Renal proteinases and kidney hypertrophy in experimental diabetes.

abstract：AIMS/HYPOTHESIS:Our aim was to examine the association between markers of insulin resistance and: (1) body fat and waist circumference, taking into account cardiorespiratory fitness in school-aged children; and (2) cardiorespiratory fitness at differing levels of body fat and waist circumference. SUBJECTS AND METHODS:...

journal_title：Diabetologia

authors： Ruiz JR,Rizzo NS,Ortega FB,Loit HM,Veidebaum T,Sjöström M

更新日期：2007-07-01 00:00:00

abstract：:To learn more about the preclinical phase of IDDM we observed for a median period of 46.5 months (range 0.5-69 months) a group of 57 siblings positive for ICA and/or IAA when first screened within 6 months of the diagnosis of the proband. Sequential blood samples and IVGTTs were obtained at intervals of 6-12 months. S...

journal_title：Diabetologia

authors： Knip M,Vähäsalo P,Karjalainen J,Lounamaa R,Akerblom HK

更新日期：1994-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The purpose of this study was to assess the therapeutic implication of leptin in insulin-deficient diabetes. METHODS:Insulin-deficient diabetes was induced by streptozotocin (STZ) in transgenic skinny mice overexpressing leptin. Plasma concentrations of glucose, insulin, and leptin were measured. The e...

journal_title：Diabetologia

authors： Miyanaga F,Ogawa Y,Ebihara K,Hidaka S,Tanaka T,Hayashi S,Masuzaki H,Nakao K

更新日期：2003-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...

journal_title：Diabetologia

authors： Tillin T,Forouhi N,Johnston DG,McKeigue PM,Chaturvedi N,Godsland IF

更新日期：2005-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS:In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and op...

journal_title：Diabetologia

authors： Perez VL,Caicedo A,Berman DM,Arrieta E,Abdulreda MH,Rodriguez-Diaz R,Pileggi A,Hernandez E,Dubovy SR,Parel JM,Ricordi C,Kenyon NM,Kenyon NS,Berggren PO

更新日期：2011-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Aggregation of islet amyloid polypeptide (IAPP) to form amyloid contributes to beta cell dysfunction in type 2 diabetes. Human but not non-amyloidogenic rodent IAPP induces islet macrophage proIL-1β synthesis. We evaluated the effect of IL-1 receptor antagonist (IL-1Ra) on islet inflammation and dysfunc...

journal_title：Diabetologia

authors： Westwell-Roper CY,Chehroudi CA,Denroche HC,Courtade JA,Ehses JA,Verchere CB

更新日期：2015-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with ty...

journal_title：Diabetologia

authors： Eliasson B,Möller-Goede D,Eeg-Olofsson K,Wilson C,Cederholm J,Fleck P,Diamant M,Taskinen MR,Smith U

更新日期：2012-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of baroreflex sensitivity. We studied the determinants of these measures obtained from cardiovascular autonomic function tests in ...

journal_title：Diabetologia

authors： Gerritsen J,Dekker JM,TenVoorde BJ,Bertelsmann FW,Kostense PJ,Stehouwer CD,Heine RJ,Nijpels G,Heethaar RM,Bouter LM

更新日期：2000-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The AERx insulin Diabetes Management system (AERx iDMS) is a liquid aerosol device that enables insulin to be administered to the peripheral parts of the lung. This study aimed to compare the pharmacokinetic and pharmacodynamic properties of insulin which is inhaled using AERx iDMS with insulin which is...

journal_title：Diabetologia

authors： Brunner GA,Balent B,Ellmerer M,Schaupp L,Siebenhofer A,Jendle JH,Okikawa J,Pieber TR

更新日期：2001-03-01 00:00:00

abstract：:Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in...

journal_title：Diabetologia

authors： Weber HE,Menahan LA,Chaudhuri SN,Shipp JC

更新日期：1977-04-01 00:00:00

abstract：:Renal tubular lesions have been studied in streptozotocin-diabetic rats after 50 days of diabetes and compared with age-matched controls. The kidney weight increased by 67% in the diabetic animals and the length of the proximal tubules increased by 22%, but no abnormalities were found. The length of the distal tubules...

journal_title：Diabetologia

authors： Rasch R

更新日期：1984-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...

journal_title：Diabetologia

authors： Shanmugam N,Todorov IT,Nair I,Omori K,Reddy MA,Natarajan R

更新日期：2006-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: ...

journal_title：Diabetologia

authors： Miele C,Beguinot F

更新日期：2012-05-01 00:00:00

abstract：:The capacity of reovirus type 3 to infect insulin-producing B cells was studied in human pancreatic cell cultures. Antibody to reovirus was labelled with fluorescein isothiocyanate and antibody to insulin was labelled with tetramethyl rhodamine isothiocyanate. By using a double-labelled immunofluorescent antibody tech...

journal_title：Diabetologia

authors： Yoon JW,Selvaggio S,Onodera T,Wheeler J,Jenson AB

更新日期：1981-04-01 00:00:00

abstract：:Overall D-glucose metabolism and 3-0-methylglucose transport were measured in the perfused heart preparation of lean and genetically obese (fa/fa) rats. Absolute values of basal and insulin-stimulated glucose metabolism were decreased in hearts of 15-week-old obese rats when compared to lean age-matched controls. Basa...

