The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes.


AIMS/HYPOTHESIS:The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS:In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and ophthalmological outcomes were assessed. RESULTS:Islets readily engrafted on the iris and there was a decrease in exogenous insulin requirements due to insulin secretion from the intraocular grafts. No major adverse effects on eye structure and function could be observed during the transplantation period. CONCLUSIONS/INTERPRETATION:Our study demonstrates the long-term survival and function of allogeneic islets after transplantation into the anterior chamber of the eye. The safety and simplicity of this procedure provides support for further studies aimed at translating this technology into the clinic.






Perez VL,Caicedo A,Berman DM,Arrieta E,Abdulreda MH,Rodriguez-Diaz R,Pileggi A,Hernandez E,Dubovy SR,Parel JM,Ricordi C,Kenyon NM,Kenyon NS,Berggren PO




Has Abstract


2011-05-01 00:00:00












  • The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.

    abstract:AIMS/HYPOTHESIS:Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how risk varies according to age, type of autoantibodies and metabolic status. METHODS:Type 1 Diabetes Tri...


    pub_type: 杂志文章


    authors: Jacobsen LM,Bocchino L,Evans-Molina C,DiMeglio L,Goland R,Wilson DM,Atkinson MA,Aye T,Russell WE,Wentworth JM,Boulware D,Geyer S,Sosenko JM

    更新日期:2020-03-01 00:00:00

  • Diurnal rhythms in the white adipose tissue transcriptome are disturbed in obese individuals with type 2 diabetes compared with lean control individuals.

    abstract:AIMS/HYPOTHESIS:Animal studies have indicated that disturbed diurnal rhythms of clock gene expression in adipose tissue can induce obesity and type 2 diabetes. The importance of the circadian timing system for energy metabolism is well established, but little is known about the diurnal regulation of (clock) gene expres...


    pub_type: 杂志文章


    authors: Stenvers DJ,Jongejan A,Atiqi S,Vreijling JP,Limonard EJ,Endert E,Baas F,Moerland PD,Fliers E,Kalsbeek A,Bisschop PH

    更新日期:2019-04-01 00:00:00

  • Continuous subcutaneous insulin infusion versus multiple daily insulin injections in patients with diabetes mellitus: systematic review and meta-analysis.

    abstract:AIMS:We compared the effects of continuous subcutaneous insulin infusion (CSII) with those of multiple daily insulin (MDI) injections on glycaemic control, risk of hypoglycaemic episodes, insulin requirements and adverse events in type 1 and type 2 diabetes mellitus. METHODS:The electronic databases MEDLINE, EMBASE an...


    pub_type: 杂志文章,meta分析,评审


    authors: Jeitler K,Horvath K,Berghold A,Gratzer TW,Neeser K,Pieber TR,Siebenhofer A

    更新日期:2008-06-01 00:00:00

  • Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay.

    abstract::Measurement of insulin autoantibodies (IAA) with a novel micro radiobinding assay which requires only 20 microl of serum was compared with that in a conventional radiobinding assay which uses 600 microl of serum. IAA were measured with both assays in samples from 94 new onset insulin-dependent diabetes mellitus (IDDM)...


    pub_type: 杂志文章


    authors: Naserke HE,Dozio N,Ziegler AG,Bonifacio E

    更新日期:1998-06-01 00:00:00

  • Hepatic glucose and lipid metabolism.

    abstract::The liver has a central role in the regulation of systemic glucose and lipid fluxes during feeding and fasting and also relies on these substrates for its own energy needs. These parallel requirements are met by coordinated control of carbohydrate and lipid fluxes into and out of the Krebs cycle, which is highly tuned...


    pub_type: 杂志文章,评审


    authors: Jones JG

    更新日期:2016-06-01 00:00:00

  • Case fatality rates after first acute coronary syndrome in persons treated for type 2 diabetes show an improving trend.

    abstract:AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...


