Abstract:
AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner. The PPARG proline for alanine substitution at position 12 (Pro12Ala polymorphism) has been related with obesity directly and via interaction with PUFA. METHODS:We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals. RESULTS:At baseline, Ala12 carriers had larger waists (p < 0.001) and, in a subset, more subcutaneous adipose tissue (SAT; lumbar 2/3; p = 0.04) than Pro12 homozygotes. There was a genotype-by-intervention interaction on 1-year weight change (p = 0.01); in the placebo arm, Pro12 homozygotes gained weight and Ala12 carriers lost weight (p = 0.001). In the metformin and lifestyle arms, weight loss occurred across genotypes, but was greatest in Ala12 carriers (p < 0.05). Troglitazone treatment induced weight gain, which tended to be greater in Ala12 carriers (p = 0.08). In the placebo group, SAT (lumbar 2/3, lumbar 4/5) decreased in Ala12 allele carriers, but was unchanged in Pro12 homozygotes (p < or = 0.005). With metformin treatment, SAT decreased independently of genotype. In the lifestyle arm, SAT (lumbar 2/3) reductions occurred across genotypes, but were greater in Ala12 carriers (p = 0.03). A genotype-by-PUFA intake interaction on reduction in visceral fat (lumbar 4/5; p = 0.04) was also observed, which was most evident with metformin treatment (p < 0.001). CONCLUSIONS/INTERPRETATION:Within the Diabetes Prevention Program, the Ala12 allele influences central obesity, an effect which may differ by treatment group and dietary PUFA intake (ClinicalTrials.gov ID no: NCT00004992).
journal_name
Diabetologiajournal_title
Diabetologiaauthors
Franks PW,Jablonski KA,Delahanty L,Hanson RL,Kahn SE,Altshuler D,Knowler WC,Florez JC,Diabetes Prevention Program Research Group.doi
10.1007/s00125-007-0826-6subject
Has Abstractpub_date
2007-12-01 00:00:00pages
2451-60issue
12eissn
0012-186Xissn
1432-0428journal_volume
50pub_type
杂志文章,多中心研究,随机对照试验相关文献
DIABETOLOGIA文献大全abstract:AIMS/HYPOTHESIS:Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study wa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4424-y
更新日期:2017-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to estimate the heritability of quantitative measures of glucose regulation obtained from a tolbutamide-modified frequently sampled IVGTT (t-FSIGT) and to correlate the heritability of the glucose-stimulated beta cell response to the tolbutamide-induced beta cell response. In a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3207-y
更新日期:2014-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:The prevalence of diabetes and heart failure is increasing, and diabetes has been associated with an increased risk of heart failure. However, whether diabetes confers the same excess risk of heart failure in women and men is unknown. The aim of this study was to conduct a comprehensive systematic revie...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-019-4926-x
更新日期:2019-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes and to assess their potential contribution to the development of the ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-013-2993-y
更新日期:2013-10-01 00:00:00
abstract::Islet amyloid polypeptide (IAPP) is overexpressed relative to insulin under several experimental conditions relevant to diabetes mellitus, including the immediate phase (7 days) following induction of streptozotocin diabetes. In the present study, IAPP and insulin gene expression were examined in chronic streptozotoci...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00418536
更新日期:1996-06-01 00:00:00
abstract::This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the met...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF01219650
更新日期:1978-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:High levels of inflammation locally in the graft during the initial days after transplantation can cause primary non-function (PNF) of grafted xenogeneic islets in NOD mice. The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1154-0
更新日期:2003-08-01 00:00:00
abstract::The effects of four sulphonylureas (gliclazide, glibenclamide, chlorpropamide and glipizide) on insulin binding and insulin action were studied in vitro using primary cultured rat hepatocytes. Cells were cultured for 20 h in the absence or presence of the sulphonylurea. The binding of insulin to rat hepatocyte monolay...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00257344
更新日期:1983-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-019-05047-w
更新日期:2020-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Aggregation of islet amyloid polypeptide (IAPP) to form amyloid contributes to beta cell dysfunction in type 2 diabetes. Human but not non-amyloidogenic rodent IAPP induces islet macrophage proIL-1β synthesis. We evaluated the effect of IL-1 receptor antagonist (IL-1Ra) on islet inflammation and dysfunc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-014-3447-x
更新日期:2015-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in well-categorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. METHODS:A longitudinal observational study was undertaken involving 1291 part...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4127-9
更新日期:2017-01-01 00:00:00
abstract::Eight obese patients and 12 normal individuals underwent a euglycaemic insulin clamp (20 and 40 mU m2-1.min-1) along with continuous infusion of 3-3H-glucose and 1-14C-palmitate and indirect calorimetry. Basal plasma glucose concentration (4.7 +/- 0.3 vs 4.4 +/- 0.2 mmol/l) was similar in the two groups, whereas hepat...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00404801
更新日期:1990-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to examine whether impaired glucose tolerance is associated with reduced suppression of glucagon concentrations. METHODS:Eighty-four non-diabetic women of Caucasian origin and 61 years of age, of whom 48 had normal glucose tolerance (NGT) and 36 had IGT, underwent a 75 g OGTT and a hyperinsuli...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s001250100003
