, p=0.005). In Cox proportional hazards modelling, after adjustment for confounding and explanatory variables, SMBG was not independently associated with all-cause mortality, but was associated with a 79% increased risk of cardiovascular mortality in patients not treated with insulin. For the 5-year cohort, time-dependent SMBG was independently associated with a 48% reduced risk of retinopathy. CONCLUSIONS/INTERPRETATION:SMBG was not independently associated with improved survival. Inconsistent findings relating to the association of SMBG with cardiac death and retinopathy may be due to confounding, incomplete covariate adjustment or chance.
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Davis WA,Bruce DG,Davis TMdoi
10.1007/s00125-006-0581-0subject
Has Abstractpub_date
2007-03-01 00:00:00pages
510-5issue
3eissn
0012-186Xissn
1432-0428journal_volume
50pub_type
杂志文章相关文献
DIABETOLOGIA文献大全abstract：:The binding of 125I-labelled insulin to human adipocytes was studied at 37 degrees C. The precipitability of the 125I-labelled insulin preparation (0.03 nmol/l) in trichloroacetic acid and the concentration of biologically active insulin (7.5 nmol/l) remained constant in buffer incubated with human adipocytes (100 mic...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF01236312
更新日期：1977-12-01 00:00:00
abstract：:In order to study the contribution of oxidant stress to the pathogenesis of experimental diabetic retinopathy, male streptozotocin diabetic Lewis rats were treated with the antioxidant and lipid-lowering compound nicanartine (80 mg/kg; n = 8, blood glucose level 16.7 +/- 3.9 mmol/l; HbA1 11.8 +/- 1.6%) by oral supplem...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050726
更新日期：1997-06-01 00:00:00
abstract：AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...
journal_title：Diabetologia
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00125-007-0695-z
更新日期：2007-08-01 00:00:00
abstract：AIMS/HYPOTHESIS:The main objective of this work was to discover new drugs that can activate the differentiation of multipotent pancreatic progenitors into endocrine cells. METHODS:In vitro experiments were performed using fetal pancreatic explants from rats and mice. In this assay, we examined the actions on pancreati...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-012-2778-8
更新日期：2013-02-01 00:00:00
abstract：:The effect of hyperglycaemia on islet transplantation in the rat has been examined in two ways, using syngeneic transplantation of 400 islets to the kidney capsule and subsequent measurement of kidney insulin content as a measurement of B-cell survival. Firstly, islets were transplanted into either diabetic or normal ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00274254
更新日期：1989-09-01 00:00:00
abstract：AIMS/HYPOTHESIS:Empagliflozin (EMPA), an inhibitor of the renal sodium-glucose cotransporter (SGLT) 2, reduces the risk of cardiovascular death in patients with type 2 diabetes. The underlying mechanism of this effect is unknown. Elevated cardiac cytoplasmic Na+ ([Na+]c) and Ca2+ ([Ca2+]c) concentrations and decreased ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-016-4134-x
更新日期：2017-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to ...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章
doi：10.1007/s00125-012-2490-8
更新日期：2012-05-01 00:00:00
abstract：AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-009-1510-9
更新日期：2009-11-01 00:00:00
abstract：AIMS/HYPOTHESIS:Low phosphate and high calcium concentrations have been linked to altered glucose tolerance and reduced insulin sensitivity in non-diabetic individuals. The aim of this study was to examine the relationships of calcium and phosphate levels and the calcium-phosphate product with the development of type 2...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-014-3241-9
更新日期：2014-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or type 2 diabetes in men in Taiwan, where the habit has become established ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-004-1532-2
更新日期：2004-10-01 00:00:00
abstract：:The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00273803
更新日期：1984-08-01 00:00:00
abstract：:Insulin dependent (IDD) and non-insulin dependent diabetes (NIDD) are separate disorders. Twin studies show that IDD cannot be entirely due to genetic causes as concordance is no more than about 50%, but there is some inherited predisposition to it as shown by HLA patterns. NIDD, on the other hand, is predominantly du...