    pub_type: 杂志文章


    authors: Winell KM,Pääkkönen R,Pietilä A,Niemi MK,Reunanen AR,Salomaa VV

    更新日期:2010-03-01 00:00:00

  • Proteomic characterisation reveals active Wnt-signalling by human multipotent stromal cells as a key regulator of beta cell survival and proliferation.

    abstract:AIMS/HYPOTHESIS:Novel strategies to stimulate the expansion of beta cell mass in situ are warranted for diabetes therapy. The aim of this study was to elucidate the secretome of human bone marrow (BM)-derived multipotent stromal cells (MSCs) with documented islet regenerative paracrine function. We hypothesised that re...


    pub_type: 杂志文章


    authors: Kuljanin M,Bell GI,Sherman SE,Lajoie GA,Hess DA

    更新日期:2017-10-01 00:00:00

  • Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals.

    abstract:AIMS/HYPOTHESIS:Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2...


    pub_type: 杂志文章


    authors: Yu DX,Sun Q,Ye XW,Pan A,Zong G,Zhou YH,Li HX,Hu FB,Lin X

    更新日期:2012-11-01 00:00:00

  • Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation.

    abstract:AIMS/HYPOTHESIS:Diabetic distal symmetrical sensory polyneuropathy (DSP) affects 20-30% of diabetic patients. Transcutaneous electrical nerve stimulation (TENS) and electrical spinal cord stimulation have been proposed as physical therapies. We performed a controlled, randomised pilot trial to compare the effects of hi...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Reichstein L,Labrenz S,Ziegler D,Martin S

    更新日期:2005-05-01 00:00:00

  • Glycated albumin but not HbA1c reflects glycaemic control in patients with neonatal diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...


    pub_type: 杂志文章


    authors: Suzuki S,Koga M,Amamiya S,Nakao A,Wada K,Okuhara K,Hayano S,Sarhat AR,Takahashi H,Matsuo K,Tanahashi Y,Fujieda K

    更新日期:2011-09-01 00:00:00

  • Comparison of the course to end-stage renal disease of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic nephropathy.

    abstract::Is the course leading to diabetic end-stage renal disease similar for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus? We identified all diabetic end-stage renal disease patients starting renal replacement therapy from 1989 to 1991 in two urban counties in Texas. Three ethnic/racial gro...


    pub_type: 杂志文章


    authors: Pugh JA,Medina R,Ramirez M

    更新日期:1993-10-01 00:00:00

  • Differential binding of sulphated insulin to adipocytes and hepatocytes.

    abstract::The polymerization and precipitation of highly purified insulins which causes major problems in portable infusion systems does not occur with sulphated insulin. To compare the biological behaviour of sulphated insulin with that of a neutral highly purified monocomponent insulin, insulin receptor studies were performed...


    pub_type: 杂志文章


    authors: Zeuzem S,Taylor R,Agius L,Albisser AM,Alberti KG

    更新日期:1984-08-01 00:00:00

  • Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.

    abstract:AIMS/HYPOTHESIS:The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. METHODS:Control and streptozotocin diabetic mice,...


    pub_type: 杂志文章


    authors: Sourris KC,Morley AL,Koitka A,Samuel P,Coughlan MT,Penfold SA,Thomas MC,Bierhaus A,Nawroth PP,Yamamoto H,Allen TJ,Walther T,Hussain T,Cooper ME,Forbes JM

    更新日期:2010-11-01 00:00:00

  • The prenatal environment and type 1 diabetes.

    abstract::There is ample evidence that environmental factors are involved in the aetiology of type 1 diabetes, but the nature and timing of the interactions are poorly understood. The intrauterine environment is known to play a role in the later development of type 2 diabetes, and this review considers a possible role in type 1...


    pub_type: 杂志文章,评审


    authors: Stene LC,Gale EA

    更新日期:2013-09-01 00:00:00

  • Differential effects of a nitric oxide donor on reperfusion-induced microvascular dysfunction in diabetic and non-diabetic rats.