更新日期:2001-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to examine the effects of bariatric surgery on microvascular complications in patients with type 2 diabetes using objective measures. METHODS:Prospective case-control study of 70 obese surgical patients with type 2 diabetes undergoing gastric bypass surgery matched for age, sex and duration of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3595-7
更新日期:2015-07-01 00:00:00
abstract::The increase in urinary albumin excretion induced by acute exercise in Type 1 (insulin-dependent) diabetic patients is associated with the urinary excretion of cationic proteins. To test whether the renal excretion of glycated albumin (more anionic than non-glycated albumin) is affected by exercise, we submitted seven...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00408356
更新日期:1991-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 1 diabetes increases the risk of peripheral ischaemia and impairs recovery once ischaemia occurs, probably because the healing process is hampered by diabetes-induced endothelial dysfunction. In normoglycaemic mice subjected to limb ischaemia, blockade of nerve growth factor (NGF) compromises repar...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1424-5
更新日期:2004-06-01 00:00:00
abstract::Ciglitazone is orally active in preventing and reversing the hyperglycaemic syndrome in C57BL/6J-ob/ob mice and it is only mildly and transiently hypoglycaemic in lean littermates (C57BL/6J-+/?). Its effect on glucose disposal in vivo was estimated by injecting glucose-6-3H/14C and following the specific activity of r...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF00284462
更新日期:1983-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:According to the consensus criteria developed for type 1 diabetes, an individual can be diagnosed with insulitis when ≥ 15 CD45+ cells are found within the parenchyma or in the islet-exocrine interface in ≥ 3 islets. The aim of this study was to determine the frequency of individuals with type 2 diabete...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4140-z
更新日期:2017-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance. MATERIALS AND METHODS:We performed a cross-sectional study of MBL protein concentratio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0381-6
更新日期:2006-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin converting enzyme inhibitor (ACEI). METHODS:We examined the effects of olmesartan, an ARB, on primary compo...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-011-2325-z
更新日期:2011-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Intensive glucose control reduces the risk of vascular complications while increasing the risk of severe hypoglycaemia at a group level. We sought to estimate individual beneficial and adverse effects of intensive glucose control in patients with type 2 diabetes. METHODS:We performed a post hoc analysi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-016-4082-5
更新日期:2016-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperlipidaemia is an independent risk factor for the progression of diabetic nephropathy, but its molecular mechanism remains elusive. We investigated in mice how diabetes and hyperlipidaemia cause renal lesions separately and in combination, and the involvement of Toll-like receptor 4 (TLR4) in the pr...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2578-1
更新日期:2012-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:We aimed to examine time trends in national perinatal outcomes in pregnancies complicated by pre-existing type 1 or type 2 diabetes. METHODS:We analysed episode-level data on all obstetric inpatient delivery events (live or stillbirth) between 1 April 1998 and 31 March 2013 (n = 813,921) using the Scot...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-017-4529-3
更新日期:2018-05-01 00:00:00
abstract::Diabetes affects 4 to 5% of the population worldwide and is the most common metabolic disorder. The number of individuals diagnosed with diabetes is rapidly increasing, especially in the developed countries and the disorder frequently leads to secondary complications such as retinopathy, nephropathy, neuropathy and ca...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s001250100623
更新日期:2001-09-01 00:00:00
abstract::The development of proteinuria and its response to insulin therapy in acute experimental diabetes was examined in 11 female rats by sequentially measuring 24 h excretion of glucose and total protein before diabetes, during 5-37 days of acute streptozotocin diabetes, during and after 7-14 days of continuous subcutaneou...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/BF03216225
更新日期:1981-07-01 00:00:00
abstract::The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental process to adapt to nutritional and metabolic challenges and is thus critical for the maintenance of a healthy energy balance. Alterations in this process during nutrient exces...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-020-05104-9
更新日期:2020-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Type 2 diabetes mellitus is associated with reduced incretin effects. Although previous studies have shown that hyperglycaemia contributes to impaired incretin responses in beta cells, it is largely unknown how hyperlipidaemia, another feature of type 2 diabetes, contributes to impaired glucagon-like pe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-012-2776-x
更新日期:2013-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS:We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL acc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-015-3861-8
更新日期:2016-04-01 00:00:00
abstract:AIM/HYPOTHESIS:The renin-angiotensin-aldosterone system is important in diabetic nephropathy, with the angiotensin-converting-enzyme DD-genotype being a renal risk factor. The D-allele is associated with higher ACE concentrations, but functional consequences in diabetes mellitus are not known. To analyse these conseque...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-003-1149-x
更新日期:2003-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association ...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-006-0435-9
更新日期:2006-11-01 00:00:00