journal_title：Diabetologia
pub_type： 杂志文章,评审
doi：10.1007/BF01236266
更新日期：1979-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-007-0865-z
更新日期：2008-01-01 00:00:00
abstract：AIMS/HYPOTHESIS:Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with insulin resistance and type 2 diabetes. However, the mechanisms by which adiponectin improves insulin sensitivity remain unclear. SUBJECTS AND METHODS...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-006-0240-5
更新日期：2006-06-01 00:00:00
abstract：:Renal tubular lesions have been studied in streptozotocin-diabetic rats after 50 days of diabetes and compared with age-matched controls. The kidney weight increased by 67% in the diabetic animals and the length of the proximal tubules increased by 22%, but no abnormalities were found. The length of the distal tubules...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00253498
更新日期：1984-07-01 00:00:00
abstract：:Non-diabetic first degree relatives of non-insulin-dependent diabetic (NIDDM) families are at increased risk of developing diabetes mellitus, and have been studied to identify early metabolic abnormalities. Hormone concentrations measured by specific enzyme immunoassays were assessed in non-diabetic relatives of North...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050805
更新日期：1997-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:The aim of this study was to assess the predictive role of autonomic reactivity in body weight loss induced by gastric bypass. METHODS:A group of 22 morbidly obese subjects, who were due to undergo a gastric bypass, were submitted, before surgery, to a euglycaemic-hyperinsulinaemic clamp, during which ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-005-1792-5
更新日期：2005-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:The 1997 American Diabetes Association classification of diabetes mellitus included a subset of Type I diabetic patients who do not need insulin for several years but eventually progress to complete insulin deficiency i. e. atypical Type I diabetes mellitus. In Caucasian populations, most Type I diabeti...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250100028
更新日期：2001-12-01 00:00:00
abstract：AIMS/HYPOTHESIS:Low-grade inflammation has been implicated in the development of Type 2 diabetes and cardiovascular disease, but its role in the pathogenesis of the metabolic syndrome is unclear. We investigated the association between C-reactive protein (CRP) levels and the development of the metabolic syndrome and di...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-004-1472-x
更新日期：2004-08-01 00:00:00
abstract：:The effect of oral vanadate on intestinal sodium-dependent glucose transport and 6-phosphofructo-1-kinase (EC 2.7.1.11) activity was examined in male Sprague-Dawley rats following a 30-day period of non-treated streptozotocin-induced diabetes. Non-treated diabetic rats were hyperglycaemic and demonstrated increased in...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00410277
更新日期：1995-04-01 00:00:00
abstract：AIMS/HYPOTHESIS:Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-019-4880-7
更新日期：2019-07-01 00:00:00
abstract：:We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species. The antibody immunohistochemically labelled beta cells in normal islets of most different mammalian ...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s001250050751
更新日期：1997-07-01 00:00:00
abstract：AIMS/HYPOTHESIS:The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-004-1534-0
更新日期：2004-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-005-1894-0
更新日期：2005-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate the effects of obesity and hyperglycaemia on beta cell function and integrity, and to study glucose-induced alterations of key...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-010-1973-8
更新日期：2011-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:The offspring of mothers with pre-gestational type 1 diabetes (PGDM) may be at increased risk of glucose intolerance and cardiovascular disease in childhood. The underlying causes of these observations, and whether they persist into adulthood, are unknown. The aim of the present study was to test the hy...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-008-1207-5
更新日期：2009-02-01 00:00:00
abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...
journal_title：Diabetologia
pub_type： 临床试验,杂志文章
doi：10.1007/s00125-011-2204-7
更新日期：2011-10-01 00:00:00
abstract：:Factor VIII-related antigen and von Willebrand factor are synthesised by and released from vascular endothelium. Acute increases in the plasma concentration of these proteins may reflect endothelial cell damage. We have thus measured the plasma concentration of factor VIII-related antigen and von Willebrand factor, to...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/BF00274221
更新日期：1987-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-007-0761-6
更新日期：2007-10-01 00:00:00
abstract：AIMS/HYPOTHESIS:Oxidative stress is associated with diabetes, hypertension and atherosclerosis. Insulin resistance is implicated in the development of these disorders. We tested the hypothesis that oxidative stress induces insulin resistance in rats, and endeavoured to identify mechanisms linking the two. METHODS:Buth...
journal_title：Diabetologia
pub_type： 杂志文章
doi：10.1007/s00125-004-1391-x
更新日期：2004-05-01 00:00:00