    abstract:AIMS/HYPOTHESIS:Diabetes is associated with a high incidence of ischaemic disease and impaired nitric oxide responses. Therefore, the aim of the present study was to assess the effect of nitric oxide on ischaemia/reperfusion (I/R)-induced microvascular responses in an experimental model of diabetes. METHODS:Leucocyte-...


    pub_type: 杂志文章


    authors: Salas A,Panés J,Rosenbloom CL,Elizalde JI,Anderson DC,Granger DN,Piqué JM

    更新日期:1999-11-01 00:00:00

  • Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

    abstract:AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...


    pub_type: 杂志文章


    authors: Rönn T,Poulsen P,Hansson O,Holmkvist J,Almgren P,Nilsson P,Tuomi T,Isomaa B,Groop L,Vaag A,Ling C

    更新日期:2008-07-01 00:00:00

  • miR-195 regulates SIRT1-mediated changes in diabetic retinopathy.

    abstract:AIMS/HYPOTHESIS:Endothelial cell (EC) damage is a key mechanism causing retinal microvascular injury in diabetes. Several microRNAs (miRNAs) have been found to regulate sirtuin 1 (SIRT1, which is involved in regulation of the cell cycle, survival and metabolism) in various tissues and disease states, but no studies hav...


    pub_type: 杂志文章


    authors: Mortuza R,Feng B,Chakrabarti S

    更新日期:2014-05-01 00:00:00

  • Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.

    abstract:AIMS/HYPOTHESIS:We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. METHODS:Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were analysed in >17,000 individuals (1,307 type 2 di...


    pub_type: 杂志文章,meta分析


    authors: Talmud PJ,Cooper JA,Gaunt T,Holmes MV,Shah S,Palmen J,Drenos F,Shah T,Kumari M,Kivimaki M,Whittaker J,Lawlor DA,Day IN,Hingorani AD,Casas JP,Humphries SE

    更新日期:2011-07-01 00:00:00

  • Direct effect of GLP-1 infusion on endogenous glucose production in humans.

    abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-1 (GLP-1) lowers glucose levels by potentiating glucose-induced insulin secretion and inhibiting glucagon release. The question of whether GLP-1 exerts direct effects on the liver, independently of the hormonal changes, is controversial. We tested whether an exogenous GLP-1 infusio...


    pub_type: 临床试验,杂志文章


    authors: Seghieri M,Rebelos E,Gastaldelli A,Astiarraga BD,Casolaro A,Barsotti E,Pocai A,Nauck M,Muscelli E,Ferrannini E

    更新日期:2013-01-01 00:00:00

  • Pharmacokinetics of continuous subcutaneous insulin infusion.

    abstract::One of the reasons for the variability of blood glucose regulation in Type 1 (insulin-dependent) diabetic patients is the huge variation in subcutaneous absorption of intermediate-acting insulin. We have investigated the variation in insulin absorption during continuous subcutaneous insulin infusion in eight such pati...


    pub_type: 杂志文章


    authors: Lauritzen T,Pramming S,Deckert T,Binder C

    更新日期:1983-05-01 00:00:00

  • Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.

    abstract:UNLABELLED:AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associate...


    pub_type: 杂志文章


    authors: Weets I,Van Autreve J,Van der Auwera BJ,Schuit FC,Du Caju MV,Decochez K,De Leeuw IH,Keymeulen B,Mathieu C,Rottiers R,Dorchy H,Quartier E,Gorus FK,Belgian Diabetes Registry.

    更新日期:2001-01-01 00:00:00

  • The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial.

    abstract:AIMS/HYPOTHESIS:The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised cont...


    pub_type: 杂志文章,随机对照试验


    authors: Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S

    更新日期:2014-05-01 00:00:00

  • Effect of the enteroinsular axis on both the A- and B-cell response to arginine after oral glucose in man.

    abstract::Studies were made on the effect of the enteroinsular axis on amino acid-induced insulin and glucagon secretion during hyperglycaemia in man. The responses of plasma immunoreactive insulin, C-peptide, and immunoreactive glucagon to arginine infusion were investigated in nine healthy subjects after induction of hypergly...


