The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes.

Abstract:

AIMS/HYPOTHESIS:The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS:In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and ophthalmological outcomes were assessed. RESULTS:Islets readily engrafted on the iris and there was a decrease in exogenous insulin requirements due to insulin secretion from the intraocular grafts. No major adverse effects on eye structure and function could be observed during the transplantation period. CONCLUSIONS/INTERPRETATION:Our study demonstrates the long-term survival and function of allogeneic islets after transplantation into the anterior chamber of the eye. The safety and simplicity of this procedure provides support for further studies aimed at translating this technology into the clinic.

journal_name

Diabetologia

journal_title

Diabetologia

authors

Perez VL,Caicedo A,Berman DM,Arrieta E,Abdulreda MH,Rodriguez-Diaz R,Pileggi A,Hernandez E,Dubovy SR,Parel JM,Ricordi C,Kenyon NM,Kenyon NS,Berggren PO

doi

10.1007/s00125-011-2091-y

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1121-6

issue

5

eissn

0012-186X

issn

1432-0428

journal_volume

54

pub_type

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