journal_title：Diabetologia

authors： Zaninetti D,Crettaz M,Jeanrenaud B

更新日期：1983-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Sympathetic nerves influence islet hormone levels in the circulation. Insights into islet sympathetic innervation and its remodelling in diabetes may impact future therapeutics. However, standard immunohistochemistry and microtome-based microscopy cannot provide an integral view of the islet neurovascul...

journal_title：Diabetologia

authors： Chiu YC,Hua TE,Fu YY,Pasricha PJ,Tang SC

更新日期：2012-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...

journal_title：Diabetologia

authors： Vella A,Bouatia-Naji N,Heude B,Cooper JD,Lowe CE,Petry C,Ring SM,Dunger DB,Todd JA,Ong KK

更新日期：2008-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...

journal_title：Diabetologia

authors： Ekelund U,Anderssen SA,Froberg K,Sardinha LB,Andersen LB,Brage S,European Youth Heart Study Group.

更新日期：2007-09-01 00:00:00

abstract：:The NOD mouse, which shows many features of human IDDM, is extensively used to evaluate the role of T lymphocytes in the pathogenesis of autoimmune diabetes. The development of diabetes in this model appears to be controlled by a finely tuned immunoregulatory balance between autoaggressive T cells and regulatory immun...

journal_title：Diabetologia

authors： Sempé P,Richard MF,Bach JF,Boitard C

更新日期：1994-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Maternal Type I (insulin-dependent) diabetes mellitus is associated with an increased risk for fetal malformations and spontaneous abortions. Although the pathogenic mechanism is not fully understood, reactive oxygen species have been shown to contribute to the pathogenesis in experimental studies. By m...

journal_title：Diabetologia

authors： Cederberg J,Basu S,Eriksson UJ

更新日期：2001-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this work was to examine the associations of average weight and weight velocity in three growth periods from birth through adolescence with type 2 diabetes incidence. METHODS:Child participants were selected from a 43 year longitudinal study of American Indians to represent three growth peri...

journal_title：Diabetologia

authors： Olaiya MT,Knowler WC,Sinha M,Kobes S,Nelson RG,Baier LJ,Muller YL,Hanson RL

更新日期：2020-09-01 00:00:00

abstract：:To assess in vivo effects of antioxidants on vascular cell adhesion molecule (VCAM)-1 expression, circulating soluble VCAM-1 and intraerythrocytic reduced glutathione (GSH) and GSH disulphide (GSSG) concentrations were evaluated in non-insulin-dependent diabetic patients without complications (9 men, 6 women, 48 +/- 6...

journal_title：Diabetologia

authors： De Mattia G,Bravi MC,Laurenti O,Cassone-Faldetta M,Proietti A,De Luca O,Armiento A,Ferri C

更新日期：1998-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved...

journal_title：Diabetologia

authors： Strey CH,Young J,Collier M,Florkowski CM,Shand BI,Scott RS

更新日期：2004-10-01 00:00:00

abstract：AIM/HYPOTHESIS:Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown. METHODS:We...

journal_title：Diabetologia

authors： Kim YK,Joung KH,Ryu MJ,Kim SJ,Kim H,Chung HK,Lee MH,Lee SE,Choi MJ,Chang JY,Hong HJ,Kim KS,Lee SH,Kweon GR,Kim H,Lee CH,Kim HJ,Shong M

更新日期：2015-04-01 00:00:00

abstract：:A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the se...

journal_title：Diabetologia

authors： Brandt R,Landmesser C,Vogt L,Hehmke B,Hanschke R,Kasbohm J,Hartmann K,Jäger B,Krantz S,Michaelis D

更新日期：1996-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although insulin resistance has been associated with accumulations of specific intramuscular fatty acids and altered subcellular localisation of lipid droplets, these concepts remain controversial. Therefore, we aimed to identify specific intramuscular fatty acids and subcellular lipid localisations ass...

journal_title：Diabetologia

authors： Holloway GP,Han XX,Jain SS,Bonen A,Chabowski A

更新日期：2014-04-01 00:00:00

abstract：:Islet amyloid polypeptide is a 37 amino acid hormone-like peptide which is the major protein component of islet amyloid deposits commonly found in patients with Type 2 (non-insulin-dependent) diabetes mellitus. Recent studies indicate that a physiologically active form of this peptide appears to be carboxyamidated and...

journal_title：Diabetologia

authors： Sowa R,Sanke T,Hirayama J,Tabata H,Furuta H,Nishimura S,Nanjo K

更新日期：1990-02-01 00:00:00

abstract：:Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and ha...

journal_title：Diabetologia

authors： Cabrera SM,Chen YG,Hagopian WA,Hessner MJ

更新日期：2016-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Neurogenin 3 (NEUROG3), a basic helix-loop-helix transcription factor that is needed for endocrine cell development in the embryonic pancreas, has been shown to induce transdifferentiation of duct cells from adult pancreas towards a neuro-endocrine phenotype. Our study explored the endocrine transdiffer...

journal_title：Diabetologia

authors： Harb G,Heremans Y,Heimberg H,Korbutt GS

更新日期：2006-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. METHODS:The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus...

journal_title：Diabetologia

authors： Gunnlaugsdottir E,Halldorsdottir S,Klein R,Eiriksdottir G,Klein BE,Benediktsson R,Harris TB,Launer LJ,Aspelund T,Gudnason V,Cotch MF,Jonasson F

更新日期：2012-03-01 00:00:00