    pub_type: 杂志文章


    authors: Shimizu I,Hirota M,Ohboshi C,Mizuno A,Shima K

    更新日期:1987-11-01 00:00:00

  • Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes--the EURODIAB Prospective Complications Study.

    abstract:AIMS/HYPOTHESIS:The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes. METHODS:A cross-sectional nested case-control study of the foll...


    pub_type: 杂志文章,多中心研究


    authors: Schram MT,Chaturvedi N,Schalkwijk CG,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

    更新日期:2005-02-01 00:00:00

  • A genetic marker at the glucokinase gene locus for type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles.

    abstract::The prevalence of Type 2 (non-insulin-dependent) diabetes mellitus is high in Mauritius, a multiethnic island nation in the southwestern Indian Ocean. Evaluation of candidate genes in the different ethnic groups represents a means of assessing the genetic component. As glucokinase is known to be a key regulator of glu...


    pub_type: 杂志文章


    authors: Chiu KC,Province MA,Dowse GK,Zimmet PZ,Wagner G,Serjeantson S,Permutt MA

    更新日期:1992-07-01 00:00:00

  • Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells.

    abstract:AIMS/HYPOTHESIS:Previous studies have implicated the glycoxidative modification of low-density lipoprotein (LDL) by glucose and aldehydes (apparently comprising both glycation and oxidation), as a causative factor in the elevated levels of atherosclerosis observed in diabetic patients. Such LDL modification can result ...


    pub_type: 杂志文章


    authors: Brown BE,Dean RT,Davies MJ

    更新日期:2005-02-01 00:00:00

  • Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery.

    abstract:AIMS/HYPOTHESIS:The intestine is the main site for glucose absorption and it has been suggested that it exhibits insulin resistance. Bariatric surgery has been shown to reverse insulin resistance and type 2 diabetes, but its effects on human intestinal metabolism are unknown. Our aim was to evaluate the effects of insu...


    pub_type: 杂志文章


    authors: Mäkinen J,Hannukainen JC,Karmi A,Immonen HM,Soinio M,Nelimarkka L,Savisto N,Helmiö M,Ovaska J,Salminen P,Iozzo P,Nuutila P

    更新日期:2015-05-01 00:00:00

  • Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue.

    abstract:AIMS/HYPOTHESIS:Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to low-doses of ultraviolet radiation (UVR) reduced weight gain and signs of diabetes in male mice fed a high-fat diet, in part via release of nitric oxide from skin. He...


    pub_type: 杂志文章


    authors: Dhamrait GK,Panchal K,Fleury NJ,Abel TN,Ancliffe MK,Crew RC,Croft K,Fernandez BO,Minnion M,Hart PH,Lucas RM,Mark PJ,Feelisch M,Weller RB,Matthews V,Gorman S

    更新日期:2020-01-01 00:00:00

  • Transcapillary escape rate and albuminuria in Type II diabetes. Effects of short-term treatment with low-molecular weight heparin.

    abstract::The relation between urinary albumin excretion rate (UAE), transcapillary escape rate of albumin (TERalb), haemostatic factors, ambulatory blood pressure, and metabolic variables was investigated in 45 Type II (non-insulin-dependent) diabetic patients without overt nephropathy or uncontrolled blood pressure. We enroll...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Nielsen S,Schmitz A,Bacher T,Rehling M,Ingerslev J,Mogensen CE

    更新日期:1999-01-01 00:00:00

  • Functional studies in patients with the glucagonoma syndrome.

    abstract::Four patients with glucagon-producing tumours of the pancreas were investigated. Fasting plasma glucagon concentrations ranged from 209--625 pmol/l. Plasma insulin concentrations were normal except in one patient, where the tumour also produced insulin (558 pmol/l). Intravenous glucose (25 g/m2) depressed the glucagon...


    pub_type: 杂志文章


    authors: Holst JJ,Helland S,Ingemannson S,Pedersen NB,von Schenck H

    更新日期:1979-09-01 00:00:00